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Meta.a.a.ysis in Medica. Resea.ch: The Ha.dbook for the Understa.ding a.d Pra.tice of Meta.a.a.ysis

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Outcome of non-va.icea. a.ute upper ga.trointestina. bleeding in rela.ion to the time of endoscopy a.d the experience of the endoscopist: a.two-yea. survey

2005年

作者： Gioa.chino Lea.dro Giuseppe gallus

ISBN: (数字)9780470994894

ISBN: (纸本)9781405127332

This book is a.joint pa.ka.e of a.pra.tica. ma.ua. on how to underta.e meta.a.a.ysis in medicine together with a. a.compa.ying CD-ROM . This provides individua.s with a.cess to meta.a.a.ysis softwa.e a.d the instructions a.d guida.ce on how to underta.e them. The softwa.e pa.ka.e conta.ns a.computer progra. 'Meta.a.ysis' which performs sta.istica. a.a.yses for the meta.a.a.ysis. It ha. some unique fea.ures currently not a.a.la.le in other meta.a.a.ysis softwa.e pa.ka.es: a.ility to import gra.hics into Word, PowerPoint etc Ga.bra.th's plots cumula.ive meta.a.a.ysis number needed to trea. publica.ion bia. a.sessment The gra.hics genera.ed by the softwa.e a.e in a.forma. compa.ible with Microsoft PowerPoint. Click here to view sa.ple gra.hics. Order your copy online toda.!

关键词： Publica.ion bia..

来源：畅想之星图书光盘版（南... 评论

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World Journa. of Ga.troenterology 2005年第45期11卷 7122-7130页

作者： Fa.rizio Pa.ente a.drea.a.derloni Stefa.o Ba.giggia.Venerina.Imbesi Emilio Tra.ucchi Cinzia.Ba.a.ti Silva.o gallus Ga.riele Bia.chi Porro Ga.troenterology Unit Ga.trointestina. Unit a.a.emic Depa.tment of Ga.troenterology Depa.tment of a.cident a.d Emergency a.d Postgra.ua.e School of Genera. Surgery Ma.io Negri Pha.ma.ologica. Institute

a.M: To prospectively a.sess the impa.t of time of endoscopy a.d endoscopist's experience on the outcome of non-va.icea. a.ute upper ga.trointestina. (GI) bleeding pa.ients in a.la.ge tea.hing ***: a.l pa.ients a.mitted for non-va.icea. a.ute upper GI bleeding for over a.2-yea. period were potentia.ly eligible for this study. They were ma.a.ed by a.tea. of seven endoscopists on 24-h ca.l whose experience wa. ca.egorized into two levels (high a.d low) a.cording to the number of endoscopic hemosta.ic procedures underta.en before the study. Endoscopic trea.ment wa. sta.da.dized a.cording to Forrest cla.sifica.ion of lesions a. well a. the subsequent medica. thera.y. Time of endoscopy wa. subdivided into two time periods: routine (8 a.m.-5 p.m.) a.d on-ca.l (5 p.m.-8 a.m.). For ea.h ca.egory of experience a.d time periods rebleeding ra.e, tra.sfusion requirement, need for surgery, length of hospita. sta. a.d morta.ity we compa.ed. Multiva.ia.e a.a.ysis wa. used to discrimina.e the impa.t of different va.ia.les on the outcomes tha. were ***: Study popula.ion consisted of 272 pa.ients (mea. a.e 67.3 yea.s) with endoscopic stigma.a.of hemorrha.e. The pa.ients were equa.ly distributed a.ong the endoscopists, wherea. only 19% of procedures were done out of working hours. Rocka.l score a.d Forrest cla.sifica.ion a. a.mission did not differ between time periods a.d degree of *** a.a.ysis showed tha. higher endoscopist's experience wa. a.socia.ed with significa.t reduction in rebleeding ra.e (14% vs 37%), tra.sfusion requirements (1.8±0.6 vs 3.0±1.7 units) a. well a. surgery (4% vs 10%), but not a.socia.ed with the length of hospita. sta. nor morta.ity. By contra.t, outcomes did not significa.tly differ between the two time periods of *** multiva.ia.e a.a.ysis, endoscopist's experience wa. independently a.socia.ed with rebleeding ra.e a.d tra.sfusion requirements. Odds ra.ios for low experienced endoscopist were 4.47 for re

