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Functional Activ.ty of Circulating Phagocytes as Potential Pretreatment Marker of Tumor Drug Resistance

Journal of Biosciences and Medicines 2019年第7期7卷 1-15页

作者： Iryna v. Prokhorov. Olga v. Yurchenko Olga N. Pyaskov.kaya Igor N. Todor galina I. Solyanik Laboratory of Molecular and Cellular Mechanisms of Metastasis R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology of NASU Kyiv Ukraine Department of Monitoring of Tumor Process and Therapy Design R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology of NASU Kyiv Ukraine

The aim of this work was a study of the functional activ.ty of neutrophils and peripheral blood monocytes in rats with the transplanted Walker carcinosarcoma as potential predictors of the sensitiv.ty of this tumor to doxorubicin treatment. This study prov.des an ev.dence that such indices of the functional activ.ty of circulating phagocytes of the tumor-bearing rats as the quantity and the phagocytosis intensity of monocytes, as well as the intensity of ROS production by monocytes and neutrophils, may reflect the degree of sensitiv.ty of the tumor to doxorubicin. So it was shown that the growth of the resistant tumor caused a significant increase of the number of circulating phagocytic cells and the intensity of phagocytosis by more than 100% (p v.riant of the tumor. The ability of blood mono-cytes and neutrophils of rats with a resistant tumor to produce ROS was also significantly different from that in intact rats and animals with the parental carcinosarcoma v.riant. The predictiv. v.lue of these indices is especially important in the dynamic monitoring of the dev.lopment of tumor drug resistance during long-term cancer chemotherapy. Considering the standard 2 - 3 week interv.l between the courses of cancer therapy and the short lifetime of circulating phagocytes, an assessment of the indices of their functional activ.ty before each subsequent course can be considered as a pretreatment assessment. Meanwhile, further studies are needed to determine the spectrum of malignant neoplasms for which the degree of tumor drug resistance correlates with the functional activ.ty of circulating phagocytes.

关键词： Circulating Phagocytes Phagocytic Activ.ty ROS Production Tumor Drug Resistance

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Deterioration in Hemodynamics Reaction, Baroreflex Sensitiv.ty, Sympathetic Nerv. Activ.ty and Redox State of Thoracic Aorta in the Experimental Model of Nitrate Tolerance and Its Pharmacological Correction

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Pharmacology & Pharmacy 2016年第1期7卷 81-88页

作者： Nikoloz v. Gongadze Tamara D. Kezeli galina v. Sukoyan Zaza Chapichadze Nino M. Dolidze Makrine Mirziashv.li Mariam Chipashv.li Department of Medical Pharmacology and Pharmacotherapy Tbilisi State Medical University Tbilisi Georgia Department of Pharmacology Faculty of Medicine I. Javakhishvili Tbilisi State University Tbilisi Georgia International Scientific Centre of Introduction of New Biomedical Technology Tbilisi Georgia Department of Pharmacology State Regulation Agency for Medical Activities Ministry of Health and Social Affairs of Georgia Tbilisi Georgia

Continuous treatment with organic nitrates causes nitrate tolerance and prov.des ev.dence for a relationship between mitochondrial complex 1 activ.ty and mitochondrial aldehyde dehydrogenase-2 (ALDH-2) with disturbances of the hemodynamics reaction during nitroglycerin (NTG) tolerance (NTGT). The purpose of this study was the ev.luation of efficacy of original oxidized form NAD-containing drug, NADCIN®, on hemodynamic reactions, baroreflex sensitiv.ty (BRS) and reflex control of splanchnic sympathetic nerv. activ.ty (SSNA), lev.l of redox-potential, activ.ty of ALDH-2 and superoxide anion generation in aortic tissue in rat model of NTGT. Fiv. groups (7 - 9 each) of male Wistar rats, including control, acute i.v. NTG (150 mcg/kg) administration, NTG tolerance NTGT treatment with NADCIN® 8 mg/kg and methylene blue (MB, 2.5 mg/kg) were used. NTGT in rats was accompanied with the greatly attenuation of hemodynamics reaction, BRS, the decreasing of the ability to reflex control of SSNA without pronounce ov.rexpression of endothelin-1 in v.ssels (aorta). In NTGT rats i.v. NTG along induced less hypotensiv. reactions and alterations in heart period v. single NTG treated group, more expressiv.ly decreased BRS (-34%) and reflex control of SSNA (-18%). NADCIN® significantly inhibits tolerance-inducing properties of the prolonged nitroglycerin infusion (max decrease of blood pressure response to nitroglycerin injection, % of normal controls: NTGT 51.2%, NADCIN® 91.6%, MB 55.8%). NADCIN® in NTGT rats after NTG i.v. administration increased reduced BRS (+37.8%, p v.rsed the decreasing of NAD/NADH ratio, ALDH-2 activ.ty and decreasing in superoxide generation in thoracic aortic tissue. Thus, course treatment with NADCIN® of NTGT rats restores hemodynamics changes, BRS and SSNA throughout the increasing of redox-potential NAD/NADH and cessate

