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Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population

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Asian Journal of Urology 2019年第1期6卷 114-121页

作者： Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang weimin gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang Department of Urology Peking University First HospitalBeijingChina Institute of Urology Peking UniversityBeijingChina National Urological Cancer Center BeijingChina Air Force General Hospital PLABeijingChina Department of Urology Peking Union Medical College HospitalBeijingChina Department of Urology Beijing Chao-Yang HospitalBeijingChina Department of Urology Armed-Police General HospitalBeijingChina Department of Urology Shanxi Medical University First HospitalTaiyuanChina Department of Urology Hebei Medical University Second HospitalShijiazhuangChina Department of Urology The General Hospital of the People’s Liberation ArmyBeijingChina Department of Urology First Affiliated Hospital of Jilin UniversityChangchunChina Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pathology The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina Department of Urology The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Urology General Hospital of Guangzhou Military Command of PLAGuangzhouChina Department of Urology West China School of MedicineChengduChina Department of Urology Shangdong Province-owned HospitalJinanChina Department of Urology Peking University Shenzhen HospitalShenzhenChina Department of Urology The Central Hospital of Jinan CityJinanChina Department of Urology Shanghai Changzheng HospitalShanghaiChina Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Urology Beijing Anzhen Hospital of Capital Medical UniversityBeijingChina Department of Urology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Urology The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Urology People’s Hospital of Xinjiang Uygur Autonomous RegionWulumuqiChina Department of Urology Guangdong General HospitalGuangzhouChina Department of Urology The First Affil

Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder ***:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December *** operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology ***:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised ***,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and *** sensitivity using FISH was obtained in high grade and muscle invasive tumors.

关键词： Bladder transitionalcell carcinoma Fluorescence in situ hybridization Detection Grade Stage

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腔内尿道会师法治疗复杂性男性尿道狭窄

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现代泌尿外科杂志 2007年第5期12卷 314-315页

作者：甘为民陈海文王子明李洪亮李和程张楠西安交通大学医学院第二附属医院泌尿外科陕西西安710004

目的总结腔内尿道会师法治疗复杂性尿道狭窄的经验。方法16例男性复杂性尿道狭窄患者,术前行耻骨上膀胱造瘘术,硬膜外麻醉下经尿道外口置入尿道内切开镜,经耻骨上膀胱造瘘口置入一软性膀胱镜经膀胱颈口顺行进入尿道。经内切开镜或软性... 详细信息

目的总结腔内尿道会师法治疗复杂性尿道狭窄的经验。方法16例男性复杂性尿道狭窄患者,术前行耻骨上膀胱造瘘术,硬膜外麻醉下经尿道外口置入尿道内切开镜,经耻骨上膀胱造瘘口置入一软性膀胱镜经膀胱颈口顺行进入尿道。经内切开镜或软性膀胱镜插入一细输尿管导管,经正道通过狭窄段尿道。沿此导管用内切开刀切开狭窄段尿道,沿正道进入膀胱,再用Otis刀彻底切开狭窄段。结果16例患者均成功地顺利完成了腔内尿道会师手术,拔除尿管后排尿通畅。平均手术时间122min。平均最大尿流率18mL/s。随访15月,F20尿道扩张器可以顺利通过。结论利用内切开镜和软性膀胱镜腔内尿道会师治疗复杂性尿道狭窄,方法简单易行,疗效确切可靠,成功率高。

关键词：尿道狭窄会师术

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Mechanism of Bragg Diffraction-Assisted Light Extraction in gan-based Light-Emitting Diodes Based on a Self-Consistent Model

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Communications in Theoretical Physics 2009年第9期52卷 545-548页

作者： LIU Wen-De gan Zi-Zhao National Institute of Metrology Beijing 100013 China School of Physics and State Key Laboratory for Artificial Microstructures and Mesoscopic Physics Peking University Beijing 100871 China

By introducing the distribution of the light energy density in gan-based light-emitting diode (LED),theLED model based on the incoherent regime and the light extraction efficiency are *** energy density asa function of the angle of incidence is calculated to demonstrate the mechanism of the light *** deviationbetween the tendencies of the transmissivity of the output layer and the extraction efficiency is also demonstrated.

