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Prenatal programing of motivated behaviors:can innate immunity prime behavior?

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Neural Regeneration Research 2023年第2期18卷 280-283页

作者： Larisa Montalvo-martínez gabriela Cruz-Carrillo Roger Maldonado-Ruiz Luis ATrujillo-Villarreal Eduardo AGarza-Villarreal Alberto Camacho-Morales Universidad Autónoma de Nuevo León Department of BiochemistryCollege of MedicineMonterreyMéxico Universidad Autónoma de Nuevo León Neurometabolism UnitCenter for Research and Development in Health SciencesMonterreyMéxico Universidad Nacional Autónoma de México Campus Juriquilla Instituto de NeurobiologíaQueretaroMéxico

Prenatal programming during pregnancy sets physiological outcomes in the offspring by integrating external or internal stimuli.Accordingly,pregnancy is an important stage of physiological adaptations to the environment where the fetus becomes exposed and adapted to the maternal milieu.Maternal exposure to high-energy dense diets can affect motivated behavior in the offs p ring leading to addiction and impaired sociability.A high-energy dense exposure also increases the pro-inflammatory cytokines profile in plasma and brain and favors microglia activation in the offspring.While still under investigation,prenatal exposure to high-energy dense diets promotes structural abnormalities in selective brain regions regulating motivation and social behavior in the offspring.The current review addresses the role of energy-dense foods programming central and peripheral inflammatory profiles during embryonic development and its effect on motivated behavior in the offspring.We provide preclinical and clinical evidence that supports the contribution of prenatal programming in shaping immune profiles that favor structural and brain circuit disruption leading to aberrant motivated behaviors after birth.We hope this minireview encourages future research on novel insights into the mechanisms underlying maternal programming of motivated behavior by central immune networks.

关键词： addiction autism behavior cytokines diet maternal immune activation prenatal programming sociability trained immunity western-diets

Risk Factors and Gender Differences for Depression in Chilean Older Adults:A Cross-Sectional Analysis from the National Health Survey 2016–2017

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International Journal of Mental Health Promotion 2022年第5期24卷 679-697页

作者： gabriela Nazar Carlos-María Alcover Yeny Concha-Cisternas Igor Cigarroa Ximena Díaz-martínez Mariela Gatica-Saavedra Fabián Lanuza Ana María Leiva-Ordónez María Adela martínez-Sanguinetti Miquel martorell Fanny Petermann-Rocha Claudia Troncoso-Pantoja Carlos Celis-Morales Departamento de Psicología Facultad de Ciencias SocialesUniversidad de ConcepciónConcepciónChile Centro de Vida Saludable Universidad de ConcepciónConcepciónChile Departamento de Psicología Facultad de Ciencias de la SaludUniversidad Rey Juan CarlosMadridEspaña Pedagogía en Educación Física Facultad de EducaciónUniversidad AutónomaTalcaChile Escuela de Kinesiología Facultad de SaludUniversidad Santo TomásLosÁngelesChile Grupo de Investigación Calidad de Vida Departamento de Ciencias de la EducaciónUniversidad del BiobíoChillánChile Depto de Psiquiatría y Salud Mental Facultad de MedicinaUniversidad de ConcepciónConcepciónChile Centro de Epidemiología Cardiovascular y Nutricional(EPICYN) Facultad de MedicinaUniversidad de La FronteraTemucoChile Biomarkers and Nutrimetabolomics Laboratory Department of NutritionFood Sciences and GastronomyFood Technology Reference Net(XIA)Nutrition and Food Safety Research Institute(INSA)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelona08028Spain Instituto de Anatomía Histología y PatologíaFacultad de MedicinaUniversidad Austral de ChileValdiviaChile Instituto de Farmacia Facultad de CienciasUniversidad Austral de ChileValdiviaChile Departamento de Nutrición y Dietética Facultad de Farmacia.Universidad de ConcepciónConcepciónChile Facultad de Medicina Universidad Diego PortalesSantiagoChile BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK Centro de Investigación en Educación y Desarrollo(CIEDE-UCSC).Departamento de Salud Pública Facultad de MedicinaUniversidad Católica de la Santísima ConcepciónConcepciónChile Laboratorio de Rendimiento Humano Grupo de Estudio en EducaciónActividad Física y Salud(GEEAFyS)Universidad Católica del MauleTalcaChile

