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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu gao Dayong wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

玉米转录因子Pl表达载体的构建及大花君子兰遗传转化体系的建立

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分子植物育种 2017年第7期15卷 2636-2641页

作者：孙威王钦美王玉章高翔王丽东北师范大学生命科学学院长春130024 贵州师范大学生命科学学院贵阳550025 沈阳农业大学林学院沈阳110866

大花君子兰是具有广泛市场价值的重要室内观赏花卉。但是,常规遗传育种周期时间长,污染率高和转化率低等原因,是君子兰遗传育种中普遍存在的问题。针对这些问题,本研究构建了以甘露糖异构酶基因(Pmi)为筛选基因并带有玉米Pl转录因子的pB... 详细信息

大花君子兰是具有广泛市场价值的重要室内观赏花卉。但是,常规遗传育种周期时间长,污染率高和转化率低等原因,是君子兰遗传育种中普遍存在的问题。针对这些问题,本研究构建了以甘露糖异构酶基因(Pmi)为筛选基因并带有玉米Pl转录因子的pBI121-Pl真核表达载体,以茎尖分生组织作为受体,进行了大花君子兰遗传转化体系的探究。确定了无菌植株的最佳遗传转化方案、准确的共培养时间和温度以及最适甘露糖筛选浓度,初步证明Pl基因已成功整合到大花君子兰基因组中并获得了转基因植株,有助于君子兰的遗传育种的研究。

关键词：大花君子兰 Pl转录因子 Pmi 遗传育种

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao gao Zhengwei wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

黄、渤海沉积物中陆源脂类有机质的组成分布与转化特征

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海洋学报 2017年第2期39卷 53-61页

作者：高寒凌邹立王凯叶曦雯中国海洋大学环境科学与工程学院山东青岛266100 中国海洋大学海洋环境与生态教育部重点实验室山东青岛266100 山东出入境检验检疫局山东青岛266001

本文对黄、渤海表层沉积物中脂类化合物的组成进行了分析研究。结果表明,黄、渤海表层沉积物有机碳的含量为0.03%~1.02%,以黄河口含量最低,黄河口外和双台子河口外,以及北黄海和南黄海中部含量较高。有机质碳稳定同位素δ13C的分布为-21... 详细信息

本文对黄、渤海表层沉积物中脂类化合物的组成进行了分析研究。结果表明,黄、渤海表层沉积物有机碳的含量为0.03%~1.02%,以黄河口含量最低,黄河口外和双台子河口外,以及北黄海和南黄海中部含量较高。有机质碳稳定同位素δ13C的分布为-21.55‰^-24.28‰,表征其陆海双重来源特征,并且海源特征由河口向海、由近岸向离岸逐渐增强。陆源脂类化合物以河口处略高,河道处略低,由河口向渤海中部和靠近渤海海峡方向迅速降低,表现出显著的河流输入特征;其形态组成由河道的游离态接近100%的绝对优势,迅速转变为渤海中部的以皂化结合态为主(大于50%),仅在渤海中部和渤海海峡附近存在小于5%的矿物结合态,转化程度较低。北黄海中部和南黄海中部泥质区的有机碳和陆源脂类化合物显著富集,但其对总有机碳的相对贡献较小;其中皂化结合态超过50%,矿物结合态小于10%,说明其具有中等偏高的转化程度。

关键词：渤海黄海沉积物有机碳脂类化合物

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钢液湍流漩涡中夹杂物运动行为

钢铁研究学报 2017年第1期29卷 32-38页

作者：赵定国高茗李新王书桓华北理工大学冶金与能源学院河北唐山063009

为研究钢液中湍流漩涡对钢中夹杂物行为的影响,采用Matlab软件对不同尺寸夹杂物所受斯托克斯阻力、重力、向心力进行分析,并构建钢液湍流漩涡中夹杂物运动行为模型。计算结果表明:漩涡中尺寸0~23μm的夹杂物以0~1m/s的初始切向速度做向... 详细信息

