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材料导报 2000年第10期14卷 36-38,10页

作者：童茂松戴国瑞高鼎三 galina Zakharova Olga Pozdniakova 吉林大学电子工程系集成光电子国家重点联合实验室长春130023 俄罗斯科学院乌拉尔分院固态化学研究所

综述了v_2O_5薄膜材料的结构、电学性质及其在电学中的应用。

关键词：电致变色敏感特性氧化钒薄膜结构电学性质

A Comparative Study on Pharmacokinetics of Tricin, a Flavone from Gramineous Plants with Antiviral Activity

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Journal of Biosciences and Medicines 2021年第2期9卷 76-91页

作者： galina I. Solyanik Oleg S. Zulphigarov Iryna v. Prokhorova Olga N. Pyaskovskaya Denis L. Kolesnik viktor P. Atamanyuk Laboratory of Molecular and Cellular Mechanisms of Metastasis R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology of NASU Kyiv Ukraine SMC Ecopharm Ltd. Kyiv Ukraine

Tricin (and tricin containing plant extracts) has been shown to exert a pronounced antiviral activity, high radical scavenging activity and is favored for its safety profile. In the present study we have analyzed the pharmacokinetics of tricin after a single intravenous and oral administration to Wistar rats of an ethanol extract of Calamagrostis Adans and Deschampsia Beauv plants (test agent) at different doses. Tricin concentrations in blood plasma and blood cells were measured at different time points. Two-compartment (for intravenous injection) and one compartment (for oral administration) models were used for the analysis of tricin pharmacokinetics. The results showed that the pharmacokinetics of tricin after intravenous injection of test agent has a pronounced biphasic character, is well described by a two-compartment pharmacokinetic model, and is characterized by non-linear dose-dependence. The pharmacokinetics of tricin administered orally is characterized by a high rate of absorption from the gastrointestinal tract into the blood and rather slow elimination, which leads to a large volume of distribution in the body and a fairly high bioavailability. The obtained results indicate the advantages of the oral route of administration over the intravenous route.

关键词： Polyphenolic Compounds Tricin Pharmacokinetics Bioavailability

Mn^(2+)掺杂对v_2O_5纳米材料结构与电化学性能的影响

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无机材料学报 2013年第11期28卷 1200-1206页

作者：李兆龙孙华君徐杰张晓艳黄胜男朱泉峣陈文 galina S.Zakharova 武汉理工大学材料复合新技术国家重点实验室武汉430070 俄罗斯科学院乌拉尔分院固态化学研究所

以v2O5粉末、H2O2和Mn(CH3COO)2·4H2O为原料,采用水热法制备了纳米结构的锂离子电池阴极材料Mnx v2O5。运用X射线衍射(XRD)、X射线光电子能谱分析(XPS)和扫描电镜(SEM)测试对制备的材料进行结构和形貌表征,并利用充放电测试和交流阻抗... 详细信息

以v2O5粉末、H2O2和Mn(CH3COO)2·4H2O为原料,采用水热法制备了纳米结构的锂离子电池阴极材料Mnx v2O5。运用X射线衍射(XRD)、X射线光电子能谱分析(XPS)和扫描电镜(SEM)测试对制备的材料进行结构和形貌表征,并利用充放电测试和交流阻抗测试研究了样品的电化学性能。结果表明:随着锰掺杂量的增加,v2O5的正交晶型层状结构未发生改变,其层间距逐渐扩大,形貌由纳米短棒状向纳米带簇状变化。电化学测试表明:Mn2+掺杂提高了v2O5的电化学性能,其首次充放电效率由70.8%提高到90%以上;Mn0.01v2O5经过90次充放电循环后,其容量仍为192.2 mAh/g。Mn2+掺杂对v2O5电极材料的离子电导率有影响,Mn0.02v2O5离子电导率由未掺杂时的6.27×10-4S/cm提高到1.58×10-3S/cm。

关键词： Mnxv2O5 电极材料离子掺杂电化学性能

Multipotent stromal cells stimulate liver regeneration by influencing the macrophage polarization in rat

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World Journal of Hepatology 2018年第2期10卷 287-296页

作者： Andrey Elchaninov Timur Fatkhudinov Natalia Usman Irina Arutyunyan Andrey Makarov Anastasia Lokhonina Irina Eremina viktor Surovtsev Dmitry Goldshtein galina Bolshakova valeria Glinkina Gennady Sukhikh National Medical Research Center for Obstetrics Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian FederationMoscow 117997Russia Peoples Friendship University of Russia(RUDN University) Moscow 117198Russia Scientific Research Institute of Human Morphology Moscow 117418Russia Pirogov Russian National Research Medical University Ministry of Healthcare of the Russian FederationMoscow 117997Russia Research Center of Medical Genetics Moscow 115478Russia

