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Co.served RB functio.s in develo.ment and tumo. suppressio.

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Pro.ein & Cell 2011年第11期2卷 864-878页

作者： gabriel M.Go.do. Wei Du Ben May Department fo. Cancer Research University of ChicagoChicagoIL 60637USA

The variety o. human cancers in which the retino.lasto.a pro.ein pRb is inactivated reflects bo.h its bro.d impo.tance fo. tumo. suppressio. and its multitude o. cellular *** evidence indicates that pRb co.tributes to.a diversity o. cellular functio.s,including cell pro.iferatio.,differentiatio.,cell death,and geno.e *** perfo.ms these diverse functio.s thro.gh the fo.matio. o. large co.plexes that include E2F transcriptio. facto.s and chro.atin *** this review we will discuss so.e o. the recent advances made in understanding the structure and functio. o. pRb as they relate to.tumo. suppressio.,and highlight research using Dro.o.hila melano.aster that reveals impo.tant,evo.utio.arily co.served functio.s o. the RB family.

关键词： RB E2F Dro.o.hila Rbf cell cycle chro.atin mo.ificatio.

Dietary supplementatio. with branchedchain amino.acids enhances milk pro.uctio. by lactating so.s and the gro.th o. suckling piglets

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Jo.rnal o. Animal Science and Bio.echno.o.y 2022年第6期13卷 1857-1870页

作者： Reza Rezaei Ana San gabriel Guo.ao.Wu Department o. Animal Science Texas A&M UniversityCollege StationTX 77843USA Ajino.o.o.Co. Inc1-15-1 KyobashiChuokuTokyo 104-8315Japan

Backgro.nd:Under current dietary regimens,milk pro.uctio. by lactating so.s is insufficient to.sustain the maximal gro.th o. their *** precurso.s o. glutamate and glutamine as well as substrates and activato.s o. pro.ein synthesis,branched-chain amino.acids(BCAAs)have great po.ential fo. enhancing milk pro.uctio. by ***:Thirty multiparo.s so.s were assigned rando.ly into.o.e o. three gro.ps:co.tro.(a co.n-and so.bean meal-based diet),the basal diet+1.535%BCAAs;and the basal diet+3.07%*** ratio.g/g)amo.g the supplemental L-iso.eucine,L-leucine and L-valine was 1.00:2.56:*** were made iso.itro.eno.s by the additio. o. appro.riate amo.nts o. *** so.s had free access to.drinking water and their respective *** number o. live-bo.n piglets was standardized to.9 per so. at d 0 o. lactatio.(the day o. parturitio.).o. d 3,15 and 29 o. lactatio.,bo.y weights and milk co.sumptio. o. piglets were measured,and blo.d samples were o.tained fro. so.s and piglets 2 h and 1 h after feeding and nursing,***:Feed intake did no. differ amo.g the three gro.ps o. *** o. asparagine,glutamate,glutamine,citrulline,arginine,pro.ine,BCAAs,and many o.her amino.acids were greater(Po. BCAA-supplemented so.s and their piglets than tho.e in the co.tro. *** with the co.tro.,dietary supplementatio. with 1.535%and 3.07%BCAAs increased(Po.centratio.s o. free and pro.ein-bo.nd BCAAs,glutamate plus glutamine,aspartate plus asparagine,and many o.her amino.acids in milk;milk pro.uctio. by 14%and 21%,respectively;daily weight gains o. piglets by 19%and 28%,respectively,while reducing preweaning mo.tality rates by 50%and 70%,***:Dietary supplementatio. with up to.3.07%BCAAs enhanced milk pro.uctio. by lactating so.s,and the gro.th and survival o. their piglets.

关键词： Branched-chain amino.acids Lactatio. Milk synthesis Milk yield Neo.atal gro.th So.

Multiscale Analysis o. Semilinear Damped Sto.hastic Wave Equatio.s

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Acta Mathematica Sinica,English Series 2023年第7期39卷 1305-1331页

作者： Aurelien Fo.ETIo.gabriel NGUETSENG Jean Lo.is Wo.KENG Department o. Mathematics Higher Teacher Training CollegeUniversity of NgaoundereP.O.Box 652BertouaCameroon Department o. Mathematics University of Yaounde IP.O.Box 812YaoundeCameroon Department o. Mathematics and Co.puter Science University of DschangP.O.Box 67DschangCameroon

In this paper we pro.eed with the multiscale analysis o. semilinear damped sto.hastic wave mo.io.s. The analysis is made by co.bining the well-kno.n sigma co.vergence metho. with its sto.hastic co.nterpart, asso.iated to.so.e co.pactness results such as the Pro.ho.o. and Sko.o.ho. theo.ems. We derive the equivalent mo.el, which is o. the same type as the micro.mo.el. o.e o. the no.elties o. the wo.k is that the co.recto. pro.lem is so.ved in the classical sense o. distributio.s,thereby allo.ing numerical co.putatio.s o. the ho.o.enized co.fficients.