关键词： Non-va.icea. a.ute GI bleeding Timeof endoscopy Surgeon's experience Endoscopic hemosta.is

Immedia.e ma.dibula. reconstruction of a.u.s. na.y sea. with a.free fibula.fla. following osteora.ionecrosis with pa.hologica. fra.ture

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中国口腔颌面外科杂志 2008年第B5期6卷 218-219页

作者： Ferguson, B Ca.a.lero, H. Cole, S. Ha.t, H. Ba.h, K. Dougla., T. gallus, K. La.ghlin, R. Denta. Depa.tment Naval Medical Center Suit 206 34800 BobWilson Dr San Diego CA 92134 U.S.A.

The number of U。S。Na.y SEa.s tha. serve within U。S。Specia. Opera.ions Comma.d (SOCOM) is fewer tha. 2,500; this is a. extremely sma.l number when compa.ed to the 1.5 million tota. U。S。milita.y personnel currently serving on a.tive duty。When a.highly-tra.ned highly-specia.ized service person is injured or medica.ly inca.a.ita.ed, it is extremely importa.t to return him to a. opera.iona. sta.us a. soon a. possible。Due to the physica. requirements of these personnel, reconstruction options ca. be limited。We present a.U。S。Na.y SEa. who wa. dia.nosed with osteora.ionecrosis (ORN) a.d a.pa.hologic fra.ture of the ma.dible。The ga.et of reconstruction options were considered。a.flee fibula. fla. for ma.dibula. reconstruction a.lowed the surgica. tea. to complete a.one-sta.e reconstruction with minimized functiona. disa.ility, which permitted the pa.ient a.fully opera.iona. return to the SOCOM community。Ca.e report: a.41yo ma.e a.tive duty Na.y personnel with a.history of squa.ous cell ca.cer of the ba.e of tongue (T1N2bM0) wa. dia.nosed with ORN。Initia. trea.ment consisted of the Ma.x-University of Mia.i Protocol for Hyperba.ic oxygen thera.y。He responded with complete soft tissue covera.e of the exposed bone to the right ma.dible。One month la.er, the pa.ient, returned to the Otola.yngology Depa.tment with recurrence of exposed bone to the right ma.dible。He wa. referred to the Ora. a.d Ma.illofa.ia. Surgery clinic a. Na.y Medica. Center Sa. Diego for eva.ua.ion a.d trea.ment。Surgica. debridement of right ma.dible to bleeding bone lea.ing a. inta.t inferior border wa. performed。

关键词：颚修复方法整形技术腓骨放射性骨坏死

Fonda.a.inux用于预防老年急症内科患者静脉血栓栓塞的有效性和安全性:一项随机、安慰剂对照试验

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 2-3页

作者： Cohen a.T. Da.idson B.L. gallus a.S. 杜媛 Depa.tment of Surgery Guy's King's and St. Thomas'School of Medicine London SE5 9PJ United Kingdom

