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Blind equalization and automatic modulation classification based on subspace for subcarrier MPSK optical communications

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Optoelectronics Letters 2017年第4期13卷 304-308页

作者： CHEN Dan guo lin-yuan WANG Chen-hao KE Xi-zheng School of Automation ＆ Information Xi ＇an University of Technology Xi＇an 710048 China Xi ＇an Polytechnic University Xi ＇an 710048 China

Equalization can compensate channel distortion caused by channel multipath effects, and effectively improve convergent of modulation constellation diagram in optical wireless system. In this paper, the subspace blind equalization algorithm is used to preprocess M-ary phase shift keying(MPSK) subcarrier modulation signal in receiver. Mountain clustering is adopted to get the clustering centers of MPSK modulation constellation diagram, and the modulation order is automatically identified through the k-nearest neighbor(KNN) classifier. The experiment has been done under four different weather conditions. Experimental results show that the convergent of constellation diagram is improved effectively after using the subspace blind equalization algorithm, which means that the accuracy of modulation recognition is increased. The correct recognition rate of 16 PSK can be up to 85% in any kind of weather condition which is mentioned in paper. Meanwhile, the correct recognition rate is the highest in cloudy and the lowest in heavy rain condition.

关键词： Blind equalization Meteorology Nearest neighbor search Optical communication Optical signal processing Optical systems Phase shift keying Signal receivers

Local aneurysmal dilatation mimicking stent malapposition and concurrent vulnerable plaque within neointima of normal lumen after drug-eluting stent implantation： primary new findings from optical coherence tomography

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Chinese Medical Journal 2012年第6期125卷 1186-1188页

作者： guo yuan-lin YANG Yue-jin GAO Zhan QIAN Jie Clinical and Research Center for Coronary Disease Fu Wai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China

Very late stent thrombosis is a life-threatening complication of implantation of drug-eluting stent （DES）. The mechanisms are still unidentified. Stent malapposition is supposed to be one debated reason. Here we report a case of 33 months after DES implanted. Observed by optical coherence tomography, we detected a lipid-rich plaque with defective fibrous cap within the neointima and many local aneurysmal dilatations between stent struts, which mimic ＂malapposition＂ on the angiogram. These indicated that vulnerable plaque hidden in the neointima at the stent segment might be a potential mechanism of very late stent thrombosis after DES implantation.

关键词： drug-eluting stent stent malapposition vulnerable plaque optical coherence tomography

Plasma apo CⅢ Levels in Relation to Inflammatory Traits and Metabolic Syndrome in Patients not Treated with Lipid-lowering Drugs Undergoing Coronary Angiography

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Biomedical and Environmental Sciences 2017年第1期30卷 1-9页

作者： WU Na Qiong LI Sha ZHANG Yan ZHU Cheng Gang guo yuan lin GAO Ying QING Ping SUN Jing LIU Geng DONG Qian LI Jian Jun Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medieal Sciences Peking Union Medical College Beijing 100037China

Objective Assessment of the comprehensive relationship among apolipoprotein CIII（apoCⅢ） levels, inflammation, and metabolic disorders is rare. Methods A total of 1455 consecutive patients not treated with lipid-lowering drugs and undergoing coronary angiography were enrolled in this cross-sectional study. A mediation analysis was used to detect the underlying role of apoCⅢ in the association of inflammation with metabolic syndrome（MetS）. Results Patients with MetS showed higher levels of apoCⅢ [95.1（73.1-131.4） vs. 81.7（58.6-112.4） μg/mL, P 〈 0.001] and inflammatory markers [high sensitivity C-reactive protein, 1.7（0.8-3.4） vs. 1.1（0.5-2.2） mg/L; white blood cell count,（6.48 ± 1.68） vs.（6.11 ± 1.67） × 10~9/L]. The levels of apoCⅢ and inflammatory markers increased with the number of metabolic risk components（all P 〈 0.001）. Furthermore, apoCⅢ levels were associated with virtually all individual MetS risk factors and inflammatory markers（all P 〈 0.05）. Importantly, the prevalence of MetS in each metabolic disorder rose as apoCⅢ levels increased（all P 〈 0.05）. Mediation analysis showed that apoCⅢ partially mediated the effect of inflammation on MetS independently from triglycerides. Conclusion Plasma apoCⅢ levels were significantly associated with the development and severity of MetS, and a role of apoCⅢ in the effect of inflammation on the development of MetS was identified.

