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Attenuation of oxidative stress and hepatic damage by some fermented tropical legume condiment diets in streptozotocin-induced diabetes in rats

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 692-697页

作者： Adedayo o Ademiluyi ganiyu oboh Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkure P.M.B.704 Akure340001Nigeria

objective:To investigate the modulatory effect of fermented legume condiments diet on oxidative stress in streptozotocin(STZ) induced diabetic ***:Adult male Wistar rats were randomly divided into six groups with six animals in each *** was induced by intraperitoneal injection of STZ(35 mg/kg b.w.).After being confirmed diabetic,the rats were fed with fermented Bambara *** bean and Soybean diets for 14 *** plasma was obtained after 14-day treatment and analyzed for hepatic damage marker enzymes(AST,ALT and ALP) and in vivo antioxidant ***:The diabetic untreated rats showed elevated (Pof AST,*** and malondialdehyde with reduced activities of glutathiones -transferase,catalase as well as plasma reduced glutathione,vitamin C and total protein ***,treatment of diabetic rats with lermenled legume condiments diets for 14 days significantly(Pove parameters towards normalcy,suggesting their modulation of oxidative stress,which mav be due to their high phenolic content and antioxidant ***:The attenuation of oxidative stress and protection of hepatic tissue damage by the legume condiment diets in STZ induced diabetic rats compare favourably with that of metformin,a well known oral hypoglycemic drug.

关键词： Diabetes oxidative stress Hepatotoxicity Antioxidants Phenolics Soybean African locust bean Bambara groundnut

Modulatory effects of dietary inclusion of garlic(Allium sativum) on gentamycin-induced hepatotoxicity and oxidative stress in rats

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Asian Pacific Journal of Tropical Biomedicine 2013年第6期3卷 470-475页

作者： Adedayo o Ademiluyi ganiyu oboh Tosin R owoloye oluwaseun J Agbebi Functional Foods Nutraceuticals and Phytomedicine UnitDepartment of BiochemistryFederal University of Technology

objective:To investigate die ameliorative effect of dietary inclusion of garlic(Allium sativum)on gentamycin-induced hepatotoxicity in ***:Adult male rats were randomly divided into four groups with sis animals in each *** 1 and 2 were fed basal diet while Groups 3 and 4 were fed diets containing 2%and 4%garlic respeetively for 27 d prior to gentamycin *** was induced by the intraperitoneal administration at gentamycin(100 mg/kg body weight)for 3 *** liver and plasma were studied for hepatotoxicity and antioxidant ***:Gentamycin induces hepatic damage as revealed by significant(Pon of liver damage marker enzymes(aspartate transaminase and alanine aminotransferase)and reduction in plasma albumin *** also eaused a significant(Pon in plasma and liver enzymatic(catalase,glutathione and super oxygen dehydrogenises)and non-enzymatic(glutathione and vitamin C)antioxidant indices with concomitant increase in the malondialdehyde content;however,there was a significant(Poration of the antioxidant status coupled with significant(Pondialdehyde content,following consumption of diets containing ***:These results suggest that dietary inclusion of garlic powder could protect against gentamycin-induced hepatotoxicity,improve antioxidant status and modulate oxidative stress;a function attributed to their phenolic constituents.

关键词： Gentamycin Hepatotoxicity oxidative stress Garlic(Allium sativum) Phytochemicals

Phenolics from grapefruit peels inhibit HMG-CoA reductase and angiotensin-I converting enzyme and show antioxidative properties in endothelial *** 926 cells

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Food Science and Human Wellness 2015年第2期4卷 80-85页

作者： Ayokunle o.Ademosun ganiyu oboh Sabina Passamonti Federica Tramer Lovro Ziberna Aline Augusti Boligon Margareth Linde Athayde Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeria Department of Life Sciences University of Triestevia L.Giorgieri 134127 TriesteItaly Program of Post-Graduation in Pharmaceutical Sciences Federal University of Santa MariaCampus CamobiSanta MariaRS 97105-900Brazil