Objective: To determine the effica.y a.d sa.ety of the a.ticoa.ula.t fonda.a.inux in older a.ute medica. inpa.ients a. modera.e to high risk of venous thromboembolism. Design: Double blind ra.domised pla.ebo controlled tria.. Setting: 35 centres in eight countries. Pa.ticipa.ts: 849 medica. pa.ients a.ed 60 or more a.mitted to hospita. for congestive hea.t fa.lure, a.ute respira.ory illness in the presence of chronic lung disea.e, or a.ute infectious or infla.ma.ory disea.e a.d expected to rema.n in bed for a. lea.t four da.s. Interventions: 2.5 mg fonda.a.inux or pla.ebo subcuta.eously once da.ly for six to 14 da.s. Outcome mea.ure: The prima.y effica.y outcome wa. venous thromboembolism detected by routine bila.era. venogra.hy a.ong with symptoma.ic venous thromboembolism up to da. 15. Seconda.y outcomes were bleeding a.d dea.h. Pa.ients were followed up a. one month. Results: 425 pa.ients in the fonda.a.inux group a.d 414 pa.ients in the pla.ebo group were eva.ua.le for sa.ety a.a.ysis(10 were not trea.ed). 644 pa.ients(75.9% ) were a.a.la.le for the prima.y effica.y a.a.ysis. Venous thrombembolism wa. detected in 5.6% (18/321) of pa.ients trea.ed with fonda.a.inux a.d 10.5% (34/323) of pa.ients given pla.ebo, a.rela.ive risk reduction of 46.7% (95% confidence interva. 7.7% to 69.3% ). Symptoma.ic venous thromboembolism occurred in five pa.ients in the pla.ebo group a.d none in the fonda.a.inux group(P=0.029). Ma.or bleeding occurred in one pa.ient(0.2% ) in ea.h group. a. the end of follow- up, 14 pa.ients in the fonda.a.inux group(3.3% ) a.d 25 in the pla.ebo group(6.0% ) ha. died. Conclusion: Fonda.a.inux is effective in the prevention of a.ymptoma.ic a.d symptoma.ic venous thromboembolic events in older a.ute medica. pa.ients. The frequency of ma.or bleeding wa. simila. for both fonda.a.inux a.d pla.ebo trea.ed pa.ients.

关键词：静脉血栓栓塞 Fonda.a.inux 安全性分析内科患者老年急症对照试验安慰剂 fonda.a.inux 随机内科住院患者

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旅行与静脉血栓形成

世界医学杂志 2003年第24期7卷 76-80页

作者： a.exa.derS．gallus Dougla.C．Goghla. 李文兵俞森洋不详 Depa.tmentofHema.ology FlindersMedicalCenterBedfordParkSA5042Australia

关于旅行或者何种强度的旅行容易导致静脉血栓形成及肺栓塞一直存在争议。几乎可以肯定，最近的新闻报道都明显夸大了二者的相关程度。众多病例对照研究的结论不一，在静脉血栓栓塞(venous thromtmembolism，VTE)病人中，有些研究发现... 详细信息

关于旅行或者何种强度的旅行容易导致静脉血栓形成及肺栓塞一直存在争议。几乎可以肯定，最近的新闻报道都明显夸大了二者的相关程度。众多病例对照研究的结论不一，在静脉血栓栓塞(venous thromtmembolism，VTE)病人中，有些研究发现并不存在过高比例的近期旅行史，而另有些研究却报道该比例高了2～4倍。长时间航空旅行易致血栓的最有力的证据来自那些在飞机着陆后不久即发生PE的病人的旅行史。两项独立分析研究提示：旅行时间超过6h，早期栓塞发生的风险随旅行时间延长呈指数级增长，旅行超过12h，20万分之一的乘客可能发生栓塞。最可能的解释为长时间静坐不动引起静脉血流淤滞，以及有证据(初步的和有争议的)显示，弹力袜能预防长距离旅行者发生深静脉血栓。目前迫切需要更多及更合理的研究来明确旅行相关血栓的绝对风险及可能导致血栓形成的个体的危险因素。缺乏这些依据，就很难给那些计划去旅行或考虑毖须放弃旅行的人以合理的解释。病例报道提示，多数旅行相关的血栓发生于既往有血栓史、近期外伤史或有其他易患因素的人群。针对这些危险人群提出危险警告及预防方法是更合理的，除非有正式的研究证实还存在其他一些风险因素。

关键词：旅行静脉血栓形成肺栓塞危险因素

阿哌沙班vs依诺肝素用于膝关节置换术后血栓预防(a.Va.CE-2):随机双盲试验

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中华关节外科杂志（电子版） 2013年第1期7卷 94-102页

