检索结果-南通市图书馆

On the strengthening and slip activity of Mg-3Al-1Zn alloy with pre-induced{1012¯}twins

Journal of Magnesium and Alloys 2023年第4期11卷 1292-1307页

作者： Jie kuang Yuqing Zhang Xinpeng Du Jinyu Zhang gang Liu Jun Sun State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049P.R.China The College of Optics&Photonics University of Central FloridaOrlandoFL 32826United States

{1012¯}twins were introduced into the magnesium(Mg)plate AZ31 via pre-rolling along its transverse direction.The plates,both with and without the pre-induced{1012¯}twins,were subjected to uniaxial tension along different directions.Using crystal plasticity modeling,we found that the strengthening effect of the pre-induced{1012¯}twins on the macroscopic flow stress primarily arised from the increased slip resistance caused by the boundaries,rather than the orientation hardening due to the twinning reorientation(although the latter did make its contribution in some specific loading directions).Besides,the pre-existing{1012¯}twins were found,by both experiments and simulation,to promote the activity of prismatic and pyramidalin the parent matrix of the material.Further analysis showed that the enhanced non-basal slip activity is related to the{1012¯}twin boundaries’low micro Hall-Petch slope ratios of non-basal slips to basal slip.With the critical resolved shear stress(CRSS)obtained from crystal plasticity modeling and the orientation data from EBSD,a probability-based slip transfer model was proposed.The model predicts higher slip transfer probabilities and thus lower strain concentration tendencies at{1012¯}twin boundaries than that at grain boundaries,which agrees with the experimental observation that the strain localization was primarily associated with the latter.The present findings are helpful scientifically,in deepening our understanding of how the pre-induced{1012¯}twins affect the strength and slip activity of Mg alloys,and technologically,in guiding the design of the pre-strain protocol of Mg alloys.

关键词： Mg alloy {1012¯}twins Strengthening Slip activity Micro Hall-Petch effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of thermal exposure on the microstructure and mechanical properties of a twin-roll cast Al-Mn-Fe-Si strip

引用

Journal of Materials Science & Technology 2022年第12期107卷 183-196页

作者： Jie kuang Xiaolong Zhao Yuqing Zhang Jinyu Zhang gang Liu Jun Sun Guangming Xu Zhaodong Wang State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

Al-Mn-Fe-Si strips were fabricated via both the twin-roll casting(TRC)and the more conventional route,direct-chill casting(DC).The two types of strips prepared were subjected to thermal exposure at a series of temperatures.Uniaxial tensile tests after the thermal exposure showed that while the DC strip presented a~74%decrease in the yield strength and~35%decrease in the ultimate tensile strength(UTS)after being exposed to 350℃for 12 h,the TRC strip,in contrast,maintained its strength at temperatures up to~460℃ for the same duration.Systematic microstructure characterization revealed that the different thermal stability in the strength of the two types of strips arised from their distinct evolution in grain morphology and second phase particles during the thermal exposure.The calculation based on Cahn-Lücke-Stüwe(CLS)model suggested that due to the highly supersaturated solute atoms,at the beginning of the thermal exposure,the TRC strip experienced a strong solute drag which reduced the grain boundary migrating velocity to a value that is orders of magnitude smaller than that in the DC strip.With the progress of the thermal exposure,the solute atoms precipitated out,forming densely distributed second phase particles.For one thing,these particles stabilized the grain structure by inducing Zener pinning pressure which could be ten times higher than that in the DC strip,depending on the temperature.For another,they acted as dislocation obstacles and compensated for the strength loss owing to decreasing solution hardening.Both effects contributed to the TRC strip’s fairly stable strength regarding thermal exposure below 460°C.The present work could guide the direct application of the TRC strips in the industry.The results should also be helpful for the development of a fundamental framework for designing advanced TRC Al strips with improved mechanical properties at elevated temperatures.

