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Possible Association of ACE Gene I/D Polymorphism With Blood Pressure——Lowering Response to Hydrochlorothiazide

Biomedical and Environmental Sciences 2007年第5期20卷 351-356页

作者： YONG ZHOU SHOU-LING WU JIAN-QING liu WAN-NIAN LIANG gai-fen liu Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Cardiology Affiliated Kailuan Hospital North China Coal Mining Medical College Tangshan 063000 Hebei China Capital Medical University Beijing 100069 China

Objective To explore the association between polymorphism in the ACE I/D gene and blood pressure-lowering response to hydrochlorothiazide （HCTZ） in 829 patients. Methods HCTZ 12.5 mg was taken once a day for six weeks. The blood pressure reduction and ratio reaching target blood pressure were compared in different ACE genotype groups. Results The reduction in SBP of patients carrying DD was greater than that in other groups carrying II or ID （12.2 mmHg versus 5.4 mmHg, 12.2 mmHg versus 4.4 mmHg, respectively, P〈0.05）. The reduction in MAP of patients carrying DD was also greater than that in other groups carrying II or ID （6.9 mmHg versus 3.9 mmHg, 6.9 mmHg versus 3.6 mmHg, respectively, P〈0.05）. The ratio reaching target blood pressure in DD groups was significantly higher than that in II or ID groups （P〈0.05）. The pre-treatment SBP, DD genotype, aldosterone levels entered the multi-linear regression model significantly and might affect the reduction of SBP. The pre-treatment DBP, aldosterone levels, DD genotype entered the multi-linear regression model significantly and might affect the reduction of DBP. The pre-treatment MAP, DD genotype, aldosterone levels entered the multi-linear regression model significantly and might affect the reduction of MAP. Conclusion ACE genotyping is associated with blood pressure-lowering response to HCTZ. Specific genotypes might be associated with the response to specific antihypertensive treatment.

关键词： Hypertension Peptidyl-dipeptidase A Genotype Treatment

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Case Fatality Rate of Severe Acute Respiratory Syndromes in Beijing

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Biomedical and Environmental Sciences 2005年第4期18卷 220-226页

作者： QI CHEN WAN-NIAN LIANG gai-fen liu MIN liu XUE-QIN XIE JIANG WU XIONG HE ZE-JUN liu School of Health Management and Education Capital University of Medical Sciences Beijing 100054 China School of Public Health Peking University Beijing 100083 China Capital University of Medical Sciences ＆ Beijing Municipal Health Bureau Beijing 100054 China Beijing Municipal Centers for Disease Prevention and Control Beijing 100013 China

To describe the case fatality rate of SARS in Beijing. Methods Data of SARS cases notified from Beijing Center for Disease Control and Prevention （BCDC） and supplemented by other channels were collected. The data were analyzed by rate calculation. Results The case fatality rate of SARS in Beijing was 7.66%, and had an ascending trend while the age of cases was getting older, and a descending trend while the epidemic developmem. The case fatality rate in Beijing was lower than that in other main epidemic countries or regions. Conclusions The risk of death increases with the increment of age of SARS patients. Beijing is successful in controlling and treating SARS.

关键词： SARS Case fatality rate Beijing

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Severe Acute Respiratory Syndrome-Retrospect and Lessons of 2004 Outbreak in China

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Biomedical and Environmental Sciences 2006年第6期19卷 445-451页

作者： WAN-NIAN LIANG TAO ZHAO ZE-JUN liu BAO-YING GUAN XIONG HE MIN liu QI CHEN gai-fen liu JIANG WU RUO-GANG HUANG XUE-QIN XIE ZHENG-LAI WU Beijing Municipal Health Bureau Beijing 100053 China Beijing Municipal Centers for Disease Control and Prevention Beijing 100013 China School of Public Health Peking University Health Science Center Beijing 100083 China School of Public Health Capital University of Medical Sciences Beijing 100069 China Department of Epidemiology Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100005 China

