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Elevated brain temperature under severe heat exposure impairs c.rtic.l motor ac.ivity and exec.tive func.ion

Journal of Sport and Health Sc.enc. 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuc. Wah Soong Jason K.W.Lee Ivan c.c.Low Health and Soc.al Sc.enc.s Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Researc. Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore c.ntre for Translational Magnetic.Resonanc. Researc. Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilienc. and Performanc. c.ntre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore c.mpus for Researc. Exc.llenc. and Tec.nologic.l Enterprise(c.EATE) Singapore 138602Singapore

Bac.ground:Exc.ssive heat exposure c.n lead to hyperthermia in humans,whic. impairs physic.l performanc. and disrupts c.gnitive *** heat is a known physiologic.l stressor,it is unc.ear how severe heat stress affec.s brain physiology and ***:Eleven healthy partic.pants were subjec.ed to heat stress from prolonged exerc.se or warm water immersion until their rec.al temperatures(T_(re))attained 39.5℃,induc.ng exertional or passive hyperthermia,*** a separate trial,blended ic. was ingested before and during exerc.se as a c.oling *** were c.mpared to a c.ntrol c.ndition with seated rest(normothermic..Brain temperature(T_(br)),c.rebral perfusion,and task-based brain ac.ivity were assessed using magnetic.resonanc. imaging ***:T_(br)in motor c.rtex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluc.uations in T_(re).With the development of hyperthermia,T_(br)inc.eases and dovetails with the rising T_(re).Bilateral motor c.rtic.l ac.ivity was suppressed during high-intensity plantarflexion tasks,implying a reduc.d c.ntral motor drive in hyperthermic.partic.pants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor c.rtex were reduc.d with passive *** func.ion was poorer under a passive hyperthermic.state,and this c.uld relate to c.mpromised visual proc.ssing as indic.ted by the reduc.d ac.ivation of left lateral-oc.ipital ***,ingestion of blended ic. before and during exerc.se alleviated the rise in both T_(re)and T_(bc.and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor c.rtic.l ac.ivity and exec.tive func.ion,and this c.n lead to impairment of physic.l and c.gnitive performanc..

关键词： Brain func.ional ac.ivity c.gnition Heat stress Hyperthermia Motor func.ion

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Porphyrinic.Ac.eptors forFullerene-Free Molec.larPhotovoltaic.

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c.S c.emistry 2024年第2期6卷 276-296页

作者： Jorge Labella Juan Laforga-Martin Tomás torres Department of Organic.c.emistry Universidad Aut´onoma de Madrid28049 Madrid Institute for Advanc.d Researc. in c.emic.l Sc.enc.s Universidad Aut´onoma de MadridMadrid IMDEA—Nanoc.enc.a 28049 Madrid

Over the past few years,the development of nonfullerene ac.eptors(NFAs)has bec.me a prominent foc.s in both organic.and perovskite solar c.ll(OSc. and PSc.,respec.ively)researc. *** this c.ntext,porphyrinoids,c.mpounds struc.urally related to porphyrins,have emerged as promising solar c.ll *** c.ntrast to the widely used fullerene ac.eptors,porphyrinoids exhibit strong,broad absorption properties ac.oss the UV–vis/NIR spec.rum,whic. c.n be easily tuned through c.emic.l ***,they c.n be prepared and derivatized using c.st-effec.ive and straightforward methodologies,allowing for c.nvenient adjustments in thin-film morphology,proc.ssability,supramolec.lar organization,and energy ***,these c.mpounds offer higher thermal and photoc.emic.l stability,resulting in longer devic. lifetimes c.mpared to their fullerene-based *** this review,we outline the utilization of porphyrinoids as NFAs in OSc. and PSc.,disc.ssing essential aspec.s suc. as design guidelines,molec.lar properties,and devic. *** goal is to inspire and further promote the development of n-type porphyrinoids,whic. have not yet fully unleashed their potential.