关键词： Hyperbo.ic sto.hastic equatio.s Wiener Pro.ess sigma co.vergence tightness o. pro.ability measures

No.el experimental techniques to.assess the time-dependent defo.matio.s o. geo.ynthetics under so.l co.finement

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Jo.rnal o. Ro.k Mechanics and Geo.echnical Engineering 2021年第2期13卷 410-419页

作者： Carina Maia Lins Co.ta Jo.ge gabriel Zo.nberg Department o. Civil Engineering Federal University of Rio Grande do NorteAv.Senador Salgado Filho 3000NatalRio Grande do Norte59078-970Brazil Department o. Civil Architectural and Enviro.mental Engineering The University of Texas at Austin301 E.Dean KeetonAustinTX78712-0280USA

A new experimental appro.ch to.assess the impact o. so.l co.finement o. the lo.g-term behavio. o. geo.ynthetics is presented in this *** experimental technique described herein includes a no.el labo.ato.y apparatus and the use o. different types o. tests that allo. generatio. o. experimental data suitable fo. evaluatio. o. the time-dependent behavio. o. geo.ynthetics under so.l *** so.l-geo.ynthetic interactio. equipment invo.ves a rigid bo. capable o. acco.mo.ating a cubic so.l mass under plane strain co.ditio.s.A geo.ynthetic specimen placed ho.izo.tally at the mid-height o. the so.l mass is subjected to.sustained vertical pressures that,in turn,induce reinfo.cement axial lo.ds applied fro. the so.l to.the *** previo.sly repo.ted studies o. geo.ynthetic behavio. under so.l co.finement,the equipment was fo.nd to.be particularly *** mino. setup mo.ificatio.s,no. o.ly interactio. tests but also.in-iso.atio. geo.ynthetic stress relaxatio. tests and so.l-o.ly tests under a co.stant strain rate can be co.ducted using the same ***,the time histo.ies o. the reinfo.cement lo.ds and co.respo.ding strains are generated thro.gho.t the *** fro. typical tests co.ducted using sand and a po.ypro.ylene wo.en geo.extile are presented to.illustrate the pro.o.ed experimental *** testing pro.edure was fo.nd to.pro.ide adequate measurements during tests,including go.d repeatability o. test *** so.legeo.ynthetic interactio. tests were fo.nd to.lead to.increasing geo.extile strains with time and decreasing reinfo.cement tensio. with *** test results highlighted the impo.tance o. measuring no. o.ly the time histo.y o. displacements but also.that o. reinfo.cement lo.ds during *** appro.ch o. using different types o. tests to.analyze the so.legeo.ynthetic interactio. behavio. is an inno.atio. that pro.ides relevant insight into.the impact o. so.l co.finement o. the time-dependent defo.matio.s o. geo.

关键词： Geo.ynthetics Geo.extile Creep Stress relaxatio. Reinfo.ced so.l Lo.g-term defo.matio.

Assessment o. po.ential impacts to.surface and subsurface water bo.ies due to.lo.gwall mining

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Internatio.al Jo.rnal o. Mining Science and Techno.o.y 2017年第1期27卷 57-64页

作者： Christo.her Newman Zacharias Agio.tantis gabriel Bo.de Jimenez Leo. Department o. Mining Engineering University of KentuckyLexingtonKY 40506USA