Depressive disorders are recognized as one of the most common mental health conditions across different age groups.However,the risk factors associated with depression among older people from low-and middle-income countries remains unclear.This study aims to identify socio-demographic,health and psychosocial-related factors associated with depression in Chilean older adults.A cross-sectional study was carried out in a representative sample of 1,765 adults aged≥60 years participants from the Chilean National Health Survey 2016–2017.Depres-sion was assessed with the Composite International Diagnostic Interview(CIDI-SF).Associations between the exposure variables and depression were investigated using Poisson regression analyses.The mainﬁndings indi-cated that women showed higher likelihood of depression than men(Prevalence Ratio(PR)=2.6[95%CI:1.40;4.89]).An increased likelihood of depression was found in older adults with chronic pain,multimorbidity(≥2 diseases),previous diagnose of depression,high perception of stress,ﬁnancial stress,and difﬁculties for social par-ticipation.In women,higher likelihood of depression was found for those with the frailty phenotype(PR:8.53[95%CI:1.68;43.32]),rheumatoid arthritis(PR:2.41[95%CI:1.34;4.34]),insomnia(PR:2.99[95%CI:1.74;5.12])and low self-rated well-being(PR:4.94[95%CI:2.26;10.79]).Men who were divorced(PR:7.10[95%CI:1.44;34.90])or widowed(PR:10.83[95%CI:3.71;31.58]),obese(PR:5.08[95%CI:1.48;17.42])and who had asthma(PR:7.60[95%CI:2.31;24.99])were associated with higher odds of depression.The currentﬁndings may have clinical implications for the early identiﬁcation of older adults more susceptible to depression and also suggest the need to implement cultural and age-sensitive strategies to promote mental health in late life.

关键词： Depression older adults aging late-life depression risk factors

Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin

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Journal of Environmental Sciences 2013年第7期25卷 1408-1418页

作者： gabriela V. Aguirre-martínez Sara Buratti Elena Fabbri Angel T. DelValls M. Laura martín-Díaz Unitwin/Unesco/WiCoP Physical Chemistry Department University of Cdiz Faculty of Marine and Environmental SciencesPolígono Río San Pedro s/n 11510 Puerto Real Cdiz Spain Andalusian Center for Marine Science and Technology (CACYTMAR) Campus Universitariode Puerto Real11510 Puerto Real Cdiz Spain University of Bologna Interdepartment Centre for Research in Environmental Sciences (CIRSA)via S. Alberto 16348123 Ravenna Italy

Although pharmaceuticals have beendetected in the environment only in the range from ng/L to μg/L, it has beendemonstrated that they can adversely affect the health status of aquatic organisms. Lysosomal membrane stability （LMS） has previously been applied as an indicator of cellularwell-being todetermine health status in bivalve mussels. The objective of this study is to evaluate LMS in Ruditapes philippinarum haemolymph using the neutral red retention assay （NRRA）. Clamswere exposed in laboratory conditions to caffeine （0.1, 5, 15, 50 μg/L）, ibuprofen （0.1, 5, 10, 50 μg/L）, carbamazepine and novobiocin （both at 0.1, 1, 10, 50 μg/L） for35days. Results show adose-dependent effect of the pharmaceuticals. The neutral red retention time measured at the end of the bioassaywas significantly reduced by 50% after exposure to environmental concentrations （p 〈 0.05）（caffeine = 15 μg/L; ibuprofen = 10 μg/L; carbamazepine = 1 μg/L and novobiocin = 1 μg/L）, compared to controls. Clams exposed to these pharmaceuticalswere considered to present adiminished health status （retention time 〈45 min）, significantlyworse than controls （96 min）（p 〈 0.05）. The predicted no environmental effect concentration （PNEC） results showed that these pharmaceuticals are very toxic at the environmental concentrations tested. Measurement of the alteration of LMS has been found to be a sensitive technique that enables evaluation of the health status of clams after exposure to pharmaceuticals under laboratory conditions, thus representing a robust Tier-1 screening biomarker.

