Micelles as potential drug delivery systems for colorectal cancer treatment

作     者：Zaynab Fatfat Maamoun Fatfat Hala Gali-Muhtasib 

作者机构：Department of BiologyAmerican University of BeirutBeirut 11072020Lebanon Center for Drug DiscoveryAmerican University of BeirutBeirut 11072020Lebanon 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第25期

页      面：2867-2880页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Polymeric micelles Drug delivery Colorectal cancer Chemotherapy Gene therapy Combination cancer therapy 

摘      要：Despite the significant progress in cancer therapy,colorectal cancer(CRC)remains one of the most fatal malignancies *** is currently the mainstay therapeutic modality adopted for CRC ***,the long-term effectiveness of chemotherapeutic drugs has been hampered by their low bioavailability,non-selective tumor targeting mechanisms,non-specific biodistribution associated with low drug concentrations at the tumor site and undesirable side *** the last decade,there has been increasing interest in using nanotechnology-based drug delivery systems to circumvent these *** nanoparticles have been developed for delivering chemotherapeutic drugs among which polymeric micelles are attractive *** micelles are biocompatible nanocarriers that can bypass the biological barriers and preferentially accumulate in tumors via the enhanced permeability and retention *** can be easily engineered with stimuli-responsive and tumor targeting moieties to further ensure their selective uptake by cancer cells and controlled drug release at the desirable tumor *** have been shown to effectively improve the pharmacokinetic properties of chemotherapeutic drugs and enhance their safety profile and anticancer efficacy in different types of *** that combination therapy is the new strategy implemented in cancer therapy,polymeric micelles are suitable for multidrug delivery and allow drugs to act concurrently at the action site to achieve synergistic therapeutic *** also allow the delivery of anticancer genetic material along with chemotherapy drugs offering a novel approach for CRC ***,we highlight the properties of polymeric micelles that make them promising drug delivery systems for CRC *** also review their application in CRC chemotherapy and gene therapy as well as in combination cancer chemotherapy.