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A cleavable self-delivery nanoparticle for tumor photo-immunotherapy

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Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 133-135页

作者： Chuan Hu huile gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of Pharmacy Sichuan UniversityChengdu 610041China

Immunotherapy of tumor attracts great attention in the past several years attributing to the potential of completely erasing primary tumor and ***,pharmaceutical companies developed many antibodies that act as immune ... 详细信息

关键词： tumor metastasis immunotherapy

The application of nitric oxide delivery in nanoparticle-based tumor targeting drug delivery and treatment

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 380-390页

作者： Lin Qin huile gao Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University

Nitric oxide(NO) shows great role in tumor biology. Recent years, more and more researches utilized NO donor in tumor targeting drug delivery and treatment. In this review, we summarized the NO donors by their endogenous and exogenous stimuli. Then the application of NO donors, which was the main aim of the review, was discussed in detailed according to their functions, including inducing tumor cell apoptosis, reversing tumor multidrug resistance, inhibiting tumor metastasis and improving drug delivery.

关键词： Nitric oxide donor Multidrug resistance Tumor metastasis Enhanced permeability and retention effect

Development and application of hyaluronic acid in tumor targeting drug delivery

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1099-1112页

作者： Zhijian Luo Yan Dai huile gao Ultrasound Diagnosis Department of the Affiliated Hospital of Southwest Medical University Southwest Medical UniversityLuzhou 646000China Department of Pharmacy of the Affiliated Hospital of Southwest Medical University Southwest Medical UniversityLuzhou 646000China Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Hyaluronic acid(HA)is a natural polysaccharide that has gained much attention due to its biocompatibility,enzyme degradation capacity and active tumor targeting *** receptor,CD44,is overexpressed in many kinds of cancers and is associated with tumor progress,infiltration and ***,many researchers have developed various HA-based drug delivery systems for CD44-mediated tumor *** this review,we systemically overview the basic theory of HA,its receptor and hyaluronidase,then we categorize the studies in HA-based drug delivery systems according to the functions of HA,including tumor-targeting materials,enzyme-sensitive biodegradable modality,pHsensitive component,reduction-sensitive component,and the gel ***,the perspective is discussed.

关键词： Hyaluronic acid Tumor-active targeting CD44 Tumor microenvironment Reduction-sensitive Enzyme-sensitive Nanoparticles

Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4327-4347页

作者： Yanyan Xu Jingyuan Xiong Xiyang Sun huile gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Healthy Food Evaluation Research Center West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041China Hongqiao International Institute of Medicine Tongren HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200336China

Cancer immunotherapy has significantly flourished and revolutionized the limited conventional tumor therapies,on account of its good safety and long-term memory ***,low patient response rates and potential immune-related side effects make it rather challenging to literally bring immunotherapy from bench to ***,it has become evident that,although the immunosuppressive tumor microenvironment(TME)plays a pivotal role in facilitating tumor progression and metastasis,it also provides various potential targets for remodeling the immunosuppressive TME,which can consequently bolster the effectiveness of antitumor response and tumor ***,the particular characteristics of TME,in turn,can be exploited as avenues for designing diverse precise targeting *** general,it is of urgent necessity to deliver nanomedicines for remodeling the immunosuppressive TME,thus improving the therapeutic outcomes and clinical translation prospects of ***,we will illustrate several formation mechanisms of immunosuppressive *** importantly,a variety of strategies concerning remodeling immunosuppressive TME and strengthening patients'immune systems,will be ***,we will discuss the existing obstacles and future perspectives in the development of antitumor ***,the thriving bloom of immunotherapy will bring vibrancy to further exploration of comprehensive cancer treatment.

关键词： Cancer immunotherapy Immunosuppressive tumor microenvironment Tumor microenvironment normalization Targeted nanomedicines Drug delivery Environment-responsive nanoparticles Combinational therapy Tumor treatment

Advances in aggregatable nanoparticles for tumor-targeted drug delivery

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Chinese Chemical Letters 2020年第6期31卷 1366-1374,F0002页

作者： Wenqi Yu Maxim Shevtsov Xianchun Chen huile gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China Institute of Cytology of the Russian Academy of Sciences(RAS) St.Petersburg 194064.Russia

Recent days,aggregatable nanoparticles,which can specifically respond to certain stimulus,have shown great potential in tumor-targeted drug delivery with prolonged retention and deeper *** this review,we summarize recent advances in design of aggregatable nanoparticles by different ***(pH and enzyme)and external(light,temperature and ROS)stimuli are introduced for a comprehensive ***,the aggregated nanoparticles usually exhibit photothermal,photoacoustic,PET and enhanced MRI contrast,which is also *** the end,we discuss about the potential applications and challenges for the future clinical translation.