关键词： lowering inflammation Plasma apo C severity Lipid prevalence obesity mediation apolipoprotein virtually

道的拓展与文的突破——乾隆帝《开惑论》分析

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北京社会科学 2016年第4期 4-12页

作者：郭院林扬州大学文学院扬州225005

乾隆帝统一新疆后,撰写了《开惑论》。依据史料,《开惑论》中所谓"浮议"有确切史实,乾隆帝此文不仅是对用兵新疆否决意见的一次总反驳,还体现了对治道的拓展。乾隆帝站在正义的高度,表明自己能够建立超迈祖上功绩的原因在于"天眷"。乾... 详细信息

乾隆帝统一新疆后,撰写了《开惑论》。依据史料,《开惑论》中所谓"浮议"有确切史实,乾隆帝此文不仅是对用兵新疆否决意见的一次总反驳,还体现了对治道的拓展。乾隆帝站在正义的高度,表明自己能够建立超迈祖上功绩的原因在于"天眷"。乾隆帝《开惑论》不仅掌握了话语权,而且颠覆了历史上士人对开疆拓土的批评。乾隆帝一方面重视史实的叙述,一方面强调思想的阐述,这样就突破了赋的外在形式特点,造成《开惑论》有别于传统的赋体。乾隆帝通过《开惑论》,重新建构并维系了中国疆域观与多民族国家观。从这个意义上讲,《开惑论》确实起到了祛疑与开惑的作用。

关键词：乾隆开惑论华夷之辩治道赋

Efficacy and Safety of Generic Dasatinib as a Second-line Treatment for Patients with Chronic Myeloid Leukemia:a Multicenter Retrospective Study in Hubei Province,China

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Current Medical Science 2018年第6期38卷 1005-1011页

作者： Li-feng CHEN guo-lin yuan Zhao-dong ZHONG Ping ZOU Deng-ju LI Yin BAO Hong-bo REN Li MENG Wei-ming LI Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Hematology Xiangyang Central HospitalXiangyang 441000China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology Xiangyang No.1 People's HospitalXiangyang 441000China Department of Hematology the First People's Hospital of JingzhouJingzhou 434000China

Dasatinib is a second-generation tyrosine kinase inhibitor (TKI)and it could be used as a second-line treatment for patients with chronic myeloid leukemia (CML).Yinishu,a generic dasatinib made in China,was approved by the China Food and Drug Administration in 2013 and it costs much less than the patented dasatinib *** present study aimed to examine the efficacy and safety of Yinishu as a second-line treatment for CML by comparing the baseline clinical characteristics,rates of adverse events and efficacy between Yinishu and SPRYCEL groups. The results showed that there were no significant differences in the rates of optimal response between Yinishu and SPRYCEL for patients who started second-line treatment because of treatment *** patients who started second-line treatment because of intolerance of first-line treatment, their levels of BCR-ABL1/ABL1 on the international scale (BCR-ABL^IS)was maintained very low throughout the course of Yinishu ***-related adverse events occurred with the same frequency in these two *** was confirmed that Yinishu was effective and safe as a second- line treatment for CML *** may be more suitable for patients who are economically unable to pay for the patented dasatinib SPRYCEL.

