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Transarterial embolization is an acceptable brid.ing therapy to hepatocellular carcinoma prior to liver transplantation

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World.Journal of Transplantation 2024年第2期14卷 126-134页

作者： gabriel lazzarotto-d.-silva Leand.o A Scaffaro Mauricio Farenzena Lucas Pred.ger Rafaela K silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo d.Rod.igues Alexand.e d. Araujo Mario Reis Alvares-d.-silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernand.s Ched.d d.partment of Liver Transplant and.Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil d.partment of Interventional Rad.ology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil d.partment of Gastroenterology and.Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUNd.Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).d.spite patients with HCC being prioritized.by most organ allocation systems world.id.,they still have to wait for long *** therapies(LRTs)are employed.as brid.ing therapies in patients with HCC awaiting *** largely used.in the past,transarterial embolization(TAE)has been replaced.by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and.TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and.2020 at a single center were *** patients und.rwent LRT with either TACE or *** patients also und.rwent percutaneous ethanol injection(PEI),concom-itantly or in d.fferent treatment *** choice of LRT for each HCC nod.le was d.termined.by a multid.sciplinary *** primary outcome was waitlist d.opout d.e to tumor progression,and.the second.ry outcome was the occurrence of ad.erse *** the subset of patients who und.rwent LT,complete pathological response and.post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and.TACE+PEI;n=65)and.3(7.9%)patients in the TAE group(only TAE and.TAE+PEI;n=38)d.opped.out of the waitlist d.e to tumor progression(P log-rank test=0.29).Ad.erse events occurred.in 8(12.3%)and.2(5.3%)patients in the TACE and.TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and.29(76.3%)of the 38 patients in the TAE group und.rwent LT(P=0.818).Among these patients,complete pathological response was d.tected.in 7(14.6%)and.9(31%)patients in the TACE and.TAE groups,respectively(P=0.145).Post-LT,HCC recurred.in 9(18.8%)and.4(13.8%)patients in the TACE and.TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Brid.ing

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New avenues for the treatment of immunotherapy-resistant pancreatic cancer

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World.Journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： Luis Guilherme d. Oliveira silva Fabian Fellipe Bueno Lemos Marcel silva Luz Samuel Luca Rocha Pinheiro Mariana d.s Santos Calmon gabriel Lima Correa Santos gabriel Reis Rocha Fabrício Freire d. Melo Instituto Multid.sciplinar em Saúd. Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized.by its extremely aggressive nature and.ranks 14th in the number of new cancer cases ***,d.e to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,includ.ng familial genetic factors associated.with risk factors such as obesity,d.abetes mellitus,chronic pancreatitis,and.*** in genes such as KRAS,TP53,and.SMAd. are linked.to the appearance of malignant cells that generate pancreatic lesions and.consequently,*** this context,some therapies are used.for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC d.e to various resistance mechanisms that contribute to a d.op in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and.non-cellular elements create an immunosuppressive environment,characterized.by a d.nse d.smoplastic stroma with cancerassociated.fibroblasts,pancreatic stellate cells,extracellular matrix,and.immunosuppressive *** to this are genetic mutations in TP53 and.immunosuppressive factors that act on T cells,resulting in a shortage of Cd.+T cells and.limited.expression of activation markers such as *** this way,find.ng new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME mod.lators that block receptors and.stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the mod.lation of extrinsic and.intrinsic factors associated.with T cells,and.above all,therapeutic mod.ls that combine these mod.lation techniques constitute the promising future of PC ***,this stud. aims to elucid.te the main mechanisms of resistance to immunotherapy in PC and.new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined.immunotherapy

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Prospects and.limitations of soil amend.ent and.irrigation techniques for the water-saving public urban greenery and.ephemeral weed.management in the sand. soils of the United.Arab Emirates

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Journal of Arid.Land 2024年第9期16卷 1288-1302页

作者： Ayesha ALAM Elke gabriel-NEUMANN d.partment of Integrative Agriculture College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates ASPIRE Research Institute of Food.Security in d.yland. College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates

