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Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation

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Chinese Chemical Letters 2015年第12期26卷 1502-1506页

作者： gao-lei wang Xi Chen Ya-Ning Chang Dan Du Zhong Li Xiao-Yong Xu Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai Collaborative Innovation Center for Biomanufacturing Technology East China University of Science and Technology Shanghai Key Laboratory of Chemical Biology School of Pharmacy

To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 6k and 6p displayed 100%inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.

关键词： Meloidogyne incognita displayed endowed moderate implied potent crops removed afford

Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors

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Chinese Chemical Letters 2017年第5期28卷 1044-1048页

作者： Fan Zhang Dang Wu gao-lei wang Shuang Hou Ping Ou-Yang Jin Huang Xiao-Yong Xu Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and TechnologyShanghai 200237China

A series of novel 1,2,3-benzotriazin-4-one derivatives were designed,synthesized and their inhibitory activities against leulcotriene A4 hydrolase aminopeptidase in vitro were *** compounds showed moderate to good activities at the concentration of 10 μmol/*** them,compound Ⅳ-16 exhibited the highest inhibitory activity up to 80.6% with an IC50 of 1.30 ± 0.20 μmol/L The compound Ⅳ-16 was also tested the proliferation inhibitory activities in THP1 human AML cell line and its binding model with LTA_4H enzyme by molecular docking was *** indicated that 1,2,3-benzotriazin-4-one was a promising scaffold for further *** relationship between structure and inhibitory activity was also preliminarily discussed.

关键词： 1 2 3-Benzotriazin-4-one Leukotriene A4 hydrolase Aminopeptidase activity In vitro Aminopeptidase inhibitors

Effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein sleeve cardiomyocytes with atrial fibrillation

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Journal of Geriatric Cardiology 2008年第1期5卷 39-42页

作者： Yang Li Yan Huang Zongbin Li Hao wang Jianguo Song Yuqi Liu lei gao Shiwen wang Institute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china

Objective To study the effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein(PY) sleeve cardiomyocytes with atrial *** Dissociation of PVs yielded single cardiomyocytes from a Landengorff column without or with pacemaker activity from long-term rapidly atrial pacing (RAP) *** current was measured with the whole-cell patch-clamp *** Compared with the control group,the rapidly atrial pacing canine PV cardiomyocytes had spontaneous diastolic depolarization and had larger If *** (Iva,1 μM),a selective inhibitor of the If current,markedly reduced If currents in the RAP from -2.66±0.4 pA/pF to -1.58±0.1 pA/pF at the test potential of-120 mV (P＜0.01,n=12).Inhibition effect of Iva of If current showed concentration-dependent range from 0.1 to 10.0μM,with IC50 of 2.2 μ M ( 1.8-2.9 μM,95% CL).Furthermore,V1/ of steady-state activated curve was shifted from -84.3±4.9 mV to -106.9±3.4 mV and k value of steady-state activated curve was changed from 12.1+2.6 mV to 9.9±3.4 mV by the application of.1.0 μM Iva ( P＜0.01,n=12).Conclusions Our study revealed that Ivarbadine may significantly decrease If of rapidly atrial pacing pulmonary vein sleeve ceUs with atrial fibdllation.(J Geriatr Cardiol 2008;5:39-42)

关键词： ivarbadine hyperpolarization activated cation anine pulmonary vein sleeves atrial fibrillation

Synthesis and Catalytic Performance on DME Conversion of Different Size SAPO-34 Crystals

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Synthesis and Catalytic Performance on DME Conversion of Dif...

Studies on Flavonoids (XII) --Synthesis of 7-0-(β-D-Mannopyranosyl) -Flavone and Determination of Its Configuration

第四届中美化学工程会议和第三届中日化工研讨会合并的三边化学工程大会

作者： Huaqun Zhou, lei gao, Zhanwen wang, Yao wang, Fei Wei Tsinghua University, China

Conversion of methanol or dimethylether (DME) to olefins (MTO or DTO) has been investigated extensively to search for an alternative economic route for supplying the basic raw materials of the petrochemical industry. Molecular sieve SAPO-34 used in MTO/DTO is recognized as the most suitable catalyst for its high activity and olefins selectivity.

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Chemical Journal of Chinese Universities 1988年第3期 86-89页

作者： Zhang Peiying, Qian lei, gao Congyuan, wang Dong Cai Mengshen (School of Pharmaceutical Sciences, Beijing Medical University, Beijing)

Introduction Flavonoids usually exist in the form of glycoside in nature. Different kinds of sugar and aglycone moieties will lead to different physiological *** natural flavonoid Dglycosides are usually β-anomers.