关键词： Al-Mn-Fe-Si strip Twin-roll casting Thermal stability Ductile fracture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

引用

Acta Pharmaceutica Sinica B 2023年第3期13卷 1071-1092页

作者： Minxuan Xu Jun Tan Liancai Zhu Chenxu Ge Wei Dong Xianling Dai Qin kuang Shaoyu Zhong Lili Lai Chao Yi Qiang Li Deshuai Lou Linfeng Hu Xi Liu Gang Kuang Jing Luo Jing Feng Bochu Wang Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region School of Biological and Chemical EngineeringChongqing University of EducationChongqing 400067China College of Modern Health Industry Chongqing University of EducationChongqing 400067China Key Laboratory of Biorheological Science and Technology(Chongqing University) Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400030China Shandong Cancer Hospital and Institute Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis(NASH)have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated.Inactive rhomboid protein 2(IRHOM2),a promising target for treatment of inflammation-related diseases,contributes to deregulated hepatocyte metabolism-associated nonalcoholic steatohepatitis(NASH)progression.However,the molecular mechanism underlying Irhom2 regulation is still not completely understood.In this work,we identify the ubiquitin-specific protease 13(USP13)as a critical and novel endogenous blocker of IRHOM2,and we also indicate that USP13 is an IRHOM2-interacting protein that catalyzes deubiquitination of Irhom2 in hepatocytes.Hepatocyte-specific loss of the Usp13 disrupts liver metabolic homeostasis,followed by glycometabolic disorder,lipid deposition,increased inflammation,and markedly promotes NASH development.Conversely,transgenic mice with Usp13 overexpression,lentivirus(LV)-or adeno-associated virus(AAV)-driven Usp13 gene therapeutics mitigates NASH in 3 models of rodent.Mechanistically,in response to metabolic stresses,USP13 directly interacts with IRHOM2 and removes its K63-linked ubiquitination induced by ubiquitin-conjugating enzyme E2N(UBC13),a ubiquitin E2 conjugating enzyme,and thus prevents its activation of downstream cascade pathway.USP13 is a potential treatment target for NASH therapy by targeting the Irhom2 signaling pathway.

关键词： Usp13 Irhom2 NASH Hepatosteatosis Ubc13 NAFLD Ubiquitination Liver inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent Progress of Aerosol Light-scattering Enhancement Factor Studies in China

引用

Advances in Atmospheric Sciences 2019年第9期36卷 1015-1026页

作者： Chunsheng ZHAO Yingli YU Ye kuang Jiangchuan TAO gang ZHAO Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Institute for Environmental and Climate Research Jinan UniversityGuangzhou 510632China

Assessment of the radiative forcing of aerosols in models still lacks sufficient input data for aerosol hygroscopicity. The light scattering enhancement factor [ f(RH, λ)] is a crucial parameter for describing aerosol hygroscopic growth properties.In this paper, we provide a survey of f(RH, λ) studies in China for the past seven years, including instrument developments of humidified nephelometers, ambient f(RH, λ) measurements in China, f(RH, λ) parameterization schemes, and f(RH, λ)applications in aerosol measurements. Comparisons of different f(RH, λ) parameterizations are carried out to check their performance in China using field measurement datasets. We also summary the parameterization schemes for predicting f(RH, λ)with aerosol chemical compositions. The recently developed methods to observe other aerosol properties using f(RH, λ)measurements, such as calculating the aerosol hygroscopicity parameter, cloud condensation nuclei number concentration,aerosol liquid water content, and aerosol asymmetry factor, are introduced. Suggestions for further research on f(RH, λ) in China are given.

关键词： aerosol hygroscopicity light-scattering enhancement factor humidified nephelometer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anti-proliferative Properties of Schinensilactone A,A Schinortriterpenoid with 7,8-Seco-1,8-cyclo Scaffold against Caco-2 by Inducing Cell Apoptosis from the Leaves of Schisandra chinensis

引用

Chinese Journal of Chemistry 2022年第11期40卷 1331-1336,I0002页

作者： Yan Liu Guo-Zhen Liu Xiao-Mao Li Peng Jiang Yong-gang Xia Hai-Xue kuang Bing-You Yang Key Laboratory of Basic and Application Research of Beiyao(Heilongjiang University of Chinese Medicine) Ministry of EducationHarbinHeilongjiang 150040China

A novel schinortriterpenoid(SNT),schinensilactone A(1),characterized by a unique 7,8-seco-1,8-cyclo-schisanartane scaffold,was isolated from the leaves of Schisandra chinensis(Turcz.)Baill,together with a new SNT(schinensilactone B,2)and two known(3,4).Their structures were elucidated using spectroscopy and X-ray diffraction.Furthermore,a hypothetical biosynthetic pathway for 1 was postulated due to its novel carbon skeleton.In addition,1 exhibited significant anti-proliferative activity against Caco-2 cells originat-ing from five different tumor cell lines,and its preliminary mechanism of action was investigated with respect to the expression of apoptosis-related proteins,including P53,Caspase 3,Bax,PUMA,and Bcl2.These biological activities would further our understanding of the food function of Schisandra chinensis leaves.

