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Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress

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World Journal of Gastroenterology 2017年第28期23卷 5146-5157页

作者： Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de oliveira Centro de Pesquisas Aggeu Magalhaes Fundacao Oswaldo Cruz Immunopathogenesis Section Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthBethesdaMDUSA and Laboratório de Doencas Parasitárias e infecciosasFaculdade de MedicinaUniversidade Federal de Minas Gerais departamento de Morfologia e Fisiologia Animal Universidade Federal Rural de Pernambuco departamento de Biofísica e Radiobiologia Universidade Federal de Pernambuco Centro Acadêmico de Vitória Universidade Federal de Pernambuco departamento de Medicina Tropical Universidade Federal de Pernambuco

AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors.

关键词：单核白血球骨头髓 mononuclear 房间房间治疗巨噬细胞谷胱甘肽肝纤维变性

Tree succession across a seasonally dry tropical forest and forest-savanna ecotone in northern Minas Gerais,Brazil

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Journal of Plant Ecology 2017年第5期10卷 859-868页

作者： Polyanne A.coelho Paola Ferreira Santos Eduardo de Paiva Paula deborah M.G.Apgaua Bruno Gini Madeira Gisele Cristina de oliveira Menino Yule Roberta Ferreira Nunes Rubens M.Santos David Y.P.Tng department of Forest Sciences Federal University of LavrasC.P.3037CEP 37200-000LavrasMinas GeraisBrazil department of General Biology State University of Montes ClarosC.P.126CEP 39401-089Montes ClarosMinas GeraisBrazil Instituto Federal Goiano C.P.66CEP 75901-970Rio VerdeGoiâniaBrazil Centre for Tropical Environmental and Sustainability Sciences College of Marine and Environmental SciencesJames Cook University14-88 McGregor RdSmithfield QLD 4878CairnsQueenslandAustralia

Aims Understanding succession in tropical forest is an important aspect of vegetation science,but to date,successional processes in sea-sonally dry tropical forests(SDtFs)have received much less atten-tion than evergreen humid tropical *** aim to fill this knowledge *** We investigated vegetation succession in SDtF areas consisting of three different successional stages(early,intermediate,late),and a SDtF-savanna ecotone in the municipal district of Juramento,north of Minas Gerais State,*** twelve 400 m2 plots in each area,we compared vegetation parameters and structural variables(absolute density and basal area)and examined the floristic composition of the tree component to find gradients of *** Findings We found evidence of species turnover along a successional gradi-ent,with the intermediate stage showing the highest species rich-ness and *** was accompanied with a significant increase in the number of tree individuals and basal area from the early to intermediate successional ***,the intermediate and late SDtF successional stages were more similar in structure and *** ecotone was the most species rich and was similar to the intermediate SDtF and early successional stage in species richness and floristic composition *** results will have implications for guiding SDtF management and recovery programs.

关键词： caatinga floristic Similarity ecotone forest succession resilience.

Is more evidence needed for thrombectomy in basilar artery occlusion? The BASICS and BEST meta- analytical approaches

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Stroke & Vascular Neurology 2021年第4期6卷 671-672,I0094-I0096页

作者： Davi J Fontoura Solla Felipe coelho Argolo Karol P Budohoski Angelos G Kolias JoséGuilherme M P Caldas Jamary oliveira-Filho Division of Neurosurgery Department of NeurologyUniversity of Sao PauloSao PauloBrazil NIHR Global Health Research Group on Neurotrauma Cambridge UniversityCambridgeUK Machine Learning for Mental Health Lab King's College LondonLondonUK Division of Neurosurgery Department of Clinical NeurosciencesAddenbrooke's HospitalCambridge UniversityCambridgeUK Radiology University of Sao PauloSao PauloBrazil Postgraduate Program in Health Sciences Federal University of BahiaSalvadorBahiaBrazil

INTRODUCTION The benefit of mechanical thrombectomy for stroke associated with anterior circulation large vessel occlusion(LVO)is well established and among the most effective treatments in medicine.1 Stroke associated with basilar artery occlusion(BAO)was not included in the seminal thrombectomy randomised clin-ical trials(RCTs).BAO accounts for 1%of the ischaemic strokes and 5%-10%of the LVO,but 70%-80%of BAO victims evolve to death or full dependence.23 The terminal nature of the brainstem and thalamic circulations may predispose to such dismal *** two RCT designed to assess the efficacy of early(dence for thrombectomy benefit for anterior circu-lation stroke is well settled;BAO stroke shares a similar physiopathology with very poor prog-nosis.