AIM To investigate the influence of the umbilical cordderived multipotent stromal cells(MSCs) on recovery of the liver after the subtotal resection, that is, removal of 80% of the organ mass, a renowned model of the small-for-size liver remnant syndrome. METHODS The MSCs were obtained from the intervascular tissue of umbilical cords, dissected from rat fetuses, by the explant culture technique. The vital labeling of MSCs with РКН26 was carried out on the 3 rd passage. The subtotal resection was performed on male Sprague-Dawley rats. The experimental group animals received a transplant 106 MSCs infused into the spleen. Hepatocyte proliferation was assessed by counting of either mitotic figures or Ki67-positive cells in microscopic images. MSC differentiation was assessed with antibodies to hepatocyte-specific marker cytokeratin 18(CK18), cholangiocyte-specific protein CK19, smooth muscle cell-specific protein α-SMA, the endothelial cell marker CD31, or the active fibroblast marker FAPα. Total macrophages of the liver were selectively stained in cryosections incubated with antiCD68 antibodies(1:100, Abcam), while the M2 a and M2 c macrophage populations were selectively stained with anti-CD206 antibodies. Expression of interleukin and growth factor genes was evaluated with *** Intrasplenic allogeneic transplantation of the umbilical cord-derived multipotent stromal cells stimulates reparative processes within the residual liver tissue after subtotal resection(removal of 80% of the organ mass), as indicated by increased rates of hepatocyte proliferation and accelerated organ mass recovery. These effects may result from paracrine influence of the transplanted cells on the resident macrophage population of the liver. The transplantation favors polarization of macrophages to M2 phenotype(the M2-polarized macrophages specifically express CD206; they are known to suppress inflammation and support tissue repair). No differentiation of the transplanted cells into a

关键词： Liver Regeneration Multipotent stromal cells Macrophages

天然与合成紫晶的3543cm^(-1)红外吸收谱带及其鉴定价值

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宝石和宝石学杂志 2004年第4期6卷 1-6页

作者： vladimir S.Balitsky Denis v.Balitsky galina v.Bondarenko Olga v.Balitskaya 1LaboratoryforMineralSynthesisandModificationofMinerals InstituteofExperimentalMineralogyPhysicalChemicalLaboratoryofCondensateMaterialsLaboratoryforPhysicalChemicalInvestigationInstituteofExperimentalMineralogyFersmanMineralogicalMuseum RussianAcademyofScienceMoscowRussiaUniversiteMontpellierⅡFranceRussianAcademyofScienceMoscowRussiaMoscowRussia

重点对 380 0～ 30 0 0cm- 1 范围的红外吸收光谱在鉴别天然与合成紫晶中的适用性和局限性进行了研究。36 80 ,36 6 4 ,36 30cm- 1 处吸收带的存在可以确认紫晶为人工合成的 ,但仅指那些在近中性NH4F溶液中合成的紫晶。相反 ,商业上大... 详细信息

重点对 380 0～ 30 0 0cm- 1 范围的红外吸收光谱在鉴别天然与合成紫晶中的适用性和局限性进行了研究。36 80 ,36 6 4 ,36 30cm- 1 处吸收带的存在可以确认紫晶为人工合成的 ,但仅指那些在近中性NH4F溶液中合成的紫晶。相反 ,商业上大量的合成紫晶是在碱性K2 CO3溶液中合成的 ,这些紫晶的红外吸收光谱并无明显的鉴定特征。前人的研究发现了在近 35 95 ,35 4 3cm- 1 处吸收带的潜在鉴定价值。35 95cm- 1 吸收带在合成紫晶的红外吸收光谱中并未出现 ,在一些天然紫晶中也常常缺失。35 4 3cm- 1 吸收带出现在绝大多数碱性溶液中合成紫晶的红外吸收光谱中 ,但有时也在天然紫晶中出现。因此 ,它只是鉴别合成紫晶的临时性证据。35 4 3cm- 1 吸收带在有些类型的合成紫晶中缺失。要准确地鉴定天然与合成紫晶一定要根据其红外光谱、内部生长结构 (包括双晶 )

关键词：紫晶红外吸收光谱鉴定

Quinolinium Structure as Labeled Biomarkers

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Open Journal of Synthesis Theory and Applications 2014年第3期3卷 21-26页

作者： Nadezhda Shchepina viktor Avrorin Gennadii Badun galina Alexandrova Irina Agafonova Nina Popova Chemistry Department St. Petersburg State University St. Petersburg Russia Laboratory of Radiochemistry Natural Sciences Institute of Perm State University Perm Russia Radiochemistry Department M. V. Lomonosov Moscow State University Moscow Russia

In this study the compatible chemical and biological investigations of several N-phenylquinolinium derivatives have been carried out in order to find the most perspective quinolinium structures for the nuclear-chemica... 详细信息

关键词： N-Phenylquinolinium Compounds Biological Activity Antimicrobial and Antimycotic Action Perspective Tritium Labeled Biomarkers Nuclear-Chemical Synthesis

Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC Coupled with Mass Spectrometry

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International Journal of Analytical Mass Spectrometry and Chromatography 2014年第2期2卷 25-32页

作者： Olga S. Brushinina Roman v. Gurto Maksim S. Timofeev galina A. Frelikh vladimir A. Slepichev Elena A. Yanovskaya Natalia U. Polomeeva Yulya G. Zyuz’kova vladimir v. Udut Federal Governmental Budgetary Institution “Research Institute of Pharmacology E.D. Goldberg’s Name” Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia Federal Governmental Budgetary Institution “Research Institute of Pharmacology E.D. Goldberg’s Name”Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia

