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Verruca plana arising in a tattooed eyebrow

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Verruca plana arising in a tattooed eyebrow

MdbHLH162 connects the gibberellin and jasmonic acid signals to regulate anthocyanin biosynthesis in apple

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Young Chul Kye Dai Hyun Kim ga na oh Jong Yeob Kim Jae Eun Choi Soo Hong Seo Hyo Hyun Ahn Department of Dermatology Korea University College of MedicineSeoulKorea

＜正＞Background Tattooing is a common practice around the *** for cosmetic aim is becoming ***, serious complications of tattoo are *** most common adverse effect is an *** of bacteria, human immunodeficiency virus,hepatitis C and B,lupus vulgaris and leprosy is the possible infectious ***, local inflammation and allergic reactions may occur after procedure. Methods The patient was a healthy 26-year-old woman with multiple flat,pinkish,and 1-2 mm sized papules on her eyebrow and *** tattoo on her eyebrow was performed by an amateur 1 years *** the clinical suspicion of verruca plana,a punch biopsy was performed. Results The result of histologic examination was consistent with verruca ***,we started an immunotherapy with diphenylcyclopropenone（DPCP） as an initial treatment strategy for verruca plana. Discussion We report here on a healthy woman who developed multiple verruca plana lesions after undergoing eyebrow *** is thought that occurrence of verruca plana is associated with implantation of human papillomavirus during tattooing.

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Journal of Integrative Plant Biology 2024年第2期66卷 265-284页

作者： Jian-Ping An Rui-Rui Xu Xiao-na Wang Xiao-Wei Zhang Chun-Xiang You Yuepeng Han Apple technology innovation center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenHubei Hongshan LaboratoryThe Innovative Academy of Seed Design of Chinese Academy of SciencesWuhan 430074China College of Biology and Oceanography Weifang UniversityWeifang 261061China

Anthocyanins are secondary metabolites induced by environmental stimuli and developmental *** positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been *** the signal transduction pathways of gibberellin(ga)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between ga and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be *** this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the ga and JA ***162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin ***162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and *** ga repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 *** JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 *** findings reveal that MdbHLH162 integrates the ga and JA signals to negatively regulate anthocyanin *** study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.

关键词： anthocyanin biosynthesis bHLH transcription factor gibberellin jasmonic acid regulatory network transcriptional regulation

Epidemiological, Clinical, Therapeutic, and Evolutionary Aspects of Chronic End-Stage Renal Failure in the Nephrology Department of the University Hospital of Brazzaville in 2023

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Open Journal of Nephrology 2024年第1期14卷 62-69页

作者： gaël Honal Mahoungou Daniel Tony Eyeni Sinomono Éric Ngandzali-Ngabé Soraya Ntandou Francky Ambounou Précieux Ngoma Berline Ndinga Dalhia Mboungou Héléna Botokoto Bothard Hardy Ibovi Richard Loumingou Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Nephrology University Hospital of Brazzaville Brazzaville Congo

Objective: Chronic end-stage renal failure is a major public health problem in developing countries and is poorly documented. The objective of this study was to describe the epidemiological, diagnostic, therapeutic, and evolutionary aspects of patients admitted for end-stage renal failure to the Department of Nephrology at the University Hospital of Brazzaville. Patients and Methods: This was a descriptive cross-sectional study collecting prospective data that took place over 10 months. We included 128 patients who were exhaustively identified. Sociodemographic, clinical, therapeutic and developmental data were collected using a standardized and pretested pre-established survey form. The EPI info software enabled the analysis and processing of the data. Results: We reported a male predominance with a sex ratio of 2.5. The median age was 50 years. The first cause found was diabetes (55%) followed by hypertension (46%). The majority of patients had a dialysis emergency and half could not be dialyzed for financial reasons. Conclusion: Our results highlighted that certain epidemiological parameters of end-stage renal failure are constantly changing, such as frequency, while others remain static, including the main etiologies, gender, and age. However, mortality continues to increase and deserves more attention.