关键词： throm occlusion basilar

Properties of a Lateritic Red Soil for Pollutant Containment

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Journal of Environmental Protection 2011年第7期2卷 923-931页

作者： Maria Eugenia Gimenez Boscov Waldemar coelho Hachich Claudio Fernando Mahler E. de oliveira 不详

In many regions of Brazil, lateritic clays are the natural candidates for the construction of compacted clay liners of waste disposal sites because of their availability and appropriate geotechnical characteristics. Lateritic soils have been extensively used in recent decades in dam and road construction, but little is known about the migration of pollutants through compacted layers of such soils. This paper describes the characteristics of a lateritic clay, representing a group of soils of significant occurrence in the State of S?o Paulo, to be employed in a clay liner of a waste disposal site. Laboratory tests to assess permeability, adsorption and diffusion of six metals through the compacted soil showed that permeability criterion may be met in the field, that the soil presents a modest capacity to retain cadmium and that constituent metal oxides may be dissolved from the soil grains by acidic solutions.

关键词： Compacted Clay Liner Lateritic Soil Permeability Cadmium Adsorption

Molecular and serology methods in the diagnosis of COVID-19: An overview

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World Journal of Methodology 2022年第3期12卷 83-91页

作者： Marcel Silva Luz Ronaldo Teixeira da Silva Júnior Gabriella Almeida Santos de Santana gabriela SantosRodrigues Henrique de Lima Crivellaro Mariana Santos Calmon Clara Faria Souza Mendes dos Santos LuisGuilherme de oliveira Silva Qesya Rodrigues Ferreira Guilherme Rabelo Mota Heloísa Heim Filipe AntônioFrança da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease-19(COVID-19)has become a pandemic,being a global health concern since december 2019 when the first cases were *** acute respiratory syndrome coronavirus 2,the COVID-19 causal agent,is aβ-coronavirus that has on its surface the spike protein,which helps in its virulence and pathogenicity towards the ***,effective and applicable diagnostic methods to this disease come as an important tool for the management of the *** use of the molecular technique PCR,which allows the detection of the viral RNA through nasopharyngeal swabs,is considered the gold standard test for the diagnosis of ***,serological methods,such as enzyme-linked immunosorbent assays and rapid tests,are able to detect severe acute respiratory syndrome coronavirus 2-specific immunoglobulin A,immunoglobulin M,and immunoglobulin G in positive patients,being important alternative techniques for the diagnostic establishment and epidemiological *** the other hand,reverse transcription loop-mediated isothermal amplification also proved to be a useful diagnostic method for the infection,mainly because it does not require a sophisticated laboratory apparatus and has similar specificity and sensitivity to ***,imaging exams provide findings of typical pneumonia,such as the ground-glass opacity radiological pattern on chest computed tomography scanning,which along with laboratory tests assist in the diagnosis of COVID-19.

关键词： COVID-19 Pandemic Diagnosis Polymerase chain reaction Molecular biology Serology

A message classifier based on multinomial Naive Bayes for online social contexts

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Journal of Management Analytics 2018年第3期5卷 213-229页

作者： Thársis Salathiel de Souza Viana Marcos de oliveira Ticiana Linhares coelho da Silva Mário Sérgio Rodrigues Falc ao and Enyo JoséTavares Gonçalves Universidade Federal do CearáQuixadáBrazil

Children and teenagers today are increasingly connected to the *** use by minors of social networks applications,and games that are connected to the internet offer the possibility of communication,can make them exposed to various *** of the most troubling threats is sexual *** the objective of this project is to create a model for classifying messages,as normal or dangerous,according to the risk they present to the *** addition to integrating the developed model with a project that analyzes the behavior of minors in a social network(Facebook),and calculates the risk of the minor be a victim of sexual ***,we use the model in the classification of messages obtained from a server of the game Minecraft,quite popular among children.

关键词： messages exchange classification social media children and teenagers protection minecraft clustering messages

Morphological Patterns of a Hymenopteran Gall on the Leaflets of Caryocar brasiliense Camb.(Caryocaraceae)

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American Journal of Plant Sciences 2012年第7期3卷 921-929页

作者： Ana Carolina Ribeiro de Castro Germano Leao demolin Leite denis coelho de oliveira Rosy Mary dos Santos Isaias departamento de Botanica Universidade Federal de Minas Gerais(UFMG)Belo HorizonteBrasil Instituto de Ciências Agrárias Universidade Federal de Minas Gerais(UFMG)Montes ClarosBrasil Instituto de Biologia Universidade Federal de Uberlandia(UFU)UberlandiaBrasil

Anatomical studies in the leaflet globoid galls of Caryocar brasiliense, the “pequi”, aimed to answer how oviposition and the feeding behavior of the galling herbivores altered the morphogenical patterns of the host plant. C. brasiliense globoid gall was 1.28 ± 0.20 mm × 0.90 ± 0.25 mm, with hairy surface;it is sessile and projected to the abaxial surface. Young galls were red while the mature ones were green. Preferentially, they were formed next to leaf margin and possessed one larval chamber containing a single galling specimen. Gall epidermis was uniseriate, with thicker cuticle and more hairy. In some spots, epidermis was substituted by periderm, which indicated the expression of a character usually absent in the leaf laminas. Morphological and anatomical features of these gall morphotype, such as its position in leaf lamina, the fact of being truly closed galls, with typical nutritive tissue involved by sclerenchyma, made them next to the pattern proposed for galls induced by some Hymenoptera.

