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A MIXED VIRTUAL ELEMEnT METHOD FOR THE BOUSSInESQ PROBLEM On POLYGOnAL MESHES

Journal of Computational Mathematics 2021年第3期39卷 392-427页

作者： gabriel n.gatica Mauricio Munar Filander A.Sequeira CI^2 MA and Departamento de Ingenieria Matemitica Universidad de ConcepcionCasilla 160-CConcepcionChile Escuela de Matemaitica Universidad NacionalCampus Omar DengoHerediaCosta Rica

In this work we introduce and analyze a mixed virtual element method(mixed-VEM)for the two-dimensional stationary Boussinesq *** continuous formulation is based on the introduction of a pseudostress tensor depending nonlinearly on the velocity,which allows to obtain an equivalent model in which the main unknowns are given by the aforementioned pseudostress tensor,the velocity and the temperature,whereas the pressure is computed via a postprocessing *** addition,an augmented approach together with a fixed point strategy is used to analyze the well-posedness of the resulting continuous *** the discrete problem,we follow the approach employed in a previous work dealing with the navier-Stokes equations,and couple it with a VEM for the convection-diffusion equation modelling the *** precisely,we use a mixed-VEM for the scheme associated with the fluid equations in such a way that the pseudostress and the velocity are approximated on virtual element subspaces of H(div)and H^(1),respectively,whereas a VEM is proposed to approximate the temperature on a virtual element subspace of H^(1).In this way,we make use of the L^(2)-orthogonal projectors onto suitable polynomial spaces,which allows the explicit integration of the terms that appear in the bilinear and trilinear forms involved in the scheme for the fluid *** the other hand,in order to manipulate the bilinear form associated to the heat equations,we define a suitable projector onto a space of polynomials to deal with the fact that the diffusion tensor,which represents the thermal conductivity,is ***,the corresponding solvability analysis is performed using again appropriate fixed-point ***,Strang-type estimates are applied to derive the a priori error estimates for the components of the virtual element solution as well as for the fully computable projections of them and the postprocessed *** corresponding rates of convergence are als

关键词： Boussinesq problem Pseudostress-based formulation Augmented formulation Mixed virtual element method.High-order approximations

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Pseudostress-BasedMixed Finite Element Methods for the Stokes Problem in Rn with Dirichlet Boundary Conditions.I:A Priori Error Analysis

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Communications in Computational Physics 2012年第6期12卷 109-134页

作者： gabriel n.gatica Antonio Marquez Manuel A.Sanchez CI2MA and Departamento de Ingenier´ıa Matem´atica Universidad de Concepci´onCasilla 160-CConcepcionChile Departamento de Construcci´on e Ingenier´ıa de Fabricacion Universidad de OviedoOviedoEspa-na.

We consider a non-standard mixed method for the Stokes problem in Rn,n∈{2,3},with Dirichlet boundary conditions,in which,after using the incompressibility condition to eliminate the pressure,the pseudostress tensor s and the velocity vector u become the only ***,we apply the Babuˇska-Brezzi theory to prove the well-posedness of the corresponding continuous and discrete *** particular,we show that Raviart-Thomas elements of order k≥0 for s and piecewise polynomials of degree k for u ensure unique solvability and stability of the associated Galerkin *** addition,we introduce and analyze an augmented approach for our pseudostress-velocity *** methodology employed is based on the introduction of the Galerkin least-squares type terms arising from the constitutive and equilibrium equations,and the Dirichlet boundary condition for the velocity,all of them multiplied by suitable stabilization *** show that these parameters can be chosen so that the resulting augmented variational formulation is defined by a strongly coercive bilinear form,whence the associated Galerkin scheme becomes well posed for any choice of finite element *** instance,Raviart-Thomas elements of order k≥0 for s and continuous piecewise polynomials of degree k+1 for u become a feasible choice in this ***,extensive numerical experiments illustrating the good performance of the methods and comparing them with other procedures available in the literature,are provided.

关键词： Mixed finite element pseudostress incompressible flow

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Magnetopause properties at the dusk magnetospheric flank from global magnetohydrodynamic simulations,the kinetic Vlasov equilibrium,and in situ observations--Potential implications for SMILE

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Earth and Planetary Physics 2024年第1期8卷 222-233页

作者： Marius Echim Costel Munteanu gabriel Voitcu Eliza Teodorescu Institute of Space Science Măgurele 077125Romania Royal Belgian Institute for Space Aeronomy 1180 BrusselsBelgium Solar-Terrestrial Centre of Excellence(STCE) 1180 BrusselsBelgium