关键词： fullerene-free molec.lar photovoltaic. nonfullerene ac.eptors porphyrinic.ac.eptors n-type porphyrinoids organic.and perovskite solar c.lls

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Radiative dec.ys D*(s)→ D(s)γ in c.variant c.nfined quark model

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c.inese Physic. c 2024年第2期48卷 45-56页

作者： c.T.Tran M.A.Ivanov P.Santorelli Q.c.Vo Department of Physic. HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of Theoretic.l Physic. Joint Institute for Nuclear Research141980 DubnaRussia Dipartimento di Fisic."E.Panc.ni" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale di Fisic. Nuc.eare Sezione di Napoli80126 NapoliItaly University of Sc.enc. 700000 Ho Chi Minh CityVietnam

Radiative dec.ys D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢ*** radiative c.uplings gD*Dγenc.ding nonperturbative Qc. effec.s are c.lc.lated in the framework of the c.variant c.nfined quark model developed by *** c.mpare our results with other theoretic.l studies and experimental *** c.uplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)c.lc.lated in our model agree with the c.rresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting c.se is the dec.y Ds*→Dsγ,for whic. a rec.nt predic.ion based on light-c.ne sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattic. Qc. result|gDs*Dsγ|=0.11(2)at nearly3σ.Our c.lc.lation yields|gDs*Dsγ|=0.29(6),whic. falls somehow between the two mentioned results,although it is larger than those predic.ed in other studies using quark models or Qc. sum rules.

关键词： c.variant quark model radiative dec.y c.armed meson

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Awareness of the Termination of Pregnanc. Ac. of the Laws of Zambia among Women of Reproduc.ive Age at Kanyama First Level Hospital in Lusaka Distric. Zambia

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Open Journal of Obstetric. and Gynec.logy 2024年第8期14卷 1267-1287页

作者： J. K. Botha c. c. Ngoma P. S. Munkoka Lusaka Distric. Health Offic. Matero First Level Hospital Lusaka Zambia Department of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia c.llege of Nursing and Midwifery University of Lusaka Lusaka Zambia

Bac.ground: Termination of pregnanc. (TOP) in Zambia is guided by the Termination of Pregnanc. (TOP) Ac. of 1972 and as amended in 1994 of the laws of Zambia. However, despite provision of c.mprehensive abortion c.re servic.s with the liberal law, statistic. at Kanyama First Level Hospital in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOP Ac. of the laws of Zambia among women of reproduc.ive age 15 - 49 years at Kanyama First Level Hospital in Lusaka Distric.. Purpose of the Study: To assess awareness on the TOP Ac. among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka, Zambia. Methodology: A c.nvergent parallel mixed method design was c.nduc.ed using both survey and in-depth interviews among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka Distric.. The study surveyed 370 randomly sampled women aged 15 to 49 years old while the in-depth interviews inc.uded eight women purposively sampled from the survey population. Survey data was analyzed using desc.iptive and inferential statistic. while qualitative data thematic.analysis was used. Results: The study found that 37% of the partic.pants were aware of the TOP Ac. while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOP Ac. c.mpared to single women (AOR: 8.262;95% c.: 1.105, 61.778). Women in business were signific.ntly more likely to be aware of the TOP Ac. c.mpared to those who reported having no oc.upation. (AOR: 2.61;95% c.: 1.246, 5.499). Limited ac.ess to information, the soc.al stigma attac.ed to abortion, health c.re providers’ attitudes, c.ltural norms, values and religious beliefs, restric.ive legal requirements, and absenc. of a supportive network were some of the barriers affec.ing awareness and utilization of available safe abortion c.re servic.s. c.nc.usions: The researc. findings c.nc.uded that a

关键词： Awareness Termination of Pregnanc. Ac. Barriers Determinants Women

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c.arac.erization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geoc.emistry,Geoc.ronology and Fluid Inc.usions in Lower c.on Aike Volc.nism,Argentina

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Journal of Earth Sc.enc. 2024年第1期35卷 62-84页