关键词： Gall Anatomy Hymenoptera Morphogenesis Pequi

Correlation between the Six-Minute Walk Test and Subjective Functional Class in Patients with Heart Failure

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World Journal of Cardiovascular Diseases 2023年第4期13卷 205-213页

作者： Davi Muzi Rios gabriela Lira devens Leticia Admiral Louzada Priscila Cabral Gomes coelho Lima Rodolfo Costa Sylvestre Vinicius Angelo Astolpho Lucas Crespo de Barros Larissa Novaes Paganini Lucas Martins Frizzera Borges Renato Giestas Serpa Osmar Araujo Calil Luiz Fernando Machado Barbosa Roberto Ramos Barbosa department of Cardiology Santa Casa de Misericórdia de Vitória Hospital Vitória Brazil School of Medicine Santa Casa de Misericórdia Vitória Brazil

Introduction: The Six-Minute Walk Test (6MWT) is an inexpensive method to objectively evaluate physical capacity or limitation and stratify prognosis in patients with Heart Failure (HF). Since the clinical perception of symptoms may be adapted or compromised, regular evaluation from medical interviews often fails to determine functional classification. This study aimed to assess the correlation between New York Heart Association Functional Class (NYHA-FC) and the distance walked in the 6MWT. Methods: We conducted a cross-sectional observational study that included patients with HF with reduced ejection fraction followed up at an outpatient service of a teaching hospital, from August 2018 to April 2019. Patients in NYHA-FC I, II, or III were included. We compared NYHA-FC subjectively obtained during the consultation with the 6MWT performed after medical consultation, and the correlation between these two parameters was assessed. Results: The study included 70 patients with HF, 41 (58.6%) of whom were female. The mean age was 61.2 ± 12.7 years. The most prevalent etiologies were dilated idiopathic cardiomyopathy (35.7%) followed by ischemic cardiomyopathy (25.7%). The mean ejection fraction was 34.1% ± 9.8%. The average distance walked in the 6MWT by NYHA-FC I patients was 437.8 ± 95.8 meters, NYHA-FC II 360.1 ± 96.4, and NYHA-FC III 248.4 ± 98.3. Functional class measured by the 6MWT was different than that estimated by NYHA-FC in 34 patients (48.6%), 23 (32.9%) for a higher functional class and 11 (15.7%) for a lower one (p = 0.07). Pearson’s correlation coefficient between NYHA-FC and the 6MWT was -0.55. Conclusion: There was a moderate correlation between the subjective NYHA-FC and the 6MWT. The 6MWT revealed a different classification from NYHA-FC in almost half of the patients. Among those who presented discrepancies between methods, 6MWT reclassification towards a higher functional class was more common.

关键词： Heart Failure Six-Minute Walk Test Functional Class

In vivo study of conductive 3D printed PCL/MWCNTs scaffolds with electrical stimulation for bone tissue engineering

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Bio-design and Manufacturing 2021年第2期4卷 190-202页

作者： Edney P.e Silva Boyang Huang Júlia V.Helaehil Paulo R.L.Nalesso Leonardo Bagne Maraiara A.de oliveira gabriela C.C.Albiazetti Ali Aldalbahi Mohamed El-Newehy Milton Santamaria-Jr Fernanda A.S.Mendonça Paulo Bártolo Guilherme F.Caetano Postgraduate Program in Biomedical Sciences University Center of Hermínio Ometto Foundation-FHOArarasSao PauloBrazil department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringUniversity of ManchesterManchester M139PLUK King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia

Critical bone defects are considered one of the major clinical challenges in reconstructive bone *** combination of 3D printed conductive scaffolds and exogenous electrical stimulation(ES)is a potential favorable approach for bone tissue *** this study,3D conductive scaffolds made with biocompatible and biodegradable polycaprolactone(PCL)and multi-walled carbon nanotubes(MWCNTs)were produced using the extrusion-based additive manufacturing to treat large calvary bone defects in *** results show that the use of PCL/MWCNTs scaffolds and ES contributes to thicker and increased bone tissue formation within the bone *** and mineralization are also significantly promoted using high concentration of MWCNTs(3 wt%)and ***,scaffolds favor the tartrate-resistant acid phosphatase(TRAP)positive cell formation,while the addition of MWCNTs seems to inhibit the osteoclastogenesis but present limited effects on the osteoclast functionalities(receptor activator of nuclear factor κβ ligand(RANKL)and osteoprotegerin(OPG)expressions).The use of ES promotes the osteoclastogenesis and RANKL expressions,showing a dominant effect in the bone remodeling *** results indicate that the combination of 3D printed conductive PCL/MWCNTs scaffold and ES is a promising strategy to treat critical bone defects and provide a cue to establish an optimal protocol to use conductive scaffolds and ES for bone tissue engineering.

关键词： Additive manufacturing Bone regeneration Bone remodeling Carbon nanotube Conductive scaffolds Electrical stimulation