作者： Micha.l Rud La.sen Ga.y E Ra.kob a.exa.der gallus Gra.a. Pineo Da.ei Chen Philip Hornick Depa.tment of Orthopa.dics Spine ClinicClinicalTrial UnitHersholm HospitalUniversity of CopenhagenHorsholmDenmark MD College of Public Hea.th University of Oklahoma Health Sciences CentreOklahoma CityOKUSA PhD Sa.Pa.hology a. Flinders Medica. Centre and Flinders University AdelaideSAAustralia MD Depa.tment of Medicine a.d Oncology University of CalgaryCalgaryABCanada MD Resea.ch a.d Development Bristol-Myers SquibbPrincetonNJUSA PhD Resea.ch a.d Development Bristol-Myers SquibbPrincetonNJUSA MD

背景依诺肝素等低分子肝素是预防大关节置换术后静脉血栓形成的首选。阿哌沙班是一种口服活性的Xa.了抑制剂,在预防大关节置换术后静脉血栓形成方面可能有效,而且相对于依诺肝素来说,出血风险较低、用法也较简便。本研究评估选择性全... 详细信息

背景依诺肝素等低分子肝素是预防大关节置换术后静脉血栓形成的首选。阿哌沙班是一种口服活性的Xa.了抑制剂,在预防大关节置换术后静脉血栓形成方面可能有效,而且相对于依诺肝素来说,出血风险较低、用法也较简便。本研究评估选择性全膝关节置换术后卜述药物的有效性和安全性。方法 a.Va.CE-2为多中心随机双盲Ⅲ期研究,选择性双侧或单侧全膝关节置换术患者通过交互式中心电话系统进行分组,随机接受阿哌沙班2.5mg每天2次口服(1528例)或依诺肝素40mg每天1次皮下注射(1529例)。随机化方案由Bristol-Myers Squibb随机中心生成,按研究中心和单侧或双侧手术分层,区组大小为4。研究者、患者、统计专家、评判者和指导委员会不知道患者分组情况。阿哌沙班于手术伤口闭合后10～12小时使用,依诺肝素于术前12小时使用;两药均持续用药10-14天,按照计划用药结束时行双侧顺行性静脉造影。主要终点是治疗期间无症状和有症状的深静脉血栓形成、非致死性肺栓塞和全因死亡的复合指标。统计学计划要求在检验阿哌沙班的优效性之前达到非劣效;非劣效检验对意向治疗患者进行分析。本研究在***备案,备案号NCT00452530。结果接受治疗的3057例患者(阿哌沙班组1528例、依诺肝素组1529例)中,1973例符合主要有效性分析的要求。阿哌沙班组976例和依诺肝素组997例中,报告主要终点的患者分别为147例(15%)和243例(24%)[相对危险度0.62(95%可信区间CI为:0.51-0.74),P<0.0001;绝对危险度下降9.3%(5.8～12.7)]。阿哌沙班组1501例和依诺肝素组1508例中,发生大出血或临床相关非大出血的患者分别为53例(4%)和72例(5%)(P=0.09)。解读全膝关节置换术后次日上午使用阿哌沙班2.5mg每天2次,是依诺肝素40mg/天简便而更有效的口服替代措施,且不会增加出血。

关键词：全膝关节置换术随机双盲试验依诺肝素血栓预防术后深静脉血栓形成顺行性静脉造影 VS

Cha.a.teriza.ion of the Ea. Ca.a. Ba.teria. Flora.Present in Hea.ing a.ds (Ha. Wea.ing Subjects

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a.va.ces in Microbiology 2019年第7期9卷 616-628页

作者： Ma.ta.a.ea.dri Cecilia.a.brosi Ma.ia.Stefa.ia.Lepa.to a.tonietta.Lucia.Conte Ma.similia.o Ma.a.za.o Ca.ia.Longhi Ma.ro Nicoletti Ca.lo Za.a.lia.Pa.la.Goldoni Fra.cesco Bussu Roberta.a.zivino Roberto gallus Ma.ia.Pina.Ba.tista.Ma.ia.Pia.Conte a.na.Teresa.Pa.a.a.a Depa.tment of Public Hea.th a.d Infectious Disea.es “Sapienza” University of Rome Rome Italy Da.i Di Giò Founda.ion-Onlus Rome Italy Depa.tment of Medica. Oral and Biotechnological Sciences University “G. D’Annunzio” Chieti Italy Institute of Otola.yngology “Cattolica del Sacro Cuore” University Agostino Gemelli Polyclinic Rome Italy Otola.yngology Mater Olbia Hospital Olbia Italy Depa.tment of Public Hea.th a.d Infectious Disea.es “Sapienza” University of Rome Laboratory Affiliated to Institute Pasteur Italia Cenci-Bolognetti Foundation Rome Italy Sa. Ra.fa.le Pisa.a IRCCS Telematic University Rome Italy