Objective To summarize lessons learned from an outbreak of severe acute respiratory syndrome （SARS） in China during the spring of 2004. Methods Data of SARS cases were officially reported by Beijing Municipal Center for Disease Control and Prevention （BCDC） and Anhui Provincial Center for Disease Control and Prevention （APCDC） and results of epidemiological investigations were collected and analyzed. Results Three generations of 11 cases of SARS were identified during the outbreak, Initial two cases were most likely to be infected in Diarrhea Virus Laboratory of National Institute of Virology, China Centers for Disease Control and Prevention and main mode of transmission was direct contact with SARS patients, Delay in detecting initial case resulted in spread of the illness at hospitals and communities with two generations of secondary cases, Conclusions SARS outbreak in 2004 has yielded following lessons for public health globally. （1） Lab bio-safety programs should be made and should be strictly abided by, Studies in highly pathogenic viruses such as SARS coronavirus should be utmost cautious, （2） Management systems of occupational exposure to virus and disease surveillance need to be strengthened to take all risk factors into account so as to detect potential patients with infectious disease as early as possible.

关键词： Severe acute respiratory syndrome (SARS) Outbreak Bio-safety Laboratory China

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A Case-control Study on Children with Guillain-barre Syndrome in North China

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Biomedical and Environmental Sciences 2003年第2期16卷 105-111页

作者： gai-fen liu ZHENG-LAI WU HU-SHENG WU QUAN-YI WANG GE-TU ZHAO-RI CHUN-YONG WANG ZHI-XUE LIANG SHU-LAN CUI JIAN-DE ZHENG Correspondenceshouldbeaddressedtogai-fenliu PekingUnionMedicalCollegeandChineseAcademyofMedicalSciencesBeijing100005China

To explore the risk factors for Guillain-barre syndrome. Methods Case-control study design was used in 51 cases of Guillain-barre syndrome,and 51 matched *** of the 51 cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C. jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using an ad hoc questionnaire, including his/her demographic information,onset of the illness, their personal hygiene and so on. Results The study showed that Guillain-barre syndrome was associated with a few factors, such as polio vaccine immunization before onset of illness (OR=7.27), no hand washing after defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with the illness (OR=9.5,P<0.001). Conclusion It is suggested that occurrence of Guillain-barre syndrome may correlate to infection of C. jejuni and poor personal hygiene in children.

关键词： Guillain-Barre syndrome (GBS) Case-control study Campylobacter jejuni

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Association between antiplatelet medication and cerebral microbleeds in stroke-free population

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Journal of Geriatric Cardiology 2022年第6期19卷 409-417页

作者： Miao-Xin YU Ya-Nan JIA Dan-Dan YANG Run-Hua ZHANG Yong JIANG Gui-Tao ZHANG Hui-Yu QIAO Hua-Lu HAN Rui SHEN Zi-Han NING Xi-Hai ZHAO gai-fen liu Yong-Jun WANG Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology the Third Hospital of Hebei Medical UniversityShijiazhuangChina Department of Radiology Beijing Geriatric HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Center for Biomedical Imaging Research Department of Biomedical EngineeringTsinghua UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina

BACKGROUND Cerebral microbleeds(CMBs)may increase the risk of future intracerebral hemorrhage and ischemic ***,It is unclear whether antiplatelet medication is associated with *** study aimed to investigate the association between antiplatelet medication and CMBs in a community-based stroke-free *** In this cross-sectional study,stroke-free participants aged 18-85 years were recruited from a community in Beijing,***,clinical,and antiplatelet medication data were collected through a questionnaire,and all participants underwent blood tests and brain magnetic resonance imaging at *** presence,count,and location of CMBs were evaluated using susceptibility-weighted *** association between antiplatelet medication and the presence of CMBs was analyzed using multivariable logistic *** associations between antiplatelet medication and CMBs by location(lobar,deep brain or infratentorial,and mixed regions)were also analyzed using multinomial logistic regression.A linear regression analysis was conducted to determine the association between antiplatelet medication and the log-transformed number of *** Of the 544 participants(mean age:58.65±13.66 years,217 males),119 participants(21.88%)had CMBs,and 64 participants(11.76%)used antiplatelet *** medication was found to be associated with CMBs at any location[odds ratio(OR)=2.39,95%CI:1.24-4.58]and lobar region(OR=2.83,95%CI:1.36-5.86),but not with the number of CMBs(β=0.14,95%CI:-0.21-0.48).Among antiplatelet medications,aspirin use was found to be associated with any CMB(OR=3.17,95%CI:1.49-6.72)and lobar CMBs(OR=3.61,95%CI:1.57-8.26).CONCLUSIONS Antiplatelet medication was associated with CMBs in stroke-free participants,particularly lobar *** antiplatelet medications,aspirin use was associated with any CMB and lobar *** findings suggest that it might be essential to optimize the management of antiplatelet medication in t