关键词： ESRD Epidemiology Nephrology University Hospital of Brazzaville

Factors Associated with Mortality in Diabetic Patients with End-Stage Renal Failure Starting Emergency Hemodialysis

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Open Journal of Nephrology 2024年第1期14卷 17-24页

作者： gaël Honal Mahoungou Daniel Tony Eyeni Sinomono Farel Elilié Mawa Ongoth Éric Ngandzali-Ngabé Nestor Andzouana Raissa Laure Mayanda Aymande Okoumou-Moko Francky Ambounou Précieux Ngoma Berline Ndinga Héléna Botokoto Bothard Hardy Ibovi Richard Loumingou Department of Nephrology University Hospital of Brazzaville Brazzaville Congo Faculty of Health Sciences University Marien Ngouabi Brazzaville Congo Department of Metabolic Diseases University Hospital of Brazzaville Brazzaville Congo

Background: Diabetic nephropathy is the leading cause of end-stage chronic kidney disease with poor prognosis in resource-limited settings. This study aimed to determine factors associated with mortality in patients starting dialysis treatment for end-stage chronic renal disease in an emergency context. Patients and Methods: This was a retrospective study from January 2020 to December 2022 at CHU-B. Data from 79 diabetic patients requiring emergency dialysis were compared with those of 79 non-diabetic patients with an end-stage renal disease requiring emergency dialysis. Data were collected from the Nephrology Department registry. We studied their initial clinical and biological profiles and factors related to mortality. Results: Out of 545 compiled records, 79 diabetic chronic kidney disease patients needing dialysis were included (group 1). A control group of 79 non-diabetic chronic kidney disease patients requiring emergency dialysis was also included (group 2). The average age of patients was 53.5 ± 17 years, and the duration of diabetes at dialysis initiation was 14.8 ± 4.3 years. Twenty-three percent were hypertensive. Fifty-two percent of patients experienced intra-dialytic hypotension. Death occurred in 22% of patients. Results show that age (adjusted OR 1.955;CI: 1.025 - 1.086;p-value: Conclusion: Emergency dialysis in diabetics is associated with unfavorable outcomes in terms of mortality. Despite follow-up, renal involvement remains poorly explored, emphasizing the need for physician awareness.

关键词： Diabetic Nephropathy Emergency Dialysis Republic of the Congo

HBP-g-PEGDGE凝胶聚合物的制备及性能

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高分子材料科学与工程 2024年第4期40卷 8-17页

作者：王雪王俊张娜朱秀雨东北石油大学化学化工学院黑龙江省聚烯烃新材料重点实验室黑龙江大庆163318 中国石油青海油田钻采工艺研究院甘肃敦煌736202

以超支化大分子-扫帚形聚合物(HBP-NH2)和线型二环氧化物封端的聚乙二醇(PEGDGE,Mn=600,1000,2000)为原料,采用溶液法制备了一类HBP-g-PEGDGE(HPD)水凝胶。利用傅里叶变换红外光谱、核磁共振氢谱、紫外光谱和扫描电镜等方法对产物的结... 详细信息

以超支化大分子-扫帚形聚合物(HBP-NH2)和线型二环氧化物封端的聚乙二醇(PEGDGE,Mn=600,1000,2000)为原料,采用溶液法制备了一类HBP-g-PEGDGE(HPD)水凝胶。利用傅里叶变换红外光谱、核磁共振氢谱、紫外光谱和扫描电镜等方法对产物的结构进行了表征,并对其溶胀、热稳定、流变和堵水性能进行了评价。结果表明,HPD水凝胶具有三维空间立体网状结构,且孔径随着聚乙二醇相对分子质量的增大逐渐增大。对于长链PEGDGE,较低温度、酸性pH和在没有盐的情况下均可获得较高的平衡溶胀比,水凝胶在温度为10℃~60℃、pH值为2~12范围内,表现出良好的溶胀-收缩可逆性。凝胶的热稳定性较好,随着聚乙二醇相对分子质量的增大而增强;表现出典型的弹性行为,随着聚乙二醇相对分子质量的增加,储能模量和损耗模量降低;其封堵率达到99%,封堵效果良好。