Gro.nd mo.ements due to.lo.gwall mining o.eratio.s have the po.ential to.damage the hydro.o.ical balance within as well as o.tside the mine permit area in the fo.m o. increased surface po.ding and changes to.hydro.eo.o.ical pro.erties. Recently, the o.fice o. Surface Mining, Reclamatio. and Enfo.cement(o.MRE) in the USA, has co.pleted a public co.ment perio. o. a newly pro.o.ed rule fo. the pro.ectio. o. streams and gro.ndwater fro. adverse impacts o. surface and undergro.nd mining o.eratio.s(80 FR 44435). With increased co.munity and regulato.y fo.us o. mining o.eratio.s and their po.ential to.adversely affect streams and gro.ndwater, no. there is a greater need fo. better predictio. o. the po.sible effects mining has o. bo.h surface and subsurface bo.ies o. water. With mining induced stress and strain within the o.erburden co.related to.changes in the hydro.eo.o.ical pro.erties o. ro.k and so.l, this paper investigates the evaluatio. o. the hydro.eo.o.ical system within the vicinity o. an undergro.nd mining o.eratio. based o. strain values calculated thro.gh a surface defo.matio. predictio. mo.el. Thro.gh accurate mo.eling o. the pre- and po.t-mining hydro.eo.o.ical system, industry perso.nel can better depict mining induced effects o. surface and subsurface bo.ies o. water aiding in the o.timizatio. o. undergro.nd extractio. sequences while maintaining the integrity o. water reso.rces.

关键词： Streams Aquifers Gro.nd strain Co.l mining

Pro.abilistic Seismic Risk Assessment in Manizales,Co.o.bia: Quantifying Lo.ses fo. Insurance Purpo.es

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Internatio.al Jo.rnal o. Disaster Risk Science 2017年第3期8卷 296-307页

作者： Mario.A. Salgado.Gálvez gabriel A. Bernal Daniela Zulo.ga Mabel C. Marulanda o.ar-Darío.Cardo.a Sebastián Henao Centre Internacio.al de Meto.es Numerics en Enginyeria(CIMNE) 08034 BarcelonaSpain INGENIAR Ltda. BogotaD.C.110221Colombia Instituto.de Estudio. Ambientales(IDEA) Universidad Nacional de Colombia Sede ManizalesManizales 170004Colombia Universidad Nacio.al de Co.o.bia Sede Manizales Manizales 170004Colombia

A fully pro.abilistic seismic risk assessment was develo.ed in Manizales, Co.o.bia, co.sidering assets o. different types. The first type includes elements that are part o. the water and sewage netwo.k, and the seco.d type includes public and private buildings. This assessment required the develo.ment o. a pro.abilistic seismic hazard analysis that acco.nts fo. the dynamic so.l respo.se,assembling high reso.utio. expo.ure databases, and the develo.ment o. damage mo.els fo. different types o. elements. The eco.o.ic appraisal o. the expo.ed assets was develo.ed to.ether with specialists o. the water utilities co.pany o. Manizales and the city administratio.. The risk assessment was perfo.med using several Co.prehensive Appro.ch to.Pro.abilistic Risk Assessment mo.ules as well as the R-System, o.taining results in terms o. traditio.al metrics such as lo.s exceedance curve, average annual lo.s, and pro.able maximum lo.s. Fo. the case o. pipelines, repair rates were also.estimated. The results fo. the water and sewage netwo.k were used in activities related to.the expansio. and maintenance strategies, as well as fo. the explo.atio. o. financial retentio. and transfer alternatives using insurance schemes based o. technical,pro.abilistic, and pro.pective damage and lo.s *** the case o. the buildings, the results were used in the update o. the technical premium values o. the existing co.lective insurance scheme.

关键词： CAPRA Earthquake insurance Manizales (Co.o.bia) Pro.abilistic seismic risk assessment Risk retentio. and transfer

Effects o. elevated carbo. dio.ide co.centratio. and so.l temperature o. the gro.th and bio.ass respo.ses o. mo.ntain maple (Acer spicatum) seedlings to.light availability

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Jo.rnal o. Plant Eco.o.y 2014年第6期7卷 535-543页

作者： gabriel Danyagri Qing-Lai Dang Faculty o. Natural Reso.rces Management Lakehead UniversityThunder BayOntario P7B 65E1Canada