关键词： neutral red pharmaceuticals bioassay haemolymph bivalves health status Manila clam

Effective use of FibroTest to generate decision trees in hepatitis C

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World Journal of Gastroenterology 2009年第21期15卷 2617-2622页

作者： Dana Lau-Corona Luís Alberto Pineda Héctor Hugo Avilés gabriela Gutiérrez-Reyes Blanca Eugenia Farfan-Labonne Rafael Núez-Nateras Alan Bonder Rosalinda martínez-García Clara Corona-Lau Marco Antonio Olivera-martínez Maria Concepción Gutiérrez-Ruiz Guillermo Robles-Díaz David Kershenobich Department of Experimental Medicine School of MedicineUniversidad Nacional Autonoma de MexicoGeneral Hospital of Mexico Department of Computer Sciences Institute for Applied Mathematics and SystemsUniversidad Nacional Autonoma de Mexico Department of Gastroenterology Lomas Altas Clinic

AIM:To assess the usefulness of FibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis C.METHODS:We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver biopsy.The FibroTest attributes of age,gender,bilirubin,apolipoprotein,haptoglobin,α2 macroglobulin,and γ-glutamyl transpeptidase were used as predictors,and the FibroTest score as the target.For testing,a 10-fold cross validation was used.RESULTS:The overall classification error was 14.9%(accuracy 85.1%).FibroTest's cases with true scores of F0 and F4 were classified with very high accuracy(18/20 for F0,9/9 for F0-1 and 92/96 for F4) and the largest confusion centered on F3.The algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 patients.The rules for the classification of patients in F0 and F4 were effective in more than 75% of the cases in which they were tested.CONCLUSION:The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression.

关键词：丙型肝炎决策树分类算法慢性肝炎结合珠蛋白载脂蛋白交叉验证纤维化

Glutamine synthetase activity and glutamate uptake in hippocampus and frontal cortex in portal hypertensive rats

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世界胃肠病学杂志：英文版 2009年第23期15卷 2893-2899页

作者： gabriela Beatriz Acosta María Alejandra Fernández Diego martín Roselló María Luján Tomaro Karina Balestrasse Abraham Lemberg Institute of Pharmacological Research (ININFA) National Research Council of Argentina (CONICET) and University of Buenos Aires Junín 956. 5th floor C1113AAD Buenos Aires Argentina Laboratory of Portal Hypertension School of Pharmacy and Biochemistry University of Buenos Aires Junín 956. 5th floor C1113AAD Buenos Aires Argentina Department of Biological Chemistry School of Pharmacy and Biochemistry University of Buenos Aires Junín 596. 5th floor C1113AAD Buenos Aires Argentina

AIM: To study glutamine synthetase (GS) activity and glutamate uptake in the hippocampus and frontal cortex (FC) from rats with prehepatic portal vein hypertension. METHODS: Male Wistar rats were divided into shamoperated group and a portal hypertension (PH) group with a regulated stricture of the portal vein. Animals were sacrificed by decapitation 14 d after portal vein stricture. GS activity was determined in the hippocampus and FC. Specific uptake of radiolabeled L-glutamate was studied using synaptosome-enriched fractions that were freshly prepared from both brain areas. RESULTS: We observed that the activity of GS increased in the hippocampus of PH rats, as compared to control animals, and decreased in the FC. A significant decrease in glutamate uptake was found in both brain areas, and was more marked in the hippocampus. The decrease in glutamate uptake might have been caused by a deficient transport function, signif icantly and persistent increase in this excitatory neurotransmitter activity. CONCLUSION: The presence of moderate ammonia blood levels may add to the toxicity of excitotoxic glutamate in the brain, which causes alterations in brain function. Portal vein stricture that causes portal hypertension modif ies the normal function in some brain regions.

关键词： Wistar大鼠谷氨酰胺合成酶活性测定额叶皮层谷氨酸海马摄取高压

Product Containing “Skin Calm Complex” Improves Barrier Effect in Vitro

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第4期4卷 234-243页

作者： María Matabuena-de Yzaguirre gabriela Bacchini Eva Vila-martínez ángeles Juarranz Department of Biology Faculty of Sciences Universidad Autónoma de Madrid Madrid Spain Medical Department Ferrer Health Care Barcelona Spain

Epidermal Barrier integrity is deteriorated in many skin conditions, including Atopic Dermatitis, and could be responsible for many of the associated clinical symptoms. The aim of this study was to determine the effect of REPAVAR ATOPIC SKIN BODY CREAM EXTREME, product containing “SKIN CALM COMPLEX” on barrier epidermis structure. Morphologic and structural evaluations were conducted on reconstructed human epidermis, by qualitative (hematoxylin/eosin- and immune-staining) and quantitative (MTT assay) techniques. Immature (Age Day 10) and mature (Day 17) sample tissues were treated with the product for 24 hours or 7 days, respectively. Morphological and quantitative analysis revealed an increase in the thickness of the epidermis in both cases after the treatment. The study by immunostaining showed that Product-treated tissues presented excellent localization of: 1) E-cadherin in keratinocytes of the spinous layer;2) Filaggrin and Loricrin, in the granular layer;and 3) increased expression of Involucrin and Keratin 10 in suprabasal layers and 4) elevated expression of Keratin 5 in the basal layer of the epidermis. The product REPAVAR ATOPIC SKIN BODY CREAM EXTREME increases the epithelial regeneration and differentiation determined by cell proliferation and the expression and localization of specific proteins, improving the epidermal barrier effect.