关键词： Schinensilactone A Schinensilactone B Natural products Terpenoids Biological activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

反预期评价构式“N_(1)不大,N_(2)不小”及其生成扩展和多层互动

引用

语文研究 2023年第3期 56-64,F0003页

作者：匡鹏飞杨刚华中师范大学语言与语言教育研究中心湖北武汉430079

“N_(1)不大,N_(2)不小”是个反预期评价构式,在传递反预期信息的同时能表达言者对N_(1)、N_(2)所属的人/物或原大小状态的正、负向评价,多用于负向评价。该构式表达反预期信息的手段主要有否定词、反预期标记和语序等,能分别体现三种... 详细信息

“N_(1)不大,N_(2)不小”是个反预期评价构式,在传递反预期信息的同时能表达言者对N_(1)、N_(2)所属的人/物或原大小状态的正、负向评价,多用于负向评价。该构式表达反预期信息的手段主要有否定词、反预期标记和语序等,能分别体现三种反预期类型,可整体反预期或局部反预期。该构式对N_(1)、N_(2)的核心要求是二者具有前大后小或大小相称的关系。N_(1)和N_(2)最好是双音节词,以使该构式整体呈四四对言格式。其语法功能多样,形式变化丰富,分句关系不单一。该构式的韵律结构多是“2+2,2+2”,分句多遵循4±1的注意力跨度,构式整体多遵循7±2的短时记忆容量限度。该构式在生成扩展过程中,展现了多种互动关系,其中N_(1)与N_(2)的互动起主体作用,对反预期信息的形成和主观评价义的产生有重要作用。

关键词：反预期构式 N_(1)不大 N_(2)不小主观评价差等否定四字格构式群

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

从引述到否认:“所谓”的表义条件、历时演变和立场表达

引用

世界汉语教学 2022年第2期36卷 182-195页

作者：杨刚匡鹏飞华中师范大学语言与语言教育研究中心

本文基于语言的“多声性”发现,“所谓”句包含引语代表的被引者声音和其他成分表示的言者声音。这两种声音的异同与“所谓”的表义有对应关系。二者无明显偏离时,“所谓”表引述;二者可能有偏离、部分偏离、完全偏离、严重偏离时,分别... 详细信息

本文基于语言的“多声性”发现,“所谓”句包含引语代表的被引者声音和其他成分表示的言者声音。这两种声音的异同与“所谓”的表义有对应关系。二者无明显偏离时,“所谓”表引述;二者可能有偏离、部分偏离、完全偏离、严重偏离时,分别构成“所谓”表不确信、轻视、不承认、贬斥等主观义的条件。“所谓”有歧解性的原因是“所谓”句正处于两种不同声音相互交往的连接点上。从引述到负面评价的过程也是言者声音越来越偏离被引者声音的过程。历时考察表明,“所谓”在先秦时已有引语标记用法,至宋代经主观化和语法化而出现引述类传信语用法。负面评价语境、紧邻被引语的位置、相对较高的使用频率都为其主观化提供了条件。它在言说类词语中既有共性的语义演变方式,也有个性的发展,在现代汉语里能与引语分离,继续语法化为只表言者态度的传信标记。“所谓”能表达中性和负面立场,言者的主观视点会影响其立场表达。

关键词：多声性主观化语法化引语标记传信标记主观视点

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

家族性结直肠癌X型的诊断与治疗

引用

中华消化外科杂志 2021年第7期20卷 828-830页

作者：谢刚匡毅重庆市沙坪坝区中医院肛肠科 400030

结直肠癌病人中约1/3存在遗传背景。家族性结直肠癌X型是指临床上符合阿姆斯特丹诊断标准Ⅱ,但基因检测无微卫星不稳定基因和DNA错配修复基因突变,肿瘤细胞基因呈微卫星稳定,需注意与Lynch综合征鉴别诊断。家族性结直肠癌X型是一类异质... 详细信息

