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Progn.stic an. predictive role of immun. microen.iron.en. in.colorectal can.er

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World Journ.l of Gastroin.estin.l On.ology 2024年第3期16卷 643-652页

作者： Olesya Kuzn.tsova Mikhail Fedyan.n.Larisa Zavalishin. Larisa Moskvin. Olga Kuzn.tsova Alexan.ra Lebedeva Alexey Tryakin.galina Kireeva Gleb Borshchev Sergei Tjulan.in.Ekaterin. Ign.tova Departmen. of Chemotherapy Federal State Budgetary Institution(N.N.Blokhin National Medical Research Center of Oncology)of the Ministry of Health of the Russian FederationMoscow 115478Russia Departmen. of Pathology Russian Medical Academy of Continuous Professional EducationMoscow 123242Russia On.oAtlas LCC Moscow 115478Russia Federal State Budgetary In.titution.n.tion.l Medical an. Surgical Cen.er n.med after n.I.Pirogov”of the Min.stry of Health of the Russian.Federation Moscow 105203Russia STOOn.O:Scien.e an. Techn.logy in.On.ology Moscow 115478Russia

Colorectal can.er(CRC)represen.s a molecularly heterogen.ous disease an. on. of the most frequen. causes of can.er-related death *** tradition.l classification.of CRC is based on.pathomorphological an. molecular character-istics of tumor cells(mucin.us,rin.-cell carcin.mas,etc.),an.lysis of mechan.sms of carcin.gen.sis in.olved(chromosomal in.tability,microsatellite in.tability,CpG islan. methylator phen.type)an. mutation.l statuses of common.y altered gen.s(KRAS,n.AS,BRAF,APC,etc.),as well as expression.sign.tures(CMS 1-4).It is also suggested that the tumor microen.iron.en. is a key player in.tumor progression.an. metastasis in.*** to the latest data,the immun. microen.iron.en. can.also be predictive of the respon.e to immun. checkpoin. *** this review,we highlight how the immun. en.iron.en. in.luen.es CRC progn.sis an. sen.itivity to systemic therapy.

关键词： Immun.score Immun. microen.iron.en. Colorectal can.er Gastroin.estin.l can.ers Predictive biomarkers Digital pathology

Olefin.Polymerization.Behavior of Titan.um(IV) Complexes with Fluorin.ted an. n.n.fluorin.ted Aliphatic Phen.xyimin. Ligan.s

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Chin.se Journ.l of Polymer Scien.e 2024年第1期42卷 52-62,I0007页

作者： Vladislav A.Tuskaev Kasim F.Magomedov Svetlan. Ch.Gagieva Dmitry A.Kurmaev Yulia V.n.lyubin. Evgen.i K.Golubev Maria D.Evseeva Viktor G.Vasil'ev galina G.n.kiforova Mikhail I.Buzin.Vyacheslav S.Bogdan.v Boris M.Bulychev Departmen. of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.n.n.smeyan.v In.titute of Organ.elemen. Compoun.s Russian Academy of SciencesMoscow119991Russian Federation En.kolopov In.titute of Syn.hetic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride an. dialkoxide com plexes with phen.xyimin. ligan.s con.ain.n. fluorin.ted an. n.n.luorin.ted aliphatic imin. fragmen.s have been.*** molecular structures of complexes 1 an. 4 were established by sin.le-crystal X-ray diffraction.*** complexes adopt a distorted octahedral coordin.tion.structure aroun. the titan.um atom an. two oxygen.atoms are situated in.tran. position.while two n.trogen.atoms an. two outgoin. ligan.s(Cl or iPrO) are situated in.cis *** of activators(MMAO-12 an. combin.tion. Et_n.ICl_(3-n.+Bu_(2)Mg) an. outgoin. ligan.(Cl or iPrO) n.ture on.the catalytic activity an. properties of the resultin. polymers was *** Ti complexes,despite the n.ture of the outgoin. ligan.s(Cl or iPrO) in.the presen.e of Al/Mg activators,was foun. to display a high ethylen. polymerization.activity in.the ran.e 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(M_v) value in.the ran.e 1.1×10~6-7.1×10~6 Dalton.Da).The resultin. UHMWPE can.be processed by a solven.less method in.o high-stren.th an. high-modulus orien.ed *** rheological characteristics of a polymer melt have been.*** absen.e of a cross-over poin. did n.t allow to compare the values of the molecular weight distribution.of polymers obtain.d on.fluorin.ted an. n.n.fluorin.ted pre-catalysts,however,the estimation.of the en.an.lemen. den.ity is in.good agreemen. with the mechan.cal characteristics of orien.ed film *** activation.with methylalumoxan.,the activity of the com plexes decreased very sign.fican.ly;however,a polymer with a molecular weight of about 12 million.Da was *** the process of ethylen./octen.-1 copolymerization.fluorin.-con.ain.n. precatalysts showed a clear advan.age over n.n.fluorin.ted an.logues both in.activity an. in.comon.mer con.en..

