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Association of low muscle strength with metabolic dysfunctionassociated fatty liver disease:A nationwide study

World Journal of gastroenterology 2023年第45期29卷 5962-5973页

作者： Gyu Bae Lee Youn Huh Sang Hyun Lee Byoungduck Han Yang-Hyun Kim Do-Hoon Kim Seon Mee Kim Youn Seon Choi Kyung Hwan Cho ga eun nam Department of Family Medicine Korea University College of MedicineSeoul 02841South Korea Department of Family Medicine Uijeongbu Eulji Medical CenterEULJI UniversityDaejeon 11759South Korea School of Electrical Engineering Korea UniversitySeoul 02841South Korea

BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAFLD in the general population in *** This nationwide representative cross-sectional study included 31649 individuals aged≥19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and *** ratios(ORs)and 95%confidence intervals(95%CIs)for MAFLD according to sex-specific quartiles of muscle strength,defined by relative handgrip strength,were calculated using multivariable logistic regression ***,multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with *** Of all the participants,29.3%had *** prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants,sexes,and age groups(P<0.001).A 1.92-fold(OR=1.92,95%CI:1.70–2.16)and 3.12-fold(OR=3.12,95%CI:2.64–3.69)higher risk of MAFLD was observed in the lowest quartile(Q1)group than in the other groups(Q2–Q4)and the highest quartile(Q4)group,*** ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner(P for trend<0.001).These associations persisted in both *** inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age,obesity,and diabetes *** patients with MAFLD,the odds of severe liver fibrosis were higher in Q1(OR=1.83,95%CI:1.25–2.69)than in other groups(Q2–Q4).CONCLUSION Among Korean adults,low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD.

关键词： Muscle strength Handgrip strength Metabolic dysfunction-associated fatty liver disease Liver fibrosis Korea National Health and Nutrition Examination Survey

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Environmentally adaptive reshaping of plant photomorphogenesis by karrikin and strigolactone signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 865-882页

作者： Young-Joon Park Bo eun nam Chung-Mo Park Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea Departmentof Biological Sciences Seoul National UniversitySeoul 08826Korea Department of Chemistry Seoul National UniversitySeoul 08826Korea

Coordinated morphogenic adaptation of growing plants is critical for their survival and propagation under fluctuating *** morphogenic responses to light and warm temperatures,termed photomorphogenesis and thermomorphogenesis,respectively,have been extensively studied in recent *** photomorphogenesis,plants actively reshape their growth and developmental patterns to cope with changes in light ***,photomorphogenesis is closely associated with diverse growth hormonal ***,accumulating evidence indicates that light-directed morphogenesis is profoundly affected by two recently identified phytochemicals,karrikins(KARs)and strigolactones(SLs).KARs and SLs are structurally related butenolides acting as signaling molecules during a variety of developmental steps,including seed *** receptors and signaling mediators have been identified,and associated working mechanisms have been explored using gene-deficient mutants in various plant *** particular interest is that the KAR and SL signaling pathways play important roles in environmental responses,among which their linkages with photomorphogenesis are most comprehensively studied during seedling *** this review,we focus on how the phytochemical and light signals converge on the optimization of morphogenic *** also discuss molecular mechanisms underlying the signaling crosstalks with an aim of developing potential ways to improve crop productivity under climate changes.

关键词： karrikins morphogenic adaptation photomorphogenesis seedling establishment strigolactones

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Polygonal multi-polymorphed Li4Ti5Oi2@rutile TiO2 as anodes in lithium-ion batteries

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Nano Research 2019年第4期12卷 897-904页

作者： Chang Hyun Hwang Hee-eun Kim Inho nam Jin Ho Bang Department ofBionano Technology Hanyang University 55 Hanyangdaehak-ro Sangnok-gu Ansan Gyeonggi-do 15588 Republic of Korea School of Chemical Engineering & Materials Science Chung-Ang University 84 Heukseok-ro Dongjak-gu Seoul 06974 Republic of Korea Department of Chemical and Molecular Engineering Hanyang University 55 Hanyangdaehak-ro Sangnok-gu Ansan Gyeonggi-do 15588 Republic of Korea

Li4Ti50i2 (LTO) has attracted considerable attention in lithium-ion battery (LIB) applications because of its favorable characteristics as an anode material. Despite its promise, the widespread use of LTO is still limited primarily due to its intrinsically poor electric and ionic con ductivities and high surface reactivity. To address these issues, we desig ned polyg onal nano architectures composed of various Li-Ti oxide crystal polymorphs by a facile synthesis route. Depending on the pH condition, this synthesis approach yields multi-polymorphed Li-Ti oxides where the interior is dominantly composed of a Li-rich phase and the exterior is a Li-deficient (or Li-free) phase. As one of these variations, a polygonal LTO-rutile TiO2 structure is formed. The rutile TiO2 on the surface of this LTO composite significantly improves the kinetics of Li^+ insertion/extraction because the channel along the o-axis in TQ2 provides a Li^+ highway due to the significantly low energy barrier for Li^+ diffusion. Moreover, the presenee of rutile TiO2, which is less reactive with a carbonate-based electrolyte, ensures Iong-term stability by suppress)ng the undesirable interfacial reaction on LTO.

