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转甲状腺素蛋白淀粉样变心肌病一家系遗传学分析

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郑州大学学报（医学版） 2024年第4期59卷 582-586页

作者：杨鹏丽刘志煜郑颖颖张文静王蕴哲肖丽莉刘刚琼郑州大学第一附属医院心血管内科郑州450052

目的:探讨转甲状腺素蛋白淀粉样变心肌病(ATTR-CM)的遗传学特征。方法:对1例以心肌肥厚所致心力衰竭为主要临床特征的ATTR-CM先证者的临床表型进行分析,通过高通量测序分析转甲状腺素蛋白(TTR)基因突变情况并进行Sanger测序验证。结果:... 详细信息

目的:探讨转甲状腺素蛋白淀粉样变心肌病(ATTR-CM)的遗传学特征。方法:对1例以心肌肥厚所致心力衰竭为主要临床特征的ATTR-CM先证者的临床表型进行分析,通过高通量测序分析转甲状腺素蛋白(TTR)基因突变情况并进行Sanger测序验证。结果:先证者发病年龄较早,临床症状复杂。先证者及其妹妹、侄子、女儿4人存在TTR基因c.A163G(***55Glu)杂合突变。结论:本研究发现了TTR基因c.A163G(***55Glu)突变导致的ATTR-CM,异常TTR沉积主要累及心脏,症状复杂且不典型。

关键词：转甲状腺素蛋白淀粉样变心肌病转甲状腺素蛋白基因突变

Vitamin D Receptor Serving as Instrument Gene to Investigate the Relationship between Vitamin D Deficiency and Hypertension: A Family-based Study

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Vitamin D Receptor Serving as Instrument Gene to Investigate...

Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

中国营养学会第十五届全国营养科学大会

作者： Lanxin Bai Chenling Qu Yinhua Feng gangqiong liu Xing Li Wenjie Li Songcheng Yu ZhengZhou University Henan University of Technology First Affiliated Hospital of Zhengzhou University

The association between vitamin D deficiency and hypertension had been observed in numerous studies. However, the results of blood pressure improvement by supplementation of vitamin D were inconsistent. The causal relationship between vitamin D deficiency and hypertension was still unclear, which was aimed to investigate in this family-based study. 1370 individuals in total from both vitamin D deficiency families and hypertension families were included. First, the heritability of vitamin D deficiency was estimated by Falconer method. Second, SNPs of vitamin D metabolic and functional pathway genes associated with vitamin D deficiency were screened by family-based association test, which was further verified in vitamin D deficiency families. Finally, family-based association test was applied to investigate the association between selected SNP associated with vitamin D deficiency and hypertension. The heritability of vitamin D deficiency was 50.4% in this familybased study. Family-based association between allele C of rs3847987 in vitamin D receptor gene and vitamin D deficiency was all observed in additive, dominant and recessive models(P<0.05). Allele C of rs3847987 was a risk factor of vitamin D deficiency(OR: 1.639, 95%CI: 1.170-2.297, P=0.004). Furthermore, family-based association of rs3847987 with hypertension was found in both additive and recessive models(P<0.05). In addition, vitamin D deficiency was associated with hypertension(OR: 1.317, 95%CI: 1.022-1.698, P=0.033). In conclusion, rs3847987 in vitamin D receptor gene was associated with both vitamin D deficiency and hypertension. Therefore, vitamin D deficiency may be a causal factor of hypertension. Methods 1370 individuals in total from both vitamin D deficiency families and hypertension families were included. First, the heritability of vitamin D deficiency was estimated by Falconer method. Second, SNPs of vitamin D metabolic and functional pathway genes associated with vitamin D deficiency were screen

关键词： family-based association heritability hypertension vitamin D deficiency

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

河南省信阳地区新型冠状病毒肺炎患者消化道症状临床特征和危险因素分析

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中华消化杂志 2020年第3期40卷 171-175页

作者：赵晔钟思鹏李芳刘刚琼王欣芳刘占举郑州大学第一附属医院消化内一科 450052 信阳市第五人民医院呼吸内科 464100 郑州大学第一附属医院呼吸内科 450052 郑州大学第一附属医院心血管内科 450052 郑州大学第一附属医院血液净化中心 450052 同济大学附属第十人民医院消化内科上海200072

回顾性分析信阳市第五人民医院106例成人新型冠状病毒肺炎(COVID-19)患者的临床特征,了解河南省信阳地区COVID-19患者消化道症状临床特征和危险因素。筛选合并消化道症状8例患者为病例组,无消化道症状16例患者为对照组,结果发现病例组... 详细信息

回顾性分析信阳市第五人民医院106例成人新型冠状病毒肺炎(COVID-19)患者的临床特征,了解河南省信阳地区COVID-19患者消化道症状临床特征和危险因素。筛选合并消化道症状8例患者为病例组,无消化道症状16例患者为对照组,结果发现病例组与对照组的临床症状、基础疾病和流行病学特征比较差异均无统计学意义(P均>0.05)。病例组中性粒细胞计数、CRP、DBil和肌红蛋白水平均高于对照组,差异均有统计学意义[OR(95%CI)分别为2.021(1.012~2.123)、1.015(1.002~1.028)、1.062(1.008~1.357)和1.091(1.000~1.921),P均<0.05]。CRP水平升高是COVID-19患者出现消化道症状的独立危险因素(P<0.05)。COVID-19患者合并消化道症状发生率为7.55%(8/106),有消化道症状者炎症活动和器官受累情况比无消化道症状者更严重。

关键词：新型冠状病毒肺炎 2019新型冠状病毒消化道症状腹泻恶心呕吐

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu Xiang Yang Jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

Effectiveness and safety of acupuncture in treatment of pregnancyrelated symptoms:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 16-26页

作者： liu Tingting liu Tongou liu Mingfu School of Traditional Chinese Medicine Clinical Medicine Hubei University of Traditional Chinese MedicineWuhan 430000China First Clinical College of Hubei University of Traditional Chinese Medicine Wuhan 430000China Department of Acupuncture and Tuina Affiliated Hospital of Hubei University of Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430000China

OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during ***:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during ***:Sixteen RCTs with a cumulative sample size of 1178 cases were *** these,964 patients were included in the *** Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low ***:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively ***,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.