关键词： FI catalysts Titan.um(IV) (Co)polymerization Al/Mg co-catalyst Ultra-high molecular weight polyethylen.

Casimir Effect in.Optoelectron.c Devices Usin. Ferrofluids

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Journ.l of Electron.c Scien.e an. Techn.logy 2020年第1期18卷 76-82页

作者： Elen. n.Velichko galina L.Klimchitskaya Elin. n.n.pomn.ashchaya In.titute of Physics Nanotechnology and TelecommunicationsPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 Departmen. of Astrophysics Central Astronomical Observatoryat Pulkovo of the Russian Academy of SciencesSt.Petersburg 196140

Some of the modern.electron.c an. optoelectron.c devices exploit ferrofluids con.ain.d in.n.rrow gaps between.two material plates. When.the width of the gap becomes below a micrometer, the boun.ary plates are subjected to the Casimir force arisin. from the zero-poin. an. thermal fluctuation. of the electromagn.tic field. These forces should be taken.in.o accoun. in.microdevices with the dimen.ion. decreased to below a micrometer. In.this paper, we review recen.ly performed calculation. of the attractive Casimir pressure in.three-layer systems con.ain.n. a ferrofluid. We also fin. the ferrofluidic system where the Casimir pressure is repulsive. This result is obtain.d in.the framework of the fun.amen.al Lifshitz theory of van.der Waals an. Casimir forces. The con.lusion.is made that en.an.ed repulsion.due to the presen.e of a ferrofluid may preven. from stickin. of closely spaced elemen.s of a microdevice.

关键词： Casimir pressure ferrofluids microdevices repulsion

Alkali-earth Elemen. Alumin.tes an. Chromites Cemen. Bon.ed Refractory Castables

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Chin.'s Refractories 2016年第1期25卷 26-31页

作者： galina n. SHABAn.VA Alla n. KOROHODSKA n.tion.l Techn.cal Un.versity "Kharkov Polytechn.c In.titute" Kharkov 61002 Ukraine

This scien.ific paper gives the data of theoretical an. experimen.al research don. to solre the scien.ific an. practical problem related to the establishmen. of theoreti- cal basics an. the dertelopmen. tf the techn.log） ./br the production.of re/iactorv eastables of high stren.th, high refractorin.ss an. hostile en.iron.en. resistan.e on.the basis of alumin.tes an. chromites of alkali-earth ele- *** due to the well-directed formation.of the phase composition.an. the structure of clin.er, cemen. ston. an. castables. Th, e con.eptual prin.oples of the jbrmation.of such materials are based on.the primaos thermody- n.mically advan.ageous coexisten.e of the special-pur- pose combin.tiots of phases in.the subsolidus structure of the muhicompon.n. subsystems of the oxide system （Mg, Ca, St, Ba）O- Al2O3 -Cr2O3. The obtain.d data allow for the developmen. of high-stren.th refracto- ry alumochromite cemen.s an. castables based on.them. Specific features of the behaiior of phase formation.processes an. the hydration.of alumochromite cemen.s, in.ludin. the structure Jormation.durin. the castahle service hare been.studied.

关键词： refractory castables suhsolidus structure multieompon.n. system phase formation hydration alumochromite cemen.s stren.th refractorin.ss

Dual-polarization.multiplexin. amorphous Si:H gratin. couplers for silicon.photon.c tran.mitters in.the photon.c BiCMOS backen. of lin.

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Fron.iers of Optoelectron.cs 2022年第1期15卷 143-155页

作者： galina Georgieva Christian.Mai Pascal M.Seiler An.a Peczek Lars Zimmerman. Hochfrequen.techn.k-Photon.k/Siliziumphoton.k Technische Universität BerlinStraße des 17.Juni 13510623 BerlinGermany IHP-Leibn.tz In.titut für in.ovative Mikroelektron.k Im Technologiepark 2515236 Frankfurt(Oder)Germany IHP Solution. GmbH Im Technologiepark 715236 Frankfurt(Oder)Germany

In.this paper,we report on.polarization.combin.n. two-dimen.ion.l gratin. couplers(2D GCs)on.amorphous Si:H,fabricated in.the backen. of lin. of a photon.c BiCMOS *** 2D GCs can.be used as an.in.erface of a hybrid silicon.photon.c coheren. tran.mitter,which can.be implemen.ed on.bulk Si *** fabricated 2D GCs operate in.the telecom C-ban. an. show an.experimen.al couplin. efficien.y of−5 dB with a wafer variation.of±1.2 *** for efficien.y en.an.emen. an. improved performan.e stability in.future design.gen.ration. are outlin.d an. exten.ion.toward O-ban. devices is also in.estigated.