关键词： Stimuli-responsive nanoparticles Size aggregation Tumor-targeted drug delivery Transformation Microenvironment modulation

Editorial of Special Issue on Tumor Microenvironment and Drug Delivery

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2016-2017,2015页

作者： huile gao Zhiqing Pang Wei He West China School of Pharmacy Sichuan UniversityChengdu 610041China School of Pharmacy Fudan UniversityShanghai 201203China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 211198China

Drug delivery to treat cancer has attracted considerably and increasingly high *** drug delivery systems are available in the market and many other promising candidates are currently under ***,the complex tumor microe... 详细信息

关键词： drug considerably delivery

Metal-organic framework-based nanomaterials for biomedical applications

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Chinese Chemical Letters 2020年第5期31卷 1060-1070页

作者： Shu Zhang Xibo Pei huile gao Song Chen Jian Wang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China West China School of Stomatology Sichuan University.Chengdu 610041China Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China

In the past decade,nanoscale metal-organic frameworks(nMOFs)have drawn a great attention due to their high porosity,wide range of pore shapes,tunable frameworks and relatively low *** the development of nanotechnology,many researchers studied the synthesis,characterization,functionalization and biotoxicity of nMOFs,and a more thorough understanding was developed about numerous nMOFs as promising platforms for biomedical *** review highlights the up-to-date progress of nMOFs related to their bio-applications such as drug delivery,bioimaging,biosensing and biocatalysis,and the common surface modification methods we re classified into four categories:covalent post-synthetically modification,coordinative post-synthetically modification,noncovalent postsynthetically modification and modification on the external *** the same time,the challenges and perspectives of nMOFs were discussed as well.

关键词： Nanoscale metal-organic framework (nMOF) Biomaterial Functionalization Biological applications Nanocarrier

Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment

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Acta Pharmaceutica Sinica B 2019年第2期9卷 410-420页

作者： Rui Liu Chuan Hu Yuanyuan Yang Jingqing Zhang huile gao Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan University Chongqing Research Center for Pharmaceutical Engineering Chongqing Medical University

Although progress has been indeed made by nanomedicines, their efficacies for cancer treatment remain low, consequently leading to failures in translation to clinic. To improve the drug delivery efficiency,nanoparticles need to change size so as to fully utilize the enhanced permeability and retention(EPR) effect of solid tumor, which is the golden principle of nanoparticles used for cancer treatment. Herein, we employed cationic small-sized red emission bovine serum albumin(BSA) protected gold nanocluster(Au NC@CBSA,21.06 nm) to both load indocyanine green(ICG) and act as imaging probe to realize theranostic. Then Au NC@CBSA-ICG was fabricated with negatively charged hyaluronic acid(HA) to form Au NC@CBSAICG@HA, which was about 200 nm to easily retain at tumor site and could be degraded by tumor-specific hyaluronidase into small nanoparticles for deep tumor penetration. The HA shell also endowed Au NC@CBSA-ICG@HA with actively targeting ability and hyaluronidase-dependent drug release. Furthermore, the quenching and recovery of fluorescence revealed the interaction between ICG and carrier, which was essential for the investigation of pharmacokinetic profiles. No matter in vitro or in vivo, Au NC@CBSAICG@HA showed markedly anti-tumor effect, and could suppress 95.0% of tumor growth on mice breast cancer model. All results demonstrated Au NC@CBSA-ICG@HA was potential for breast cancer therapy.

关键词： Size-shrinkage Drug release Photothermal therapy Theranostic Breast cancer

The progress and perspective of nanoparticle-enabled tumor metastasis treatment

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2037-2053页

作者： Wei Zhang Fei Wang Chuan Hu Yang Zhou huile gao Jiang Hu Department of Orthopedics Sichuan Provincial People’s Hospital&Sichuan Academy of Medical Sciences&Affiliated Hospital of University of Electronic Science and TechnologyChengdu 610072China Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of Pharmacy Sichuan UniversityChengdu 610041China

As one of the most serious threats to human being,cancer is hard to be treated when metastasis ***’s worse,there are few identified targets of metastasis for drug ***,it is important to develop strategies to prevent metastasis or treat existed *** review focuses on the procedure of metastasis,and first summarizes the targeting delivery strategies,including primary tumor targeting drug delivery,tumor metastasis targeting drug delivery and hijacking circulation ***,as a promising treatment,the application of immunotherapy in tumor metastasis treatment is introduced,and strategies that stimulating immune response are reviewed,including chemotherapy,photothermal therapy,photodynamic therapy,ferroptosis,sonodynamic therapy,and ***,the challenges and perspective about nanoparticle-enabled tumor metastasis treatment are discussed.

关键词： Nanoparticles Tumor metastasis Tumor targeting drug delivery Immunotherapy Photodynamic therapy Ferroptosis Nanovaccines Stimulating immune response