Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019:A scoping review
作者机构：Cardiovascular Diseases Research CenterBirjand University of Medical SciencesBirjandIran Department of PhysiologyJiroft University of Medical SciencesJirofIran Center for Research on Medicinal Plants and Traditional MedicineInstitute of Medical Research and Medicinal Plants StudiesMinistry of Scientific Research and InnovationsYaoundeCameroon
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2021年第11卷第8期
页 面：327-334页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：SARS-CoV-2 Flavonoids Kaempferol Quercetin Immunomodulation Anti-inflammatory Antiviral effects
摘 要：Severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)is a novel coronavirus identified at the end of *** is recognized as the causative agent of coronavirus disease 2019(COVID-19).Flavonoids have been shown to exhibit therapeutical effect on complications related to *** present study reviews possible therapeutic benefits of flavonoids on *** Web of Science,PubMed,Scopus,and Google Scholar were searched using keywords:“COVID-19,“SARS-CoV-2,“Kaempferoland“Quercetinin the Title/*** published articles in the English language until August 2020 were *** and quercetin showed antiviral properties such as inhibition of protein kinase B and phosphorylation of protein kinase and blocking effects on a selective channel(3a channel)expressed in SARS-CoV infected *** also reduced the level of reactive oxygen species,expression of inducible nitric oxide synthase,pro-inflammatory mediators including TNF-α,IL-1α,IL-1β,IL-6,IL-10,and IL-12 p70,and *** and quercetin might exert beneficial effects in the control or treatment of COVID-19 because of their antiviral,antioxidant,anti-inflammatory,and immunomodulatory effects.
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