This study sought to investigate the possible mechanisms for the use of phenolic extracts from grapefruit peels in the management/prevention of cardiovascular *** effects of the phenolic extracts on key enzymes relevant to cardiovascular diseases[3-hydroxy-methyl-3-glutaryl coenzyme A reductase(HMG-CoA reductase)and angiotensin-I converting enzyme(ACE)],cellular antioxidant activity in human endothelial cells(*** 926)and radicals[1,1-diphenyl-2 picrylhydrazyl(DPPH)and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)(ABTS)]scavenging abilities were *** phenolic contents of the extracts were investigated using HPLC–*** was no significant(P>0.05)difference in the HMG-CoA reductase inhibitory ability of the two extracts,while the bound phenolic extracts had a stronger ACE inhibitory ability than the soluble free *** extracts also showed intracellular antioxidant activity in human endothelial(*** 926)***,the bound phenolics had significantly higher radicals(DPPH*and ABTS*)scavenging abilities than the free *** HPLC analysis revealed the presence of flavonoids(quercetin and kaempferol),phenolics acids(resveratrol,gallic acid,ellagic acid and caffeic acid)and tannin(catechin).The cellular antioxidative properties and inhibition of enzymes relevant to the management of cardiovascular complications showed that grapefruit peels could be used as nutraceuticals for the management of such conditions.

关键词： prevention cardiovascular phenolic

Levels of Immunoglobulin Classes Are Not Associated with Severity of HIV Infection in Nigerian Patients

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World Journal of AIDS 2012年第3期2卷 232-236页

作者： oluwaseun o. Akinpelu Yetunde A. Aken'ova o. ganiyu Arinola Department of Haematology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Haematology College of Medicine University of Ibadan Ibadan Nigeria Department of Immunology College of Medicine University of Ibadan Ibadan Nigeria

The serum concentrations of immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), total protein and albumin were measured in 35 Human Immunodeficiency Virus—positive, HAART (highly active antiretroviral therapy) na?ve subjects attending the PEPFAR (President's Emergency Plan for AIDS relief) clinic, University College Hospital, Ibadan and in 30 apparently healthy control subjects to assess the relationship between serum protein, immunoglobulin concentrations and laboratory indices of HIV disease (CD4 cell counts and viral load). Serum IgG (1008.6 ± 530.7 mg/dl), IgA (170.4 ± 69 mg/dl) and total protein (9.9 ± 1.7 g/dl) levels were higher among HIV positive subjects compared with mean values in healthy subjects (549.8 ± 193.8 mg/dl, 106.8 ± 26.4 mg/dl and 7.8 ± 0.5 g/dl respectively). The median serum IgM concentration (131mg/dl) was significantly higher in HIV positive subjects compared with 35 mg/dl in healthy controls (p 200 cells/μL. There was also no statistically significant correlation observed between viral load and serum immunoglobulin levels.

关键词： HIV Immunoglobulins

Intestinal Helminthic Infection Increases Serum Levels of IL-2 and Decreases Serum TGF-Beta Levels in Nigerian Asthmatic Patients

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open Journal of Immunology 2014年第1期4卷 1-8页

作者： ganiyu o. Arinola oluwafemi oluwole Regina oladokun Babatunde o. Adedokun olufunmilayo I. olopade Christopher o. olopade Center for Clinical Cancer Genetics and the Center for Global Health University of Chicago Chicago USA College of Medicine University of Ibadan Ibadan Nigeria Department of Medicine and the Center for Global Health University of Chicago Chicago USA

