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Hole cleaning evaluation and installation spacing optimization of cuttings bed remover in extended-reach drilling

Petroleum Science 2024年第3期21卷 2005-2022页

作者： Shuo Peng Wen-jun Huang De-Li gao MOE Key Laboratory of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China

In extended-reach or long-horizontal drilling,cuttings usually deposit at the bottom of the *** cuttings accumulate to a certain thickness,complex problems such as excessive torque and drag,tubing buckling,and pipe stuck probably occur,which results in a lot of non-productive time and remedial *** bed remover can efficiently destroy deposited cuttings in time through hydraulic and mechanical stirring *** paper aims to build a method for hole cleaning evaluation and installation spacing optimization of cuttings bed remover to improve the wellbore cleaning ***,a Computational Fluid Dynamics approach with Eulerian—Eulerian multiphase model was utilized to investigate the mechanism of cuttings transportation,and a new type of cuttings bed remover was ***,an evaluation method of hole cleaning effect of remover was *** that,the effects of several drilling parameters on hole cleaning including flow rate of drilling fluid,rotational speed of drillpipe,rate of penetration,wellbore size,rheological property of drilling fluid,and remover eccentricity on the performance of cuttings bed remover were *** results demonstrate that the new type of remover with streamline blade performs better than conventional *** efficiency of hole cleaning is greatly improved by increasing the rotational speed of drillpipe,flow rate of drilling fluid,remover eccentricity,and 6 rpm Fann dial reading for drilling *** higher rate of penetration and large wellbore size result in worse hole *** findings can serve as an important guide for the structure optimization design of cuttings bed remover and installation spacing of removers.

关键词： Extended-reach drlling Drilling hydraulics Cuttings transport Hole cleaning Cuttings bed remover

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Ripening and rot:How ripening processes influence disease susceptibility in fleshy fruits

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Journal of Integrative Plant Biology 2024年第9期66卷 1831-1863页

作者： shan Li Yu Zhao Pan Wu Donald Grierson Lei gao State Key Laboratory of Plant Diversity and Specialty Crops Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China Plant and Crop Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughboroughLE125RDUK Hubei Hongshan Laboratory Wuhan 430070China

Fleshy fruits become more susceptible to pathogen infection when they ripen;for example,changes in cell wall properties related to softening make it easier for pathogens to infect *** need for high-quality fruit has driven extensive research on improving pathogen resistance in important fruit crops such as tomato(Solanum lycopersicum).In this review,we summarize current progress in understanding how changes in fruit properties during ripening affect infection by *** changes affect physical barriers that limit pathogen entry,such as the fruit epidermis and its cuticle,along with other defenses that limit pathogen growth,such as preformed and induced defense *** plant immune system also protects ripening fruit by recognizing pathogens and initiating defense responses involving reactive oxygen species production,mitogen-activated protein kinase signaling cascades,and jasmonic acid,salicylic acid,ethylene,and abscisic acid *** phytohormones regulate an intricate web of transcription factors(TFs)that activate resistance mechanisms,including the expression of pathogenesis-related *** tomato,ripening regulators,such as RIPENING INHIBITOR and NON_RIPENING,not only regulate ripening but also influence fruit defenses against ***,members of the ETHYLENE RESPONSE FACTOR(ERF)family play pivotal and distinct roles in ripening and defense,with different members being regulated by different *** also discuss the interaction of ripening-related and defense-related TFs with the Mediator transcription *** the ripening processes in climacteric and non-climacteric fruits share many similarities,these processes have broad applications across fruiting *** research on the individual contributions of ERFs and other TFs will inform efforts to diminish disease susceptibility in ripe fruit,satisfy the growing demand for high-quality fruit and decrease food waste and related economic losses.

关键词： fleshy fruit pathogen phytohormones ripening transcription factors

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Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe

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Light(Science & Applications) 2024年第9期13卷 1741-1756页

作者： Wei Ren Xichuan Ge Meiqi Li Jing Sun Shiyi Li Shu gao Chunyan shan Baoxiang gao Peng Xi Department of Biomedical Engineering National Biomedical Imaging CenterCollege of Future TechnologyPeking UniversityBeijing 100871China Key Laboratory of Analytical Science and Technology of Hebei Province College of Chemistry and Material ScienceHebei UniversityBaoding 071002China School of Life Sciences Peking UniversityBeijing 100871China National Center for Protein Sciences Peking UniversityBeijing 100871China