关键词： acupuncture pregnancy nausea vomiting sleep initiation and maintenance disorders low back pain pelvic pain mood abnormalities Meta-analysis systematic review

Stochastic Unit Commitment with High-Penetration Offshore Wind Power Generation in Typhoon Scenarios

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 535-546页

作者： Yanqi liu Dundun liu Hongcai Zhang State Key Laboratory of Internet of Things for Smart City and Department of Electrical and Computer Engineering University of MacaoMacao 999078China University of Macao Zhuhai UM Science and Technology Research Institute ZhuhaiChina

To tackle the energy crisis and climate change,wind farms are being heavily invested in across the *** China's coastal areas,there are abundant wind resources and numerous offshore wind farms are being *** secure operation of these wind farms may suffer from typhoons,and researchers have studied power system operation and resilience enhancement in typhoon ***,the intricate movement of a typhoon makes it challenging to evaluate its spatial-temporal *** published papers only consider predefined typhoon trajectories neglecting *** address this challenge,this study proposes a stochastic unit commitment model that incorporates high-penetration offshore wind power generation in typhoon *** adopts a data-driven method to describe the uncertainties of typhoon trajectories and considers the realistic anti-typhoon mode in offshore wind farms.A two-stage stochastic unit commitment model is designed to enhance power system resilience in typhoon *** formulate the model into a mixed-integer linear programming problem and then solve it based on the computationally-efficient progressive hedging algorithm(PHA).Finally,numerical experiments validate the effectiveness of the proposed method.

关键词： Unit commitment two-stage stochastic programming offshore wind farm typhoon

Devolatilization of high viscous fluids with high gravity technology

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Chinese Journal of Chemical Engineering 2024年第7期71卷 249-257页

作者： Jibing Qi Youzhi liu Yandong liu Taiyuan University Taiyuan 030032China Shanxi Province Key Laboratory of Higee-Oriented Chemical Engineering North University of ChinaTaiyuan 030051China

Volatile organic compounds(VOCs)are generally toxic and harmful substances that can cause health and environmental *** removal of VOCs from polymers has become a key *** effective devolatilization to remove VOCs from high viscous fluids such as polymer is necessary and is of great *** this study,the devolatilization effect of a rotating packed bed(RPB)was studied by using polydimethylsiloxane as the viscous fluid and acetone as the *** devolatilization rate and liquid phase volume(KLa)have been *** results indicated that the optimum conditions were the high-gravity factor of 60,liquid flow rate of 10 L·h^(-1),and vacuum degree of 0.077 *** dimensionless correlation of KLa was established,and the deviations between predicted and experimental values were less than±28%.The high-gravity technology will result in lower mass transfer resistance in the devolatilization process,enhance the mass transfer process of acetone,and improve the removal effect of *** work provides a promising path for the removal of volatiles from polymers in combination with high-gravity *** can provide the basis for the application of RPB in viscous fluids.

关键词： High-gravity technology Devolatilization rate High viscous fluid Volatile organic compounds(VOCs)

Polar solvent induced in-situ self-assembly and oxygen vacancies on Bi_(2)MoO_(6)for enhanced photocatalytic degradation of tetracycline

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Nano Research 2024年第6期17卷 4951-4960页

作者： Fangyan liu Dongyue Su Weizhen liu Baiquan liu Chuan liu Hong Wang Mengye Wang State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275China School of Materials Sun Yat-Sen UniversityShenzhen 518107China School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and RecyclingSouth China University of TechnologyGuangzhou 510006China

It has been proved to be an effective route to efficiently ameliorate photocatalytic performance of catalysts via designing three-dimensional(3D)hierarchical nanostructures and constructing oxygen vacancies(VOs).However,controlling the self-assembly of organization into 3D hierarchical nanostructures while introducing VOs in photocatalysts remains a ***,we reported an ethylene glycol(EG)mediated approach to craft 3D hydrangea-structure Bi_(2)MoO_(6)with VOs for efficient photocatalytic degradation of *** manipulating the EG concentration during the fabrication process,the influence of EG concentration on the Bi_(2)MoO_(6)structure was systematically *** could promote the self-assembly of Bi_(2)MoO_(6)nanosheets to form a 3D hierarchical *** with 2D nanoplates,3D hierarchical architecture enhanced the surface area and the amount of active sites of Bi_(2)MoO_(6).In addition,the reduction effect of EG on metallic oxide enabled the generation of VOs in Bi_(2)MoO_(6).The VOs adjusted the electronic structure of Bi_(2)MoO_(6),which not only enhanced the light harvesting,but also facilitated the simultaneous utilization of photo-induced electrons and holes to form reactive oxygen species(·O2−and·OH)for the efficient tetracycline decomposition.3D Bi_(2)MoO_(6)hydrangea with VOs achieved a 79.4%removal efficiency of tetracycline after 75 *** work provides a simple yet robust EG-mediated strategy,which not only promotes the self-assembly of nano-catalysts into 3D hierarchical architectures,but also crafts tunable VOs for highly efficient photocatalysis.

关键词： three-dimensional(3D)hierarchical nanostructures tunable oxygen vacancies ethylene glycol(EG)-mediated strategy bismuth molybdate photocatalytic degradation tetracycline