为研究钢液中湍流漩涡对钢中夹杂物行为的影响,采用Matlab软件对不同尺寸夹杂物所受斯托克斯阻力、重力、向心力进行分析,并构建钢液湍流漩涡中夹杂物运动行为模型。计算结果表明:漩涡中尺寸0~23μm的夹杂物以0~1m/s的初始切向速度做向心运动,逐渐聚集至涡心,其跃迁轨迹呈螺旋锥形,跃迁角、跃迁起点和终点与粒径、涡速相关。粒径、涡速越大,跃迁角越大,跃迁终点离涡心越远;而大于此尺寸范围的夹杂物惯性作用较强,离心运动趋势较大,重力将超过斯托克斯阻力成为主要作用力。通过水模拟实验得出漩涡中夹杂物的运动轨迹为螺旋锥形,与理论模型结果一致。

关键词：湍流漩涡夹杂物向心运动轨道跃迁

Flammability Properties of Composites of Wood Fiber and Recycled Plastic

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Chinese Forestry Science and Technology 2008年第2期7卷 23-28页

作者： gao li wang Zheng CHANG liang Research Institute of Wood Industry, China Academy of Forestry, Beijing100091, P. R. China

Flammability properties of composites of wood fiber and recycled plastic were evaluated by the cone calorimeter and oxygen index chamber. Results were shown as follows: 1) Wood-PVC composite showed worse thermal stability on time to ignition (TTI) and mean heat release rate (MHRR), but better performance on heat release rate (HRR) and mean efficient heat of combustion (MEHC); wood-PP composite had better thermal stability properties, but was worse on other fire performance; 2) Compared with wood-PVC composite, wood-PP composite showed excellent thermal stability, but behaved dangerous as a whole; 3) Coupling agent PAPI changed fire performance of wood-PP composite and showed a longer TTI, lower EHC but higher HRR. It can be concluded that flame resistance treatment should be considered if wood-plastic composites are used as decorated materials.

关键词： recycled plastic composite flammability properties

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun wang Shuai wang Yan li libo Chen Handong Jiao Zhijing Yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (liMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** liMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of liMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of liMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable liMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： lithium manganese iron phosphate High energy density lithium-ion batteries Reaction mechanism Tap density

经济结构调整对人口城镇化与土地城镇化协调性的影响差异

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中国人口·资源与环境 2018年第5期28卷 93-104页

作者：朱高立邹伟王雪琪南京农业大学公共管理学院江苏南京210095

人口城镇化与土地城镇化是城镇化的核心内容,两者的协调发展水平直接关系到城镇化发展的质量。利用动态修正的协调度模型测算出中国31个省市的人口城镇化与土地城镇化协调度,在此基础上,实证研究了不同类型经济结构对全国及东、中、西... 详细信息

人口城镇化与土地城镇化是城镇化的核心内容,两者的协调发展水平直接关系到城镇化发展的质量。利用动态修正的协调度模型测算出中国31个省市的人口城镇化与土地城镇化协调度,在此基础上,实证研究了不同类型经济结构对全国及东、中、西三大区域城镇化协调度的影响机制、方向及程度。研究表明:(1)各省市的城镇化协调度虽然呈逐年上升态势,但整体仍然处于较低水平。(2)城镇化协调度演变具有阶段性特征,2007年以前各省市的城镇化协调度增长幅度较小,之后增幅明显加快。(3)城镇化协调度存在空间分异现象,整体上,协调度呈由东向西递减态势。(4)固定资产投资/GDP(投资结构)的提高对城镇化协调度提升的贡献最大,原因可能是固定资产投资可以通过短期的需求效应和长期的供给效应促进人口城镇化与土地城镇化的发展。城乡收入差距(城乡收入分配结构)的拉大则会显著降低城镇化协调性水平,原因可能是城乡收入差距的拉大一方面会使得城镇相对农村拥有更大的吸引力,从而促使农村人口流入城镇寻求收入上的相对均衡;另一方面收入差距的拉大会降低社会的边际消费倾向,从而弱化社会经济活力,阻碍土地城镇化进程,因此需要通过平衡城乡间的资源分配,提高农村地区的人力资本来缩小城乡收入差距。(5)影响东、中、西地区城镇化协调度的关键经济结构因素存在地区差异,其中,固定资产投资/GDP(投资结构)是影响东部地区城镇化协调度最主要的因素;城乡居民储蓄额/GDP(金融结构)对中部和西部地区城镇化协调度的提高均有最大贡献。因此,地方政府在制定城镇化发展政策时应分区域对症下药。

关键词：经济结构人口城镇化土地城镇化协调发展

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang gao Xinyue wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease