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Characterization of some bacterial strains isolated from the Egyptian eastern and northern coastlines with antimicrobial activity of Bacillus zhangzhouensis OMER4

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Acta Oceanologica Sinica 2022年第3期41卷 86-93页

作者： Mohamed O.Soliman Waleed B.Suleiman Mohamed M.Roushdy Eman N.Elbatrawy Ahmed M.gad Department of Botany and Microbiology Faculty of ScienceAl-Azhar UniversityCairo 11884Egypt The Regional Center for Mycology and Biotechnology Al-Azhar UniversityCairo 11884Egypt Microbiology Laboratory Marine Environmental DivisionNational Institute of Oceanography and FisheriesAlexandria 11865Egypt

Marine microorganisms were considered to be important sources of marine bioactive *** major objective of the study was to isolate and characterize bacteria with antimicrobial activities from the various marine environment of *** this respect,thirty-five bacterial isolates were recovered from sediment samples collected from different spots along the Egyptian Red Sea coastline and Alexandria coastline during the summer season of 2017 and *** to the morphological,physiological,and biochemical characteristics,the bacterial isolates were clustered into 13 groups designated as A,B,…,***,14 Gram-negative and 21 Grampositive bacteria were *** isolated bacterial strains were screened for their potentiality for antimicrobial agent(s)production against ten indicator *** Mo13 was showed high antimicrobial activity against all empirical ***,the most promising marine bacterial isolate with code MO13 was identified as Bacillus zhangzhouensis OMER4 according to the phenotypic characterization through morphological,physiological,and biochemical tests as well as genotypic characterization through the 16 S rDNA *** bioactive components were extracted with ethyl acetate,then analyzed using GC-MS and the substantial component was recognized as phenol,2,4-bis(1,1-dimethyl ethyl).

关键词： marine bacteria natural product Egyptian coastline antimicrobial Bacillus zhangzhouensis GC-MS characterization

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Geochemical and Environmental Evaluation of Um Shashoba Gold Mine Area,Southeastern Desert,Egypt

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Acta Geologica Sinica(English Edition) 2011年第4期85卷 881-898页

作者： Mohamed Abdallah gad DARWISH Geology Department Aswan Faculty of ScienceSouth Valley UniversityPost No.81528 AswanEgypt

A suite of elements（Ag,Au,Ba,Bi,Cd,Co,Cr,Cu,Ga,Hf,Hg,Mn,Mo,Ni,Pb,Rb,Sb,Se, Sr,Te and Zn）,total organic carbon（TOC）and pH were analyzed in stream sediment and tailing samples from Um Shashoba area,in order to evaluate Au placer and the sediments being impacted by old mining *** results were examined using statistical,graphical and mapping *** spite of the results revealing that Au and most of the elements in sediments were in general significantly lower than those in tailing,Au was concentrated in the NE and SW parts forming Au *** is remarkably a close association of Au with Hg and Sb;both are useful as pathfinder elements for Au *** of pH could not control a fate of analyzed elements,whereas TOC and Mn oxides and hydroxides could uptake some elements Au,Ba,Co,Cr,Hg,Ni,and *** results also indicated that the sediments were contaminated by anthropogenic factors causing moderate,strong to very strong pollution with respect to Bi,Se and Te,***,geogenic factors could also contribute elemental enrichment to the drainage system and cause significant toxicity level.

关键词： geochemical exploration environmental evaluation Um Shashoba gold mine Egypt

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Geochemistry of the High Dam Lake sediments,south Egypt:implications for environmental significance

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International Journal of Sediment Research 2013年第4期28卷 544-559页

作者： Mohamed Abdallah gad DARWISH Geology department Faculty of ScienceAswan University