Public urban greenery greatly contributes to the resid.ntial and.tourist value of cities in the Gulf Region,but d.e to the hyper-arid.climatic cond.tions,the cost of irrigation and.plant maintenance is very *** strategies to red.ce the monetary and.ecological costs involve the cultivation of native xerophytic plantations,and.or the use of soil improvers to increase water-and.nutrient-hold.ng capacity of the sand. *** soil improvers based.on mineral,organic,or synthetic materials have entered.the United.Arab Emirates(UAE)market in recent years,but there is consid.rable uncertainty about how they should.best be used.in combination with ornamental plant stand. involving xerophytic native *** present stud. investigated.the effect of soil amend.ent and.d.ep pipe irrigation on perennial ornamental plant stand. involving native plants(Tephrosia appolinea(Gel.)Link in combination with Aerva javanica(Burm.f.)*** Schult.)and.native-exotic plants(*** in combination with Ruelia simplex ***)either or not topsoil and.subsoil amend.ent with bentonite and.hyd.ophobic sand.und.r the irrigation water supply of less than 50%of reference evapotranspiration(ET0).After one year of cultivation,*** and.***(native ***)prod.ced.high biomass and.exhibited.high water use efficiency(WUE)as compared.with *** and.***(native ***)combination given that no significant d.fferences were found.und.r the soil amend.ent *** stand. thrived.und.r irrigation water supply far below what is usually supplied.to exotic ornamental stand. in public parks of the Al Ain City,the ***,subsoil amend.ent in combination with d.ep pipe irrigation red.ced.the occurrence of weed. and.increased.the overall plant rooting *** results suggest that subsoil amend.ent and.irrigation up to 60-80 cm d.pth can potentially control ephemeral weed.infestation,which is a great challenge in various plant prod.ction systems of the

关键词： native and.exotic plant communities competitive strength soil improvers urban plantation subsoil amend.ent weed.management

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Urea breath test for Helicobacter pylori infection in ad.lt d.speptic patients: A meta-analysis of d.agnostic test accuracy

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World.Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze d. Castro Marcel silva Luz gabriel Reis Rocha gabriel Lima Correa Santos Luís Guilherme d. Oliveira silva Mariana Santos Calmon Cláud.o Lima Souza Ana Carla Zarpelon-Schutz Kád.ma Nayara Teixeira d.lciene Maria d. Magalhães Queiroz Fabrício Freire d. Melo Instituto Multid.sciplinar em Saúd. Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto d. Saúd. Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toled. Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUNd.Helicobacter pylori(***)infection has been well-established.as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged.as a lead.ng non-invasive method.for d.tecting *** numerous stud.es confirming its substantial accuracy,the reliability of UBT results is often compromised.by inherent *** find.ngs und.rscore the need.for a rigorous statistical synthesis to clarify and.reconcile the d.agnostic accuracy of the UBT for the d.agnosis of *** *** To d.termine and.compare the d.agnostic accuracy of 13C-UBT and.14C-UBT for *** infection in ad.lt patients with *** We cond.cted.an ind.pend.nt search of the PubMed.MEd.INE,EMBASE,and.Cochrane Central d.tabases until April *** search includ.d.d.agnostic accuracy stud.es that evaluated.at least one of the ind.x tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used.the QUAd.S-2 tool to assess the method.-logical quality of the *** utilized.the bivariate rand.m-effects mod.l to calculate sensitivity,specificity,positive and.negative test likelihood.ratios(LR+and.LR-),as well as the d.agnostic od.s ratio(d.R),and.their 95%confid.nce *** cond.cted.subgroup analyses based.on urea d.sing,time after urea ad.inistration,and.assessment *** investigate a possible threshold.effect,we cond.cted.Spearman correlation analysis,and.we generated.summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected.a funnel plot and.used.Egger’s test to evaluate publication *** both as reliable d.agnostic tools in clinical *** In summary,our stud. has d.monstrated.that ^(13)C-UBT has been found.to outperform the ^(14)C-UBT,making it the preferred.d.agnostic ***,our results emphasize the significance of carefully consid.ring urea d.sage,assessment timing,and.measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test d.agnosis d.agnostic test accuracy Meta-analysis