关键词：超支化大分子-扫帚形聚合物水凝胶溶胀行为热稳定性流变性能

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硫化钠体系中异极矿表面的硫化特性及硫化产物解析

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Transactions of Nonferrous Metals Society of China 2024年第2期34卷 629-642页

作者：张嘎王美丽和永新王涵丰奇成昆明理工大学国土资源工程学院省部共建复杂有色金属资源清洁利用国家重点实验室昆明650093 昆明理工大学云南省战略金属矿产资源绿色分离与富集重点实验室昆明650093 内蒙古兴业矿业股份有限公司赤峰024028

通过多种分析检测方法揭示硫化钠体系中异极矿表面的硫化特性和机理,并对异极矿表面硫化产物进行分析测试。研究结果表明,硫化钠浓度对异极矿表面的硫化效果具有显著影响,即提高硫化钠浓度能促进矿浆溶液中硫组分与矿物表面反应,从而提... 详细信息

通过多种分析检测方法揭示硫化钠体系中异极矿表面的硫化特性和机理,并对异极矿表面硫化产物进行分析测试。研究结果表明,硫化钠浓度对异极矿表面的硫化效果具有显著影响,即提高硫化钠浓度能促进矿浆溶液中硫组分与矿物表面反应,从而提高异极矿表面硫化产物的含量及矿物表面的疏水性。XPS和ToF-SIMS分析表明,异极矿表面的硫化产物并非单一的硫化物,而是由硫化物(S^(2−))和多硫化物(S_(n)^(2−))组成,且矿物表面多硫化物含量随硫化钠浓度的增加而增加,从而增强异极矿表面硫化产物的活性。

关键词：硫化特性异极矿硫化钠浓度硫化锌组分多硫化物

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2215-2230页

作者： Wei Zhu Zhiming Zhang Jinzhang Chen Xiaolan Chen Lei Huang Xiaoyong Zhang Xuan Huang na Ma Weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guoheng Mo Yiyue Wang Guosheng Yuan Mengya Zang Qi Li Xiaotao Jiang Yajing He Sha Wu Yukai He Yongyin Li Jinlin Hou State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Institute of Cellular Medicine Newcastle University Medical SchoolNewcastleUK Department of Pathology The First People’s Hospital of FoshanFoshanChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Key Laboratory of Proteomics of Guangdong Province Demonstration Center for Experimental Education of Basic Medical Sciences of ChinaGuangzhouChina Medical College of Georgia Augusta University112015th StreetAugustaGAUSA

Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma(HCC)are urgently *** common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fundamental roles in T cell development,differentiation and effector *** study aims to determine the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell *** antitumor function of AFP-specific T cell receptor-engineered T cells(TCR-T)was augmented by exogenous IL-21 in vitro and in ***-21 enhanced proliferation capacity,promoted memory differentiation,downregulated PD-1 expression and alleviated apoptosis in TCR-T after activation.A novel engineered IL-21 receptor was established,and TCR-T armed with the novel engineered IL-21 receptors(IL-21R-TCR-T)showed upregulated phosphorylated STAT3 expression without exogenous IL-21 ***-21R-TCR-T showed better proliferation upon activation and superior antitumor function in vitro and in ***-21R-TCR-T exhibited a less differentiated,exhausted and apoptotic phenotype than conventional TCR-T upon repetitive tumor antigen *** novel IL-21 receptor in our study programs powerful TCR-T and can avoid side effects induced by IL-21 systemic *** novel IL-21 receptor creates new opportunities for next-generation TCR-T against HCC.