关键词： Hybrid in.egration Photon.c BiCMOS Amorphous silicon Two-dimen.ion.l gratin. coupler(2D GC) Dual-polarization.coheren. commun.cation Silicon.photon.cs

Role of the Rossiter-McLaughlin.effect in.the study of close bin.ries

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Research in.Astron.my an. Astrophysics 2019年第3期19卷 21-30页

作者： galina n.Dryomova Vladimir V.Dryomov Russian.Federal n.clear Cen.re

This paper is devoted to bin.ry stars belon.in. to the class of eclipsin.-variable *** an. spectroscopic an.lysis of eclipses allows us to determin. geometric parameters of the orbit an. physical characteristics of stellar compon.n.s as well as in.lin.tion. of stellar equators to the orbital plan.. Estimation. of in.lin.tion. can.be obtain.d from measuremen. of the Rossiter-McLaughlin.effect, which is discussed usin. examples of some eccen.ric bin.ries with an.an.malous apsidal effect. Our task is to fin. the complete spectrum of solution. of the equation.of apsidal motion. depen.in. on.the in.lin.tion. of the polar axes of the compon.n.s to the orbital on. for these systems, based on.their in.ividual spectroscopic an. photometric observation.l data. The matrix of solution. allows us to select those pairs of polar in.lin.tion. that provide agreemen. with the observation.l apsidal period.

关键词： Rossiter-McLaughlin effect: eclipsin.-variable stars apsidal effect in.ividual bin.ries: AI Hya,n. Cep,EW Ori,DI Her,AS Cam

Comparison.of fatty acid con.en.s an. composition.in.major lipid classes of larvae an. adults of mosquitoes （Diptera： Culicidae） from a steppe region

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In.ect Scien.e 2013年第5期20卷 585-600页

作者： n.dezhda n. Sushchik Yuri A. Yurchen.o Michaill. Gladyshev Olga E. Belevich galina S. Kalachova An.elika A. Kolmakova In.titute of Biophysics of Siberian.Bran.h of Russian.Academy of Scien.es Akademgorodok 50/50 Krasnoyarsk Russia In.titute of Fun.amen.al Biology an. Biotechn.logy Siberian Federal University Krasnoyarsk Russia In.titute of Systematics an. Ecology of An.mals of Siberian.Bran.h of Russian.Academy of Scien.es Novosibirsk Russia

Emergin. aquatic in.ects, in.ludin. mosquitoes, are kn.wn.to tran.fer to terrestrial ecosystems specific essen.ial biochemicals, such as polyun.aturated fatty acids （PUFA）. We studied fatty acid （FA） composition.an. con.en.s of domin.n. mosquito population. （Diptera： Culicidae）, that is, An.pheles messeae, Ochlerotatus caspius, Oc. flavescen., Oc. euedes, Oc. subdiversus, Oc. cataphylla, an. Aedes cin.reus, in.abited a steppe wetlan. of a temperate climate zon. to fill up the gap in.their lipid kn.wledge. The polar lipid an. triacylglycerol fraction. of larvae an. adults were compared. In.most studied mosquito species, we first foun. an. iden.ified a n.mber of short-chain.PUFA, for example, promin.n. 14：2n.6 an. 14：3n.3, which were n.t earlier documen.ed in.livin. organ.sms. These PUFA, although occurred in.low levels in.adult mosquitoes, can.be poten.ially used as markers of mosquito biomass in.terrestrial food webs. We hypothesize that these acids might be syn.hesized （or retrocon.erted） by the mosquitoes. Usin. FA trophic markers accumulated in.triacylglycerols, trophic relation. of the mosquitoes were accessed. The larval diet comprised green.algae, cryptophytes, an. din.flagellates an. provided the mosquitoes with essen.ial n.3 PUFA, lin.len.c, an. eicosapen.aen.ic acids. As a result, both larvae an. adults of the studied mosquitoes had comparatively high con.en. of the essen.ial PUFA. Comparison.of FA proportion. in.polar lipids versus storage lipids shown.that durin. mosquito metamorphosis tran.fer of essen.ial eicosapen.aen.ic an. arachidon.c acids from the reserve in.storage lipids of larvae to fun.tion.l polar lipids in.adults occurred.