We derived the properties of the terrestrial magnetopause(MP)from two modeling approaches,one global–fluid,the other local–kinetic,and compared the results with data collected in situ by the Magnetospheric Multiscale 2(MMS2)*** used global magnetohydrodynamic(MHD)simulations of the Earth’s magnetosphere(publicly available from the nASA-CCMC[national Aeronautics and Space Administration–Community Coordinated Modeling Center])and local Vlasov equilibrium models(based on kinetic models for tangential discontinuities)to extract spatial profiles of the plasma and field variables at the Earth’s *** global MHD simulations used initial solar wind conditions extracted from the OMnI database at the time epoch when the MMS2 observes the *** kinetic Vlasov model used asymptotic boundary conditions derived from the same in situ MMS measurements upstream or downstream of the *** global MHD simulations provide a three-dimensional image of the magnetosphere at the time when the MMS2 crosses the *** Vlasov model provides a one-dimensional local view of the MP derived from first principles of kinetic *** MMS2 experimental data also serve as a reference for comparing and validating the numerical simulations and *** found that the MP transition layer formed in global MHD simulations was generally localized closer to the Earth(roughly by one Earth radius)from the position of the real MP observed by the *** also found that the global MHD simulations overestimated the thickness of the MP transition by one order of magnitude for three analyzed variables:magnetic field,density,and tangential *** MP thickness derived from the local Vlasov equilibrium was consistent with observations for all three of these *** overestimation of density in the Vlasov equilibrium was reduced compared with the global MHD *** discuss our results in the context of future SMILE(Solar wind Magnetosphere Ionosphere Link Explorer)campaigns for observing

关键词： magnetopause magnetohydrodynamic numerical simulations Vlasov equilibrium Magnetospheric Multiscale observations

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zavaleta non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

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Introducing the n^th-Order Features Adjoint Sensitivity Analysis Methodology for nonlinear Systems (n^th-FASAM-n): II. Illustrative Example

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American Journal of Computational Mathematics 2024年第1期14卷 43-95页

作者： Dan gabriel Cacuci Center for nuclear Science and Energy University of South Carolina Columbia USA

This work highlights the unparalleled efficiency of the “nth-Order Function/ Feature Adjoint Sensitivity Analysis Methodology for nonlinear Systems” (nth-FASAM-n) by considering the well-known nordheim-Fuchs reactor dynamics/safety model. This model describes a short-time self-limiting power excursion in a nuclear reactor system having a negative temperature coefficient in which a large amount of reactivity is suddenly inserted, either intentionally or by accident. This nonlinear paradigm model is sufficiently complex to model realistically self-limiting power excursions for short times yet admits closed-form exact expressions for the time-dependent neutron flux, temperature distribution and energy released during the transient power burst. The nth-FASAM-n methodology is compared to the extant “nth-Order Comprehensive Adjoint Sensitivity Analysis Methodology for nonlinear Systems” (nth-CASAM-n) showing that: (i) the 1st-FASAM-n and the 1st-CASAM-n methodologies are equally efficient for computing the first-order sensitivities;each methodology requires a single large-scale computation for solving the “First-Level Adjoint Sensitivity System” (1st-LASS);(ii) the 2nd-FASAM-n methodology is considerably more efficient than the 2nd-CASAM-n methodology for computing the second-order sensitivities since the number of feature-functions is much smaller than the number of primary parameters;specifically for the nordheim-Fuchs model, the 2nd-FASAM-n methodology requires 2 large-scale computations to obtain all of the exact expressions of the 28 distinct second-order response sensitivities with respect to the model parameters while the 2nd-CASAM-n methodology requires 7 large-scale computations for obtaining these 28 second-order sensitivities;(iii) the 3rd-FASAM-n methodology is even more efficient than the 3rd-CASAM-n methodo

关键词： nordheim-Fuchs Reactor Safety Model Feature Functions of Model Parameters High-Order Response Sensitivities to Parameters Adjoint Sensitivity Systems

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Cotton pads-derived carbon materials/reduced graphene oxide modified with polypyrrole for electrode of supercapacitors

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Journal of Energy Chemistry 2024年第7期94卷 41-53页

作者： Ofelia MArias-Pinedo Elvis OLopez Ivonne EMonje RSoria-Martinez Antony Bazan-Aguilar Clemente Alfredo Luyo Caycho gabriel Angel Planes Angelica Maria Baena-Moncada Laboratorio de Investigacion de Electroquimica Aplicada Facultad de Ciencias de la Universidad Nacional de IngenieriaAv.Tupac Amaru 210RimacLimaPeru Department of Experimental Low Energy Physics Brazilian Center for Research in Physics(CBPF)Rio de Janeiro22290-180Brazi Universidad Tecnologica del Peri Av.Arequipa 26515046 LimaPeru Centeror theevelopmentof Adanced Materials and nanotechlogy Universidad NacionaldeIngeneria33LimaP Departamento de Quimica Universidad Nacional de Rio CuartoInstituto de Investigaciones en Tecnologias Energeticas y Materiales Avanzados(IITEMA)Ruta Nac.36Km 601(X5804BYA)RioCuartoCordobaArgentina

This study investigates the influence of electropolymerization conditions on the deposition of polypyrrole(PPy)onto cotton-derived carbon fiber(CF)modified with reduced graphene oxide(rGO)for supercapacitors applications using an experimental/theorical *** surface modification of CF by rGO and/or by PPy electrodeposited at 10,25 and 50 mV s^(-1) was thoroughly examined physicochemical and *** electrodes comprising CF-rGo-PPy,synthesized via electropolymerization at 25 mV s^(-1),demonstrated a remarkable increase in capacitance,showcasing~742 F g^(-1) compared to 153 F g^(-1) for ***,n_(2)-surface area,XPS,and TD-DFT approach revealed that the higher capacitance observed in CF-rGo-PPy electrodes underscores the influence of morphology and charged nitrogen species on the electrochemical performance of these modified ***,this electrode material achieves a specific capacitance retention of~96%of their initial capacitance after 10000 cycles at 0.5 A g^(-1) measured in a two-electrodes cell *** work also discusses the influence of the scan rate used for pyrrole electropolymerization on the pseudocapacitance contribution of PPy and its possible effect on the porosity of the *** results highlight the importance of appropriate electropolymerization conditions that allow obtaining the synergistic effect between CF,rGO and PPy.