The goal of the present work is to perform a geochemical assessment of High Dam Lake bottom sediments for determining the fate,dispersion and levels of trace elements causing environmental pollution,and provided an access to their probable *** sediment samples were analyzed using ICP-MS for 20 elements;Ag,Ba,Cr,Cu,Ga,Hf,Mn,Pb,Rb,Sc,Sc,Sn,Sr,Ta Th Ti,T1,U,V and Zr,and their obtained data were treated using statistical,graphical and mapping *** results showed the data set of all analyzed elements affected by outliers and extreme values that caused deviation away from *** Wallis test revealed that median of some trace clement levels in Lake sediments,was not significantly different and other elements rejected the Null *** analyzed elements had high values of median and mean in sediments of Lake Nubia rather than Lake Nasser and their normalization gave the same results of calculated environment ***,Lake Nubia sediments possessed high combined EF levels of Th,Sc,Sn,Ag,Zr,Hf,Ta,Sr,U,Ti,V,Cr,and Mn,causing significant contamination,which was great potentially related to industrial,agricultural,urbanization and mining ***,combined EF of Se,Cu,Ga,Pb,Ba,Rb,and Tl,which are highly elevated in southern Lake Nasser sediments owing to their source are great possibly derived from Lake Nubia and geogenic *** decreasing distance towards the High Dam body,the contaminant elements were diminished due to reduction in the environmental factors and Sudanese pollution sources leading to the northern Lake Nasser considered to be less ***,the present study is an environmental alert for contaminated sediments that carried contaminants and considered the secondary source of pollution impact on ecosystem,and subsequently,their environmental risk on Human health.

关键词： Geochemistry High Dam Lake sediments Environmental significance South Egypt

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技术轨道延伸与破解技术路径锁定研究——以光刻产业为例

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科学学研究 2023年第6期41卷 1014-1026页

作者：杨武陈培 gad David 孙世强北京科技大学经济管理学院北京100083

以光刻为代表的系列产业处于“技术路径锁定”的困局,能否走向更深层次的技术突破和产业变革取决于能否破解“技术路径锁定”。以光刻为例,通过近期科学研究与技术主路径的关联,将技术轨道延伸和扩展至最新研究前沿,揭示可能发生技术改... 详细信息

以光刻为代表的系列产业处于“技术路径锁定”的困局,能否走向更深层次的技术突破和产业变革取决于能否破解“技术路径锁定”。以光刻为例,通过近期科学研究与技术主路径的关联,将技术轨道延伸和扩展至最新研究前沿,揭示可能发生技术改进和技术突破的领域,为后发国家实现技术赶超、破解技术锁定提供了机会。研究发现光刻的技术轨道演化方向为:纳米压印技术、脱模技术、掩膜定位和EUV光刻胶工艺;主路径上光刻技术主要来自发达国家,但通过扩展和延伸,逐渐有大量的中国研究成果出现,在一定程度上技术轨道与科学研究存在关联,但也有差异;关于如何破解技术路径锁定,可以从顺轨创新型路径和技术跨越型路径两个维度采取不同的破解策略。本研究对于发现技术突破窗口,破解发达国家对我国的“技术路径锁定”具有重要的现实意义。

关键词：技术路径锁定技术轨道技术突破光刻产业

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专利家族视角下技术演化路径依赖研究——以光刻技术为例

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科技进步与对策 2022年第23期39卷 1-11页

作者：杨武陈培 gad David 北京科技大学经济管理学院北京100083

以专利家族为研究视角,阐述技术路径动态演化过程中的路径依赖。专利家族自引会对技术主路径造成干扰,通过对主路径进行调整,提出一种修正技术主路径的新思路。研究发现:光刻技术在“投影对准和曝光系统—浸没式投影物镜—浸没式光刻材... 详细信息

以专利家族为研究视角,阐述技术路径动态演化过程中的路径依赖。专利家族自引会对技术主路径造成干扰,通过对主路径进行调整,提出一种修正技术主路径的新思路。研究发现:光刻技术在“投影对准和曝光系统—浸没式投影物镜—浸没式光刻材料—光刻胶”4个阶段经历了“路径消解—路径产生与路径依赖—路径消解与突破”的动态演化过程。在此过程中,以荷兰阿斯麦、德国蔡司和日本东京电子为代表的专利家族发挥重要作用。其中,以阿斯麦为核心的利益联盟垄断核心技术,强化光刻技术发展的路径依赖作用,占据市场领先地位。研究结论有助于深化对路径依赖理论的认知,通过揭示光刻技术路径演化过程及企业演化格局,为后发国家突破技术路径依赖提供实践启示。

关键词：专利家族技术演化技术路径依赖光刻技术

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光刻机产业技术扩散与技术动态演化——对“卡脖子”技术的启示

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中国科技论坛 2022年第9期 73-84页

作者：杨武陈培 gad David 北京科技大学经济管理学院北京100083

在当前中美贸易摩擦升级、“卡脖子”技术频繁出现的背景下,研究光刻技术扩散与动态演化对攻克“卡脖子”技术、突破全局具有重要意义。本文利用专利引证数据构建引文网络,并通过局部向前搜索、局部向后搜索和关键路径3种不同的主路径... 详细信息

