Characteristics of alcoholic liver disease and predictive factors for mortality of patients with alcoholic cirrhosis

作     者：Yan-Di Xie Bo Feng Yan Gao Lai Wei 

作者机构：Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immuno-therapy for Liver Disease 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2013年第12卷第6期

页      面：594-601页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：alcoholic liver disease model for end-stage liver disease mortality prognostic factors risk factors 

摘      要：BACKGROUND:Alcoholic liver disease is one of the major chronic liver diseases *** aim of the study was to describe the clinical characteristics of alcoholic liver disease and to compare the predictive values of biochemical parameters,complications,Child-Turcotte-Pugh score,model for end-stage liver disease(MELD)score and discriminant function score for the mortality of in-hospital or 3-month after discharge of patients with alcoholic cirrhosis(AC).METHODS:A retrospective record review and statistical analysis were performed on 205 consecutive patients with the discharge diagnosis of alcoholic liver *** models were used to predict the mortality of patients with *** number of variceal hemorrhage,infection,hepatic encephalopathy and hepatocellular carcinoma was analyzed asnumbers of complications.Model 1 consisted of creatinine,white blood cell count,international normalized ratio andnumbers of complications.Model 2 consisted of MELD *** 3includednumbers of complicationsand MELD ***:The risk of developing AC was significant for patients with alcohol consumption of higher than 80 g/d(OR=2.807,P0.050)and drinking duration of longer than 10 years(OR=3.429,P0.028).The area under curve for predicting inhospital mortality of models 1,2 and 3 was 0.950,0.886 and 0.911(all P0.001),*** area under curve for predicting the 3-month mortality of models 1,2 and 3 was 0.867,0.878 and0.893(all P0.001),***:There is a dose-dependent relationship between alcohol consumption and the risk of developing *** score has a better predictive value than Child-TurcottePugh or discriminant function score for patients with AC,and model 1 or 3 is better than model 2.