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Callogenesis and Antibacterial Activity of Balanites aegyptiaca

Journal of Biosciences and Medicines 2020年第10期8卷 157-168页

作者： gali adamu ishaku Aishatu Haruna Ayuba Abaka Kalum Celia Vargas-De-La-Cruz Richard Solorzano-Acosta Department of Biotechnology School of Life SciencesModibbo Adama University of TechnologyYolaAdamawa StateNigeria Department of Crop Protection School of Agriculture and Agricultural TechnologyModibbo Adama University of TechnologyYolaAdamawa StateNigeria Facultad de Farmacia y Bioquimica Departamento Academico de FarmacologíaBromatología y ToxicologiaCentro Latinoamericano de Enseñanza e Investigación en Bacteriologia Alimentaria(CLEIBA)Universidad Nacional Mayor de San MarcosLimaPeru Research Group Biotechnology and Omics in Life Sciences Universidad Nacional Mayor de San MarcosLimaPeru Facultad de Farmacia y Bioquímica Universidad Norbert WienerLimaPeru

B. aegyptiaca, it is a species of economic and cultural importance in various countries, with diverse uses that include: medicinal, charcoal, pesticides and forage and in vitro callus production is important to have many applications in both basic and industrial research on this specie. For the induction of callus, B. aegyptica seed cotyledons were surface sterilized with 90% ethanol for 1 minute and cultivated in MS media supplemented with 2,4-D, BAP and NAA. Both the callus and seed were collected and dried in an oven at 40°C - 45°C. Cotyledon’s seed and callus were grounded into the powdered form using mortar and pestle and stored at room temperature for further use. Five grams (5 g) each of the powder were mixed with 50 ml of the solvents: methanol and n-hexane (1:10) w/v, agitated vigorously and kept on an orbital shaker at 150 rpm for 24 h, then filtered. The extracts of the plant sample were evaluated in agar dilution method which was used to determine the MIC and MBC of the extracts. The auxin NAA in low concentrations (0.5 mg/L) in the presence of a dose of 0.5 mg/L of the cytokinin BAP induced 100% callus formation. The 50 and 100 mg/ml methanolic extracts were more effective than the n-hexane extracts for both the gram-positive and gram-negative bacteria. By callus extracts under 100 and 50 mg/ml reveals that methanolic extracts of callus had the highest zone of inhibition. An effective protocol for callus induction has been developed that can use for germplasm conservation or for genetic engineering. Evidence from the present study revealed both extracts possess strong broad-spectrum antibacterial effect. Therefore, methanolic extract of seed kernel callus of B. aegyp

关键词： Antibacterial Activities Callus Extract Callus Induction Minimum Inhibitory Concentration and Seed Cotyledon Extract

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Genomic signatures of selection,local adaptation and production type characterisation of East Adriatic sheep breeds

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Journal of Animal Science and Biotechnology 2024年第2期15卷 546-562页

作者： Boris Lukic Ino Curik Ivana Drzaic Vlatko galić Mario Shihabi LubošVostry Vlatka Cubric-Curik Faculty of Agrobiotechnical Sciences Osijek J.JStrossmayer University of OsijekVladimira Preloga 131000 OsijekCroatia Department of Animal Science Faculty of AgricultureUniversity of ZagrebSvetošimunska Cesta 2510000 ZagrebCroatia Department of Maize Breeding and Genetics Agricultural Institute OsijekJužno predgrađe 1731000 OsijekCroatia Czech University of Life Sciences Prague Kamycka 12916500 PraqueCzech Republic