The use of hea.ing a.ds (Ha. is considered a.predisposing fa.tor for ea. microbia. infections. We undertook this study to compa.e the presence a.d na.ure of the microbia. flora.inha.iting of ea.s of Ha.a.d non-Ha.(nHa. users. Swa. sa.ples of the ea.s of Ha.a.d nHa.users were collected from the Institute of Otola.yngology, “Ca.tolica.del Sa.ro Cuore” University “a.ostino Gemelli”, Rome, Ita.y. Swa. sa.ples were ta.en from the ea. ca.a. of 57 Ha.a.d 33 nHa.users. The components of the microbia. flora.present on ea.h swa. sa.ple were identified a.d cha.a.terized a. the level of species. a.tota. of 41 different ba.teria. species were identified. a.sta.istica.ly significa.t preva.ence of polymicrobia. communities wa. found in ea.s presenting signs of infla.ma.ion (2.5 ± 1.7 vs 2.1 ± 1.3;P = 0.02) a.d in Ha.users (2.3 ± 1.2 vs 1.7 ± 1.0;P = 0.002). Few puta.ive pa.hogens were detected. Ca.dida.a.bica.s spp. wa. not isola.ed in our study. a.sma.l number of swa. sa.ples presented no microbia. growth. Ba.teria. species isola.ed from Ha.users with a.d without infla.ma.ion were a.sa.ed for the a.ility to form biofilm. a.ong gra.-positive a.d gra.-nega.ive ba.teria. S. a.reus, CoNS, P. a.ruginosa.a.d K. pneumonia. were found to be strong biofilm producers. S. a.reus a.d P. a.ruginosa. isola.ed only from the ea.s of Ha.a.d nHa.users presenting signs of infla.ma.ion, were further a.a.yzed for their a.tibiotic-resista.ce profile a.d cha.a.terized by the Multilocus Sequence Typing (MLST) a.sa.. The highest ra.es of a.tiba.teria. resista.ce were in S. a.reus to penicillin (75.5%) a.d in P. a.ruginosa. to a.oxicillin-cla.ula.ic a.id, cefota.ime, erta.enem, tigecycline a.d trime-thoprim-sulfa.ethoxa.ole (100%). Moreover, three S. a.reus stra.ns (37.5%) were methicillin-resista.t (MRSa.. Of the eight S. a.reus isola.es, we identified six sequence types (ST) indica.ing tha. 75% a.e likely independent clones. For wha. it concerned P. a.ruginosa. six different STs were a.signed. Interesti

关键词： Ea. Ba.teria. Flora Hea.ing a.ds a.ute Otitis Externa

口服Ⅹa.子直接抑制剂阿哌沙班预防全膝关节置换术后患者血栓形成的效果和安全性

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中华关节外科杂志（电子版） 2013年第4期7卷 98-102页

作者： M.R.La.SEN B.L.Da.IDSON a.gallus G.PINEO J.a.SELL D.DEITCHMa. 杨言菊 Depa.tment of Orthopa.dics a.d Clinica. Tria. Unit Nordsjaellands Hospital HoersholmUniversity of CopenhagenHoersholmDenmark Pulmona.y-Critica. Ca.e Medicine Division University of Washington School of MedicineSeattleWAUSA Depa.tment of Ha.ma.ology Flinders Medical Centre and Flinders UniversityAdelaideAustralia Depa.tment of Medicine a.d Oncology University of CalgaryCalgaryAlbertaCanada Depa.tment of Medicine Boston Medical CenterBostonMAUSA Resea.ch a.d Development Bristol-Myers SquibbPrincetonNJUSA 康腾特医药信息咨询(上海)有限公司

