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Anticonvulsant Effects of Chrysanthellum americanum L. (Vatke) Aqueous Extract in Mice Pilocarpine Model of Epilepsy and Associated Memory Impairment: Role of Antioxidant Defense System and Cholinergic Transmission

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Journal of Biosciences and Medicines 2023年第6期11卷 81-102页

作者： Yvette Nguezeye Fanta Sabine Adeline Yadang Simon Pale Vanessa Tita Jugha Hart Mann Alain Youbi Mambou Raymond Bess Bila Tambong Ako Ojongnkpot Germain Sotoing Taiwe gabriel agbor agbor Elisabeth Ngo Bum Centre for Research on Medicinal Plants and Traditional Medicine Institute of Medical Research and Medicinal Plants Studies Yaoundé Cameroon Department of Biological Sciences Faculty of Science University of Ngaoundere Ngaoundéré Cameroon Department of Animal Biology and Conservation Faculty of Science University of Buea Buea Cameroon

Chrysanthellum americanum (L.) Vatke is a medicinal plant used by the traditional healers to treat epilepsy and associated memory impairment. This work aims at evaluating the anticonvulsant effects of Chrysanthellum americanum aqueous extract in mice pilocarpine model of epilepsy and associated memory loss. Mice were administered orally Chrysanthellum americanum aqueous extract (27.69, 69.22, 138.45, 276.9 mg/kg, prepared from the whole part) for test groups, intraperitoneally 300 mg/kg sodium valproate for the positive control group or orally 10 mL/kg distilled water for the negative control group, respectively, during a period of seven consecutive days. On the first day, temporal lobe epilepsy was induced by intraperitoneal injection of 360 mg/kg pilocarpine one hour after the administration of different treatment to mice, and the occurrence of status epilepticus was evaluated. On the second day, the anticonvulsant property was measured after the intraperitoneal injection of a sub-convulsive dose of picrotoxin (1 mg/kg). On the seventh day, the anti-amnesic properties of the extract were evaluated in the epileptic mice using the T-maze and open field paradigms. The results show that Chrysanthellum americanum extract significantly (p Chrysanthellum americanum (276.9 mg/kg) likewise sodium valproate (300 mg/kg) significantly (p Chrysanthellum americanum aqueous extract has anticonvulsant effects against pilocarpine induced-epileptic seizures and memory impairment. These properties could be mediated by the amelioration of antioxidant defense system and cholinergic neurotransmission in epileptic mice, which could partly justify the use of Chrysanthellum americanum in the traditional medicine for the treatment of epilepsy.

关键词： Chrysanthellum americanum Epilepsy Memory Impairment Oxidative Stress Cholinergic Transmission

Modulation of the in vitro Oxidative Stress and Erythrocyte Cell Membrane Integrity Using Aqueous, Hydroethanolic and Ethanolic Stem-Barks Extracts of Greenwayodendron suaveolens (Engl. & Diels) Verdc

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Pharmacology & Pharmacy 2024年第3期15卷 39-61页

作者： Patrick Hervé Diboue Betote Moustapha Gambo Abdoulaye Francis Ngolsou Esther Del Florence Ndedi Moni Adeline Sabine Fanta Yadang Fidel Castro Lah Weyepe gabriel A. agbor Nga Nnanga Maximilienne Ascension Nyegue Laboratory of Pharmacology and Drugs Discovery Centre for Research on Medicinal Plants and Traditional Medicine Institute of Medical Research and Medicinal Plants Studies Yaoundé Cameroon Laboratory of Microbiology Department of Microbiology Faculty of Science University of Yaoundé I Yaoundé Cameroon Multidisciplinary Laboratory Department of Galenical Pharmacy and Pharmaceutical Law Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Physicochemical and Pharmaceutical Sciences Faculty of Health Sciences Abdou Moumouni University Niamey Niger Department of Pharmaceutical and Biological Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laboratory of Pharmaceutical Technology Centre for Research on Medicinal Plants and Traditional Medicine Institute of Medical Research and Medicinal Plants Studies Yaoundé Cameroon