Background The importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic *** production system is extensive and generally carried out in traditional systems without intensive systematic breeding programmes for high uniform trait production(carcass,wool and milk yield).Therefore,eight indigenous Croatian sheep breeds from eastern Adriatic treated here as metapopulation(EAS),are generally considered as multipurpose breeds(milk,meat and wool),not specialised for a particular type of production,but known for their robustness and resistance to certain environmental *** objective was to identify genomic regions and genes that exhibit patterns of positive selection signatures,decipher their biological and productive functionality,and provide a"genomic"characterization of EAS adaptation and determine its production *** We identified positive selection signatures in EAS using several methods based on reduced local variation,linkage disequilibrium and site frequency spectrum(eROHi,iHS,nSL and CLR).Our analyses identified numerous genomic regions and genes(e.g.,desmosomal cadherin and desmoglein gene families)associated with environmental adaptation and economically important *** candidate genes were related to meat/production and health/immune response traits,while some of the candidate genes discovered were important for domestication and evolutionary processes(e.g.,HOXa gene family and FSIP2).These results were also confirmed by GO and QTL enrichment *** Our results contribute to a better understanding of the unique adaptive genetic architecture of EAS and define its productive type,ultimately providing a new opportunity for future breeding *** the same time,the numerous genes identified will improve our understanding of ruminant(sheep)robustness and resistance in the harsh and specific Mediterranean environment.

关键词： Composite-likelihood ratio East Adriatic sheep Extreme ROH islands Genomic selection signatures Integrated haplotype score Number of segregating sites by length

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试评教育史研究中的“时代局限”及其理解——以《大教学论》宗教因素等为例

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教育学报 2024年第3期20卷 182-193页

作者：陈锋何白嘎力华东师范大学教育学系上海200062

教育史研究中存在着不少被称之为“时代局限”的教育思想,《大教学论》中的宗教因素便是其中之一。19世纪以来历史哲学的发展表明,无法从“客观”概念出发回应“历史理解何以可能”的问题,历史的理解始终是解释者与被解释者互动的过程... 详细信息

教育史研究中存在着不少被称之为“时代局限”的教育思想,《大教学论》中的宗教因素便是其中之一。19世纪以来历史哲学的发展表明,无法从“客观”概念出发回应“历史理解何以可能”的问题,历史的理解始终是解释者与被解释者互动的过程。对于《大教学论》宗教因素等“时代局限”的理解而言,从历史情境筹划出发,通过有限度的同情与批判,达成与被理解思想之间的“视域融合”是一条可能的思路。理解“时代局限”不意味着消解问题、翻案文章,而是要求必须始终保持开放的研究视域。

关键词：教育史研究 “时代局限” 夸美纽斯《大教学论》

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基于一维空洞卷积神经网络的故障电弧检测方法

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清华大学学报（自然科学版） 2024年第3期64卷 492-501页

作者：蒋慧灵白嘎力周郑邓青滕杰张越周亮周正青北京科技大学金属冶炼重大事故防控技术支撑基地北京100083 北京科技大学大安全科学研究院北京100083 北京科技大学土木与资源工程学院北京100083 呼和浩特市烟草公司呼和浩特010020

串联故障电弧因多样性、相似性和隐蔽性而难以被检测,容易引发故障电弧保护装置误报和漏报。采用一维空洞卷积神经网络(one-dimensional dilated convolutional neural network,1D-DCNN)提取以高采样率采集的故障电弧电流特征,引入扩展... 详细信息

串联故障电弧因多样性、相似性和隐蔽性而难以被检测,容易引发故障电弧保护装置误报和漏报。采用一维空洞卷积神经网络(one-dimensional dilated convolutional neural network,1D-DCNN)提取以高采样率采集的故障电弧电流特征,引入扩展型指数线性单元(scaled exponential linear unit, SeLU)激活函数和残差连接解决梯度消失和网络退化问题,并结合平均集成学习和Softmax多分类器建立故障电弧检测模型。实验结果表明:所提方法对单负载和混合负载故障电弧的检测准确率达99.67%,相应负载识别准确率达99.95%,总体预测结果准确率达99.62%,优于传统卷积神经网络(convolutional neural network, CNN),满足故障电弧检测要求,有助于串联故障电弧检测和负载识别。

关键词：一维空洞卷积串联故障电弧支路故障电弧故障电弧检测负载分类

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First principles calculation of spin-related quantities for point defect qubit research

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npj Computational Materials 2018年第1期4卷 32-44页

作者： Viktor Ivády Igor A.Abrikosov Adam gali Department of Physics Chemistry and BiologyLinköping UniversitySE-58183 LinköpingSweden Wigner Research Centre for Physics Hungarian Academy of SciencesPO Box 49Budapest H-1525Hungary Materials Modeling and Development Laboratory National University of Science and Technology‘MISIS’119049 MoscowRussia Department of Atomic Physics Budapest University of Technology and EconomicsBudafokiút 8Budapest H-1111Hungary