关键词： light-emitting diodes extraction efficiency Bragg diffraction photonic crystals

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简单芳香族醛、酮化合物相转移催化Kishner-Wolff反应

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高等学校化学学报 1985年第4期6卷 336-338页

作者：黄起鹏余康唐仕昆甘伟民王辉梁柏龄黄沃林中山大学化学系

Kishner-wolff反应(简称K-W反应)是1911—1912年发现的,它是还原醛和酮的腙或缩氨脲为烃的著名方法。黄鸣龙、Cram、Grundon等人曾研究过此反应。1979年,我们用冠醚作相转移催化剂实现了相转移催化K-W反应。本文探讨了相转移催化K-W反... 详细信息

Kishner-wolff反应(简称K-W反应)是1911—1912年发现的,它是还原醛和酮的腙或缩氨脲为烃的著名方法。黄鸣龙、Cram、Grundon等人曾研究过此反应。1979年,我们用冠醚作相转移催化剂实现了相转移催化K-W反应。本文探讨了相转移催化K-W反应的适用范围。研究了八个芳香族醛、酮化合物的还原,其结果列于表1。

关键词：相转移催化剂黄鸣龙缩氨脲冠醚醛和酮还原

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东北典型盐碱湿地碳排放的水深临界阈值及其温度依赖性

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湖泊科学 2025年第1期37卷 159-170,I0015-I0017页

作者：李姝臻刘强甘罗扬武海涛王波北京师范大学环境学院水环境模拟国家重点实验室北京100875 北京师范大学环境学院教育部水沙科学重点实验室北京100875 中国科学院长春分院长春130022 吉林莫莫格国家级自然保护区白城137316

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(CH_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量... 详细信息

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(CH_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量的特征,本研究以莫莫格湿地为主要研究区,选取5种代表性植被(芦苇(Phragmites australis)、扁秆藨草(Bolboschoenus planiculmis)、三江藨草(Schoenoplectus nipponicus)、香蒲(Typha orientalis ***)和碱蓬(Suaeda glauca)),布设Marsh Organ中型实验生态系统模拟不同水深生境,揭示CH_(4)和二氧化碳(CO_(2))排放通量变化及其环境影响因子。结果表明,莫莫格湿地-10~50 cm水深范围内5种代表性植被生长季CH_(4)排放通量范围为0.07~86.74 mg/(m^(2)·h),平均值为8.89 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量;在研究水深范围内,代表性植被生长季CO_(2)排放通量范围为10.59~1891.08 mg/(m^(2)·h),平均值为450.12 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量。不同植被对碳排放的贡献量有所差异,具体来说,芦苇和香蒲的CH_(4)排放通量最高,而藨草的CO_(2)排放通量最高。碳排放随水深变化呈现分段规律,CH_(4)排放随水深变化呈现先增加后减少的趋势,而CO_(2)则呈现相反规律,随水深变化先减小后增加,其水深临界阈值均出现在22 cm处。在不同水深范围内,CO_(2)排放对于水深的敏感性均大于CH_(4),且当水深大于22 cm时,CH_(4)和CO_(2)均呈现出更高的水深敏感性。碳排放在不同水深范围对温度的敏感程度不同,当水深小于22 cm时,CH_(4)和CO_(2)均呈现出更高的温度敏感性,然而当水深大于22 cm时,二者对温度均不敏感。结果表明升温背景下,东北典型盐碱湿地水陆过渡区关键生态系统在不同水深范围内呈现出不对称的响应模式,频繁的水位波动会极大地改变湿地碳排放格局,从而影响到湿地碳功能的稳定发挥。

关键词：碳排放水深温度依赖性莫莫格湿地阈值

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Low limit of detection of the Algan/gan-based sensor by the Kelvin connection detection technique

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Microsystems & Nanoengineering 2021年第4期7卷 35-44页

作者： Hanyuan Zhang Ying gan Shu Yang Kuang Sheng Ping Wang College of Electrical Engineering Zhejiang University310027 HangzhouChina Biosensor National Special Laboratory Department of Biomedical EngineeringZhejiang University310027 HangzhouChina Hangzhou Global Scientific and Technological Innovation Center Zhejiang University310027 HangzhouChina