Pneumonia, a respiratory infection induces acute or chronic inflammation, characterized by increased activity of lymphocytes and neutrophils, thus generating oxygen-free radicals that decrease the endogenous antioxidants defence system. The aim of this experimental study focused on the capacity of nontoxic aqueous, hydroethanolic and ethanolic extracts of Greenwayodendron suaveolens (Engl. & Diels) Verdc. subsp. suaveolens to regulate free reactive species and protein inflammation generated by infectious disease. The phytochemical screenings of G. suaveolens extracts were carried out according to precipitation and colorimetric methods. The total antioxidant and flavonoid contents were determined by the Folin-Ciocalteu and Aluminium Chloride ethanolic methods. The efficiency of G. suaveolens extracts on free radicals was evaluated using DPPH•, ABTS+•, and FRAP methods. The anti-inflammatory properties of extracts were evaluated according to in vitro protein (BSA) denaturation, Proteinase Inhibitory Action, and Red Blood Cell Membrane stabilization assays. The G. suaveolens aqueous, hydroethanolic and ethanolic extracts were used for the acute toxicity assessment according to the OECD protocol. The obtained results showed the presence of flavonoids, phenols, polyphenols, tannins, anthocyanins, alkaloids, terpenoids, and sterols as secondary metabolites families in G. suaveolens extracts. The highest contents of total antioxidants and flavonoids were highlighted in the hydroethanolic extract. However, it’s the G. suaveolens aqueous extract that showed the best free radical DPPH• and ABTS+• scavenging activities (SC50) of 11.06 μg/mL and 15.16 μg/mL respectively. The highest ferric-reducing activity was found in G. suaveolens ethanolic extract with 866.23 μg EGA/mg of dry weight. The hydroethanolic extract has shown a high anti-inflammatory activity through BSA denaturation and erythrocyte membrane haemolysis with i

关键词： Greenwayodendron suaveolens Secondary Metabolites Oxidative Stress Antioxidant Activity Anti-Inflammatory Properties and Oral Acute Toxicity

Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019:A scoping review

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Asian Pacific Journal of Tropical Biomedicine 2021年第8期11卷 327-334页

作者： Mohammad Reza Khazdair Akbar Anaeigoudari gabriel A.agbor Cardiovascular Diseases Research Center Birjand University of Medical SciencesBirjandIran Department of Physiology Jiroft University of Medical SciencesJirofIran Center for Research on Medicinal Plants and Traditional Medicine Institute of Medical Research and Medicinal Plants StudiesMinistry of Scientific Research and InnovationsYaoundeCameroon

Severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)is a novel coronavirus identified at the end of *** is recognized as the causative agent of coronavirus disease 2019(COVID-19).Flavonoids have been shown to exhibit therapeutical effect on complications related to *** present study reviews possible therapeutic benefits of flavonoids on *** Web of Science,PubMed,Scopus,and Google Scholar were searched using keywords:“COVID-19”,“SARS-CoV-2”,“Kaempferol”and“Quercetin”in the Title/*** published articles in the English language until August 2020 were *** and quercetin showed antiviral properties such as inhibition of protein kinase B and phosphorylation of protein kinase and blocking effects on a selective channel(3a channel)expressed in SARS-CoV infected *** also reduced the level of reactive oxygen species,expression of inducible nitric oxide synthase,pro-inflammatory mediators including TNF-α,IL-1α,IL-1β,IL-6,IL-10,and IL-12 p70,and *** and quercetin might exert beneficial effects in the control or treatment of COVID-19 because of their antiviral,antioxidant,anti-inflammatory,and immunomodulatory effects.

关键词： SARS-CoV-2 Flavonoids Kaempferol Quercetin Immunomodulation Anti-inflammatory Antiviral effects

Antioxidant Effect of Herbs and Spices on Copper Mediated Oxidation of Lower and Very Low Density Lipoprotein

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中国天然药物 2010年第2期8卷 114-120页

作者： gabriel A.agbor Joe A.Vinson Julius E.Oben Jeanne Y.Ngogang CRPMT Institute of Medical Research and Medicinal Plants StudiesP.O Box 6163Yaoundé Cameroon Department of Chemistry University of ScrantonScrantonPennsylvania18510 USA Department of Biochemistry University of YaoundéICameroon Department of Physiological Sciences Faculty of Medicine and Biomedical SciencesUniversity of YaoundéICameroon

AIM:The present study investigates the antioxidant effect of two extracts(hydrolyzed and non-hydrolyzed)of five herbs and eight spices in the prevention of LDL+VLDL oxidation promoted by cupric ***:The polyphenolic concentrations of these extracts were measured using Folin-Ciocalteu *** antioxidant quality was analyzed by the determination of lag-time,concentration of polyphenol that will inhibit 50%of oxidation of LDL+VLDL(IC50)and phenol antioxidant index(PAOXI). RESULTS:The hydrolyzed extracts had significant higher polyphenol concentration,longer lag-time,lower IC50 and higher PAOXI than the non-hydrolyzed extracts(P<0.001).Thus,hydrolyzed extract contains better quantity and quality polyphenolic antioxidant than the non-hydrolyzed *** hydrolyzed and non-hydrolyzed extracts were better antioxidants than Vitamin E in the inhibition of LDL+VLDL ***:The reaction rate and concentration of conjugated diene formed suggested that all the extracts had similar reaction mechanism in the prevention of copper mediated LDL+VLDL oxidation.