关键词： Experimental Model of Nitroglycerin Tolerance Baroreflex Sensitiv.ty Aldehyde Dehydrogenase Redox-Potential Splanchnic Sympathetic Nerv. Activ.ty

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Tumor cell death v.sualization of renal cell carcinoma under the combined effect of the Gratiola officinalis extract and cyclophosphamide using fluorescent staining methods

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Journal of Innov.tiv. Optical Health Sciences 2021年第5期4卷 46-52页

作者： Artyom Mylnikov.Nikita Nav.lokin Dmitry Mudrak Natalya Polukonov. Alla Bucharskaya galina Maslyakov. Saratov.State Medical Univ.rsity named after V.I.Razumovsky 112 Bolshaya Kazachia Street Saratov 410012Russia National Research Saratov.State Univ.rsity 83 Astrakhanskaya Street Saratov 410012Russia National Research Tomsk State Univ.rsity 36 Lenin Avenue Tomsk 634050Russia

Objectiv. of the study:We used fluorescence imaging methods of apoptosis and necrosis in human renal carcinoma A498 tumor cells in v.tro to rev.al the indicated forms of cell death under the combined effect of flav.noid-containing extract of Gratiola officinalis and cytostatic(cyclo-phosphamide).Materials and methods:The dyes were propidium iodide and acridine orange,which were used in the"aliv. and dead"*** test helped us to identify the total number of dead cells in the forms of necrosis and apoptosis and the number of cells in which apoptosis had started,it was characterized by the appearance of apoptotic bodies or nucleus ***:We found the most pronounced cytotoxic activ.ty at the ratio of extract of Gratiola officinalis and cyclophosphamide concentrations of 1∶*** number of liv.ng cells decreased when exposed to the ratio of extract and cytostatic concentrations of 2∶*** the ratio of concentration of the extract relativ. to the cytostatic increased to 3∶1,the cytostatic activ.ty of the extract began to appear,the total number of tumor cells *** number of cells with nucleus pyknosis and the number of cells with apoptosis signs significantly increased at a 3∶1 ratio of extract and cytostatic concentrations,which confirms the presence of pro-apoptotic activ.ty of the studied *** trend indicates the dependence of a certain form of cell death(apoptosis,necrosis)on the ratio of extract and cytostatic doses,and it also demon-strates the cytostatic and cytotoxic effects of this ***:Fluorescence methods of inv.stigation in the"aliv. and dead"test allowed us to v.sualize the forms of cell death of human kidney carcinoma A498 by combined exposure to the fiav.noid-containing extract of Gratiola officinalis and cytostatic(cyclophosphamide)24 h after *** found that the combination with a concentration ratio of the extract and cyclophosphamide of 3:1 has the greatest effectiv.ness due to stimulation of t

关键词： A498 cell line Gratiola officinalis extract antitumor activ.ty cytostatic activ.ty flav.noids fluorescent methods kidney cancer

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STM Study on the Rectifying Performance of Molibdo-v.nadophosphate Polyanions

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Soft Nanoscience Letters 2014年第2期4卷 24-30页

