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Advances in nanomaterials for brain microscopy

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Nano Research 2018年第10期11卷 5144-5172页

作者： Jackson T. del Bonis-O'Donnell Linda Chio gabriel F. Dorlhiac lan R. McFarlane Markita P. Landry Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA Biophysics Graduate Group University of California Berkeley CA 94720 USA Innovative Genomics Institute (IGI) Berkeley CA 94720 USA California Institute for Quantitative Biosciences QB3 University of California Berkeley CA 94720 USA Chan-Zuckerberg Biohub San Francisco CA 94158 USA

Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and function. To further improve our understanding of the emergent properties and functions of neural circuits, we need to directly visualize the relationship between brain structure, neuron activity, and neurochemistry. Advances in the chemical and optical properties of nanomaterials, and developments in deep-tissue microscopy, may help to overcome the current challenges of in-vivo brain imaging, particularly when imaging the brain through optically-dense brain tissue, skull, and scalp. Developments in nanomaterials may enable the implementation of tunable chemical functionality for neurochemical targeting and sensing, and fluorescence stability for long-term imaging. In this review, we summarize the current methods used for brain microscopy and describe the diverse classes of nanomaterials recently offered as contrast agents and functional probes for microscopic optical imaging of the brain.

关键词： nanomaterials neuroscience imaging microscopy

Combination of hydrotreating and delayed coking technologies for conversion of residue

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Chinese Journal of Chemical Engineering 2023年第11期63卷 209-219页

作者： José A.D.Munoz gabriel Páez Jorge Ancheyta Instituto Mexicano del Petróleo Eje Central Lázaro Cárdenas Norte 152Col.San Bartolo AtepehuacanMéxico City 07730México

Residue conversion by combining catalytic hydrotreating and delayed coking has been evaluated comparatively with both processes *** operating conditions are defined to achieve the greatest economic benefit for upgrading an atmospheric residue from a heavy crude oil.A literature model was adapted to simulate the hydrotreating reactor,and for delayed coking,correlations reported in the literature were *** results with both approaches were employed to calculate the techno-economic feasibility of the combined process *** combination of hydrotreating and delayed coking presented an increase in light fractions of 29% and a reduction in coke production of 47.8%.Based on the calculated net benefit values,it was demonstrated that the combination of hydrotreating and delayed coking is technically and economically better than using each process alone,with highest benefit of 57.7 USD·m^(-3).

关键词： Economic benefit Heavy oil Hydrotreating delayed coking

Current strategies to induce liver remnant hypertrophy before major liver resection

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World Journal of Hepatology 2021年第11期13卷 1629-1641页

作者： Celeste del Basso Martin Gaillard Panagiotis Lainas Stella Zervaki gabriel Perlemuter Pierre Chagué Laurence Rocher Cosmin Sebastian Voican Ibrahim Dagher Hadrien Tranchart Department of Minimally Invasive Digestive Surgery Antoine Béclère HospitalClamart 92140France Department of Hepato-Gastroenterology and Nutrition Antoine Béclère HospitalClamart 92140France Department of Radiology Antoine Béclère HospitalClamart 92140France

Hepatic resection is the gold standard for patients affected by primary or metastatic liver tumors but is hampered by the risk of post-hepatectomy liver *** recent impro-vements,liver surgery still requires excellent clinical judgement in selecting patients for surgery and,above all,efficient pre-operative strategies to provide adequate future liver *** aim of this article is to review the literature on the rational,the preliminary assessment,the advantages as well as the limits of each existing technique for preparing the liver for major hepatectomy.