关键词：抗氧化剂药草水解多酚

Penetrating Abdominal Trauma: Experience in A Teaching Hospital, Calabar, Southern Nigeria

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International Journal of Clinical Medicine 2012年第5期3卷 426-430页

作者： Maurice Asuquo Mark Umoh Victor Nwagbara gabriel Ugare Cyril agbor Emmanuel Japhet Department of Surgery University of Calabar Teaching Hospital Calabar Nigeria

Background: Penetrating abdominal trauma (PAT) typically involves the violation of the abdominal cavity by a gun-shot wound (GSW) or stab wound Recently several studies have favored a more conservative approach as opposed to mandatory exploratory laparotomy. Methods: Patients admitted in the University of Calabar Teaching Hospital (UCTH), Calabar, with PAT from January 2008 to December 2010 were prospectively studied based on a questionnaire. The total number of patients with PAT was compared with total number of emergencies, traumatic injuries and abdominal trauma seen during the same period. Results: A total of 48 patients presented with abdominal trauma: PAT 29 (60%) and blunt abdominal trauma (BAT) 19 (40%). The ages of the patients (28 male, 1 female) ranged from 3 - 62 years (mean 28.1 years). Gunshot wound (GSW) 11 (38%) patients, stab wound 8 (27.6%) patients and machete cut 4 (13.8%) patients ranked first, second and third respectively as causes of PAT. The commonest organ injury was perforation of the small intestine. Four (13.8%) patients were managed conservatively while 25 (86.2%) patients had laparotomy. The duration of admission ranged from 2 - 19 days (mean 10.5 days). Morbidity [surgical site infection (SSI)] and mortality were recorded in 2 (6.9%) and 3 (10.3%) patients respectively. Conclusion: Key areas that require attention have been highlighted. Revamping the ailing economy and gainful employment for youths are paramount areas that require prompt, dedicated and sustained intervention for reduction in violent crimes.

关键词： Penetrating Abdominal Trauma Pattern Management

Blunt Abdominal Trauma in a Teaching Hospital, Calabar, Nigeria

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International Journal of Clinical Medicine 2012年第7期3卷 693-696页

作者： Maurice Asuquo Victor Nwagbara Mark Umoh gabriel Ugare Cyril agbor Emmanuel Japhet Anthonia Ikpeme Department of Radiology University of Calabar Teaching Hospital Calabar Nigeria Department of Surgery University of Calabar Teaching Hospital Calabar Nigeria

Background: Road traffic injury remains a major source of blunt abdominal trauma (BAT). Road traffic injury and other forms of trauma have become a major health problem throughout the world especially in low and middle-income countries. In a previous study (2005-2007), abdominal trauma constituted 79 (4.8%) of trauma cases;BAT, 40 (53%) and penetrating abdominal trauma (PAT), 39 (47%). Effective policies on road safety should be developed based on local research and not on adapted models. We present this study to highlight the possible effect of legislation on the ban of the use of motorcycles on blunt abdominal trauma. Methods: Patients that presented to the University of Calabar Teaching Hospital, Calabar with BAT from 2008-2010 were prospectively studied based on a questionnaire following the legislation prohibiting the use of motorcycles. Results: A total of 12,083 patients presented during the study period, trauma patients totaled 4942 (41%), of this, 48 (1%) suffered abdominal trauma: BAT 19 (40%), penetrating abdominal trauma (PAT) 29 (60%). The age range of the patients was from 5 to 48 years (mean 26.6 years) with a M:F = 5.3:1. Road traffic accident (RTA) 17 (90%) [Motorvehicle 7 (37%), motorcycles 10 (53%)] was the commonest cause of trauma. The spleen was the commonest injured organ 14 (74%). Conclusion: Road traffic injury constitutes a public health challenge and the hallmark is prevention. Legislation prohibiting the use of motorcycles may have been responsible for the reduction in BAT.

关键词： Blunt Abdominal Trauma Prevention Motorcycles

Cytotoxicity and in vivo Toxicological Screening of a Polyherbal Product,Nefang

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Cytotoxicity and in vivo Toxicological Screening of a Polyhe...