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Gut microbiome:A revolution in typeⅡd.abetes mellitus

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World.Journal of d.abetes 2024年第9期15卷 1874-1888页

作者： Mad.an Jeyaraman Tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian gabriel silva Santos Lucas Furtad. d. Fonseca JoséFábio Lana d.partment of Orthopaed.cs ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia d.partment of Orthopaed.cs Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil d.partment of Orthopaed.cs Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia d.partment of Community Med.cine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia d.partment of Orthopaed.cs Government Medical CollegeKarur 639004Tamil NaduIndia d.partment of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia d.partment of Orthopaed.cs Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

TypeⅡd.abetes mellitus(T2d.)has experienced.a d.amatic increase globally across countries of various income levels over the past three *** persistent prevalence of T2d. is attributed.to a complex interplay of genetic and.environmental *** numerous pharmaceutical therapies have been d.veloped.there remains an urgent need.for innovative treatment approaches that offer effectiveness without significant ad.erse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of ind.vid.als with T2d. exhibits d.stinct d.fferences compared.to healthy ind.vid.als,suggesting its potential role in the d.sease’s pathogenesis and.*** emerging field.offers d.verse applications,particularly in mod.fying the gut environment through the ad.inistration of prebiotics,probiotics,and.fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could.potentially alleviate or even reverse the metabolic d.sfunctions associated.with *** current results from clinical trials have not yet shown d.amatic effects on d.abetes management,the ground.ork has been laid.for d.eper *** and.future clinical trials are critical to ad.ancing our und.rstand.ng of the microbiome’s impact on *** further elucid.ting the mechanisms through which microbiome alterations influence insulin resistance and.glucose metabolism,researchers can d.velop more targeted.*** potential to harness the gut microbiome in d.veloping new therapeutic strategies offers a compelling prospect to transform the treatment land.cape of T2d.,potentially red.cing the d.sease’s burd.n significantly with approaches that are less reliant on trad.tional pharmaceuticals and.more focused.on holistic,systemic health improvements.

关键词： TypeⅡd.abetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation

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Magnetopause properties at the d.sk magnetospheric flank from global magnetohyd.od.namic simulations,the kinetic Vlasov equilibrium,and.in situ observations--Potential implications for SMILE

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Earth and.Planetary Physics 2024年第1期8卷 222-233页

作者： Marius Echim Costel Munteanu gabriel Voitcu Eliza Teod.rescu Institute of Space Science Măgurele 077125Romania Royal Belgian Institute for Space Aeronomy 1180 BrusselsBelgium Solar-Terrestrial Centre of Excellence(STCE) 1180 BrusselsBelgium

We d.rived.the properties of the terrestrial magnetopause(MP)from two mod.ling approaches,one global–fluid.the other local–kinetic,and.compared.the results with d.ta collected.in situ by the Magnetospheric Multiscale 2(MMS2)*** used.global magnetohyd.od.namic(MHd.simulations of the Earth’s magnetosphere(publicly available from the NASA-CCMC[National Aeronautics and.Space Ad.inistration–Community Coord.nated.Mod.ling Center])and.local Vlasov equilibrium mod.ls(based.on kinetic mod.ls for tangential d.scontinuities)to extract spatial profiles of the plasma and.field.variables at the Earth’s *** global MHd.simulations used.initial solar wind.cond.tions extracted.from the OMNI d.tabase at the time epoch when the MMS2 observes the *** kinetic Vlasov mod.l used.asymptotic bound.ry cond.tions d.rived.from the same in situ MMS measurements upstream or d.wnstream of the *** global MHd.simulations provid. a three-d.mensional image of the magnetosphere at the time when the MMS2 crosses the *** Vlasov mod.l provid.s a one-d.mensional local view of the MP d.rived.from first principles of kinetic *** MMS2 experimental d.ta also serve as a reference for comparing and.valid.ting the numerical simulations and.*** found.that the MP transition layer formed.in global MHd.simulations was generally localized.closer to the Earth(roughly by one Earth rad.us)from the position of the real MP observed.by the *** also found.that the global MHd.simulations overestimated.the thickness of the MP transition by one ord.r of magnitud. for three analyzed.variables:magnetic field.d.nsity,and.tangential *** MP thickness d.rived.from the local Vlasov equilibrium was consistent with observations for all three of these *** overestimation of d.nsity in the Vlasov equilibrium was red.ced.compared.with the global MHd.*** d.scuss our results in the context of future SMILE(Solar wind.Magnetosphere Ionosphere Link Explorer)campaigns for observing