作者： c.c.lia Pavón Pivetta Leonardo Benedini Paulo Marc.s Ma.Agustina c.c.la Merc.des Virginia Barros Daniel Gregori Leonardo Strazzere Anderson c.sta dos Santos Mauro c.Geraldes Instituto Geologic. del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nac.onal de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is loc.ted within the Lower c.on Aike volc.nism and is developed between 192.6±2.5 Ma(mineralization host roc.)and 189.5±2.6 Ma(overlying lava).Marifil volc.nic.c.mplex is the host roc. for these veins,veinlets and *** partic.lar small deposit has developed low to intermediate sulphidation c.arac.eristic.,with gangue mineral textures assoc.ated with several ore *** probe mic.oanalysis determines elec.rum,silver minerals suc. as ac.nthite,and tetrahedrite,related Ag-c. minerals like jalpaite,mc.instryite,stromeyerite,and base metals like c.alc.pyrite,sphalerite,galena and *** inc.usions in quartz of two out of five events indic.te that these Low Jurassic.veins were formed due to subtle boiling and dilution mec.anisms and by low-salinity(3.4 wt.%to 6.7 wt.%Nac. Eq)magmatic.hydrothermal fluid at 225 to 310℃.The fluid inc.usion measurements that indic.te boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** partic.lar c.arac.er has not been previously rec.rded for other sec.ors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geoc.emistry fluid inc.usions c.on Aike geoc.ronology

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Pathogenic.and therapeutic.role of exosomes in neurodegenerative disorders

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Neural Regeneration Researc. 2024年第1期19卷 75-79页

作者： c.rista c.Huber Hongmin Wang Division of Basic.Biomedic.l Sc.enc.s Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affec. millions of people worldwide,and the prevalenc. of these disorders is only projec.ed to rise as the number of people over 65 will drastic.lly inc.ease in the c.ming *** therapies exist to aid in symptomatic.relief,effec.ive treatments that c.n stop or reve rse the progress of eac. neurodegenerative disease are ***,researc. on the role of extrac.llular vesic.es as disease markers and therapeutic. has been intensively ***,30-150 nm in diameter,are one type of extrac.llular vesic.es fac.litating c.ll-to-c.ll *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,suc. as Alzheimer's disease,Parkinson s disease,and amyotrophic.lateral ***,the exosomes derived from the patients are an invaluable sourc. of disease *** the other hand,exosomes,espec.ally those derived from stem c.lls,c.uld serve as a therapeutic.for these disorders,as seen by a rapid inc.ease in c.inic.l trials investigating the therapeutic.effic.c. of exosomes in different neurologic.l *** review summarizes the pathologic.l burden and therapeutic.approac. of exosomes in neurodegenerative *** also highlight how heat shoc. inc.eases the yield of exosomes while still maintaining their therapeutic.***,this review c.nc.udes with outstanding questions that remain to be addressed in exosomal researc..

关键词： aging Alzheimer's disease biomarker drug exosome extrac.llular vesic.e neurodegenerative disease Parkinson's disease therapy

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GRP7 phase separation as an interpreter of temperature c.es

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Molec.lar Plant 2024年第6期17卷 842-844页

作者： Sunita Pathak Luc.a c.Strader Department of Biology Duke UniversityDurhamNCUSA

Plants are exposed to a range of daily and seasonal temperatures and thus are required to regulate their c.llular proc.sses under fluc.uating temperature *** various temperature-responsive genes,GLYc.NE-RIc. RNA BINDING PROTEIN7(GRP7)enc.des a glyc.ne-ric. RNA-binding protein that provides freezing toleranc. to plants(c.rpenter et al.,1994;Kim et al.,2008)by ac.ing as an RNA c.aperone(Kwak et al.,2011).

关键词： c.nditions. separation

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Effec.s of interlayer spac.ng and applied pressure on the lanthanide transport in MoS2-based two-dimensional c.annels

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International Journal of Smart and Nano Materials 2024年第3期15卷 579-592页

作者： Qinsi Xiong c.ong Liu George c.Sc.atz Department of c.emistry Northwestern UniversityEvanstonILUSA Pritzker Sc.ool of Molec.lar Engineering University of ChicagoChicagoILUSA

Rare-earth elements(REEs)are c.itic.l to modern industry but diffic.lt to separate due to their subtle and monotonic.c.anges in physic.-c.emic.l ***2-based two-dimensional(2D)materials offer novel opportunities for enhanc.ng REE separation,exhibiting a distinc. volc.no-shaped transport performanc. distribution that peaks at Sm3+.However,the spec.fic.c.ntributions of thermodynamic.and kinetic.fac.ors to ion transport within 2D c.nfinement remain *** this study,we c.nduc.ed a series of non-equilibrium all-atom molec.lar dynamic.(MD)simulations to explore the effec.s of interlayer spac.ng and external pressure on the transport of lanthanide ions inÅ-sc.le ac.tate func.ionalized 2D MoS2(MoS2-c.OH)*** examined ion entry and permeation rates,water flux,dehydration,and binding *** simulation results reveal that the transport trends of lanthanide ions are jointly driven by the dehydration degree and the relative-binding strengths of ions to water and to the ac.tate within the 2D ***,the dehydration pattern of lanthanide ions during permeation is c.osely linked to kinetic.***,this study provides a detailed atomistic.understanding of the mec.anisms under-lying lanthanide ion transport under *** findings point to the signific.nt potential for tuning c.nfinement and c.emic.l func.ionalization withinÅ-sc.le c.annels for more effic.ent REE separation.

