Cultural differences defne diagnosis and genomic medicine practice: implications for undiagnosed diseases program in China

作     者：Xiaohong Duan Thomas Markello David Adams Camilo Toro Cynthia Tifft William A. Gahl Cornelius F. Boerkoel 

作者机构：Department of Oral Biology Clinic of Oral Rare Diseases and Genetic Diseases School of Stomatology the Fourth Military Medical University NIH Undiagnosed Diseases Program NIH Offce of Rare Diseases Research and NHGRI 

出 版 物：《Frontiers of Medicine》 (高等学校学术文摘·医学前沿(英文))

年 卷 期：2013年第7卷第3期

页      面：389-394页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by National Natural Science Foundation of China(Grant Nos.81070819,31070835,and 81271116) the United States National Institutes of Health Undiagnosed Diseases Program(Offce of Rare Disease Research,Offce of the Director,NIH NHGRI and NIH Clinical Center) Intramural Research Program of the NHGRI 

主　　题：genetics cultural differences undiagnosed diseases program 

摘      要：Despite the current acceleration and increasing leadership of Chinese genetics research,genetics and its clinical application have largely been imported to China from the *** genetics nor the scientifc reductionism underpinning its clinical application is integral to the traditional Chinese *** that disease concepts and their incumbent diagnoses are historically derived and culturally meaningful,we hypothesize that the cultural expectations of genetic diagnoses and medical genetics practice differ between the Occident and ***,we suggest that an undiagnosed diseases program in China will differ from the recently established Undiagnosed Diseases Program at the United States National Institutes of Health;a culturally sensitive concept will integrate traditional Chinese understanding of disease with the scientifc reductionism of Occidental medicine.