作者： Sergey A. Kov.lev.kiy Fedor I. Dalidchik galina v. Nizov. Ev.enii M. Balashov Department of Kinetics and Catalysis Semenov Institute of Chemical Physics Russian Academy of Sciences Moscow Russia

Scanning tunneling spectroscopy (STS) was used for inv.stigation of rectification properties of molecules with spatial asymmetry. The molecules of cetyltrimethylammonium deriv.tiv.s of 10-molibdo-2-v.nadophosphate-anions [PMo10v.O40]﹣5 (CTMv.) were adsorbed on a surface of pyrolytic graphite (HOPG). Consequently, both good diode properties and J(v.-curv.s reproducibility of the film were rev.aled. The v.lidity of the single-lev.l model for the ev.luation of the system parameters is discussed.

关键词： STM Molecular Diodes Heteropolyoxometalates Rectifiers

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Ocean dynamic noise energy flux directiv.ty in the 400 Hz to 700 Hz frequency band

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Chinese Journal of Acoustics 2007年第2期26卷 102-110页

作者： v.adimir A. Shchurov.galina F. Iv.nov. Marianna v. Kuyanov. Helen S. Tkachenko v.I. Il'ichev.Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences 43 Baltiyskaya St. VladivostokRussia 690041

Results of field studies of underwater dynamic noise energy flux directiv.ty at two wind speeds, 6 m/s and 12 m/s, in the 400 Hz to 700 Hz frequency band in the deep open ocean are presented. The measurements were made by a freely drifting telemetric combined system at 500 m depth. Statistical characteristics of the horizontal and v.rtical dynamic noise energy flux directiv.ty are considered as functions of wind speed and direction. Correlation between the horizontal dynamic noise energy flux direction and that of the wind was determined; a mechanism of the horizontal dynamic noise energy flux generation is related to the initial noise field scattering on ocean surface wav.s.

关键词： Ocean dynamic noise energy flux directiv.ty in the 400 Hz to 700 Hz frequency band

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Study of possibility of cell recognition in brain tumors

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Frontiers of Optoelectronics 2020年第4期13卷 371-380页

作者： Yulia S.MAKLYGINA Alexei S.SKOBELTSIN Tatiana A.SAv.LIEv. galina v.PAv.Ov. Iv.n v.CHEKHONIN Olga I.GURINA Anastasiya A.Chernyshev. Sergey A.Cherepanov.v.ctor B.LOSCHENOv Prokhorov.General Physics Institute of the Russian Academy of Sciences Moscow 119991.Russia National Research Nuclear Univ.rsity MEPhI Moscow 115409Russia Institute of Gene Biology Russian Academy of SciencesMoscow 119334Russia Burdenko Neurosurgical Institute Moscow 125047Russia Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health Moscow 119034.Russia

The brain has an exceptionally high requirement for energy metabolism,with glucose serv.ng as the exclusiv. energy ***,including glioblastoma,hav. a high glucose uptake and rely on aerobic glycolysis for energy *** alternation of high-efficiency oxidativ. phosphorylation to a low-efficiency aerobic glycolysis pathway(Warburg effect)prov.des macromolecules for biosynthesis and *** research indicates that the specific metabolism in the tumor tissue and nonnal brain tissue in the glioma allows the use of 5-aminolev.linic acid(5 ALA)-induced protoporphyrin IX(PpIX)and methylene blue(MB)to monitor and correct the dev.lopment of the *** focus is on the detection of the differences between tumor cells and tumorassociated macrophages/microglia using spectroscopic and microscopic methods,based on the fluorescent signals and the difference in the drug accumulation of photosensitizers(PSs).Since 5 ALA has long been used effectiv.ly in the clinic for fluorescent surgical nav.gation,it was employed as an agent to identify the localization of tumor tissue and study its composition,particularly tumor and immune cells(macrophages),which hav. also been shown to activ.ly accumulate ***,since PpIX is photodynamically activ.,it can be considered effectiv. as the main target of tumor tissue for further successful photodynamic *** was employed to v.sualize resident microglia,which is important for their activ.tion/deactiv.tion to prev.nt the reprogramming of the immune cells by the ***,using two drugs,it is possible to prev.nt crosstalk between tumor cells and the immune cells of different geneses.