The Algan/gan-based sensor is a promising POCT(point-of-care-testing)device featuring miniaturization,low cost,and high *** is an effective protein biomarker for the early diagnosis of HF(heart failure).In this work,a novel Algan/gan device with the Kelvin connection structure and the corresponding detection technique was *** technique can effectively suppress the background noise and improve the SNR(signal-to-noise ratio).A BNP detection experiment was carried out to verify the effectiveness of this *** is shown that compared with that of the traditional detection method,the LOD(limit of detection)was improved from 0.47 ng/mL to 1.29 pg/*** BNP detection experiment was also carried out with a traditional electrochemical Au-electrode sensor with the same surface functionalization *** Algan/gan sensor showed a better LOD than the Au-electrode ***,the influence of Algan/gan sensor package on background noise was investigated with the mechanism of the noise source ***,based on the optimized package,the optimal SNR quiescent operating point of the Algan/gan sensor was *** biasing the sensor at the optimal quiescent operating point and immobilizing the magnetic beads with anti-BNP on the gate of the Algan/gan sensor,the LOD for BNP detection was further improved to 0.097 pg/mL.

关键词： Algan/gan limit noise

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Correlate light-matter interactions in different spectral regimes

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Light(Science & Applications) 2022年第4期11卷 455-456页

作者： Qiaoqiang gan Material Science Engineering Physical Science EngineeringKing Abdullah University of Science and TechnologyThuwalSaudi Arabia Electrical Engineering University at BuffaloThe State University of New YorkBuffaloNYUSA

Using mid-infrared plasmons to trigger visible surface enhanced Raman spectroscopy signals within a nanocavity represents new opportunities for fundamental investigation of light-matter interaction within quantum regimes,requiring improved sensing capabilities enabled by well-designed nano/microstructures and characterization systems.

关键词： light cavity visible

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EXACT AND DISCRETIZED DISSIPATIVITY OF THE PANTOGRAPH EQUATION

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Journal of Computational Mathematics 2007年第1期25卷 81-88页

作者： Siqing gan School of Mathematical Sciences and Computing Technology Central South University Changsha 410075 China

The analytic and discretized dissipativity of nonlinear infinite-delay systems of the form x＇（t） = g（x（t）,x（qt））（q∈ （0, 1）, t 〉 0） is investigated. A sufficient condition is presented to ensure that the above nonlinear system is dissipative. It is proved the backward Euler method inherits the dissipativity of the underlying system. Numerical examples are given to confirm the theoretical results.

关键词： Infinite delay Pantograph equation Backward Euler method Dissipativity.

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2012 Nepal-China Friendship Week Held in Nepal

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Voice of Friendship 2013年第1期 27-28页

作者： Gao weimin gan Qianyi

The year of 2012 was designated the "China-Nepal Friendship Exchange Year" by the Chinese and Nepalese governments,and,as one of the important cultural exchange programs, the 2012 Nepal-China Friendship Week, co-sponsored by the CPAFFC and the World Culture Net(WCN) of Nepal,was held from November 30 to December 6. The CPAFFC organized an 18-member Delegation of

关键词： delegation Minister officials Tibet border designa

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Dynamic crossover in [VIO^(2+)][Tf_(2)N-]_(2) ionic liquid

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Chinese Physics B 2021年第1期30卷 374-379页

作者： gan Ren Departments of Physics&Key Laboratory of Photonic and Optical Detection in Civil Aviation Civil Aviation Flight University of ChinaGuanghan 618307China

Ionic liquids usually behave as fragile liquids,and the temperature dependence of their dynamic properties obeys supper-Arrhenius *** this work,a dynamic crossover is observed in([VIO^(2+)][Tf_(2)N-]_(2)) ionic liquid at the temperature of 240-800 *** diffusion coefficient does not obey a single Arrhenius law or a Vogel-Fulcher-Tammann(VFT) relation,but can be well fitted by three Arrhenius laws or a combination of a VFT relation and an Arrhenius *** origin of the dynamic crossover is analyzed from correlation,structure,and *** gets a stronger backward correlation at a lower temperature,as shown by the fractal dimension of the random *** temperature dependence function of fractal dimension,heterogeneity order parameter,and thermodynamic data can be separated into three regions similar to that observed in the diffusion *** two crossover temperatures observed in the three types of data are almost the same as that in diffusion coefficient fitted by three Arrhenius *** results indicate that the dynamic crossover of[VIO2+][Tf2 N-]2 is attributed to the heterogeneous structure when it undergoes cooling.

关键词： ionic liquids dynamic crossover heterogeneity order parameter fractal dimension fragile

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