关键词： Liver regeneration Major hepatectomy Liver insufficiency Future liver remnant Portal vein embolization

From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

Existence of Weakly Efficient Solutions in Vector Optimization

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Acta Mathematica Sinica,English Series 2008年第4期24卷 599-606页

作者： Lucelina BATISTA SANTOS Marko ROJAS-MEDAR gabriel RUIZ-GARZóN Departamento de Matemática Universidade Federal do Paraná.CP.019081CEP:81531990Curitiba-PRBrazil Universidad del Bío-Bío Facultad de Ciencias Departamento de Ciencias BásicasCampus Fernando MayCasilla 447ChillánChile Departamento de Estadística e I.O. Universidad de CádizE.U.E.EmpresarialesPor-vera 5411403 Jerez de la FronteraSpain

In this paper, we present an existence result for weak efficient solution for the vector optimization problem. The result is stated for invex strongly compactly Lipschitz functions.

关键词： vector optimization weak efficiency generalized convexity Clarke generalized gradient

Temperature changes in the root ecosystem affect plant functionality

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Plant Communications 2023年第3期4卷 197-214页

作者： Mary Paz González-García Carlos M.Conesa Alberto Lozano-Enguita Victoria Baca-González Bárbara Simancas Sara Navarro-Neila María Sánchez-Bermúdez Isai Salas-González Elena Caro gabriel Castrillo Juan C.del Pozo Centro de Biotecnología y Genómica de Plantas(UPM-INIA/CSIC) Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agrariay Alimentaria-CSIC(INIA/CSIC)Campus Montegancedo28223 Pozuelo de Alarcón(Madrid)Spain Departamento de Biotecnología-Biología Vegetal Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de Madrid(UPM)28040 MadridSpain Undergraduate Program in Genomic Sciences Center for Genomics SciencesUniversidad Nacional Autonóma de MéxicoAv.Universidad s/n.Col.ChamilpaCuernavaca 62210MorelosMéxico Future Food Beacon of Excellence&School of Biosciences University of NottinghamSutton BoningtonUK

Climate change is increasing the frequency of extreme heat events that aggravate its negative impact on plant development and agricultural *** experiments designed to study plant adaption to heat stress apply homogeneous high temperatures to both shoot and ***,this treatment does not mimic the conditions in natural fields,where roots grow in a dark environment with a descending temperature *** high temperatures severely decrease cell division in the root meristem,compromising root growth,while increasing the division of quiescent center cells,likely in an attempt to maintain the stem cell niche under such harsh ***,we engineered the TGRooZ,a device that generates a temperature gradient for in vitro or greenhouse growth *** root systems of plants exposed to high shoot temperatures but cultivated in theTGRooZ grow efficiently and maintain their functionality to sustain proper shoot growth and ***,gene expression and rhizosphere or root microbiomecomposition are significantly less affected in TGRooZ-grown roots than in high-temperature-grown roots,correlating with higher root *** data indicate that use of the TGRooZ in heat-stress studies can improve our knowledge of plant response to high temperatures,demonstrating its applicability from laboratory studies to the field.

关键词： heat stress root temperature gradient nutrition gene expression microbiome

Software SOLEEC Applied for Parabolic Trough Solar Collector Designing

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Journal of Mechanics Engineering and Automation 2014年第7期4卷 565-574页

作者： Ernesto Enciso-Contreras Juan gabriel Barbosa-Saldafia Jose Alfredo Jimenez-Bemal Claudia del Carmen Gutierrez-Torres SEPI-ESIME Zacatenco-LABINTHAP lnstituto Politecnico Nacional Mexico City 07738 Mexico

The present work describes software SOLEEC （copyright 03-2012-070510302900-01 Mexico）, a numerical tool for PTC （parabolic trough collector） designing. Software SOLEEC is divided into two main parts. The first one allows solar resource assessment for a specific place on the Earth. The computation and assessment can be done for a specific day on the year, for one specific month and the monthly averages along the year. The last one gives annual charts such as： solar constant, Earth declination, insolation hours, and sunrise and sunset hours. The second part has four different execution options for PTC designing, that is, using options one and two user can get five different designs based on receiver outer diameter evaluating solar radiation data along the full year or only one solar radiation value （monthly）, on the other hand options three and four were developed to compute the thermal evaluation for an operating collector for twelve solar radiation values （annually） or a specific month computation, respectively.

关键词： Software PTC solar radiation.