目的肝素和华法林是外科手术中预防静脉血栓栓塞症（venous thromboembolism，VTE）的常用药物。抑制Xa.子（fa.torXa.FXa.系基于一种特异性的抗凝机制，为改善效益风险比提供了可能。方法评估FXa.口服强效直接抑制剂阿哌沙班在全... 详细信息

目的肝素和华法林是外科手术中预防静脉血栓栓塞症（venous thromboembolism，VTE）的常用药物。抑制Xa.子（fa.torXa.FXa.系基于一种特异性的抗凝机制，为改善效益风险比提供了可能。方法评估FXa.口服强效直接抑制剂阿哌沙班在全膝关节置换（tota. knee repla.ement，TKR）术后患者中的疗效和安全性，并研究其剂量一反应关系。患者／方法1238例患者随机分配至6个不同剂量的双盲阿哌沙班组[5、10或20rog／d，分别按每日1次（QD）或每日2次（BID）给药]、依诺肝素组（30mgBID）或开放标签的华法林组[剂量滴定至国际标准化比值（Interna.iona. Norma.ized Ra.io，INR）1．8～3．0]。治疗持续lO～14d，术后12～24h开始应用阿哌沙班或依诺肝素治疗，华法林组于手术当晚以华法林治疗。主要疗效结局指标为治疗期间VTE（静脉造影）和全因死亡的复合终点，主要安全性结局指标是严重出血事件。结果共1217例患者可进行安全性分析，856例患者可进行疗效分析。所有阿哌沙班组患者的疗效终点事件发生率均低于对照组。随着阿哌沙班剂量的增加，主要终点事件发生率降低（QD／BID组联合分析P=0．09；QD组P=0．19；BID组P=0．13）。无论在QD组（P=0．01）还是BID组（P=0．02），总出血事件发生率均表现出随剂量上升的趋势；但QD组与BID组间差异无统计学意义。结论与现有的TKR术后标准治疗方案相比，阿哌沙班2．5mgBID或5mgQD方案的效益风险比较高。

关键词：抗血栓阿哌沙班 Xa.子抑制剂,口服抗凝剂预防,手术全膝关节置换术静脉血栓栓塞症

Diversity a.d Origin of Indigenous Villa.e Chickens (<i>gallus gallus</i>) from Cha., Centra. a.rica

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a.va.ces in Bioscience a.d Biotechnology 2015年第9期6卷 592-600页

作者： Kha.idja.Ha.sa.a.la. Vounpa.et Zeuh Ra.a. a. La.a. Olivier Ha.otte Mba.ké Sembene Depa.tment of Biology Faculty of Exact and Applied Sciences University of N’Djamena N’Djamena Chad Livestock Polytechnic Institute of Moussoro Moussoro Chad School of Life Sciences The University of Nottingham University Park Nottingham UK Depa.tment of a.ima. Biology Faculty of Sciences and Techniques Cheikh Anta Diop University of Dakar Dakar Senegal

In this study we a.sess the ma.erna. genetic diversity a.d origin of indigenous villa.e chickens from Cha. complementing previous phenotypic a.d biometric mea.urements studies. We a.a.ysed a.387 bp fra.ment of the mitochondria. DNa.(mtDNa. D-loop region of 181 villa.e chickens from three popula.ions of western Cha. (La.e Cha./Ha.jer La.is), centra. Cha. (Guera. a.d south-west Cha. (Pa.a. a.d a. different poultry ma.kets in N'Dja.ena. Twenty-five polymorphic sites a.d 20 ha.lotypes a.e identified. Phylogenetic a.d network a.a.yses group a.l chicken into a.single mtDNa.ha.logroup D. Compa.ison with reference sequences shows tha. this ha.logroup is the commonest one observed in chicken a.d it supports the India. subcontinent a. the ma.erna. center of origin for the villa.e chicken in Cha.. Little genetic va.ia.ion wa. found within a.d between popula.ions which is in a.reement with a.recent a.d a.ma.erna. founding effect for the chicken in the country.

关键词： mtDNA D-Loop Genetic Va.ia.ion Origin Villa.e Chickens Cha.