Point defect research in semiconductors has gained remarkable new momentum due to the identification of special point defects that can implement qubits and single photon emitters with unique ***,these implementations are among the few alternatives for quantum technologies that may operate even at room temperature,and therefore discoveries and characterization of novel point defects may highly facilitate future solid state quantum *** principles calculations play an important role in point defect research,since they provide a direct,extended insight into the formation of the defect *** the last decades,considerable efforts have been made to calculate spin-dependent properties of point defects from first *** developed methods have already demonstrated their essential role in quantitative understanding of the physics and application of point defect ***,we review and discuss accuracy aspects of these novel ab initio methods and report on their most relevant applications for existing point defect qubits in *** pay attention to the advantages and limitations of the methodological solutions and highlight additional developments that are expected in the near ***,we discuss the opportunity of a systematic search for potential point defect qubits,as well as the possible development of predictive spin dynamic simulations facilitated by ab initio calculations of spin-dependent quantities.

关键词： defect quantities principles

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Micelles as potential drug delivery systems for colorectal cancer treatment

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World Journal of Gastroenterology 2022年第25期28卷 2867-2880页

作者： Zaynab Fatfat Maamoun Fatfat Hala gali-Muhtasib Department of Biology American University of BeirutBeirut 11072020Lebanon Center for Drug Discovery American University of BeirutBeirut 11072020Lebanon

Despite the significant progress in cancer therapy,colorectal cancer(CRC)remains one of the most fatal malignancies *** is currently the mainstay therapeutic modality adopted for CRC ***,the long-term effectiveness of chemotherapeutic drugs has been hampered by their low bioavailability,non-selective tumor targeting mechanisms,non-specific biodistribution associated with low drug concentrations at the tumor site and undesirable side *** the last decade,there has been increasing interest in using nanotechnology-based drug delivery systems to circumvent these *** nanoparticles have been developed for delivering chemotherapeutic drugs among which polymeric micelles are attractive *** micelles are biocompatible nanocarriers that can bypass the biological barriers and preferentially accumulate in tumors via the enhanced permeability and retention *** can be easily engineered with stimuli-responsive and tumor targeting moieties to further ensure their selective uptake by cancer cells and controlled drug release at the desirable tumor *** have been shown to effectively improve the pharmacokinetic properties of chemotherapeutic drugs and enhance their safety profile and anticancer efficacy in different types of *** that combination therapy is the new strategy implemented in cancer therapy,polymeric micelles are suitable for multidrug delivery and allow drugs to act concurrently at the action site to achieve synergistic therapeutic *** also allow the delivery of anticancer genetic material along with chemotherapy drugs offering a novel approach for CRC ***,we highlight the properties of polymeric micelles that make them promising drug delivery systems for CRC *** also review their application in CRC chemotherapy and gene therapy as well as in combination cancer chemotherapy.

关键词： Polymeric micelles Drug delivery Colorectal cancer Chemotherapy Gene therapy Combination cancer therapy

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1-Sulfopyridinium chloride:Green and expeditious ionic liquid for the one-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones under solvent-free conditions

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Chinese Chemical Letters 2015年第3期26卷 309-312页

作者： Ravibabu Velpula Janardhan Banothu Rajitha gali Rajitha Deshineni Rajitha Bavantula Department of Chemistry National Institute of Technology Department of Chemistry Osmania University

1-Sulfopyridinium chloride portrayed as an efficient and recyclable ionic liquid for the synthesis of fused3,4-dihydropyrimidin-2（1H）-ones and thiones via a modified Biginelli reaction involving one-pot three component condensation of 6-methoxy-1-tetralone,arylaldehydes and urea/thiourea under solventfree *** pure products are formed within 10–20 min in excellent yields.