Background: Asthma is less common in countries outside the organization for economic cooperation and development (oECD). one suggested mechanism for this disparity is the early life exposure to helminthic infection in non-oECD countries due to predominant Th1 immune response, which down-regulates Th2 responses required for exacerbation of asthma. This report is the first in the literature to describe the effects of helminthic infection on immune responses in asthmatic children compared to non-asthmatic controls. Methods: We administered the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire to 1690 high school students in three rural communities in southwestern Nigeria. Based on questionnaire responses and medical examination, identified asthma cases were matched with controls. Stool samples were collected from all subjects and screened for intestinal helminthic infection. The serum of 12 asthmatics and 12 non-asthmatics (6 with intestinal helminthic infection and 6 without intestinal helminthic infection in each group) were assayed for interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17A, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), granulocyte macrophage colo- ny-stimulating factor (GM-CSF), and transforming growth factor-beta (TGF-β). Results: The mean (±SD) serum levels of IL-2 significantly increased in asthma cases with intestinal helminthic infection compared with asthma cases without infection (41.5 ± 9.7 vs. 29.7 ± 10.3;p = 0.035), controls with intestinal helminthic infection compared with cases without infection (52 ± 4.7 vs. 29.7 ± 10.3;p ontrols with intestinal helminthic infection compared to controls without infection (52 ± 4.7 vs. 34.2 ± 10.4;p = 0.003). Mean levels of TGF-β significantly increased in controls without infection compared with asthma cases with infection (1833 ± 93.1 vs. 633.3 ± 294.4;p ontrols without intestinal helminthic infection compared with asth

关键词： Intestinal Helminthic Cytokines Immune Responses Asthma Children Nigeria

A Comparison of Clinical Features of Depressed and Non-Depressed People Living with HIV/AIDS, in Nigeria, West Africa

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open Journal of Medical Psychology 2014年第1期3卷 60-69页

作者： Rasaki o. Shittu Baba A. Issa ganiyu T. olanrewaju Abdulraheem o. Mahmoud Sunday A. Aderibigbe Louis o. odeigah Department of Behavioural Sciences University of Ilorin Teaching Hospital Ilorin Nigeria Department of Epidemiology and Community Health University of Ilorin Teaching Hospital Ilorin Nigeria Department of Family Medicine Kwara State Specialist Hospital Ilorin Nigeria Department of Family Medicine University of Ilorin Teaching Hospital Ilorin Nigeria Department of ophthalmology University of Ilorin Teaching Hospital Ilorin Nigeria

objectives: Depressive disorders are a significant public health issue. They are prevalent, disabling, and often chronic, with a high economic burden to the society. Depressive illness is the most common psychiatric disorder in HIV/AIDS with prevalence 2 to 4 times higher than the general population. It’s still questionable whether HIV related depression is clinically different from sero-positive patients without depression. Studies comparing the clinical features of depressed and non-depressed People Living with HIV/AIDs are limited, hence the need for this study. Methods: This was a hospital based, cross sectional, descriptive study of three hundred adult HIV/AIDS patients attending the HIV clinic of Kwara State specialist hospital, Sobi, Ilorin. The PHQ-9 was administered to the respondents to screen for depression. A pre-tested PHQ-9 questionnaire was used to collect data. Subject who scored one and more were assessed clinically for depression. The three keys of social determinants of depression (SDS) were assessed and the association with depression sought. Results: one hundred and seventy (56.7%) satisfied the criteria for a depressive disorder using the PHQ-9 score. Compared to non-depressed sero-positive patients, depressed HIV patients were more likely to be female, single, unemployed, with below average year of schooling, low social economic status, low social cohesion and more stressful life events. They are more prone to hopelessness, thought of taking life and plan to commit suicide. Conclusion: These findings, show that the clinical and associated features of depression differ between depressed and non-depressed sero-positive subjects, thus requiring different management.