Aims So.e shade-to.erant understo.y tree species such as mo.ntain maple(Acer spicatum L.)exhibit light-fo.aging gro.th *** in enviro.mental co.ditio.s,such as the rise o. carbo. dio.ide co.centratio.([Co.(2)])in the atmo.phere and so.l warming,may affect the perfo.mance o. these species under different light *** investigated ho. elevated[Co.(2)]and so.l warm-ing influence the gro.th and bio.ass respo.ses o. mo.ntain maple seedlings to.light *** The treatments were two.levels o. light(100%and 30%o. the ambient light in the greenho.se),two.Co.(2)](392μmo. mo.^(−1)(ambient)and 784μmo. mo.^(−1)(elevated))and two.so.l tempera-tures(Tso.l)(17 and 22℃).After o.e gro.ing seaso.,we measured seedling height,ro.t co.lar diameter,leaf bio.ass,stem bio.ass and ro.t *** findings We fo.nd that under the ambient[Co.(2)],the high-light level increased seedlings height by 70%and 56%at the lo. Tso.l and high Tso.l,*** the elevated[Co.(2)],ho.ever,the high-light level increased seedling height by 52%and 13%at the lo. Tso.l and high Tso.l,*** respo.ses o. bio.asses to.light generally fo.lo.ed the respo.se patterns o. height gro.th under bo.h[Co.(2)]and Tso.l and the magnitude o. bio.ass respo.se to.light was the lo.est under the elevated[Co.(2)]and warmer *** results suggest that the elevated[Co.(2)]and warmer Tso.l under the pro.ected future climate may have negative impact o. the co.o.izatio. o. o.en sites and fo.est cano.y gaps by mo.ntain maple.

关键词： mo.ntain maple elevated Co.(2) so.l warming light availability height bio.ass

Antimicro.ial Use in Co.mercial Po.ltry Pro.uctio. Systems in Kiambu Co.nty, Kenya: A Cro.s-Sectio.al Survey o. Kno.ledge, Attitudes and Practices

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o.en Jo.rnal o. Animal Sciences 2021年第4期11卷 658-681页

作者： James G. Ndukui Jo.eph K. Gikunju gabriel o. Abo.e James M. Mbaria Department o. Public Health Pharmacology and Toxicology College of Agriculture and Veterinary Sciences University of Nairobi Kenya Department o. Nursing Catholic University of Eastern Africa Langata Campus Nairobi Kenya Department o. Medical Labo.ato.y Sciences College of Health Science Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

Backgro.nd: Antibio.ic resistance is putting the co.mercial po.ltry pro.uctio. systems acro.s the glo.e at risk o. lo.ses due to.the failure o. treatments fo. animals and human health which has been asso.iated with o.... 详细信息

Background: Antibiotic resistance is putting the commercial poultry production systems across the globe at risk of losses due to the failure of treatments for animals and human health which has been associated with overuse and misuse of antibiotics in poultry farming. One possible approach to the resistance problem is ensuring adequate knowledge, attitudes, and practices on antimicrobial use by farmers on commercial production systems across the globe are applied. Therefore, the current study was carried out to determine factors that could promote antimicrobial use in commercial poultry production systems of Kiambu County, Kenya. Materials and Methods: A descriptive cross-sectional survey was conducted on commercial poultry production systems of Kiambu County to determine the level of knowledge, attitudes, and practices on antimicrobial use. One hundred and fifty-six (n = 156) semi-structured questionnaires imprinted in a mobile Open data kit were administered to capture the level of knowledge, attitudes, and practices on antimicrobial usage in commercial poultry production systems of Kiambu County. Results: Out of the 156 commercial poultry farmers who participated in this study, females accounted for (64%) with 51% of them keeping layers between 50 - 500 birds as medium scale farmers. In the study,o.t-family:Verdana;"> mo.t o. the farmers were 45 years and abo.e (61%) and they had o.tained a seco.dary level o. educatio. (34%). We further no.ed that 67% o. th

关键词： Antimicro.ial Use Antimicro.ial Resistance KAPs Co.mercial Po.ltry Pro.uctio. Multidrug Resistance

The Meaning o. ＂Existence＂ and the Co.tingency o. Sense

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Fro.tiers o. Philo.o.hy in China 2014年第1期9卷 109-129页

作者： Markus gabriel Intematio.al Centre fo. Philo.o.hy University of Bonn D53012 Bonn Germany

In this paper I argue first fo. a revisio.ary o.to.o.y, that is, fo. an understanding o. ＂existence＂ as the pro.erty o. a field no. to.be empty. In this co.text, I distinguish between ＂metaphysics＂（the theo.y o. to.ality o. o. fundamental reality） and ＂o.to.o.y＂（the systematic investigatio. into.the meaning o. ＂existence＂）. In the seco.d part, I pro.ide a sketch fo. a co.respo.ding revisio.ary theo.y o. the mo.alities in light o. the new o.to.o.y pro.o.ed.

关键词： o.to.o.y wo.ld metaphysics mo.alities co.tingency necessity,sense