Mitochondria are crucial organelles closely associated with cellular metabolism and *** DNA(mtDNA)encodes a variety of transcripts and proteins essential for cellular ***,the interaction between the inner membrane(IM)and mtDNA remains elusive due to the limitations in spatiotemporal resolution offered by conventional microscopy and the absence of suitable in vivo probes specifically targeting the ***,we have developed a novel fluorescence probe called HBmito Crimson,characterized by exceptional photostability,fluorogenicity within lipid membranes,and low saturation *** successfully achieved over 500 frames of lowpower stimulated emission depletion microscopy(STED)imaging to visualize the IM dynamics,with a spatial resolution of 40 *** utilizing dual-color imaging of the IM and mtDNA,it has been uncovered that mtDNA tends to habitat at mitochondrial tips or branch points,exhibiting an overall spatially uniform ***,the dynamics of mitochondria are intricately associated with the positioning of mtDNA,and fusion consistently occurs in close proximity to mtDNA to minimize pressure during cristae *** healthy cells,>66%of the mitochondria are Class III(i.e.,mitochondria>5μm or with>12 cristae),while it dropped to<18%in *** dynamics,orchestrated by cristae remodeling,foster the even distribution of ***,in conditions of apoptosis and ferroptosis where the cristae structure is compromised,mtDNA distribution becomes *** findings,achieved with unprecedented spatiotemporal resolution,reveal the intricate interplay between cristae and mtDNA and provide insights into the driving forces behind mtDNA distribution.

关键词： metabolism saturation utilizing

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Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

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Petroleum Science 2024年第1期21卷 458-474页

作者： Jie-Li Wang Wen-jun Huang De-Li gao MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep *** paper aims to predict the casing burst strength with considerations of both wear and ***,the crescent wear shape is simplified into three categories according to common mathematical ***,based on the mechano-electrochemical(M-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are ***,the accuracy of different prediction models is validated by numerical simulation,and the main influence factors on casing strength are *** last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is *** results show that the existence of wear defects results in a stress concentration and enhanced M-E interaction on corrosion depth *** accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded *** burst strength of the casing will be overestimated by more than one-third if the M-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

关键词： Deep well Casing integrity Casing wear Casing corrosion Burst strength

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Engineering high-performance dielectric chiral shells with enhanced chiral fields for sensitive chiral biosensor

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Rare Metals 2024年第3期43卷 1197-1206页

作者： Yi-Fan Wang shan-shan Huang Zhen-Dong Dai Shi-Lin Xian Xuan-Nan Wu Fu-Hua gao Yi-Dong Hou College of Physics Sichuan UniversityChengdu610065China Graduate School of Sichuan University Sichuan UniversityChengdu610065China

Chiral metamaterials have been a topic of significant research interest in recent years due to their potential for various applications in nanophotonic devices and chiral ***,the intrinsic Ohmic loss in surface plasmonic resonance has limited their practical use,resulting in large light dissipation and weak chiroptical ***,we report on the development of high-performance dielectric chiral shells(DCS)through a two-step Si deposition process on a self-assembled microsphere *** form DCS sample completely oyercomes the cancelation effect originated from the disorder property of the micro-sphere monolayer in macroscale,and at a wavelength of approximately 710 nm,the measured optimal chiral signal(g-factor)and transmittance can reach up to 0.7 and 0.3,*** strong chiroptical effect comes from the asymmetric circular displacement currents(i.e.,magnetic modes)enabled by the specific shell *** chiral shell geometry,electromagnetic properties,sensor sensitivity of chiral molecules and figure of merit are systematically *** DCSs demonstrate highly sensitive detection of chiral biomolecules owing to their easily accessible geometry and enhanced uniform chiral field.

关键词： Dielectric chiral shells(DCS) Si deposition Magnetic resonance Highly sensitive sensor Chiral field

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Visualisation and Heat Transfer Performance of Mini-Channel Flat Heat Pipe with a Binary Mixture

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Journal of Thermal Science 2024年第5期33卷 1712-1725页

作者： FAN gaoting TANG Aikun CAI Tao shan Chunxian PAN jun JIN Yi School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Jiangsu Jinhe Energy Technology Co.Ltd Zhenjiang 212400China

To unravel the intricacies of two-phase gas-liquid flow characteristics and heat transfer behavior,an array mini-channel gravity plate heat pipe(AMGPHP)is proposed in this work,which allows for observing the internal changes in the state of the working *** flow patterns such as pool flow,columnar flow,and slug flow,are experimentally explored and analyzed in *** is found that the optimal volume fill ratio is 20%by utilizing start-up time and thermal resistance as performance evaluation *** this fill ratio,a medium optimization strategy by blending ethanol within R141b is proposed and *** comparison to pure working fluids,the heat transfer performance of AMGFHP in the binary fluid has been significantly augmented due to temperature and concentration shifts resulting from disparate boiling *** the 10%volume fraction ethanol blending condition,the equivalent thermal conductivity of the heat pipe is dramatically elevated,with a value of 3110 W/(m·℃),along with the reduction of the minimum start-up power to 4 *** general,applying such a medium to heat pipes has considerable potential in practical applications.