关键词： Atopic Dermatitis Epidermal Barrier Epithelial Regeneration and Differentiation

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” in VitroReconstructed Epidermis

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第5期4卷 309-315页

作者： María Matabuena de Yzaguirre gabriela Bacchini Emili Gil Luna Eva Vila-martínez Department of Biology Faculty of Sciences Universidad Autónoma de Madrid Madrid Spain Medical Department Ferrer Health Care Barcelona Spain

Atopic dermatitis is classified as a chronic inflammatory skin disease, which is characterized by alterations in barrier function and immune system of the skin. In a previous study, the efficacy of REPAVAR ATOPIC SKIN BODY CREAM EXTREME (a product containing “SKIN CALM COMPLEX”) on the epidermal barrier structure was demonstrated. However, the product has also been formulated to improve inflammation and itching. The aim of this study is to analyze product effectiveness on skin inflammation and itching which is associated with atopic dermatitis, by quantification of IL-1α and IL-8 interleukins secreted by human keratinocytes from reconstructed epidermis by ELISA assay. Mature (aged 17 days) sample tissues were treated with pro-inflammatory agents (PBS 1X and LPS) and with the product containing synergistic mix from plants extracts and Dihydroavenanthramide D, among other ingredients (“SKIN CALM COMPLEX”) for 24 hours. Measuring the amounts of interleukins by ELISA assay showed 1) decreased levels of IL-1α and 2) no differences about IL-8 secretion. Product REPAVAR ATOPIC SKIN BODY CREAM EXTREME has an anti-inflammatory effect on the release of pro-inflammatory cytokines, becoming an effective preventive agent on inflammation and itching due to maintenance and improvement of the keratinocyte epidermal structure.

关键词： Atopic Dermatitis Anti-Inflammatory Effect In Vitro Assay

Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice

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World Journal of Gastroenterology 2009年第9期15卷 1065-1071页

作者： Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera gabriela A martín Laboratory of Radioisotopes School of Pharmacy and BiochemistryUniversity of Buenos AiresJunín 954 (C1113AAB)Buenos AiresArgentina Institute of Immunooncology Dr. Ernesto Crescenti Av. Córdoba 3200 (C1187AAS)Buenos AiresArgentina National Research Council (CONICET) Av. Rivadavia 1917 (C1033AAJ)Buenos AiresArgentina

AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes.

关键词：细胞生长氨基胍癌肿瘤胰腺癌内皮型一氧化氮合酶铜锌超氧化物歧化酶转移血管内皮生长因子

Branched Polyamines Functionalized with Proposed Reaction Pathways Based on 1H-NMR, Atomic Absorption and IR Spectroscopies

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American Journal of Analytical Chemistry 2014年第16期5卷 1090-1101页

作者： Vicente Cervantes-Mejía Elizabeth Baca-Solis Judith Caballero-Jiménez Rosario Merino-García Jesús Cruz-Gatica gabriela Moreno-martínez Yasmi Reyes-Ortega Chemical Center Sciences Institute Autonomous University of Puebla Puebla México

Three novel branched polyamines N,N,N’,N’-tetrakis-[3((pyridine-2-methyl)-amine) propyl]-1,4- butanediamine (1), N,N,N’,N’-tetrakis-[N-((2-methylpyridine)ethyl)propanamide]ethylenediamine (2) and N,N,N’,N’-tetrakis-[3((2-hidroxibenziliden)-amine)propyl]-1,4-butanediamine (3), were synthesized starting from 2-pyridinecarboxaldeyde with DAB-Am-4 for 1, PAMAM G0 for 2 and from salicylaldehyde with DAB-Am-4 for 3. The pathway reactions have been proposed by 1H-NMR, IR and Atomic Absorption Spectroscopy. The optimal reaction time was set by IR spectroscopy following aldehyde? peak modification. 1 and 2 were obtained as both hydrochlorides and as free amines and 3 only as free imine. These polyamines were characterized by UV-Vis, IR, 1H-NMR and 13C-NMR and Mass Spectrometry.

关键词： Branched Polyamines Functionalization Reactions IR NMR Atomic Absorption Spectroscopy