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Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis

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World Journal of Gastroenterology 2015年第1期21卷 318-325页

作者： Moran Lavie Tzipora Manovitz Daphna Vilozni Sarina levy-Mendelovich Ifat Sarouk Ilana Weintraubv david Shoseyov Malena cohen-Cymberknoh Joseph Rivlin Ori Efrati Pediatric Pulmonary Unit and the National Center for Cystic Fibrosis Edmond and Lily Safra Children’s HospitalSheba Medical CenterTel Hashomer 52621Israel Cystic Fibrosis Center and Pediatric Pulmonary Unit Hadassah Hebrew University Medical CenterJerusalem 91120Israel Cystic Fibrosis Center Carmel Medical CenterHaifa 34362Israel

AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome(DIOS) in Israeli cystic fibrosis(CF) ***: This is a multi-center,comparative,retrospective study in which we reviewed the medical records of all CF patients from three major CF centers in Israel who were treated in the period from 1980 to *** diagnosed with DIOS were defined as the study *** patients were diagnosed with DIOS based on their clinical presentation and typical findings on either abdominal X-ray or computerized tomography *** the control group,CF patients with no DIOS were matched to the patients in the study group for age,sex,and cystic fibrosis transmembrane conductance regulator(CFTR) *** both groups,the collected data included age,sex,CFTR genotype,weight,height,and body mass *** data included respiratory function tests in the last five years prior to the study,respiratory function test immediately before and after the DIOS event,number of hospitalizations,sputum culture results,and CFrelated conditions diagnosed according to the CF clinical practice *** the study group,data on the DIOS treatment and tendency for DIOS recurrence were also ***: The medical charts for a total of 350 CF patients were *** the 350 CF patients,26(7.4%) were diagnosed with *** control group included 31 CF patients with no DIOS *** mean follow-up period was 21.6 ± 8.2 *** total of DIOS episodes in the follow-up period was *** distribution of DIOS episodes was as follows: 6/26(23.1%) study patients had one episode of DIOS intheir lifetime,7/26(26.9%) had two episodes,7/26(26.9%) had three episodes,and 6/26(23.1%) had four or more *** to the control group,DIOS patients had a significantly higher incidence of meconium ileus in the past(65.4% vs 0%,respectively,P < 0.02),more Aspergillus ***(34.6% vs 3.2%,respectively,P < 0.02),and a higher number of hospitali

关键词： Distal intestinal obstruction syndrome Cystic fibr

Cultural differences defne diagnosis and genomic medicine practice: implications for undiagnosed diseases program in China

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Frontiers of Medicine 2013年第3期7卷 389-394页

作者： Xiaohong Duan Thomas Markello david Adams Camilo Toro Cynthia Tifft William A. gahl Cornelius F. Boerkoel Department of Oral Biology Clinic of Oral Rare Diseases and Genetic Diseases School of Stomatology the Fourth Military Medical University NIH Undiagnosed Diseases Program NIH Offce of Rare Diseases Research and NHGRI

Despite the current acceleration and increasing leadership of Chinese genetics research,genetics and its clinical application have largely been imported to China from the *** genetics nor the scientifc reductionism underpinning its clinical application is integral to the traditional Chinese *** that disease concepts and their incumbent diagnoses are historically derived and culturally meaningful,we hypothesize that the cultural expectations of genetic diagnoses and medical genetics practice differ between the Occident and ***,we suggest that an undiagnosed diseases program in China will differ from the recently established Undiagnosed Diseases Program at the United States National Institutes of Health;a culturally sensitive concept will integrate traditional Chinese understanding of disease with the scientifc reductionism of Occidental medicine.

关键词： genetics cultural differences undiagnosed diseases program

AFLOW-XtalFinder:a reliable choice to identify crystalline prototypes

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npj Computational Materials 2021年第1期7卷 264-283页

作者： david Hicks Cormac Toher Denise CFord Frisco Rose Carlo De Santo Ohad levy Michael J.Mehl Stefano Curtarolo Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Center for Autonomous Materials Design Duke UniversityDurhamNC 27708USA Department of Physics NRCNP.O.Box 9001Beer-Sheva 84190Israel

The accelerated growth rate of repository entries in crystallographic databases makes it arduous to identify and classify their prototype *** open-source AFLOW-XtalFinder package was developed to solve this *** symbolically maps structures into standard designations following the AFLOW Prototype Encyclopedia and calculates the internal degrees of freedom consistent with the International Tables for *** ensure uniqueness,structures are analyzed and compared via symmetry,local atomic geometries,and crystal mapping techniques,simultaneously grouping them by *** software(i)distinguishes distinct crystal prototypes and atom decorations,(ii)determines equivalent spin configurations,(iii)reveals compounds with similar properties,and(iv)guides the discovery of unexplored *** operations are accessible through a Python module ready for workflows,and through command line *** the 4+million compounds in the *** repositories are mapped to their ideal prototype,allowing users to search database entries via symbolic ***,15,000 unique structures—sorted by prevalence—are extracted from the AFLOW-ICSD catalog to serve as future prototypes in the Encyclopedia.