关键词： Supercapacitors Cotton pads-derived carbon fibers rGO PPy TD-DFT

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Identific tion of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Journal of Animal Science and Biotechnology 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn gabriel A.Zayas Eduardo E.Rodriguez Laura M.Jensen Raluca G.Mateescu Peter J.Hansen Department of Animal Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applied Systems Biology La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattle, more than 50% of the energy input to produce a unit of beef is consumed by the female that produced the calf. Development of genomic tools to identify females with high genetic merit for reproductive function could increase the profitability and sustainability of beef *** Genome-wide association studies(GWAS) were performed using a single-step genomic best linear unbiased prediction approach on pregnancy outcome traits from a population of Angus–Brahman crossbred heifers. Furthermore, a validation GWAS was performed using data from another farm. Heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SnPs. In the discovery population, heifers were bred in winter breeding seasons involving a single round of timed artificial insemination(AI) followed by natural mating for 3 months. Two phenotypes were analyzed: pregnancy outcome to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PEBS;n = 1,725). The heritability was estimated as 0.149 and 0.122 for PAI and PEBS, respectively. In the PAI model, one quantitative trait locus(QTL), located between 52.3 and 52.5 Mb on BTA7, explained about 3% of the genetic variation, in a region containing a cluster of γ-protocadherin genes and SLC25A2. Other QTLs explaining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PEBS model, a large QTL on BTA7 was synonymous with the QTL for PAI, with minor QTLs located on BTA5, 9, 10, 11, 19, and 20. The validation population for pregnancy status at the end of the breeding season were Angus–Brahman crossbred heifers bred by natural mating. In concordance with the discovery population, the large QTL on BTA7 and QTLs on BTA10 and 12 were *** In summary, QTLs and candidate SnPs identified were associated with pregnancy outcomes in beef heifers, including a large QTL associated with a group of protocadherin genes. Confirmation of these associations

关键词： Beef cattle Fertility GWAS QTL

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Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEn-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： noemi Gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza Joan Brunet gabriel Capellá Heather Hampel Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBEROnC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEn tumor suppressive function,have been proposed as an alternative mechanism of PTEn inactivation in PTEn-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEn.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

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Exploring fs-laser irradiation damage subthreshold behavior of dielectric mirrors via electrical measurements

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High Power Laser Science and Engineering 2024年第2期12卷 24-32页

作者： Petrisor gabriel Bleotu Radu Udrea Alice Dumitru Olivier Uteza Maria-Diana Mihai Dan Gh Matei Daniel Ursescu Stefan Irimiciuc Valentin Craciun Extreme Light Infrastructure-nuclear Physics(ELI-nP) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)MagureleRomania Doctoral School of Physics University of BucharestMagureleRomania LULI-CnRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Apel Laser IlfovRomania Aix-Marseille University CNRSLP3 UMR 7341MarseilleFrance Horia Hulubei national Institute for R&D in Physics and nuclear Engineering(IFIn-HH) MagureleRomania University Politehnica of Bucharest BucharestRomania national Institute for Lasers Plasma and Radiation Physics MagureleRomania

With ultrafast laser systems reaching presently 10 PW peak power or operating at high repetition rates,research towards ensuring the long-term,trouble-free performance of all laser-exposed optical components is *** work is focused on providing insight into the optical material behavior at fluences below the standardized laser-induced damage threshold(LIDT)value by implementing a simultaneous dual analysis of surface emitted particles using a Langmuir probe(LP)and the target current(TC).HfO_(2) and ZrO_(2) thin films deposited on fused silica substrates by pulsed laser deposition at various O_(2) pressures for defect and stoichiometry control were irradiated by Gaussian,ultrashort laser pulses(800 nm,10 Hz,70 fs)in a wide range of *** TC and LP collected signals were in good agreement with the existing theoretical description of laser–matter interaction at an ultrashort time *** approach for an in situ LIDT monitoring system provides measurable signals for below-threshold irradiation conditions that indicate the endurance limit of the optical surfaces in the single-shot energy scanning *** LIDT value extracted from the LP-TC system is in line with the multipulse statistical analysis done with ISO 21254-2:2011(E).The implementation of the LP and TC as on-shot diagnostic tools for optical components will have a significant impact on the reliability of next-generation ultrafast and high-power laser systems.

关键词： HfO_(2) in situ detection Langmuir probe laser-induced damage threshold target current ZrO_(2)

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