关键词： flat heat pipe mini-channel visualisation two-phase flow binary mixtures thermal performance

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非物质文化遗产赋能乡村振兴的路径选择——基于湖南湘西州的调查分析

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中南民族大学学报:人文社会科学版 2023年第9期43卷 78-85,184页

作者：高俊山中南民族大学马克思主义学院湖北武汉430074

党的二十大报告提出的全面推进乡村振兴战略中包含的产业兴旺、生态宜居、乡风文明等各项要求,都与非物质文化遗产的保护与利用紧密相连。非物质文化遗产的合理保护与利用是国家全面实施乡村振兴战略、推进乡村发展的重要路径。以湖南... 详细信息

党的二十大报告提出的全面推进乡村振兴战略中包含的产业兴旺、生态宜居、乡风文明等各项要求,都与非物质文化遗产的保护与利用紧密相连。非物质文化遗产的合理保护与利用是国家全面实施乡村振兴战略、推进乡村发展的重要路径。以湖南湘西州为研究范本,分析非物质文化遗产赋能乡村振兴的现实必要性,从文化传承、产业发展、传统文化的创造性转化和创新性发展等角度,梳理非物质文化遗产赋能乡村振兴过程中存在的现实困难,并从文化赋能、人才赋能、产业赋能、创新赋能等方面提出了解决问题的具体路径。

关键词：非物质文化遗产乡村振兴中华优秀传统文化

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Progress in the generation of spinal cord organoids over the past decade and future perspectives

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Neural Regeneration Research 2024年第5期19卷 1013-1019页

作者： Gang Zhou Siyuan Pang Yongning Li jun gao Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of International Medical Service Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

Spinal cord organoids are three-dimensional tissues derived from stem cells that recapitulate the primary morphological and functional characteristics of the spinal cord in *** emerging bioengineering methods have led to the optimization of cell culture protocols,spinal cord organoids technology has made remarkable advancements in the past *** literature search found that current spinal cord organoids do not only dynamically simulate neural tube formation but also exhibit diverse cytoarchitecture along the dorsal-ventral and rostral-caudal ***,fused organoids that integrate motor neurons and other regionally specific organoids exhibit intricate neural circuits that allows for functional *** qualities make spinal cord organoids valuable tools for disease modeling,drug screening,and tissue *** utilizing this emergent technology,researchers have made significant progress in investigating the pathogenesis and potential therapeutic targets of spinal cord ***,at present,spinal cord organoid technology remains in its infancy and has not been widely applied in translational *** of the next generation of spinal cord organoids will depend on good manufacturing practice standards and needs to focus on diverse cell phenotypes and electrophysiological functionality evaluation.

关键词： development organoid-on-a-chip pluripotent stem cells progress spinal cord diseases spinal cord organoids vascularization

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Effi cacy of partial and complete resuscitative endovascular balloon occlusion of the aorta in the hemorrhagic shock model of liver injury

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World Journal of Emergency Medicine 2024年第1期15卷 10-15页

作者： Yi shan Yang Zhao Chengcheng Li Jianxin gao Guogeng Song Tanshi Li Department of Emergency Medicine Chinese PLA Medical SchoolBeijing 100853China Department of Emergency Medicine the Sixth Medical Center of PLA General HospitalBeijing 100048China Department of Emergency Medicine School of MedicineSouth China University of TechnologyGuangzhou 510006China Department of Emergency Medicine the First Medical Center of PLA General HospitalBeijing 100853China

BACKGROUND:Resuscitative endovascular balloon occlusion of the aorta(REBOA)can temporarily control traumatic ***,its prolonged use potentially leads to ischemia-reperfusion injury(IRI).Partial REBOA(pREBOA)can alleviate ischemic burden;however,its security and eff ectiveness prior to operative hemorrhage control remains ***,we aimed to estimate the effi cacy of pREBOA in a swine model of liver injury using an experimental sliding-chamber ballistic ***:Twenty Landrace pigs were randomized into control(no aortic occlusion)(n=5),intervention with complete REBOA(cREBOA)(n=5),continuous pREBOA(C-pREBOA)(n=5),and sequential pREBOA(S-pREBOA)(n=5)*** the cREBOA and C-pREBOA groups,the balloon was inflated for 60 *** hemodynamic and laboratory values were compared at various observation time *** samples immediately after animal euthanasia from the myocardium,liver,kidneys,and duodenum were collected for histological assessment using hematoxylin and eosin ***:Compared with the control group,the survival rate of the REBOA groups was prominently improved(all P<0.05).The total volume of blood loss was markedly lower in the cREBOA group(493.14±127.31 mL)compared with other groups(P<0.01).The pH was significantly lower at 180 min in the cREBOA and S-pREBOA groups(P<0.05).At 120 min,the S-pREBOA group showed higher alanine aminotransferase(P<0.05)but lower blood urea nitrogen compared with the cREBOA group(P<0.05).CONCLUSION:In this trauma model with liver injury,a 60-minute pREBOA resulted in improved survival rate and was effective in maintaining reliable aortic pressure,despite persistent *** tolerance time for aortic occlusion in Zone I for non-compressible torso hemorrhage was feasible with both continuous partial and sequential partial measures,and the significant improvement in the severity of acidosis and distal organ injury was observed in the sequential pREBOA.

关键词： Non-compressible torso hemorrhage Liver injury Ischemia-reperfusion injury Resuscitative endovascular balloon occlusion of the aorta

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Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-Wen Sun Fu-shan Wang Yan gao Fu-Qing Wei Jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

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