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Journal of Hydrodynamics 2009年第5期21卷 614-621页

作者： ZHANG Jin-hong YAN Chang-qi gao Pu-zhen College of Nuclear Science and Technology Harbin Engineering University Harbin 150001 China

Gas-liquid two-phase flow occurs increasingly in some dynamic devices operating in the oceanic condition. The relative data are limited with respect to flow characteristics, so the present study is to investigate systematically single-phase pressure drop, and to develop the theory for frictional factor under the roiling condition. Using deionized water as the test fluid, a series of experiments of single-phase flow were conducted in pipe with the inner diameter of 34.5 ram. The test section was horizontally settled on the rolling apparatus, and its regularity was similar to simple harmonic motion. It is found that the pressure drop during rolling motion fluctuate with the change of the rolling period and rolling angle, which is significantly different from fluid motion in a steady state. By the contrast between experiment results and stable-state theory values, existing correlations can not predict present frictional factor very well. Therefore, in the present article, the single-phase frictional factor is correlated with the Reynolds number for rolling motion, and its computated results agree well with experimental data.

关键词： single-phase flow pressure drop friction factor horizontal pipe rolling motion

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li zhen Ma Jin-Hua gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

ERRATUM TO “CHARACTERISTICS OF PRESSURE DROP AND CORRELATION OF FRICTION FACTORS FOR SINGLE-PHASE FLOW IN ROLLING HORIZONTAL PIPE”

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Journal of Hydrodynamics 2009年第6期21卷 868-868页

作者： ZHANG Jin-hong YAN Chang-qi gao Pu-zhen College of Nuclear Science and Technology Harbin Engineering University Harbin 150001 China

This is the erratum to the article [zhang Jin-hong, Yan Chang-qi, gao Pu-zhen, Journal of Hydrodynamics, 2009, 21(5)]. The Fig.5 is corrected.

关键词： CHARACTERISTICS OF PRESSURE DROP AND CORRELATION OF FRICTION FACTORS FOR SINGLE-PHASE FLOW IN ROLLING HORIZONTAL PIPE ERRATUM TO

水热法合成MCM-41分子筛时添加辅助烃的影响

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无机化学学报 1999年第1期15卷 104-109页

作者：董晋湘徐红刘光焕高振起吴锋太原理工大学精细化学研究所北京理工大学材料与化学工程学院

０前言中孔ＭＣＭ－４１分子筛是Ｍｏｂｉｌ公司１９９２年开发的一种具有２－１０ｎｍ孔径的新型分子筛材料。由于其独特的孔径范围和表面特性，相关研究已经成为国际分子筛研究领域的热点课题，对它的合成、表征和催化作用已进行了许... 详细信息

０前言中孔ＭＣＭ－４１分子筛是Ｍｏｂｉｌ公司１９９２年开发的一种具有２－１０ｎｍ孔径的新型分子筛材料。由于其独特的孔径范围和表面特性，相关研究已经成为国际分子筛研究领域的热点课题，对它的合成、表征和催化作用已进行了许多研究［１～７］。Ｍｏｂｉｌ公司的...

关键词： MCM-41 水热合成辅助烃分子筛

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氟康唑胶囊的人体药动学及其生物等效性

中国抗生素杂志 2007年第2期32卷 120-122,I0001页

作者：林建阳郜琪臻冯婉玉中国医科大学附属第一医院沈阳110001

目的对18名健康志愿者单剂量口服两种氟康唑胶囊后的血药浓度经时过程以及两者的生物等效性进行评价。方法采用LC/M S法测定人血浆中氟康唑浓度,18名健康受试者随机分组、自身交叉口服单剂量600m g氟康唑受试制剂和参比制剂进行生物等... 详细信息

目的对18名健康志愿者单剂量口服两种氟康唑胶囊后的血药浓度经时过程以及两者的生物等效性进行评价。方法采用LC/M S法测定人血浆中氟康唑浓度,18名健康受试者随机分组、自身交叉口服单剂量600m g氟康唑受试制剂和参比制剂进行生物等效性评价。结果采用3P 97计算两制剂的主要药动学参数:cm ax分别为(9315±1527)和(8928±1583)μg/L,Tm ax分别为(1.9±0.7)和(2.0±0.7)h,t1/2分别为(32.4±6.1)和(32.6±6.4)h,用梯形法计算,AUC0-t分别为(358749±75003)和(345997±78438)μg.h/L,AUC0-∞分别为(415346±101655)和(401636±100638)μg.h/L。结论两种氟康唑胶囊具有生物等效性。