关键词： fluorescent diagnostics spectroscopic method v.deo fluorescent method photosensitizer(PS) brain microglia macrophages 5-aminolev.linic acid(5 ALA) methylene blue(MB)

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3-Phenyl/Pyridinyl Deriv.tiv.s of <i>Trans</i>-2-(aryl/heteryl)v.nyl-3<i>H</i>-quinazolin-4-ones: Synthesis and Fluorescent Properties

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International Journal of Organic Chemistry 2012年第1期2卷 56-63页

作者： Emiliya v. Nosov. Tatyana v. Stupina galina N. Lipunov. Marina S. v.lov. Pav.l A. Slepukhin v.lery N. Charushin Department of Organic Chemistry Chemical Technology Institute Urals Federal University Ekaterinburg Russia Postov.ky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences Ekaterinburg Russia

Nov.l 3-phenyl/pyridinyl-trans-2-(aryl/heteryl)v.nyl-3H-quinazolin-4-ones 3a,b, 4a, 5a, 7a and their 6,7-difluoro de- riv.tiv.s 3c,d, 4b, 5b, 7b hav. been obtained by condensation of the correspondent 2-methylquinazolin-4-ones 1, 6 with aromatic (heterocyclic) aldehydes in the presence of ZnCl2 (AcONa) or by the reaction of 2-methyl-3,1-benzoxazin-4- ones 2 with the Shiff bases. Effects of aryl(heteryl) substituents on photophysical properties of (aryl/heteryl) quinazolinylethenes hav. been studied.

关键词： Styryl Benzazines Fluorinated Quinazolin-4-Ones Uv and FL Spectra X-Ray Trans-cis-Isomerisation 2-Methylquinazolinones 2-Methyl-3 1-benzoxazinones

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Ov.rloading of differentiated Caco-2 cells during lipid transcytosis induces glycosylation mistakes in the Golgi complex

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BIOCELL 2021年第3期45卷 773-783页

作者： galina N.DENISOv. Iv.N D.DIMOv.ANNA v.ZAITSEv. LINARD J.ARTIUX ALEXANDER A.MIRONOv.NATALIA R.KARELINA Department of Anatomy Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of Biochemistry Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of Heart and v.ssel Surgery Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia The FIRC Institute of Molecular Oncology Milan20139Italy

Ov.rloading the intestine enterocytes with lipids induced alteration of the Golgi complex(GC;Sesorov. et al.,2020)and could cause glycosylation ***,using differentiated Caco-2 cells with the established 0[I]blood group phenotype(no expression of the blood antigens A and B[AgA,AgB]under normal conditions)as a model of human enterocytes we examined whether the ov.rloading of these cells with lipids could cause errors in the Golgi-dependent *** demonstrated that under these conditions,there were alterations of the GC and the appearance of lipid droplets in the *** cells produced AgA and *** suggested that after ov.rloading of enterocytes with lipids,AgA were mistakenly synthesized in indiv.dual enterocytes by the Golgi *** mistakes could explain why in the absence of AgA and AgB antibodies against them exist in the blood.

关键词： Golgi Blood group antigens Glycosylation errors Enterocyte Lipid transcytosis Caco-2 cells

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The characteristic pattern of multiple colored layers in coastal stratified lakes in the process of separation from the White Sea

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Journal of Oceanology and Limnology 2018年第6期36卷 1962-1977页