关键词： micro-polygon structure Li-Ti oxide multi-polymorphs Li4Ti5Oi2@ rutile TiO2 anode lithium-ion batteries

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Reconstruction of cervical necrotizing fasciitis defect with the modified keystone flap technique:Two case reports

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World Journal of Clinical Cases 2024年第7期12卷 1305-1312页

作者： Wonseok Cho eun A Jang Kyu nam Kim Department of Plastic and Reconstructive Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea

BACKGROUND Cervical necrotizing fasciitis(CNF)is a rare,aggressive form of deep neck space infection with significant morbidity and mortality *** surgical debridement acts as the cornerstone of CNF treatment;however,it often results in defects requiring complex *** SUMMARY We report two cases in which the keystone flap(KF)was used for CNF defect coverage:Case 1,an 85-year-old patient with CNF in the anterior neck,and Case 2,a 54-year-old patient with CNF in the posterior *** patients received empirical intravenous antibiotic therapy and underwent serial debridement,enabling adequate wound preparation and *** final defect size measured 5.5 cm×12 cm in Case 1 and 6 cm×11 cm in Case *** defect coverage,we employed an 8 cm×19 cm type II KF based on perforators from the superior thyroid artery in Case 1 and a 9 cm×18 cm type II KF based on perforators from the transverse cervical artery in Case *** flaps showed complete *** postoperative complications occurred in both cases,and favorable outcomes were observed at 7-and 6-month follow-ups in case 1 and 2,*** We effectively treated CNF-associated defects using the KF technique;KF is viable for covering CNF defects in carefully selected cases.

关键词： Fasciitis Necrotizing Debridement Plastic surgery Dermatologic surgical procedures Case report

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Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines

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Chinese Journal of Integrative Medicine 2021年第7期27卷 551-560页

作者： Lee ga-Young Lee Jin-Seok Son Chang-Gue Lee nam-Hun Department of Clinical Oncology Cheonan Korean Medicine Hospital of Daejeon UniversityCheonan31099Republic of Korea Liver&Immunology Research Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon35235Republic of Korea Department of Internal Medicine Graduated School of Korean MedicineUniversity of DaejeonDaejeon34520Republic of Korea

Colorectal cancer(CRC)is one of the most prevalent and lethal cancer types around the *** of the CRC patients are treated with chemotherapeutic drugs alone or ***,up to 90%of metastatic cancer patients experience the failure of treatment mostly because of the acquired drug resistance,which can be led to multidrug resistance(MDR).In this study,we reviewed the recent literature which studied potential CRC MDR reversal agents among herbal medicines(HMs).Among abundant HMs,6 single herbs,Andrographis paniculata,Salvia miltiorrhiza,Hedyotis diffusa,Sophora flavescens,Curcuma longa,Bufo gargarizans,and 2 formulae,Pien Tze Huang and Zhi Zhen Fang,were found to overcome CRC MDR by two or more different mechanisms,which could be a promising candidate in the development of new drugs for adjuvant CRC chemotherapy.

关键词： colorectal cancer drug resistance herbal medicine

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Change in subfoveal choroidal thickness after argon laser panretinal photocoagulation

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 505-509页

作者： ga eun Cho Hee Yun Cho Yun Taek Kim Department of Ophthalmology Ewha Womans University School of Medicine Department of Ophthalmology Hanyang University School of Medicine

AIMTo evaluate changes in subfoveal choroidal thickness (SFCT) and macular thickness as measured by enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) after argon laser panretinal photocoagu... 详细信息

关键词： choroidal thickness diabetic retinopathy EDI-OCT macular edema panretinal photocoagulation

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3D engineered tissue models for studying human-specific infectious viral diseases

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Bioactive Materials 2023年第3期21卷 576-594页

作者： Kyeong Seob Hwang eun U Seo Nakwon Choi Jongbaeg Kim Hong nam Kim Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research Institute Yonsei UniversitySeoul03722Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea

Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ *** on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin *** these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent *** infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is ***,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were ***,recent studies have shown that these models can recapitulate infection-associated *** this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral ***,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection ***,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection ***,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.