关键词： chronic myeloid leukemia generic dasatinib second-line treatment efficacy safety

Lipoprotein(a) as a Marker for Predicting the Presence and Severity of Coronary Artery Disease in Untreated Chinese Patients Undergoing Coronary Angiography

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Biomedical and Environmental Sciences 2018年第4期31卷 253-260页

作者： SUN Di ZHAO Xi LI Sha ZHANG Yan WU Na Qiong ZHU Cheng Gang guo yuan lin GAO Ying QING Ping LIU Geng DONG Qian LI Jian Jun Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College

Objective Low-density lipoprotein cholesterol（LDL-C） has been well known as the risk factor of coronary artery disease（CAD）. However, the role of lipoprotein（a） [Lp（a）] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp（a） on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C. Methods We consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162 patients were diagnosed with CAD. Gensini score（GS） was used to assess the severity of CAD. Lp（a） was measured by immunoturbidimetric method. Results Patients with CAD had higher level of LDL-C and Lp（a） compared with non-CAD（P 〈 0.05）. Multivariable logistic regression revealed that Lp（a）〉 205 mg/L（highest tertile） predicted 1.437-fold risk for CAD（95% CI： 1.108-1.865, P = 0.006） and 1.480-fold risk for high GS（95% CI： 1.090-2.009, P = 0.012） respectively. Interestingly, concomitant elevated level of Lp（a） and LDL-C conferred the highest risk for both presence [OR = 1.845, 95% CI： 1.339-2.541, P 〈 0.001] and severity [OR = 1.736, 95% CI： 1.188-2.538, P = 0.004] of CAD. Conclusion Lipoprotein（a） is a useful marker for predicting the presence and severity of CAD, especially combined with LDL-C.

关键词： Lipoprotein(a) LDL-C Coronary artery disease Chinese

Circulating MicroRNAs as Novel Diagnostic Biomarkers for Very Early-onset(≤40 years) Coronary Artery Disease

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Biomedical and Environmental Sciences 2016年第8期29卷 545-554页

作者： DU Ying YANG Sheng Hua LI Sha CUI Chuan Jue ZHANG Yan ZHU Cheng Gang guo yuan lin WU Na Qiong GAO Ying SUN Jing DONG Qian LIU Geng LI Jian Jun Division of Dyslipidemia State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseaseCAMS and PUMC

Objective Very early-onset coronary artery disease （CAD） is a great challenge in cardiovascular medicine throughout the world, especially regarding its early diagnosis. This study explored whether circulating microRNAs （miRNAs） could be used as potential biomarkers for patients with very early-onset CAD. Methods We performed an initial screening of miRNA expression using RNA isolated from 20 patients with angiographically documented very early-onset CAD and 20 age- and sex-matched normal controls. For further confirmation, we prospectively examined the miRNAs selected from 40 patients with very early-onset CAD and 40 angiography-normal controls. Results A total of 22 overexpressed miRNAs and 22 underexpressed miRNAs were detected in the initial screening. RT-qPCR analysis of the miRNAs obtained from the initial screening revealed that four miRNAs including miR-196-5p, miR-3163-3p, miR-145-3p, and miR-190a-5p exhibited significantly decreased expression in patients compared with that in controls （P〈0.05）. The areas under the receiver operating characteristic curve for these miRNAs were 0.824 （95% CI, 0.731-0.917; P〈0.001）, 0.758 （95% CI, 0.651-0.864; P〈0.001）, 0.753 （95% CI, 0.643-0.863; P〈0.001）, and 0.782 （95% CI, 0.680-0.884; P〈0.001）, respectively, in the validation set. Conclusion To our knowledge, this is an advanced study to report about four serum miRNAs （miR-196-5p, miR-3163-3p, miR-145-3p, and miR-190a-5p） that could be used as novel biomarkers for the diagnosis of very early-onset CAD.