Phosphorus fractions and sorption dynamics in the sediments of two Ca-SO4 water reservoirs in the central Argentine Andes

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International Journal of Sediment Research 2017年第3期32卷 442-451页

作者： José gabriel León Fernando Luis Pedrozo Pedro Félix Temporetti Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA)CCT Mendoza Departamento General de Irrigación Gobierno de Mendoza Espaa y Barcala Instituto de Investigaciones en Biodiversidad y Medio Ambiente (INIBIOMA) CONICET-Universidad Nacional del Comahue

Phosphorus（P） fractionation and sorption behavior were studied in the sediments of two calcium-sulfate(Ca-SO4: Ca2+170 mg L-1; SO42-400 mg L-1) water reservoirs in the southern central Argentine Andes-El Carrizal Reservoir（ECR）,which stratifies in summer and El Nihuil Reservoir（ENR）,which is vertically mixed throughout the year. Sediment size classes reflected the lithology of both basins and the reservoirs relative location: ECR（downstream from a valley adjacent to a mountain environment） had higher clay proportions while the sand fraction was more important in ENR（just next to a mountain environment）.In both reservoirs, the chemical composition revealed low alteration and calcium enrichment. Total P content was relatively high(1.1-1.6 mg P kg-1dry weight) as expected from the contribution of marine formations. P fractionation was dominated by Ca-P（ECR, 69% and ENR, 63%） followed by organic-P（23%）in summer-anoxic ECR and by iron/aluminum（Fe/Al）-P（27%） in oxic ENR. Batch experiments showed that sorption behavior in ECR had a typical Langmuir isotherm plot while in ENR that model fitted only at low dissolved P values(<5 mg PL-1) and co-precipitation evidence was observed at higher P concentrations. It is proposed that lower Fe/Al-P content in anoxic（ECR） vs. oxic（ENR） sediments results from the P released from iron-bound phosphorus due to sulfate reduction-ferrous sulfide formation in an anoxic environment. This condition should enable ECR sediments to adsorb P into fresh oxidized iron,and ENR sediments to co-precipitate P with calcium due to Fe/Al-P saturation, as observed in batch experiments. This paper constitutes the first description of phosphorus content and dynamics in reservoir sediments in arid central western Argentina, where water sulfate concentrations are naturally high due to basin lithology.

关键词： Reservoir Internal load Phosphorus binding Calcareous watershed Southern Central Andes

Use of recycled concrete aggregates in asphalt mixtures for pavements:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第5期9卷 725-741页

作者： Juan gabriel Bastidas-Martínez Fredy Alberto Reyes-Lizcano Hugo Alexander Rondón-Quintana Faculty of Engineering Universidad Piloto de ColombiaBogotáDC 110231Colombia Faculty of Engineering Pontificia Universidad JaverianaBogotáDC 110131Colombia Facultad del Medio Ambiente y Recursos Naturales Universidad Distrital Francisco Joséde CaldasBogotáDC 110131Colombia

Large quantities of natural aggregates(NA)are required in the manufacturing of asphalt mixtures for *** extraction of NA generates high environmental impacts that negatively affect environmental preservation and *** alternative materials obtained in construction and demolition processes in civil construction worked have been studies as possible replacements for NA,with the purpose of reducing these environmental *** foregoing study presents a state of knowledge review referring to the use of recycled concrete aggregates(RCA)when these are used in the manufacturing of asphalt mixtures(mainly hot-mix asphalt HMA type).Environmental aspects are presented,as well as possible benefits and limitations of using RCA as replacements for NA in asphalt ***,it is not possible to establish a behavior pattern,since the characteristics of the RCA are very heterogeneous and vary from the original source of the *** is highlighted from the literature that RCA has a wide potential for use in the manufacture of asphalt mixtures,since in most studies,the mixtures with these materials comply the quality requirements contemplated by the construction specifications,mainly in low-volume ***,based on the literature review,some recommendations and suggestions are presented for future research.

关键词： Recycled concrete aggregates Asphalt mixtures Mechanical properties Volumetric composition