关键词： 3D engineered tissue model Infectious viral disease Infection route Pathology In vivo-mimicking

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Advanced polymer materials-based electronic skins for tactile and non-contact sensing applications

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InfoMat 2023年第7期5卷 1-42页

作者： Feifei Yin Hongsen Niu eun-Seong Kim Young Kee Shin Yang Li nam-Young Kim Department of Electronics Engineering Kwangwoon UniversitySeoulRepublic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Seoul National UniversitySeoulRepublic of Korea School of Information Science and Engineering University of JinanJinanthe People's Republic of China

Recently,polymer materials have been at the forefront of other materials in building high-performance flexible electronic skin(e-skin)devices due to con-spicuous advantages including excellent mechanical flexibility,good compatibil-ity,and high ***,most research works just paid considerable attention and effort to the design,construction,and possible application of e-skins that reproduce the tactile perception of the human skin sensory *** with tactile sensing devices,e-skins that aim to imitate the non-contact sensing features in the sensory system of human skin tend to avoid undesired issues such as bacteria spreading and mechanical *** further promote the development of e-skins to the human skin sensory system where tactile perception and non-contact sensing complement each other,significant progress and advances have been achieved in the field of polymer materials enabled e-skins for both tactile perception and non-contact sensing *** this review,the latest progress in polymer material-based e-skins with regard to tactile,non-contact sensing capabilities and their practical applications are *** fabrication strategies of polymer materials and their role in building high-performance e-skins for tactile and non-contact sensing are ***,we also review the research works that integrated the polymer-based tactile and non-contact e-skins into robots and prostheses,smart gloves,and VR/AR devices and addressed some representative problems to dem-onstrate their suitability in practical applications in human–machine ***,the current challenges in the construction of high-performance tactile and non-contact e-skins are highlighted and promising properties in this direction,by taking advantage of the polymer materials,are outlined.

关键词： electronic skins human-machine interaction non-contact sensing polymer materials tactile sensing

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Stress-Strain Partitioning Analysis in Dual Phase Steels

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Journal of Iron and Steel Research International 2011年第S1期18卷 310-311页

作者： eun-Joon Chun nam-Hyun Kang Yong-Ho Park Man-Been Moon Department of Materials Science and Engineering Pusan National UniversityBusan 609-735South Korea Hyundai HYSCO R&D center 313Donggok-riSongsan-myeonDangjin-gunChungnam 343-831South Korea

Dual-Phase (DP) steels are made of ductile ferrite phase and hard martensite *** it became crucial in progress of automotive industry to save fuel consumption and reduce total weight of vehicles,we need more accurate estimation of distribution to mechanical properties in total amounts of *** steels have considerable difference of mechanical levels in each phase including ferrite and *** is why this study focuses on deconvolution of experimental tensile curve into ferrite and martensite using EBSD for calculation of phase volume fractions and Swift *** for certain parameter of each phase was conducted to produce the deconvolution curves.

关键词： dual phase steel Swift equation EBSD stress-strain partitioning

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OsWRKY65 enhances immunity against fungal and bacterial pathogens in rice

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The Crop Journal 2024年第2期12卷 470-481页

作者： Seungmin Son Giha Song Suhyeon nam Jinjeong Lee Duk-Ju Hwang eun-Jung Suh Sang Ryeol Park National Institute of Agricultural Sciences Rural Development AdministrationJeonju 54874Republic of Korea Department of Agriculture Forestry and BioresourcesPlant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Department of Crop Science and Biotechnology Jeonbuk National UniversityJeonju 54896Republic of Korea

Diverse bacterial and fungal pathogens attack plants,causing biotic stress and severe yield losses *** losses are expected to become more serious as climate change improves conditions for many ***,identifying genes conferring broad-spectrum disease resistance and elucidating their underlying mechanisms provides important resources for plant *** transcription factors affect plant growth and stress ***,the functions of many WRKY proteins remain to be ***,we demonstrated the role of rice(Oryza sativa)WRKY groupⅢtranscription factor OsWRKY65 in ***65 localized to the nucleus and acted as transcriptional *** and molecular functional analyses showed that OsWRKY65 increases resistance to the fungal pathogen Fusarium fujikuroi through downregulation of ga signaling and upregulation of JA ***,OsWRKY65 modulated the expression of the key genes that confer susceptibility or resistance to Xanthomonas oryzae *** to enhance immunity against the *** particular,OsWRKY65directly bound to the promoter region of OsSWEET13 and repressed its *** together,our findings demonstrate that the OsWRKY65 enhances resistance to fungal and bacterial pathogens in rice.

关键词： Bacterial blight Bakanae disease Broad-spectrum disease resistance Oriza sativa OsWRKY65 Rice

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