关键词： medication 3.0T antiplatelet

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Extending homogeneous fluidization flow regime of Geldart-A particles by exerting axial uniform and steady magnetic field

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Chinese Journal of Chemical Engineering 2024年第1期65卷 169-177页

作者： Qiang Zhang Wankun liu Hengjun gai Quanhong Zhu College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China School of Chemical&Environmental Engineering China University of Mining&Technology-BeijingBeijing 100083China

The homogeneous/particulate fluidization flow regime is particularly suitable for handling the various gas–solid contact processes encountered in the chemical and energy *** work aimed to extend such a regime of Geldart-A particles by exerting the axial uniform and steady magnetic *** the action of the magnetic field,the overall homogeneous fluidization regime of Geldart-A magnetizable particles became composed of two parts:inherent homogeneous fluidization and newly-created magnetic *** the former remained almost unchanged whereas the latter became broader as the magnetic field intensity increased,the overall homogeneous fluidization regime could be extended *** for Geldart-A nonmagnetizable particles,certain amount of magnetizable particles had to be premixed to transmit the magnetic *** others,the mere addition of magnetizable particles could broaden the homogeneous fluidization *** added content of magnetizable particles had an optimal value with smaller/lighter ones working *** added magnetizable particles might raise the ratio between the interparticle force and the particle *** the magnetic field was exerted,the homogeneous fluidization regime was further expanded due to the formation of magnetic stabilization flow *** more the added magnetizable particles,the better the magnetic performance and the broader the overall homogeneous fluidization ***/lighter magnetizable particles were preferred to maximize the magnetic performance and extend the overall homogeneous fluidization *** phenomenon could be ascribed to that the added magnetizable particles themselves became more Geldart-A than-B type as their density or size decreased.

关键词： Fluidized-bed Fluidization Geldart-A particles Flow regimes Extend Magnetic stabilization

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Comprehensive analyses of the proteome and ubiquitome revealed mechanism of high temperature accelerating petal abscission in tree peony

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Horticultural Plant Journal 2024年第1期10卷 205-222页

作者： Chunying liu Ziqi liu Yanchao Yuan Yuxi Zhang Yifu Fang Junqiang Chen Shupeng gai Key Laboratory of Plant Biotechnology in Shandong Province College of Life SciencesQingdao Agricultural UniversityQingdaoShandong 266109China Shandong Academy of Forestry JinanShandong 250014China

Tree peony(Paeonia suffruticosa Andrews)is a well-known ornamental plant with high economic value,but the short fluorescence is a key obstacle to its ornamental value and industry *** temperature accelerates flower senescence and abscission,but the associated mechanisms are poorly *** this study,the tandem mass tag(TMT)proteome and label-free quantitative ubiquitome from tree peony cut flowers treated with 20℃for 0 h(RT0),20℃or 28℃for 60 h(RT60 or HT60)were examined based on morphological observation,***,6970 proteins and 1545 lysine ubiquitinated(Kub)sites in 844 proteins were *** residues(such as glutamate and aspartate)neighboring the Kub sites were in preference,and 36.01%of the Kub sites were located on the protein *** differentially expressed proteins(DEPs)and Kub-DEPs in HT60 vs RT60 were mainly enriched in ribosomal protein,protein biosynthesis,secondary metabolites biosynthesis,flavonoid metabolism,carbohydrate catabolism,and auxin biosynthesis and signaling revealed by GO and KEGG analysis,accompanying the increase of endogenous abscisic acid(ABA)accumulation and decrease of endogenous indoleacetic acid(IAA)***,the expression patterns of six enzymes(SAMS,ACO,YUC,CHS,ANS and PFK)putatively with Kub modifications were analyzed by proteome and real-time quantitative *** cell-free degradation assays showed PsSAMS and PsACO proteins could be degraded via the 26 S proteasome system in tree peony ***,a working model was proposed for the acceleration of flower senescence and abscission by high *** summary,all results contributed to understanding the mechanism of flower senescence induced by high temperature and prolonging fluorescence in tree peony.