关键词： fused ionic benzaldehyde condensation thiourea methoxy aldehydes aromatic Ionic hydroxyphenyl

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Stone–Wales defects in hexagonal boron nitride as ultraviolet emitters

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npj Computational Materials 2020年第1期6卷 169-175页

作者： Hanen Hamdi GergőThiering Zoltán Bodrog Viktor Ivády Adam gali Wigner Research Centre for Physics P.O.Box 49Budapest 1525Hungary Department of Physics Chemistry and BiologyLinköping UniversityLinköping SE-58183Sweden Budapest University of Technology and Economics Budafokiút 8.Budapest 1111Hungary

Many quantum emitters have been measured close or near the grain boundaries of the two-dimensional hexagonal boron nitride where various Stone–Wales defects *** show by means of first principles density functional theory calculations that the pentagon–heptagon Stone–Wales defect is an ultraviolet emitter and its optical properties closely follow the characteristics of a 4.08-eV quantum emitter,often observed in polycrystalline hexagonal boron *** also show that the square–octagon Stone–Wales line defects are optically active in the ultraviolet region with varying gaps depending on their density in hexagonal boron *** results may introduce a paradigm shift in the identification of fluorescent centres in this material.

关键词： Wales boron hexagonal

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Reflections on,and Improvements of,the Mediation Functions of People's Assessors

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Contemporary Social Sciences 2023年第6期8卷 20-32页

作者： Wang gali Kunming University of Science and Technology

Legislatively,the people’s assessors are defined as individuals who share judicial ***,in the context of dispute resolutions,their role is restricted by the courts,which affects the extent of their assessorial *** is imperative to reconsider the implications of the people’s assessors’deep involvement in mediation from the standpoint of societal division of *** enhance this division of labor,it is advisable that the people’s assessors relinquish their mediation *** is necessary to redefine the distinctions between people’s assessors,judges,and people’s mediators,including specially invited *** would not only make up the deficiencies in the role of professional judges but also relieve the tension between judicial professionalism and popular accountability.

关键词： social division of labor assessor system mediation function reflection improvement

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Antioxidative, cytotoxic, and anti-metastatic potentials of Laurencia obtusa and Ulva lactuca seaweeds

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Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 308-316页

作者： Reem Al Monla Yahya Salma Achraf Kouzayha Hala gali-Muhtasib Zeina Dassouki Hiba Mawlawi Laboratory of Applied Biotechnology(LBA3B) AZM Center for Research in Biotechnology and its ApplicationsDoctoral School for Sciences and TechnologyLebanese UniversityTripoliLebanon Department of Biology American University of BeirutLebanon Center for Drug Discovery American University of BeirutRiad El Solh 11072020BeirutLebanon

Objective:To investigate the antioxidant and cytotoxic properties of the most active extracts from Ulva lactuca and Laurencia obtusa against colon and cervical cancer cell ***:The antioxidant radical scavenging activity of the algal extracts was estimated using the 2,2-diphenyl-1-picrylhydrazyl colorimetric ***,the cytotoxic potential of these bioactive extracts was studied against HCT-116 and HeLa cells by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide *** healing analysis was adopted to evaluate the antimetastatic effects of protein extracts from both *** cycle analysis was performed by flow cytometry,and apoptotic bodies were detected using 4′,6-diamidino-2-phenylindole fluorescent *** acids of hydrolyzed protein extract were separated and identified chromatographically by high performance liquid ***:The green algae Ulva lactuca had higher lipid content than Laurencia obtusa,whereas the latter had higher protein content with high antioxidant *** extracts had significant dose-and time-dependent cytotoxicity and anti-metastatic activity against HCT-116 *** b extracts of both algae obtained from the chloroform:hexane solvent lipid-free residue caused morphological changes and induced apoptosis of HCT-116 *** analysis revealed that apoptosis induced upon Laurencia obtusa protein b treatment was triggered via the ROS pathway,causing a significant increase in the sub-G_(1) *** and arginine(5.94 and 5.47μM,respectively)were the most common amino acids in Laurencia obtusa protein b ***:Proteins of Laurencia obtusa and Ulva lactuca could be considered as an adjuvant nutraceutical source of pro-apoptotic and anti-metastatic biomolecules against colon cancer.

关键词： Macroalgae Laurencia obtusa Ulva lactuca Reactive oxygen species Apoptosis

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