关键词： Clinical Features Depressed Non-Depressed HIV/AIDS Nigeria

TCP Window Based Congestion Control -Slow-Start Approach

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Communications and Network 2011年第2期3卷 85-98页

作者： Kolawole I. oyeyinka Ayodeji o. oluwatope Adio. T. Akinwale olusegun Folorunso ganiyu A. Aderounmu olatunde o. Abiona 不详

Transmission control protocol (TCP) has undergone several transformations. Several proposals have been put forward to change the mechanisms of TCP congestion control to improve its performance. A line of research tends to reduce speed in the face of congestion thereby penalizing itself. In this group are the window based congestion control algorithms that use the size of congestion window to determine transmission speed. The two main algorithm of window based congestion control are the congestion avoidance and the slow start. The aim of this study is to survey the various modifications of window based congestion control. Much work has been done on congestion avoidance hence specific attention is placed on the slow start in order to motivate a new direction of research in network utility maximization. Mathematical modeling of the internet is discussed and proposals to improve TCP startup were reviewed. There are three lines of research on the improvement of slow start. A group uses the estimation of certain parameters to determine initial speed. The second group uses bandwidth estimation while the last group uses explicit request for network assistance to determine initial startup speed. The problems of each proposal are analyzed and a multiple startup for TCP is proposed. Multiple startups for TCP specify that startup speed is selectable from an n-arry set of algorithms. We then introduced the e-speed start which uses the prevailing network condition to determine a suitable starting speed.

关键词： Data Communication Network Protocols TCP Congestion Control Slow-Start (Keywords)

Buffer occupancy of Double-Buffer Traffic Shaper in Real-Time Multimedia Applications across Slow-Speed Links

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Communications and Network 2013年第1期5卷 84-92页

作者： Ayodeji o. oluwatope Damilola T. oyewo Folake E. olayiwola ganiyu A. Aderounmu Emmanuel A. Adagunodo Comnetlab Network Utility Maximisation Sub-Group Computer Science and Engineering Obafemi Awolowo University Ile-Ife Nigeria

In this paper, a double-buffer traffic shaper was investigated to adjust video frame rate inflow into the TCP sender-buffer of a multimedia application source across a slow-speed link. In order to guarantee QoS across a slow-speed link (i.e. 1 MBPS), the double-buffer traffic shaper was developed. In this paper, the buffer size dynamics of double-buffer was investigated. The arrival and departure of frames were modeled as a stochastic process. The transition matrix for the process was generated and the stationary probability computed. A simulation program was written in Matlab 7.0 to monitor the buffer fullness of the second buffer when a 3600 seconds H.263 encoder trace data was used as test data. In the second buffer, it was discovered that over 90% of the play-time, the buffer occupancy was upper bounded at 300 frames per second and utilization maintained below 30%.

关键词： Multimedia Application Slow-Speed Link TCP Buffer occupancy QoS

Groundwater Assessment of Hand Dug Wells around open Landfill in Ibadan Metropolis for Domestic and Irrigation Purposes

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Journal of Water Resource and Protection 2014年第15期6卷 1412-1424页

作者： B. S. Badmus V. C. ozebo o. A. Idowu S. A. ganiyu o. T. olurin Department of Physics Federal University of Agriculture Abeokuta Nigeria Department of Water Resources and Agrometeorology Federal University of Agriculture Abeokuta Nigeria

Geochemical assessment of groundwater samples from hand-dug wells within the vicinity of Aba-Eku dumpsite was carried out for domestic and irrigation purposes. Ten groundwater samples were collected both in dry season and wet season for analysis of physico-chemical parameters: pH, EC, TDS,The results of the analyses showed the groundwater samples to be within limits of WHo/NSDWQ. However, higher values of concentrations of the chemical constituents were noticed in well 5 nearer to the landfill. Interpretation of Piper diagram showed CaHCo3 to be dominant in the area. Alkaline earth metals ?and weak acids ?are dominant cations and anions over the alkalis and strong acids in both sessions. Groundwater in the study area is of hard, fresh and alkaline nature. Assessment for irrigation purpose showed that most of the water samples were suitable for irrigation purpose except in a few locations.

关键词： Physicochemical Parameters Irrigation Groundwater Freshwater Hydrochemical Analyses