关键词： Python symbolic crystalline

A COMET BEARING DOWN ON JUPITER

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英语学习 1994年第12期 64-69页

作者： david levy 柯凡

本文作者david levy是一位业余天文爱好者,是苏梅克-利维9号慧星的发现者之一。作者在文中叙述了他和专业天文学家苏梅克夫妇一起发现9号慧星的经过。文章刊登在美国Smithsonian杂志第六期上,选注时略有删节。

关键词： A COMET BEARING DOWN ON JUPITER 天文学家

Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis

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World Journal of Gastroenterology 2017年第15期23卷 2673-2684页

作者： Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir david Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A levy Multi Organ Transplant Program University Health Network Department of Laboratory Medicine and Pathology University Health Network Gastroenterology Hepatology and Nutrition DivisionThe Hospital for Sick Children

AIMTo determine the effect of overexpression of fibrinogen-like protein 2 (FGL2) on regulatory T cell (Treg) and effector T (Teff) cell function on T cell-induced colitis in Rag1-/- *** and Teff cells from fgl2-/-, fgl2+/+, and fgl2Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/- *** vitro, fgl2Tg Treg had enhanced immunosuppressive activity, and fgl2Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice (fgl2+/+) into Rag1-/- mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/- Treg were only partially protective. In mice that received fgl2Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2Tg mice did not produce *** we show that fgl2Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease.

关键词： Fibrinogen-like protein 2 Colitis Regulatory T cells Transgenic mouse Inflammatory bowel disease

A Reinforcement Learning based Self-optimizing QoS Controller Framework for Distributed Services

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A Reinforcement Learning based Self-optimizing QoS Controlle...

Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

2010 Chinese Control and Decision Conference

作者： david levy School of Electric and Information Engineering University of Sydney

＜正＞QoS control is complicated by limited knowledge of system characteristics and continuous evolving features in modern distributed *** this paper,we propose a practical reinforcement learning based self-optimized QoS controller algorithm with the ability to guarantee differentiated average response time requirements for different service *** proposed solution consists of two key contributions:the reinforcement learning based self-optimizing control algorithm and full evaluations of this control *** on the prototype show that standard reinforcement learning can learn and self- optimize the control knowledge efficiently in feasible training time with only partial system knowledge.

关键词： QoS Control Self-optimizing Reinforcement Learning

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael levy Anais R.Briant Etienne Javouhey Sophie Breinig Julia Dina Marion Caseris Francois Angoulvant Stephane Leteurtre Morgan Recher david W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine Research Center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the pediatric intensive care unit(PICU).Secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive SARS-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental SARS-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French PICU registry(PICURe)between September 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SARS-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to SARS-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SARS-CoV-2 mortality in the French pediatric population was *** though the imputability of SARS-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit SARS-CoV-2

Right versus left fully robotic live donor nephrectomy and open kidney transplantation:Does the laterality of the donor kidney really matter?

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Asian Journal of Urology 2023年第4期10卷 453-460页

作者： Brianna Ruch Deki Tsering Chandra Bhati Dhiren Kumar Muhammad Saeed Seung Duk Lee Aamir Khan Daisuke Imai david Bruno Marlon levy Adrian Cotterell Amit Sharma Hume-Lee Transplant Center Virginia Commonwealth UniversityRichmondVAUSA Division of Transplant Surgery University of MarylandBaltimoreMDUSA

Objective Robotic-assisted live donor nephrectomy(LDN)is being gradually adopted across transplant *** left donor kidney is preferred over right due to anatomical factors and ease of *** aimed to study donor and recipient outcomes after robotic procurement and subsequent open implantation of right and left *** All fully robotic LDNs and their corresponding open kidney transplants performed at our center between February 2016 and December 2021 were retrospectively *** Out of 196 robotic LDN(49[right]vs.147[left]),10(5.1%)donors had intra-operative events(6.1%[right]vs.4.8%[left],p=0.71).None of the LDN required conversion to open *** operative times were comparable for the two ***(13.3%)was the most common post-operative *** was no mortality in either LDN ***,we report our outcomes on 156 recipients(39 right and 117 left allografts)excluding robotic implants,exports,and pediatric *** were no significant differences between right and left kidney recipients with respect to 1-year post-transplant patient survival(100.0%vs.98.1%,p=0.45)or graft survival(93.9%vs.97.1%,p=0.11),or delayed graft function(7.7%vs.5.1%,p=0.55).Conclusion Non-hand-assisted robotic live donor nephrectomies can be safely performed with excellent *** LDN was not associated with higher incidence of complications compared to left *** implantation of robotically procured right renal allografts was not associated with higher risk of recipient complications.

关键词： Robotics Laparoscopy Donor nephrectomy Complication Renal transplant Outcome

Review on squeaking hips

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World Journal of Orthopedics 2015年第10期6卷 812-820页

作者： Yadin david levy Selin Munir Shane Donohoo William Lindsay Walter Specialist Orthopaedic Group Mater Clinic Silesco Pty Ltd Mater Clinic Australia

Squeaking is a well-recognized complication for hardon-hard *** nature of squeaking is not yet completely understood however it is considered a multifactorial ***,implant,and surgical factors play a role in *** is believed that mechanisms damaging the fluid film lubrication in which these bearings function optimally have a critical *** mechanisms include edge loading,stripe wear,impingement,third body particles and ceramic *** resonance of metallic parts can produce noise in the human audible range hence the implant metallurgic composition and design may play a *** positioning can facilitate impingement and edge loading enhancing the occurrence of *** recent introduction of large heads(> 36 mm) 4th generation ceramic-on-ceramic bearing may accentuate the conditions facilitating noise formation; however the current literature is ***,squeaking may manifest in extreme hip positions or during normal gait cycle however it is rarely associated with *** of patients with squeaking include clinical and radiographic *** tomography is recommended as it can better reveal ceramic breakage and implant *** treatments for most squeaking patients include reassurance and activity *** for some,noise can be a problem,requiring further surgical *** the occurrence of ceramic fracture,implant failure,extreme components malposition,instability and impingement,surgery should be *** review will aim to discuss the current literature regarding squeaking.

关键词： Squeaking Total hip arthroplasty Ceramicon-ceramic Lubrication Edge loading Metal-on-metal