结直肠癌病人中约1/3存在遗传背景。家族性结直肠癌X型是指临床上符合阿姆斯特丹诊断标准Ⅱ,但基因检测无微卫星不稳定基因和DNA错配修复基因突变,肿瘤细胞基因呈微卫星稳定,需注意与Lynch综合征鉴别诊断。家族性结直肠癌X型是一类异质性极大的家族性结直肠癌,目前病因尚不清楚,可参照散发性结直肠癌进行诊断、治疗、随访和预防。笔者介绍1例家族性结直肠癌X型病人的诊断与治疗经验,旨在为该病的临床诊断提供参考。

关键词：结直肠肿瘤家族性结直肠癌X型 Lynch综合征诊断治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

女性高管对企业技术创新的影响:基于高层梯队理论与风险偏好理论视角

引用

科技管理研究 2023年第24期43卷 164-170页

作者：雷刚旷婷玥广东科技学院管理学院广东东莞523083 澳门城市大学商学院中国澳门999078

多元化的高管组成对于高管团队在提升创造性思维﹑提高企业业绩以及发挥榜样示范等方面起着重要作用,应促进女性在企业创新中更大程度发挥自身价值。为此,依托高层梯队理论与风险偏好理论,以2008—2021年中国A股上市公司为研究样本,通过... 详细信息

多元化的高管组成对于高管团队在提升创造性思维﹑提高企业业绩以及发挥榜样示范等方面起着重要作用,应促进女性在企业创新中更大程度发挥自身价值。为此,依托高层梯队理论与风险偏好理论,以2008—2021年中国A股上市公司为研究样本,通过Tobit模型讨论女性高管对企业技术创新的影响及作用机制,并进一步检验企业产权异质性和产品市场竞争在其中所起作用。结果发现:女性高管能够显著促进企业技术创新;女性高管对企业技术创新的促进作用在非国有企业﹑产品市场竞争更加激烈和市场化程度更高的样本中更显著。因此,企业应主动完善女性高管的选聘及晋升机制,结合女性高管特征与实际工作任务赋予并扩大女性高管相应的职能权限;同时,适当增加配置女性高管数量和比例,并构建年轻女性高管梯次培养链。

关键词：女性高管科技女性企业技术创新高层梯队理论风险偏好

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gold nanoparticle-based paper sensor for ultrasensitive and multiple detection of 32 （fluoro）quinolones by one monoclonal antibody

引用

Nano Research 2017年第1期10卷 108-120页

作者： Juan Peng Liqiang Liu Liguang Xu Shanshan Song Hua kuang gang Cui Chuanlai Xu State Key Laboratory of Food Science and Technology Jiangnan University Wuxi 214122 China School of Food Science and Technology Jiangnan University Wuxi 214122 China

For rapid and simultaneous detection of （fluoro）quinolones, a broadly specific monoclonal antibody （mAb） that recognizes 32 （fluoro）quinolone antibiotics was prepared using a mixture of a norfloxacin derivative and a sarfloxacin derivative as the hapten. An immunochromatographic strip based on gold nanoparticles （AuNPs） was then assembled with goat anti-mouse antibody and antigen （sarfloxacin coupled to ovalbumin）, used to form the C line and T line, respectively. This antigen competes with the （fluoro）quinolones in a sample incubated with mAbs labeled with AuNPs. The strip can detect 32 （fluoro）quinolones including oxolinic acid, nalidixic acid, miloxacin, pipemidic acid, piromidic acid, rosoxacin, cinoxacin, norfloxacin, pefloxacin, lomfloxacin, enofloxacin, fleroxacin, ciprofloxacin, enrofloxacin, dafloxacin, orbifloxacin, sparfloxacin, gemifloxacin, besifloxacin, balofloxacin, gatifloxacin, moxifloxacin, nadifloxacin, ofloxacin, marbofloxacin, flumequine, pazufloxacin, prulifloxacin, sarafloxacin, difloxacin, trovafloxacin, and tosufloxacin in milk within 10 min with the naked eye. The cut-off values of the strip range from 1 to 100 ng/mL and the limits of detection are 0.1- 10 ng/mL. The strip does not cross-react with antibiotics including tetracycline, sulfamethazine, ampicillin, erythromycin, aflatoxin B1, or gentamicin. In short, this immunochromatographic strip is a very useful tool for the primary screening of （fluoro）quinolones in milk.

关键词：（fluoro）quinolones,gold nanoparticle,monoclonal antibody,paper sensor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：