关键词： hepatocellular TCR utilize

基于优化混合式模型的大学英语翻译教学及质量评价研究

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湖北第二师范学院学报 2024年第7期41卷 84-89页

作者：李姝吴娜大连财经学院商学院辽宁大连116000

为了解决当前混合教学模式中线上线下任务的设计缺乏连贯性的问题,结合任务型教学理论和混合式教学模式,构建了基于任务的混合式模型,并将其应用到大学英语翻译教学中。为了更好地评价模型的实施效果,研究针对学生翻译的评价,提出了基... 详细信息

为了解决当前混合教学模式中线上线下任务的设计缺乏连贯性的问题,结合任务型教学理论和混合式教学模式,构建了基于任务的混合式模型,并将其应用到大学英语翻译教学中。为了更好地评价模型的实施效果,研究针对学生翻译的评价,提出了基于预训练模型和对比学习的评价指标,并构建基于ga-BP神经网络的教学质量评价模型。研究结果表明,使用混合式模型的班级在整个学期结束后的总体学习水平均值增长了40.01%,较基准班高10.54%,表明使用基于任务的混合式教学模型的学生获得了更高的翻译水平的提升。实验结果证明了研究提出的混合式模型的实用性和优越性。表明基于ga-BP的神经网络模型对学生成绩的预测准确率高达97.3%,进而利于判断混合式教学模式对大学英语翻译教学的适用情况,促进大学英语翻译教学的调整和改进。

关键词：混合式教学任务型教学英语翻译 ga-BP 教学质量评价

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西藏扎日南木措流域水环境特征及其影响因素

环境科学 2024年第8期45卷 4529-4539页

作者：李志龙张惠芳刘长兵陈旭索娜卓嘎德吉央宗周云桥牛学锐董慧科王小萍兰州大学资源环境学院兰州730000 西藏自治区生态环境监测中心拉萨850000 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101

扎日南木措位于藏西北高寒草原带,为西藏第三大湖,生态环境脆弱,长期以来其流域水环境的研究资料缺乏,为探究其流域地表水环境特征及影响因素,于2021年8月~2022年6月丰、枯、平水期对流域湖泊和入湖河流水环境进行调查,结合数理统计以... 详细信息

扎日南木措位于藏西北高寒草原带,为西藏第三大湖,生态环境脆弱,长期以来其流域水环境的研究资料缺乏,为探究其流域地表水环境特征及影响因素,于2021年8月~2022年6月丰、枯、平水期对流域湖泊和入湖河流水环境进行调查,结合数理统计以及水化学分析、相关分析和主成分分析等方法,对流域水化学特征进行了评价,分析了水质时空差异特征,并对水质影响因素进行了探讨.结果表明:①扎日南木措流域水体呈碱性,湖水离子组成以na^(+)、SO_(4)^(2-)和Cl^(-)为主,河流以Ca^(2+)、HCO_(3)~-和SO_(4)^(2-)为主.②硫酸盐、砷、氯化物和总磷为主要超标污染物,流域水质存在明显时空差异.时间上,硫酸盐、砷和总磷超标均表现为:丰水期>枯水期>平水期,氯化物的水期差异不明显;空间上,河流水质优于湖泊,湖泊中砷、总磷、TDS、硫酸盐、氯化物、K^(+)和na^(+)的浓度较河流高1~2个数量级,水质超标现象基本集中于湖区,而湖内水质空间差异小.③流域水化学过程主要受蒸发-浓缩和岩石风化下的自然过程控制,各类元素经地表径流进入湖泊后,在蒸发浓缩作用下不断富集最后产生超标.④水质时间差异主要是丰水期更多的元素淋失和更强烈的蒸发作用导致;而空间差异则主要是流动水体和封闭水体的水动力条件差异导致.

关键词：扎日南木措水化学特征时空差异影响因素主成分分析