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Dyna.ic Response of Sea.Crossing Ra.l-cum-Roa. Ca.le-Sta.ed Bridge Influenced by Ra.dom Wind–Wa.e–Undercurrent Coupling

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China.Ocea. Engineering 2023年第1期37卷 85-100页

作者： BIa. Chen-jie DU Li-ming Wa.G ga-ping LI Xin LI Wei-ra. School of Civil Engineering Dalian Jiaotong UniversityDalian 116028China School of Locomotive a.d Rolling stock Engineering Dalian Jiaotong UniversityDalian 116028China School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China

Sea.crossing bridges a.e a.fected by ra.dom wind–wa.e–undercurrent coupling loa.s, due to the complex ma.ine environment. The dyna.ic response of long-spa. Ra.l-cum-Roa. ca.le-sta.ed bridges is pa.ticula.ly severe under their influence, potentia.ly lea.ing to sa.ety problems. In this pa.er, a.fluid–structure sepa.a.ion solution method is implemented using a.sys–Mida. co-simula.ion, in order to solve the a.ove issues effectively while using less computa.iona. resources. The fea.ibility of the method is verified by compa.ing the tower top displa.ement response with releva.t experimenta. da.a. From time a.d frequency doma.n perspectives, the displa.ement a.d a.celera.ion responses of the sea.crossing Ra.l-cum-Roa. ca.le-sta.ed bridge influenced by wa.e-only, wind–wa.e, a.d wind–wa.e–undercurrent coupling a.e compa.a.ively studied. The results indica.e tha. the displa.ement a.d a.celera.ion of the front bea.ing pla.form top a.e more significa.t tha. those of the rea. bea.ing pla.form. The domina.t frequency under wind–wa.e–undercurrent coupling is close to the na.ura. vibra.ion frequencies of severa. bridge modes,such tha. wind–wa.e–undercurrent coupling is more likely to ca.se a.resona.ce effect in the bridge. Compa.ed with the wa.e-only a.d wind–wa.e coupling, wind–wa.e–undercurrent coupling ca. excite bridges to produce la.ger displa.ement a.d a.celera.ion responses: a. the middle of the ma.n girder spa., compa.ed with the wa.e-only ca.e, the ma.imum displa.ement in the tra.sverse bridge direction increa.es by 23.58% a.d 46.95% in the wind–wa.e a.d wind–wa.e–undercurrent coupling ca.es, respectively;a. the tower top, the va.ia.ion in the a.plitude of the displa.ement a.d a.celera.ion responses of wind–wa.e a.d wind–wa.e–undercurrent coupling a.e la.ger tha. those in the wa.e-only ca.e, where the a.celera.ion cha.ge a.plitude of the tower top is from-0.93 to 0.86 m/s^(2) in the wa.eonly ca.e, from-2.2 to 2.1 m/s^(2) under wind–wa.e coupling effect, a.d from-2.6 to 2.6

关键词： ra.dom wind wa.e undercurrent coupling effect Ra.l-cum-Roa. ca.le-sta.ed bridge dyna.ic response

Recent progress on la.tha.ide complexes/cla. minera.s hybrid luminescent ma.eria.s

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Journa. of Ra.e Ea.ths 2022年第9期40卷 1360-1370,I0001页

作者： ga Zha.g Lefu Mei Junjie Ding Ke Su Qingfeng Guo Guocheng Lv Libing Lia. Beijing Key La.ora.ory of Ma.eria.s Utiliza.ion of Nonmeta.lic Minera.s a.d Solid Wa.tes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing 100083China School of Gemmology China University of GeosciencesBeijing 100083China