关键词： Flavonoids 7-O-(β-D-Mannopyranosyl)-flavone Synthesis Determination of configuration

基于混沌更新策略的蜂群算法在SVM参数优化中的应用

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计算机工程与科学 2017年第1期39卷 199-205页

作者：高雷阜王飞辽宁工程技术大学优化与决策研究所辽宁阜新123000

针对支持向量机的参数寻优缺乏数学理论指导,传统人工蜂群算法易陷入长期停滞的不足,而混沌搜索算法具有很好的随机性和遍历性,提出了基于混沌更新策略人工蜂群支持向量机参数选择模型(IABC-SVM)。该模型利用混沌搜索对侦察蜂搜索方式... 详细信息

针对支持向量机的参数寻优缺乏数学理论指导,传统人工蜂群算法易陷入长期停滞的不足,而混沌搜索算法具有很好的随机性和遍历性,提出了基于混沌更新策略人工蜂群支持向量机参数选择模型(IABC-SVM)。该模型利用混沌搜索对侦察蜂搜索方式进行改进,有效提高蜂群算法搜索效率。以UCI标准数据库中的数据进行数值实验,采用ACO-SVM、PSO-SVM、ABC-SVM作为对比模型,实验表明了IABC在SVM参数优化中的可行性和有效性,具有较高的预测准确率和较好的算法稳定性。

关键词：支持向量机参数寻优人工蜂群算法混沌搜索预测准确率

核酸适配体封盖的介孔二氧化硅纳米颗粒用于肌红蛋白的检测

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高等学校化学学报 2017年第2期38卷 187-192页

作者：高蕾王青羊小海王柯敏邓鹏张华李志平湖南大学化学生物传感与计量学国家重点实验室化学化工学院生物纳米与分子工程湖南省重点实验室长沙410082

利用核酸适配体封盖的介孔二氧化硅纳米颗粒构建了一种新型、简便及免标记的肌红蛋白定量检测方法.首先,用肌红蛋白核酸适配体将荧光小分子罗丹明6G封盖在介孔颗粒内,当存在目标物肌红蛋白时,由于介孔颗粒上的核酸适配体可特异性结合肌... 详细信息

利用核酸适配体封盖的介孔二氧化硅纳米颗粒构建了一种新型、简便及免标记的肌红蛋白定量检测方法.首先,用肌红蛋白核酸适配体将荧光小分子罗丹明6G封盖在介孔颗粒内,当存在目标物肌红蛋白时,由于介孔颗粒上的核酸适配体可特异性结合肌红蛋白而脱离介孔颗粒表面,进而释放介孔颗粒内的罗丹明6G,使溶液荧光强度增强.实验结果表明,荧光强度与肌红蛋白的浓度呈正相关,通过荧光强度的变化可实现对肌红蛋白的定量检测.该方法的检出限低至1.1 nmol/L,且选择性好,可满足临床医学的检测要求.

关键词：核酸适配体肌红蛋白介孔二氧化硅纳米颗粒

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燃气轮机燃烧室的现状及发展趋势

能源研究与信息 2017年第3期33卷 159-166页

作者：高磊汪军上海理工大学能源与动力工程学院上海200093

针对我国燃气轮机燃烧室污染物排放的现状,介绍了各国对民用航空和工业用燃气轮机的排放规定,分析了燃气轮机燃烧室主要污染物的生成机理、影响因素以及减少污染物排放的措施.对先进的低污染燃烧室中具有代表性和发展前景的四种类型燃... 详细信息

针对我国燃气轮机燃烧室污染物排放的现状,介绍了各国对民用航空和工业用燃气轮机的排放规定,分析了燃气轮机燃烧室主要污染物的生成机理、影响因素以及减少污染物排放的措施.对先进的低污染燃烧室中具有代表性和发展前景的四种类型燃烧室作了简要的介绍,它们分别为双环预混旋流(TAPS)燃烧室、贫油预混预蒸发(LPP)燃烧室、富油燃烧-焠熄-贫油燃烧(RQL)低污染燃烧室以及驻涡燃烧室(TVC).并且介绍了高温升燃烧室的研究现状以及关键技术难题.最后,对燃烧室火焰筒多斜孔冷却、冲击/多斜孔复合冷却、层板冷却以及冲击/气膜冷却等四种方式的现状进行了讨论.

关键词：燃烧室低污染高温升冷却方式

Ventricular Septal Defect Spontaneous Close Induced by Transcatheter: A Case Report

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South China Journal of Cardiology 2007年第4期8卷 218-219,224页

作者： Qilian Xie Jun wang lei gao Zhen wang Milin Zhang Kunshen Liu The Center of Congenital Heart Disease The First Hospital of Hebei Medical UniversityHebei Medical University Shifiazhuang 050031 China

Congenital ventricular septal defect （VSD） spontaneous close induced by transcatheter treatment is rare and has not yet been reported. We report on one case of VSD spontaneous close induced by transcatheter treatmen... 详细信息

关键词： congenital ventricular septal defect transcatheter