关键词： MicroRNA Biomarker Early-onset coronary artery disease

A randomized comparative study of using enoxaparin instead of unfractionated heparin in the intervention treatment of coronary heart disease

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Chinese Medical Journal 2006年第5期119卷 355-359页

作者： CHEN Ji-lin CHEN Jue QIAO Shu-bin guo yuan-lin WU Yong-jian DAI Jun yuan Jin-qing QIN Xue-wen YANG Yue-jin GAO Run-lin Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China

Background Low molecular weight heparin （LMWH） was more effective than unfractionated heparin （UFH） in treating acute coronary syndrome （ACS）. However, it remains uncertain whether LMWH can be used in patients undergoing percutaneous coronary intervention （PCI） instead of UFH. This study aimed to evaluate the efficacy and safety of using enoxaparin instead of UFH in the intervention treatment of patients with coronary heart disease （CHD） .Methods From October 2003 to Febuary 2005, 966 patients with CHD were enrolled into this study. Among 966 patients, 455 patients received the PCI, including 283 patients with Non-ST segment elevation ACS （NSTEACS）, 511 patients did not received PCI due to mild, moderate lesions or were suitable for coronary artery bypass graft （CABG）. The 966 patients were randomized to enoxaparin group （484 patients） and UFH group （482 patients）. Patients in the enoxaparin group were given enoxaparin at least twice subcutaneously （1 ms/kg, q12 h） before catheterization. Plasma anti-Xa activity was determined 1-8 hours after the last dose of enoxaparin was determined. The catheterization was performed within 8 hours after the last dose of enoxaparin. The sheath was removed immediately after the procedure. Patients in the UFH group were given UFH 25 mg intravenously before coronary angiography. Additional 65 mg was given intravenously if PCI was to be performed. The sheath was removed 4 hours after the procedure. Results A total of 227 patients in the enoxaparin group and 228 patients in the UFH group received PCI. In the enoxaparin group, one patient developed acute thrombosis during PCI and resulted in acute myocardial infarction （AMI）, no acute or subacute thrombosis was found during hospitalization. In the UFH group, no acute or subacute thrombosis occurred during PCI procedure and hospitalization. Therefore, the incidence of major adverse cardiovascular events （MACEs） during the hospitalization was 0.44% in the enoxaparin group and 0 in the

关键词： enoxaparin unfractionated heparin percutaneous coronary intervention

Impact of Smoking Status on Lipoprotein Subfractions： Data from an Untreated Chinese Cohort

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Biomedical and Environmental Sciences 2017年第4期30卷 235-243页

作者： ZHAO Xi ZHANG Hui Wen ZHANG Yan LI Sha XU Rui Xia SUN Jing ZHU Cheng Gang WU Na Qiong GAO Ying guo yuan lin LIU Geng DONG Qian LI Jian Jun Division of Dyslipidemia State Key Laboratory of Cardiovascular DiseaseFu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical SciencesPeking Union Medical College

Objective Cigarette smoking is one of the established risk factors of atherosclerotic cardiovascular disease, however, its impact on lipids is not completely understood, especially in the Chinese population. Therefore, this study evaluated the impact of smoking status （non, former, and current smoking） on the distribution of lipoprotein subfractions in untreated patients with angina-like chest pain. Methods A total of 877 patients were consecutively enrolled and divided into nonsmoking （n = 528）, former smoking （n = 103）, and current smoking （n = 256） groups. Both low- and high-density lipoprotein cholesterol （LDL-C and HDL-C） subfractions were measured using the Quantimetrix Lipoprint System. The distributions of lipoprotein subfractions were evaluated among the groups. Results Compared with nonsmoking subjects, the current smoking group had significantly lower large/medium HDL-C （both P 〈 0.001） concentration and large HDL subfraction percentage but higher small HDL-C and medium LDL-C concentrations as well as medium LDL subfraction percentage. Importantly, former smoking subjects showed elevated levels of large HDL-C concentration, large HDL particle percentage, and mean LDL particle size and attenuation in small HDL/LDL percentages and small LDL-C concentration, but these levels did not reach the optimal status compared with those of the non-smoking group （data not shown）. Conclusion Smoking has an adverse impact on the lipoprotein subfractions, presented as lower large HDL particles besides higher small HDL and medium LDL particles, whereas smoking cessation could reverse these change to a certain degree.

关键词： Smoking Smoking cessation Lipoprotein subfractions Chinese