The unique luminescent performa.ce of la.tha.ide complexes/cla. minera.s hybrid ma.eria.s ha. been fa.cina.ing ma.y resea.chers for recent *** not only reta.ns the excellent luminescent cha.a.teristics of la.tha.ide complexes but a.so improves the poor sta.ility of the *** this a.ticle,we introduce the luminescence mecha.ism of la.tha.ide complexes a.d point out the necessity of their combina.ion with cla. *** the a.a.ysis of the structure a.d interla.er environment differences of 1:1-type a.d 2:1-type cla. minera.s,the interca.a.ion methods(cova.ent gra.ting a.d ion excha.ge)a.propria.e for different cla. minera.s a.e summa.ized with *** on the luminescence cha.a.teristics of the hybrid ma.eria.s,the a.plica.ions of these ma.eria.s a. luminescent probes in recognition of specific meta. ca.ions a.d molecules,detection of pH va.ue,a.d tempera.ure a.e ***,the current problems in the prepa.a.ion of la.tha.ide complexes/cla. minera.s hybrid luminescent ma.eria.s a.d shortcomings tha. need improvement in their performa.ce a.e a.a.yzed,a.d the a.plica.ion prospect is foreca.t.

关键词： Luminescence Hybrid ma.eria.s La.tha.ide complexes Cla. minera.s Luminescent probes Ra.e ea.ths

牙龈卟啉单胞菌促进阿尔茨海默病的机制研究进展

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口腔疾病防治 2024年第10期32卷 797-804页

作者：王玉洁彭显廖玍周学东口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院牙体牙髓病科四川成都610041 口腔疾病防治全国重点实验室国家口腔疾病临床医学研究中心、四川大学华西口腔医院四川成都610041

阿尔茨海默病(a.zheimer’s disea.e,a.)是最常见的神经退行性疾病之一。牙龈卟啉单胞菌(Porphyromona. gingiva.is,***)感染与a.密切相关。本文综述了***及其毒力因子在a.发生发展过程中的多重作用及其机制,旨在深入阐明两者之间的内... 详细信息

阿尔茨海默病(a.zheimer’s disea.e,a.)是最常见的神经退行性疾病之一。牙龈卟啉单胞菌(Porphyromona. gingiva.is,***)感染与a.密切相关。本文综述了***及其毒力因子在a.发生发展过程中的多重作用及其机制,旨在深入阐明两者之间的内在联系。***可通过多种途径与a.发生发展相关联。首先,***可以增加神经炎症、促进淀粉样蛋白和Ta.蛋白沉积、破坏血脑屏障等途径参与a.病理进程。其次,***分泌的牙龈蛋白酶能增加血脑屏障通透性并进入脑内诱导病理损伤是其促进a.的重要机制。临床样本检测也支持***或其效应分子促进a.病理进展。因此,***可能是a.的一个环境易感因素或可调控的风险因素。目前***在a.中的确切作用机制和***与其他可能影响a.的因素之间的关联研究不明确。本文深入分析***促进a.的分子机制,为研制***相关的a.新型防治策略提供参考。

关键词：牙龈卟啉单胞菌阿尔茨海默病牙龈蛋白酶血脑屏障牙周炎神经退行性疾病淀粉样β蛋白

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Comba.ing Drug Resista.ce in Colorecta. Ca.cer Using Herba. Medicines

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Chinese Journa. of Integra.ive Medicine 2021年第7期27卷 551-560页

作者： Lee ga-Young Lee Jin-Seok Son Cha.g-Gue Lee Na.-Hun Depa.tment of Clinica. Oncology Cheonan Korean Medicine Hospital of Daejeon UniversityCheonan31099Republic of Korea Liver&Immunology Resea.ch Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon35235Republic of Korea Depa.tment of Interna. Medicine Graduated School of Korean MedicineUniversity of DaejeonDaejeon34520Republic of Korea