在当前中美贸易摩擦升级、“卡脖子”技术频繁出现的背景下,研究光刻技术扩散与动态演化对攻克“卡脖子”技术、突破全局具有重要意义。本文利用专利引证数据构建引文网络,并通过局部向前搜索、局部向后搜索和关键路径3种不同的主路径分析方法来描述光刻技术知识扩散路径,进行对比分析,并对光刻技术动态演化的阶段进行了识别与分析。研究结果表明:美、日、德先发优势明显,光刻技术的扩散由台积电、阿斯麦等大公司主导;技术发展前期,主要侧重器件制造和工艺的改进,而在后期则注重光刻材料的研发,从2015年开始技术扩散方向主要集中在EUV光刻胶材料;与全球范围内光刻技术扩散趋势相比,我国进入光刻领域较晚,技术扩散能力不强且尚未出现在技术扩散主路径中。本研究从技术扩散路径和技术动态演化两个角度揭示了光刻技术扩散的客观规律和特征,丰富了“卡脖子”技术的理论研究,为我国技术路径选择提供企业和技术层面的决策支持与经验依据,以期对突破发达国家的核心技术锁定带来一定的启示。

关键词：光刻机产业 “卡脖子”技术技术扩散技术演化

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Feature selection approach using ensemble learning for network anomaly detection

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 283-293页

作者： Doreswamy Mohammad Kazim Hooshmand Ibrahim gad Department of Computer Science Mangalore UniversityMangaloreIndia

Feature selection is essential for prioritising important attributes in data to improve prediction quality in machine learning *** different selection techniques identify different feature sets,relying on a single method may result in risky *** authors propose an ensemble approach using union and quorum combination techniques with five primary individual selection methods which are analysis of variance,variance threshold,sequential backward search,recursive feature elimination,and least absolute selection and shrinkage *** proposed method reduces features in three rounds:(i)discard redundant features using pairwise correlation,(ii)individual methods select their own feature sets independently,and(iii)equalise individual feature *** equalised individual feature sets are combined using union and quorum *** the combined and individual sets are tested for network anomaly detection using random forest,decision tree,K-nearest neighbours,Gaussian Naive Bayes,and logistic regression *** experimental results on the UNSW-NB15 data set show that random forest with union and quorum feature sets yields 99 and 99.02% f1_score with minimum 6 and 12 features,*** results on the NSL-KDD data set show that random forest with union and quorum gets 99.34 and 99.21% f1_score with a minimum of 28 and 18 features.

关键词： union ensemble network

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Whole-Plant Live Imaging of Reactive Oxygen Species

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Molecular Plant 2019年第9期12卷 1203-1210页

作者： Yosef Fichman gad Miller Ron Mittler The Division of Plant Sciences and Interdisciplinary Plant Group College of AgricultureFood and Natural ResourcesChristopher S.Bond Life Sciences Center University of Missouri1201 Rollins StreetColumbiaMO 65201USA The Mina and Everard Goodman Faculty of Life Sciences Bar-llan UniversityThe Gonda Medical Diagnostic Research Building(204)Room 211Ramat-Gan 52900Israel Department of Surgery University of Missouri School of Medicine1 Hospital DriveColumbiaMO 65212USA

Reactive oxygen species(ROS)are key regulators of numerous subcellular,cellular,and systemic *** function in plants as an integral part of many different hormonal,physiological,and developmental pathways,as well as play a critical role in defense and acclimation responses to different biotic and abiotic *** many ROS imaging techniques have been developed and utilized in plants,a wholeplant imaging platform for the dynamic detection of ROS in mature plants is *** we report a robust and straightforward method for the whole-plant live imaging of ROS in mature plants grown in *** new method could be used to study local and systemic ROS signals in different genetic variants,conduct phenotyping studies to identify new pathways for ROS signaling,monitor the stress level of different plants and mutants,and unravel novel routes of ROS integration into stress,growth regulation,and development in *** demonstrate the utility of this new method for studying systemic ROS signals in different A rabidopsis mutants and wound responses in cereals such as wheat and corn.