作者： Elena D.KRASNOv. Dmitry N.MATORIN Tatiana A.BELEv.CH Ludmila E.EFIMOv. Anastasiia v.KHARCHEv. Natalia M.KOKRYATSKAYA galina N.LOSYUK Daria A.TODORENKO Dmitry A.v.RONOv.Sv.tlana v.PATSAEv. Biological Faculty of Lomonosov.Moscow State Univ.rsity Leninskye Gory 1bld.12Moscow 119234Russia Faculty of Geography Lomonosov Moscow State University GSP-1 Leninskye Gory1Moscow 119991Russia Faculty of Physics Lomonosov Moscow State UniversityLeninskye Gory1Moscow 119991Russia N.Lav.rov.Federal Center for Integrated Arctic Research Russian Academy of SciencesSevernoj Dviny Emb.23Arkhangelsk 163000Russia A.A.Kharkev.ch Institute for Information Transmission Problems Russian Academy of SciencesBolshoy Karetny Per.19bld.1Moscow 127051Russia A.N.Belozersky Institute of Physico-Chemical Biology Lomonosov Moscow State UniversityLeninskye Gory1Bld.40Moscow 119991Russia

An unusual feature of the saline stratified lakes that were formed due to ongoing postglacial uplift on the White Sea coast is the presence of sev.ral differently colored thin layers in the zone with sharp gradients. Colored layers in fiv. lakes at v.rious stages of separation from the sea were inv.stigated using optical microscopy, spectrophotometry, spectrofluorimetry, and photobiology. The upper greenish colored layer located in the aerobic strata of all lakes near the compensation depth of 1% light penetration contains green algae. In the chemocline, another layer, brightly green, red or pink, is dominated by mixotrophic flagellates. Despite the v.ry low light intensities and the presence of H 2 S, activ. photosynthesis by these algae appears to be occurring, as indicated by high v.lues of the maximum quantum yield of primary photochemistry, electron transport activ.ty, photosynthetic activ.ty of photosystem II, the fraction of activ. centers, and low v.lues of heat dissipation. In the reduced zone of the chemocline, a dense green or brown suspension of anoxygenic phototrophs(green sulfur bacteria) is located.

关键词： algal blooms coastal lakes chemocline fluorescence kinetics Arctic White Sea

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Alterations of morphology of lymphoid organs and peripheral blood indicators under the influence of gold nanoparticles in rats

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Journal of Innov.tiv. Optical Health Sciences 2016年第1期9卷 47-56页

作者： Alla B.Bucharskaya Sv.tlana S.Pakhomy Olga v.Zlobina galina N.Maslyakov. Olga v.Matv.ev. Irina O.Bugaev. Nikita A.Nav.lokin Boris N.Khlebtsov.v.adimir A.Bogatyrev.Nikolai G.Khlebtsov.v.lery v.Tuchin Saratov.State Medical Univ.rsity 112 B.Kazach'ya str.Saratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 13 Entuziastov Prospekt.Saratov 410049Russia Saratov.State Univ.rsity 83 Astrakhanskaya str.Saratov 410012Russia§Institute of Precise Mechanics and Control of Russian Academy of Sciences 24Rabochaya str.Saratov 410028Russia Interdisciplinary Laboratory of Biophotonics Tomsk State Univ.rsity 36 Lenina str.Tomsk 634050Russia

At present,gold nanoparticles(GNPs)are widely used in biomedical applications such as cancer diagnostics and ***,the potential toxicity hazards of these nanomaterials and human safety concerns are gaining significant ***,we report the effects of prolonged peroral administration of GNPs with different sizes(2,15 and 50 nm)on morphological changes in lymphoid organs and indicators of peripheral blood of laboratory *** experiment was conducted on 24 white mongrel male rats weighing 180–220 g,gold nanospheres sizes 2,15 and 50nm were administered orally for 15 days at a dosage of 190g/kg of animal body *** GNPs were conjugated with polyethylene glycol to increase their biocompatibility and *** size-dependent decrease of the number of neutrophils and lymphocytes was noted in the study of peripheral blood,especially pronounced after administration of GNPs with size of 50 *** stimulation of myelocytic germ of hematopoiesis was recorded at morphological study of the bone *** signs of strengthening of the processes of differentiation and maturation of cellular elements were found in lymph nodes,which were showed as the increasing number of immunoblasts and large *** quantitativ. changes of cellular component morphology of lymphoid organs due to activ.tion of migration,proliferation and di®erentiation of immune cells indicate the presence of immunostimulation effect of GNPs.

关键词： Gold nanoparticles lymphoid organs morphological changes bone marrow examination

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