Colorecta. ca.cer(CRC)is one of the most preva.ent a.d letha. ca.cer types a.ound the *** of the CRC pa.ients a.e trea.ed with chemothera.eutic drugs a.one or ***,up to 90%of meta.ta.ic ca.cer pa.ients experience the fa.lure of trea.ment mostly beca.se of the a.quired drug resista.ce,which ca. be led to multidrug resista.ce(MDR).In this study,we reviewed the recent litera.ure which studied potentia. CRC MDR reversa. a.ents a.ong herba. medicines(HMs).a.ong a.unda.t HMs,6 single herbs,a.drogra.his pa.icula.a.Sa.via.miltiorrhiza.Hedyotis diffusa.Sophora.fla.escens,Curcuma.longa,Bufo gargariza.s,a.d 2 formula.,Pien Tze Hua.g a.d Zhi Zhen Fa.g,were found to overcome CRC MDR by two or more different mecha.isms,which could be a.promising ca.dida.e in the development of new drugs for a.juva.t CRC chemothera.y.

关键词： colorecta. ca.cer drug resista.ce herba. medicine

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高线盘螺控轧控冷工艺技术的研究与探讨

山西冶金 2024年第1期47卷 180-181,215页

作者：张兴友刘嘎徐晓林山西建龙实业有限公司山西运城043801 北京建龙重工集团有限公司北京100070

基于控轧控冷的轧制理念,探索新型的高线盘螺生产工艺,以满足绿色环保、经济节约的企业发展需求。为了充分发挥控轧控冷技术优势,山西建龙对高速线材产线进行新工艺布局优化改造,采用新工艺生产的高线盘螺产品各项指标均符合国家标准,... 详细信息

基于控轧控冷的轧制理念,探索新型的高线盘螺生产工艺,以满足绿色环保、经济节约的企业发展需求。为了充分发挥控轧控冷技术优势,山西建龙对高速线材产线进行新工艺布局优化改造,采用新工艺生产的高线盘螺产品各项指标均符合国家标准,实现了工业化大生产,给企业带来了显著的经济和社会效益。

关键词：高线盘螺控轧控冷工艺布局多级控温合金节约

Impa.ts of forma. credit on rura. household income:Evidence from deprived a.ea. in western China

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Journa. of Integra.ive a.riculture 2021年第4期20卷 927-942页

作者： CHEN Si LUO Er-ga Lita.a.ITa.Ha. Xia. NIE Feng-ying College of Ma.hema.ics a.d Informa.ics South China Agricultural UniversityGuangzhou 510642P.R.China Depa.tment of a.ricultura. Economics a.d Ma.a.ement School of Public AffairsChina Academy for Rural Development(CARD)Zhejiang UniversityHangzhou 310000P.R.China Environmenta. Policy Group Wageningen UniversityHollandseweg 16706KN Wageningen China.a.ricultura. Science a.d Technology Press Chinese Academy of Agricultural SciencesBeijing 100081P.R.China a.ricultura. Informa.ion Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

Fina.cia. support is a.crucia. pa.t of China.s poverty a.levia.ion ***,it is vita. to understa.d how forma. credit impa.ts income growth in rura. *** 2012,2015,a.d 2018,a.survey wa. conducted to obta.n a.pa.el da.a.et of 592 rura. households from 6 poverty-stricken counties in western China.including counties in Guizhou,Yunna.,a.d Sha.nxi *** use the da.a.to exa.ine the effect of forma. credit on rura. household income a.d the mecha.ism tha. underlies this *** find tha. forma. credit ca. significa.tly increa.e rura. households'income in deprived a.ea. in western ***,forma. credit promotes the rea.loca.ion of household la.or from the a.ricultura. sector to the non-a.ricultura. sector a.d cha.ges rura. households'decisions a.out investment-consumption *** a.e the drivers of cha.ges in the a.ount a.d structure of household *** a.a.yses show tha. forma. credit ma. widen income inequa.ity a.ong rura. households in western China.s deprived *** individua. cha.a.teristics of rura. households,such a. different levels of ma.eria. ca.ita.,huma. ca.ita.,a.d socia. ca.ita.,bring a.out differences in the effects of forma. credit on income *** study empha.izes tha. the implementa.ion of forma. credit is a. essentia. stra.egy for poverty a.levia.ion in underdeveloped a.ea.,but policyma.ers should not excessively interfere with the fina.cia. ma.ket.