关键词： Tree peony Proteome Ubiquitome High temperature Flower senescence

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Defect spinel oxides for electrocatalytic reduction reactions

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Nano Research 2024年第5期17卷 3547-3570页

作者： Zhijuan liu Jinyu Guo Lu-yu liu fen Wang Zhijie Kong Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsKey Laboratory of Special Environmental Functional Materials(Zhengzhou University)Ministry of EducationGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Electrocatalytic reduction reactions play a crucial role in electrochemical energy conversion and storage technology,which are emerging technologies to ameliorate environmental *** oxides are widely explored in electrocatalytic oxidation reactions but have a poor intrinsic ability to reduction reactions,making their electrocatalytic ability less *** improve this,defect engineering is a valuable method for regulating the electronic structure and coordination ***,this manuscript discusses the use of defect spinel oxides in electrocatalytic reduction reactions,including the different types of defects,construction methods,and characterization *** also outlines the various applications of defect spinel oxides in different electrocatalytic reduction ***,it goes over the challenges and future outlooks for defect *** review aims to thoroughly explain how defect spinels work in electrocatalytic reduction reactions and serve as a helpful guide for creating effective electrocatalysts.

关键词： defect spinel oxides electrochemical reduction reactions electrocatalytic mechanism dynamic evolution

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Relationship Between Short-chain Fatty Acids and Parkinson’s Disease:A Review from Pathology to Clinic

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Neuroscience Bulletin 2024年第4期40卷 500-516页

作者： Wen-Xiang Duan fen Wang Jun-Yi liu Chun-feng liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhou215004China Department of Neurology Dushu Lake Hospital affiliated to Soochow UniversitySuzhou215125China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversitySuzhou215123China

Parkinson’s disease(PD)is a complicated neurodegenerative disease,characterized by the accumulation ofα-synuclein(α-syn)in Lewy bodies and neurites,and massive loss of midbrain dopamine *** evidence suggests that gut microbiota and microbial metabolites are involved in the development of *** these,short-chain fatty acids(SCFAs),the most abundant microbial metabolites,have been proven to play a key role in brain-gut *** this review,we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor *** research should focus on further elucidating the role of SCFAs in neuroinflammation,as well as developing novel strategies employing SCFAs and their derivatives to treat PD.

关键词： Parkinson’s disease Short-chain fatty acids Microbial metabolites Brain-gut-microbiota axis

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DLF-YOLOF:an improved YOLOF-based surface defect detection for steel plate

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Journal of Iron and Steel Research International 2024年第2期31卷 442-451页

作者： Guang-hu liu Mao-xiang Chu Rong-fen Gong Ze-hao Zheng School of Electronic and Information Engineering University of Science and Technology LiaoningAnshan114051LiaoningChina

Surface defects can affect the quality of steel *** methods based on computer vision are currently applied to surface defect detection of steel ***,their real-time performance and object detection of small defect are still *** improved object detection network based on You Only Look One-level Feature(YOLOF)is proposed to show excellent performance in surface defect detection of steel plate,called ***,the anchor-free detector is used to reduce the network ***,deformable convolution network and local spatial attention module are introduced into the feature extraction network to increase the contextual information in the feature ***,the soft non-maximum suppression is used to improve detection accuracy ***,data augmentation is performed for small defect objects during training to improve detection *** show the average precision and average precision for small objects are 42.7%and 33.5%at a detection speed of 62 frames per second on a single GPU,*** shows that DLF-YOLOF has excellent performance to meet the needs of industrial real-time detection.

关键词： Steel surface defects detection YOLOF Anchor-free detector Small object detection Real-time detection

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