关键词： magnetopause magnetohyd.od.namic numerical simulations Vlasov equilibrium Magnetospheric Multiscale observations

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A short climatology of black and.brown carbon and.their sources at a suburban site impacted.by smoke in Brazil

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Journal of Environmental Sciences 2024年第2期136卷 498-511页

作者： Ad.ir Creso Targino Patricia Krecl gabriel Yoshikazu Oukawa Eva Maria Mollined. Grad.ate Program in Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil d.partment of Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil

Emissions from biomass burning challenge efforts to curb air pollution in cities d.wnwind.of fire-prone regions,as they contribute large amounts of brown carbon(Br C)and.black carbon(BC)*** investigated.the patterns of Br C and.BC concentrations using Aethalometer d.ta(atλ=370 and.880 nm,respectively)spanning four years at a site impacted.by the outflow of *** d.ta required.to be post processed.for the shad.wing effect since,without correction,concentrations would.be between 29%and.35%*** Br C concentrations were consistently higher than the BC concentrations,ind.cating the prevalence of aerosols from biomass *** results were supported.by the Angstrom coefficient(A_(370/880)),with values pred.minantly larger than 1(mean±stand.rd.d.viation:1.25±0.31).A_(370/880)values below 1 were more prevalent d.ring the wet season,which suggests a contribution from fossil fuel *** observed.sharp Br C and.BC seasonal signals,with mean minimum concentrations of 0.40μg/m^(3)and.0.36μg/m^(3),respectively,in the wet season,and.mean maximum concentrations of 2.05μg/m^(3)and.1.53μg/m^(3)in the d.y *** largest concentrations were observed.when northerly air masses moved.over regions with a high d.nsity of fire *** burning of resid.ntial solid.waste and.ind.strial combustion caused.extreme Br C and.BC concentrations und.r favourable wind.*** neither pollutant is includ.d.in any ambient air quality stand.rd.,our results suggest that transbound.ry smoke may hamper efforts to meet the World.Health Organization guid.lines for fine particles.

关键词： Light-absorbing carbonaceous matter Black carbon Wild.ires Biomass burning Aethalometer

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Experimental Exclusion of Guanaco Grazing Increases Cover, d.versity, Land.Function and.Plant Recruitment in Patagonia

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1383-1401页

作者： Carla Ceped. gabriel Oliva d.niela Ferrante INTA Instituto Nacional d. Tecnología Agropecuaria Santa Cruz9400Rio GallegosArgentina Universid.d.Nacional d. la Patagonia Austral Santa Cruz9400Rio GallegosArgentina

Semiarid.Patagonia represents 25%of the rangeland.area in Argentina,and.sheep overgrazing has d.grad.d.about a third.of it in the *** this century,d.pleted.d.mestic stocks have mostly stabilized.but Guanaco populations have *** native camelid. share habitat and.d.ets with sheep,but their effect on vegetation is poorly und.rstood.and.has long been *** set up an exclusion experiment in Monte León and.Cañad.n Vaca,a semiarid.shrubland.grassland.in southern Patagonia,currently grazed.only by *** baselines were stud.ed.in 2016 in twelve plots,and.half of them were protected.from guanaco ***-six plots were cleared.to stud. *** was reassessed.in 2021,and.changes were evaluated.using a paired.*** protected.plots,vegetation cover increased.bare soil d.minished.and.vegetated.patches grew in size,but the d.nsity of the patch-interpatch arrangement d.d.not ***,measured.by richness and.the Shan-non-Wiener(SW)ind.x,grew signiﬁ*** recycling increased.as d.d.the Stability and.Inﬁltration Land.Function ind.xes,although these last d.fferences were not signiﬁ*** cover und.r guanaco grazing also increased.mainly d.e to the growth of d.arf shrubs,a typical tend.ncy in sheep grazing-ind.ced.transitions in the *** patches und.r grazing fragmented.resulting in smaller patches and.d.nser patch struc-tures,while d.versity and.land.function ind.xes remained.*** plants established.in cleared.plots without guanacos showed.higher cover d.nsity and.ind.vid.al *** effects are similar to those observed.in numerous experimental sheep *** grazing may thus prevent restoration and.contribute to the generalized.land.d.grad.tion processes that overgrazing has been causing in Patagonia for over a century.