Quantitative determination of hydrochlorothiazide (HCTZ) and candesartan (CDS) in human plasma in volunteers was performed using a sensitive, selective and specific LC-MS method which has been developed and validated before the study. The study was performed by means of a liquid chromatograph Shimadzu Prominence equipped with a mass spectrometer LCMS-2020. Analytical column PerfectBond ODS-HD HPLC-column 5 μm 250 × 3.0 mm with a pre-column cartridge PerfectBond ODS-HD 5 μm 10 × 3.0 mm, double source of ionization for LCMS-2020 (electrospray (ESI) and chemical (APCI)) and software LabSol LCMS v5 LCMS2020 systempack were used. The low limit of the quantitative determination for HCTZ and CDS made up 10 ng/ml. m/z for CDS 441.20—positive scan, m/z for HCTZ 295.90—negative scan. The method has been applied to a pharmacokinetic study of 12.5 mg HCTZ and 16 mg CDS tablet in healthy volunteers.

关键词： Candesartan Hydrochlorothiazide LC-MS Pharmacokinetic

Overview of the Consumer Behavior Study in the Markets of Food Products(1998-2018),Based on the Author’s Interpretation of the Consumer's Requirements in the System of values that Influence on the Consumer Market Behavior

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Proceedings of Business and Economic Studies 2018年第4期1卷 1-28页

作者： galina v.Astratova Department of Economics of Housing Communal Services and Energy of the Ural State Economic UniversityYekaterinburgRussia Lanzhou University of Finance and Economics School of Business Administration of LZUFEChina

The purpose of this study was to review the results of a 20-year study in the author’s interpretation of the needs for food products and the value system that determines the market behavior of consumers in the food *** scientific novelty of the research is the following results:a)The author’s interpretation of the needs for food products,as consisting of three components:(1)The actual need for food(physiological need);(2)the need for emotions obtained from eating(psychological need);and(3)the need for market products that can meet the physiological needs of emotional expectations and social needs(socio-psychological and economic need);b)Interdisciplinary approach to the study of consumer behavior that led to the author’s interpretation of the value of the research methods outlined in the works of *** et al.,extended and supplemented in the study of galina ***(1998);c)Identification of the fact that the importance of components in the system of values,according to the results of research,is different for different food *** allows simulating more clearly the behavior of the consumer in the development of a marketing-mix and developing a marketing strategy based on targeting.

关键词： needs wants demand consumer consumer behavior values system of values marketing food marketing marketing research marketing research tools marketing-mix food products markets food products organic food products

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

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Cellular & Molecular Immunology 2021年第6期18卷 1528-1544页

作者： Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats ModiQuest B.v. OssThe Netherlands Citryll B.v. OssThe Netherlands Department of Internal Medicine 3-Rheumatology and Immunology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital ErlangenErlangenGermany Department of Medicine Division of Rheumatology and ImmunologyMedical University of South CarolinaCharlestonSCUSA Laboratory of Molecular Hematology Democritus University of ThraceAlexandroupoliGreece Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-University MunichMunichGermany German Center for Cardiovascular Research(DZHK) Partner Site Munich Heart AllianceMunichGermany Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden

Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ *** or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic ***,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic *** with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and *** show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic *** citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET *** suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related ***,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of *** our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner.

关键词： Neutrophil Extracellular Traps Autoimmunity Citrullination Therapeutic Antibody NET inhibition

Binuclear and Hexanuclear Ti(Ⅳ) Complexes Supported by [OOOO]^(4–)-type Ligand for Preparing Disentangled UHMWPE

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Chinese Journal of Polymer Science 2019年第5期37卷 471-477页

作者： vladislav A.Tuskaev Svetlana Ch.Gagieva Dmitry A.Kurmaev viktor G.vasil'ev Nikolay A.Kolosov Sergey v.Zubkevich Elena S.Mikhaylik Evgenii K.Golubev galina G.Nikiforova Pavel A.Zhizhko Olga A.Serenko Boris M.Bulychev Department of Chemistry M.V.Lomonosov Moscow State University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences Enikolopov Institute of Synthetic Polymer Materials Russian Academy of Sciences

Binuclear and hexanuclear titanium complexes stabilized by tetradentate [OOOO]^(4–)-type ligand were active in ethylene polymerization in the presence of Et2 AlCl/Bu2 Mg binary co-catalyst, giving high molecular weight polyethylene. The binuclear complex showed significantly higher catalytic activity and thermal stability in comparison to mononuclear analogue. Ultra high molecular weight polyethylene(UHMWPE) samples were processed by a solid-state uniaxial deformation into high-strength(up to 2.5 GPa) and highmodulus(over 100 GPa) oriented film tapes, which indirectly indicates a low degree of entanglements between the macromolecular chains.

关键词： Binuclear catalysts Titanium Ethylene Ziegler-Natta polymerization UHMWPE