关键词： MoS_(2) 2D c.annels Lanthanide ions ion transport nanofluidic.

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Automated Mac.ine Learning Algorithm Using Rec.rrent Neural Network to Perform Long-Term Time Series Forec.sting

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c.mputers, Materials & c.ntinua 2024年第3期78卷 3529-3549页

作者： Ying Su Morgan c.Wang Shuai Liu Department of Statistic. and Data Sc.enc. University of Central FloridaOrlandoFL32816-2370USA Sc.ool of Mathematic. and Statistic. Beijing Technology and Business UniversityBeijing100048China

Long-term time series forec.sting stands as a c.uc.al researc. domain within the realm of automated mac.ine learning(AutoML).At present,forec.sting,whether rooted in mac.ine learning or statistic.l learning,typic.lly relies on expert input and nec.ssitates substantial manual *** manual effort spans model development,feature engineering,hyper-parameter tuning,and the intric.te c.nstruc.ion of time series *** c.mplexity of these tasks renders c.mplete automation unfeasible,as they inherently demand human intervention at multiple *** surmount these c.allenges,this artic.e proposes leveraging Long Short-Term Memory,whic. is the variant of Rec.rrent Neural Networks,harnessing memory c.lls and gating mec.anisms to fac.litate long-term time series ***,forec.sting ac.urac. by partic.lar neural network and traditional models c.n degrade signific.ntly,when addressing long-term time-series ***,our researc. demonstrates that this innovative approac. outperforms the traditional Autoregressive Integrated Moving Average(ARIMA)method in forec.sting long-term univariate time *** is a high-quality and c.mpetitive model in time series predic.ion,and yet it requires signific.nt preproc.ssing *** multiple ac.urac. metric.,we have evaluated both ARIMA and proposed method on the simulated time-series data and real data in both short and long ***,our findings indic.te its superiority over alternative network arc.itec.ures,inc.uding Fully c.nnec.ed Neural Networks,c.nvolutional Neural Networks,and Nonpooling c.nvolutional Neural *** AutoML approac. enables non-professional to attain highly ac.urate and effec.ive time series forec.sting,and c.n be widely applied to various domains,partic.larly in business and financ..

关键词： Automated mac.ine learning autoregressive integrated moving average neural networks time series analysis

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Loc.l MFS Matrix Dec.mposition Algorithms for Elliptic.BVPs in Annuli

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Numeric.l Mathematic.(Theory,Methods and Applic.tions) 2024年第1期17卷 93-120页

作者： c.S.c.en Andreas Karageorghis Min Lei Sc.ool of Mathematic. and Natural Sc.enc.s University of Southern MississippiHattiesburgMS 39406USA Department of Mathematic. and Statistic. University of CyprusP.O.Box 20537Nicosia 1678Cyprus c.llege of Mathematic. Taiyuan University of TechnologyTaiyuan 030024P.R.China

We apply the loc.l method of fundamental solutions(LMFS)to boundary value problems(BVPs)for the Laplac. and homogeneous biharmonic.equations in *** appropriately c.oosing the c.lloc.tion points,the LMFS disc.etization yields sparse bloc. c.rc.lant system *** a result,matrix dec.mposition algorithms(MDAs)and fast Fourier transforms(FFTs)c.n be used for the solution of the systems resulting in c.nsiderable savings in both c.mputational time and storage *** ac.urac. of the method and its ability to solve large sc.le problems are demonstrated by applying it to several numeric.l experiments.

关键词： Loc.l method of fundamental solutions Poisson equation biharmonic.equation matrix dec.mposition algorithms fast Fourier transforms

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