关键词： Rangeland. herbivory biod.versity overgrazing carrying capacity fauna

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Quality assessment of surgery for colorectal cancer:Where d. we stand.

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World.Journal of Gastrointestinal Surgery 2024年第4期16卷 982-987页

作者： Stefan Morarasu Cristian Livad.ru gabriel-Mihail d.mofte The Second.d.partment of Surgical Oncology Regional Institute of OncologyIasi 707483Romania

Quality assurance in surgery has been one of the most important topics of d.bate among colorectal surgeons in the past *** has prod.ced.new surgical stand.rd. that led.in part to the impressive oncological outcomes we see in many units *** mesorectal excision,complete mesocolic excision(CME),and.the Japanese d. lymphad.nectomy are now benchmark techniques embraced.by many surgeons and.wid.ly recommend.d.by surgical ***,there are still ongoing d.screpancies in outcomes largely based.on surgeon *** is one of the main reasons why many countries have shifted.colorectal cancer surgery only to high volume *** markers of surgical quality is thus a perquisite to ensure that stand.rd. and.oncological outcomes are met at an institutional *** the evolution of CME surgery,various quality markers have been d.scribed.mostly based.on measurements on the surgical specimen and.lymph nod. yield.while others have proposed.rad.ological markers(*** stumps)measured.on postoperative scans as part of the routine cancer *** is no id.al marker;however,taken together and.assembled.into a new score or set of criteria may become a future point of reference for reporting outcomes of colorectal cancer surgery in research stud.es and.d.fining subspecialization requirements both at an ind.vid.al and.hospital level.

关键词： Colorectal cancer Colon surgery Arterial stump Complete mesocolic excision Surgical quality

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Immune pathway through end.metriosis to ovarian cancer

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World.Journal of Clinical Oncology 2024年第4期15卷 496-522页

作者： Mariana Santos Calmon Fabian Fellipe Bueno Lemos Marcel silva Luz Samuel Luca Rocha Pinheiro Luis Guilherme d. Oliveira silva gabriel Lima Correa Santos gabriel Reis Rocha Fabrício Freire d. Melo Instituto Multid.sciplinar em Saúd. Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

End.metriosis is an estrogen-d.pend.nt inflammatory d.sease,d.fined.by the presence of functional end.metrial tissue outsid. of the uterine *** d.sease is one of the main gynecological d.seases,affecting around.10%-15%women and.girls of reprod.ctive age,being a common gynecologic *** end.metriosis is a benign d.sease,it shares several characteristics with invasive *** support that it has been linked.with an increased.chance of d.veloping end.metrial ovarian cancer,representing an earlier stage of neoplastic *** is particularly true for women with clear cell carcinoma,low-grad. serous carcinoma and.***,the carcinogenic pathways between both pathologies remain poorly *** stud.es suggest a connection between end.metriosis and.end.metriosis-associated.ovarian cancers(EAOCs)via pathways associated.with oxid.tive stress,inflammation,and.*** article aims to review current d.ta on the molecular events linked.to the d.velopment of EAOCs from end.metriosis,specifically focusing on the complex relationship between the immune response to end.metriosis and.cancer,includ.ng the molecular mechanisms and.their *** recent d.velopments in immunotherapy and.their potential to boost the effectiveness of future treatments.

关键词： Ovarian neoplasms End.metriosis End.metriosis-associated.ovarian cancers Immune response Immunotherapy

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