关键词： live imaging ROS stress systemic signaling whole plant

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Uncoupling tumor necrosis factor-αand interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

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BIOCELL 2022年第3期46卷 769-783页

作者： RAGHDA A.SOLIMAN RANA A.YOUNESS TAMER M.MANIE EMAD KHALLAF MOHAMED EL-SHAZLY MONA ABDELMOHSEN HEBA HANDOUSSA MOHAMED Z.gad Pharmaceutical Biology Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt School of Life and Medical Sciences University of Hertfordshire Hosted by Global Academic FoundationNew Administrative Capital11578Egypt Breast Surgery Department National Cancer InstituteCairo UniversityCairoEgypt General Surgery Department Faculty of MedicineCairo UniversityCairoEgypt Department of Phytochemistry National Research CentreGiza12622Egypt Biochemistry Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Triple Negative Breast Cancer(TNBC)immunotherapy has recently shown promising ***,some TNBC patients presented with *** of the reasons was attributed to the excessive release of cytokines at the tumor microenvironment(TME)such as Tumor necrosis factor alpha(TNF-α)and Interleukin-10(IL-10).Fine regulation of these cytokines’levels via non-coding RNAs(ncRNAs)might alleviate the immune quiescent nature of TME at TNBC ***,the extrapolation of ncRNAs as therapeutic tools is highly ***,disentanglement the nature for the isolation of natural compounds that could modulate the ncRNAs and their respective targets is an applicable translational therapeutic ***,this study aimed to targeting the chief immune suppressive cytokines at the TME(TNF-αand IL-10)via ncRNAs and to examine the effects of Rosemary aerial parts extract on the expression levels of these ncRNAs in *** revealed miR-17-5p as a dual regulator of TNF-αand ***,an intricate interaction has been shown between miR-17-5p and the oncogenic lncRNAs:MALAT1 and *** down of MALAT1 and/or H19 caused an induction in miR-17-5p and reduction in TNF-αand IL-10 expression ***-17-5p was found to be down-regulated,while TNF-α,IL-10,MALAT1 and H19 were up-regulated in BC *** expression of miR-17-5p in MDA-MB-231 cells reduced TNF-α,IL-10,MALAT1 and H19 expression levels,as well as several BC *** a translational approach,ursolic acid(UA)isolated from rosemary induced the expression of miR-17-5p,MALAT1 and decreased H19 expression *** conclusion,this study suggests miR-17-5p as a tumor suppressor and an immune-activator miRNA in BC through tuning up the immunological targets TNF-α,IL-10 at the TME and the oncological mediators MALAT1 and H19 lncRNAs.

关键词： Breast cancer Tumor microenvironment Cytokines TNF-α IL-10 miR-17-5p MALAT1 H19 lncRNAs miRNA Ursolic acid

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The Yellow Spot Pattern of Salamander (Salamandra infraimmaculata) in Various Habitats at the Southern Border of Its Distribution in Israel

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Open Journal of Animal Sciences 2023年第1期13卷 114-125页

作者： gad Degani gad Ish Am Amit Biran Ish Am Neria Yatom Amir Marshansky Sivan Margalit Eitan Nissim Hava Goldstein Niva Shaked MIGAL—Galilee Research Institute Kiryat Shmona Israel Faculty of Science and Technology Tel-Hai Academic College Kiryat Shmona Israel Kibbutz Sasa Upper Galilee Israel Kibbutz Yehiam Galil Maaravi Israel Israel Nature and Parks Authority Jerusalem Israel

The present study describes the different color-pattern phenotypes of yellow spots on the black back of Salamandra infraimmaculata in various habitats at the southern border of its distribution in Israel. At Tel Dan, we photographed 454 salamanders in moist habitats where water flows year round;100 of these were sampled to measure the percentage of yellow and black color on the back, and the number of spots on the head. At Kibbutz Sasa, 201 salamanders were photographed, of which 62 were sampled for the measurements. In Kibbutz Yehiam, 200 salamanders were photographed, and 60 were sampled for the measurements. At all sites, about a third of the salamanders were photographed more than once. For all three populations, yellow spots on the salamander back were found in one row, two rows or scattered. For two indices (proportion of yellow/black and number of spots on the head), the Dan population (under wet, running water all year round conditions) differed from the two other populations of salamanders (under semi-arid mountain conditions). The number of yellow spots on the head of the salamanders in the three populations varied from 1 to 7. In all populations, 4 spots pattern was the most common. In the Dan population, there were significantly more salamanders with 1 to 3 spots on their head than in the Sasa or Yehiam populations. No difference was found in the number of head spots for Sasa vs. Yehiam salamanders. The percentage of yellow on the black back was significantly larger for the Dan salamanders vs. the two other populations. The main question examined was whether there is an effect of the habitat conditions in isolated populations on the spot pattern on the salamander back. The answer is positive and is supported by previous studies.

关键词： Salamandra infraimmaculata Color-Pattern Habitats Spots Yellow

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