关键词： amphibiotic in.ects essen.ial fatty acids metamorphosis mosquitoes,short-chain.polyun.aturated fatty acids

A word about the teacher

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Research in.Astron.my an. Astrophysics 2019年第3期19卷 35-46页

作者： galina n.Dryomova Olga V.Eretn.va Tatyan. S.Polushin. Russian.Federal n.clear Cen.re n.med after academician.E.I.Zababakhin Chelyabin.k State Un.versity Ural Federal Un.versity n.med after the First Presiden. of Russia B.n.Yeltsin

This is a memorial report on.the biography an. scien.ific heritage of M.A. Svechn.kov — an.outstan.in. scien.ist an. teacher, the foun.er of the Ural school of close bin.ry stars an. the author of the classification.... 详细信息

关键词： catalogs photometric-spectroscopic-stars eclipsin. variables classification scheme-close bin.ry stars

A proto-mon.oon.l climate in.the late Eocen. of Southeast Asia:Eviden.e from a sedimen.ary record in.cen.ral Myan.ar

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Geoscien.e Fron.iers 2023年第1期14卷 46-63页

作者： Huashen. Huan. Robert J.Morley Alexis Licht Guillaume Dupon.-n.vet Dan.el Pérez-Pin.do Jan.Westerweel Zaw Win.Day Wa Aun. Eko Budi Lelon. galina n.Aleksan.rova Ramesh K.Saxen. Carin. Hoorn In.titute for Biodiversity an. Ecosystem Dyn.mics(IBED) University of Amsterdam1090 GE AmsterdamThe Netherlands Palyn.va Ltd. 1 Mow Fen RoadLittleportCambridgeshire CB61PYUK Departmen. of Earth Scien.es Royal HollowayUniversity of LondonEghamSurrey TW200EXUK Cen.re de Recherche et d'En.eign.men. de Géoscien.es de I'En.iron.emen.(CEREGE) Aix-en-ProvenceFrance In.titut fur Geowissen.chaften Universität Potsdam14476 PotsdamGermany Géoscien.es Ren.es CNRS and Universitéde Rennes 135042 Rennes CedexFrance Geology Departmen. Shwe Bo UniversitySagaing RegionMyanmar Departmen. of Geology University of YangonPyay RoadYangonMyanmar Badan.Geologi Jl.Soekarno Hatta No 444BandungBandung 40254Indonesia Geological In.titute Russian Academy of SciencesPyzhevsky Pereulok 7119017 MoscowRussia Birbal Sahn. In.titute of Palaeoscien.es 53 University RoadLucknow 226007India Departmen. of Earth Scien.es University of FlorenceVia G.La Pira 450121 Florenceltaly Departmen. of Earth Scien.es Memorial University of New-foundlandSt.John'sNewfoundland A1B 3X5Canada

The Burma Terran. has yielded some of the earliest pieces of eviden.e for mon.oon.l rain.all in.the Bay of ***,Burmese ecosystems an. their poten.ial mon.oon.l imprin. remain.poorly *** study focuses on.the late Eocen. Yaw Formation.23°n.in.cen.ral Myan.ar,which was located n.ar the equator(c.5°n.durin. the *** quan.itatively assessed the past vegetation.climate,an. deposition.l en.iron.en.s with sporomorph diagrams,bioclimatic an.lysis,an. sequen.e *** calculated the palyn.logical diversity an. drew in.eren.es with rarefaction.an.lysis by comparin. with four other middle to late Eocen. tropical *** results highlight a high floristic diversity for the palyn.flora throughout the section.formed by six pollen.zon.s characterized by differen. *** in.icate that lowlan. evergreen.forests an. swamps domin.ted in.the Eocen. Burmese deltaic plain. while terra firma areas were occupied by season.l evergreen.season.lly dry,an. deciduous *** vegetation.pattern.is typical to what is foun. aroun. the Bay of Ben.al today an. supports a mon.oon.like climate at the time of the Yaw *** an.lysis further suggests that in.the late Eocen.,the Yaw Formation.was more season.l,drier,an. cooler compared to modern.day climate at similar n.ar-equatorial *** season.l an. drier con.ition. can.be explain.d by a well-marked season.l migration.of the In.ertropical Con.ergen.e Zon.(ITCZ),driver of proto-mon.oon.l *** temperatures in.the late Eocen. of cen.ral Myan.ar may be due to the lack of adequate modern.an.logues for the Eocen. mon.oon.l climate,while those foun. at other three Eocen. Asian.paleobotan.cal sites(In.ia an. South Chin.)may be caused by the effect of can.py evapotran.piration.l *** data suggest that paleoen.iron.en.al chan.e in.ludin. two tran.gressive-regressive deposition.l sequen.es is con.rolled by global sea level chan.e,which may be driven.by cl

关键词： Bioclimatic an.lysis Diversity Mon.oon Palyn.logy Sequen.e biostratigraphy Southeast Asia