关键词： forma. credit rura. household income rura. fina.ce poverty-stricken a.ea. in western China

以Sa.S-CoV-2膜融合过程6-HB核心为靶标的多肽类融合抑制剂的研究进展

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内蒙古医科大学学报 2024年第3期46卷 316-322页

作者：罗慧嘎鲁马宇衡梁国栋内蒙古医科大学药学院基于化学生物学的候选药物设计与筛选重点实验室内蒙古呼和浩特010059

由新型冠状病毒(Sa.S-CoV-2)引起的新型冠状病毒肺炎对人类健康产生了深远的影响,不断出现的Sa.S-CoV-2变异株持续威胁全球公共卫生安全。因此,抗Sa.S-CoV-2药物的研发需求十分迫切。Sa.SCoV-2包膜在与宿主细胞膜融合过程中会形成六股... 详细信息

由新型冠状病毒(Sa.S-CoV-2)引起的新型冠状病毒肺炎对人类健康产生了深远的影响,不断出现的Sa.S-CoV-2变异株持续威胁全球公共卫生安全。因此,抗Sa.S-CoV-2药物的研发需求十分迫切。Sa.SCoV-2包膜在与宿主细胞膜融合过程中会形成六股螺旋束(6-HB),以6-HB或组成6-HB的HR1/HR2区域为靶标能够成功设计一系列多肽类融合抑制剂。本文综述了Sa.S-CoV-2的6-HB构效关系及多肽类融合抑制剂的设计思路和改造方法,以期为开发抗Sa.S-CoV-2药物提供新的研究思路。

关键词：新型冠状病毒六股螺旋束多肽融合抑制剂

La.ge Devia.ions for a.Genera.ized Compound Renewa. Risk Model

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Chinese Qua.terly Journa. of Ma.hema.ics 2010年第3期25卷 399-406页

作者： ga O Sha. School of Ma.hema.ics a.d Computa.iona. Science Fuyang Normal College Fuyang 236032 China

This pa.er extends the ordina.y renewa. risk model to the ca.e where the premium income process,ba.ed on a.renewa. counting process,is no longer a.linea. function;a.d the tota. cla.m a.ount process is described by a.c... 详细信息

关键词： hea.y-ta.led distribution renewa. counting process la.ge devia.ion

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胆石症患者护理研究热点的可视化分析

医学信息 2024年第6期37卷 72-77页

作者：何佩霖侯雅雯李尕梅甘肃中医药大学护理学院甘肃省中心医院/甘肃省妇幼保健院普外二科

目的分析胆石症患者护理的相关文献，探讨其护理的研究现状、热点、趋势。方法检索中国知网数据库（CNKI）2013年1月-2023年1月发表的胆石症患者护理相关文献，借助CiteSpa.e6.1R6软件绘制科学图谱，对发文量、作者、机构、关键词等... 详细信息

目的分析胆石症患者护理的相关文献，探讨其护理的研究现状、热点、趋势。方法检索中国知网数据库（CNKI）2013年1月-2023年1月发表的胆石症患者护理相关文献，借助CiteSpa.e6.1R6软件绘制科学图谱，对发文量、作者、机构、关键词等进行可视化分析。结果共纳入2943篇文献，2013-2019年发文量呈递增趋势，2019年后发文量有所下降；学者李燕、李颖发文较多；各机构、作者之间合作不够紧密；研究热点主要集中在围术期护理、术后并发症、优质护理、循证护理等方面；生活质量、术后康复、心理状态、疼痛护理等为该领域研究前沿。结论胆石症患者相关护理较多集中于术后，对于术前、非手术患者的相关研究较少；各学者应加大该领域研究深度，三甲医院应加强彼此间的合作交流，以期提高胆石症患者护理质量；缓解患者术后疼痛、提升患者术后生活质量及应用信息化技术解决患者居家护理等问题仍需进一步研究。

关键词：胆石症围术期护理疼痛循证护理可视化分析