关键词：氟康唑胶囊液质联用药动学生物等效性

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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美洛昔康贴剂裸鼠经皮吸收的初步研究

药学学报 2007年第12期42卷 1320-1322页

作者：郜琪臻杨丽英丁平田何仲贵中国医科大学第一附属医院药剂科辽宁沈阳110001 沈阳药科大学药学院辽宁沈阳110016

Meloxicam concentration in skin was determined following topical administration of meloxicam patches in hairless *** were analysized by HPLC coupled with microdialysis sampling technique,in which in vivo recovery of probe was characterized by the retrodialysis *** was indicated that the in vivo recovery of the probe was 14.0%.The range of steady state concentration of meloxicam in dialysate was 24-50 ng·mL-1,and that was 170-360 ng·mL-1 in the hairless mouse *** state concentration of meloxicam was reached shortly after the application of meloxicam patches,which was maintained during the period of experiment.

关键词：美洛昔康微渗析经皮吸收贴剂

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man Chen Shuo Zhang Shi-qi gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

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生物可降解型石杉碱甲微球的研究

沈阳药科大学学报 2007年第5期24卷 259-262,279页

作者：高萍郜琪臻徐晖魏静丁平田陈大为沈阳药科大学药学院辽宁沈阳110016 中国医科大学附属第一医院药局辽宁沈阳110001

目的制备能够在一个月甚至更长时间内缓释石杉碱甲的注射型生物可降解微球。方法选用端基不封口的PLA或PLGA、采用简单的O／W乳化溶剂挥发法制备微球；详细考察了微球的形态、粒径及分布、载药量和包封率；用透析法测定微球的体外药... 详细信息

目的制备能够在一个月甚至更长时间内缓释石杉碱甲的注射型生物可降解微球。方法选用端基不封口的PLA或PLGA、采用简单的O／W乳化溶剂挥发法制备微球；详细考察了微球的形态、粒径及分布、载药量和包封率；用透析法测定微球的体外药物释放曲线。结果成功地将石杉碱甲包裹入聚合物中；制得的微球表面光滑，但不同材料制得的微球内部结构不同，粒径全部小于250gm，粒径分布较窄，载药量的质量分数在4％～6．5％内，包封率的质量分数在45％～65％内，比用端基封口的聚合物制备的微球包封率高15倍以上；体外释药试验表明，载有石杉碱甲的3种微球能够在5～7周内缓释药物。结论利用生物可降解型微球缓释石杉碱甲是可行的。

关键词：石杉碱甲微球聚乳酸聚乳酸聚乙醇酸共聚物体外释放

DETECTION OF ARYLSULFATASE A IN LEUKOCYTES AND URINES OF LATE INFANTILE METACHROMATIC LEUKODYSTROPHY: REPORT OF 3 CASES

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中华医学杂志(英文版) 1988年第11期101卷 797-797页

作者： Wang De-fen Zhao Ke-wei Zeng Ji-Sheng Li Li-qun Sun Yue-xia gao qi-zhen Department of Pediatrics Ruijin Hospital Shanghai Second Medical University Shanghai Division of Clinical Biochemistry Ruijin Hospital Shanghai Second Medical University Shanghai

Two male siblings and one female from two unrelated families were affected by late infantile metachromatic leukodystrophy (MLD) with similar clinical manifestations. Arylsulfatase A (ASA) activities in dialyzed urines and in leukocytes were deter mined. Urinary ASA activities of patients at a pH optimum of 5.0 were below the lower limit of the normals, but increased when assays were carried out at pH 5.6, while it fell in normals or non-MLD patients with a rise in pH. Leukocyte ASA activities in a proband were also below the lower limit of normal controls. Urinary ASA activities of 3 of 4 parents were normal. Leukocyte ASA activities in all of the parents were intermediate between those of the pro bands and those of normal controls. Urinary ASA determination might be used as a screening test for MLD patients but not reliable for heterozygote detection. The confirmation of the diagnosis should rely upon leukocyte or fibroblastic ASA determination.

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