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木质素水热解聚研究进展

化学与粘合 2018年第6期40卷 435-439页

作者：陈冰玉郝国夏张瀚文邸明伟东北林业大学材料科学与工程学院黑龙江哈尔滨150040

木质素是由苯丙烷单元通过C-C键和醚键连接而成的天然高分子材料,结构中含有大量的芳香基以及甲氧基、酚羟基、醇羟基、羰基、醛基等基团,是自然界唯一能提供可再生芳香化合物的非石油资源,其如何被有效利用一直受到人们的关注,尤其是... 详细信息

木质素是由苯丙烷单元通过C-C键和醚键连接而成的天然高分子材料,结构中含有大量的芳香基以及甲氧基、酚羟基、醇羟基、羰基、醛基等基团,是自然界唯一能提供可再生芳香化合物的非石油资源,其如何被有效利用一直受到人们的关注,尤其是通过化学解聚的方法将木质素转化为化工单体:以代替石油基产品是近年来木质素开发利用的研究热点。基于木质素的结构,从木质素的水热解聚出发,综述了木质素在酸催化水热解聚、碱催化水热解聚及其它介质中水热解聚的研究进展,对其存在问题和解决方法进行了合理分析,并对未来木质素水热解聚的发展方向进行了展望。

关键词：木质素解聚水热酸催化碱催化

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu Min guo Jianxin Zhao hao Zhang Gang Wang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

Frequency and size change of ice–snow avalanches in the central Himalaya:A case from the Annapurna Ⅱ glacier

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Advances in Climate Change Research 2024年第3期15卷 464-475页

作者： Yao LI Yi-Fei CUI Jian-Sheng hao Zheng-Tao ZHANG hao WANG Jian guo Shuo-Fan WANG State Key Laboratory of Hydroscience and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Hydrosphere Sciences of the Ministry of Water Resources Beijing 100084China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of National Safety and Emergency Management Beijing Normal UniversityBeijing 100875China Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China

Glaciers have retreated and shrunk in High Mountain Asia since the mid-20th century because of global warming,leading to glacier instability and hazardous iceesnow ***,the complex relationship between iceesnow avalanches and factors such as climate and potential triggers are difficult to understand because of the lack of observational ***,we addressed iceesnow avalanches on the Annapurna Ⅱ glacier in Nepal,Central *** constructed an iceesnow avalanche history using long-term multi-source remote sensing images(1988-2021)and mapped the velocity fields of glaciers using cross-correlation analysis on SAR and optical ***,we investigated the impact of climate change and earthquakes on the frequency and size of iceesnow *** results demonstrate that the frequency of iceesnow avalanches has increased from 10 in 1988 to 27 in 2020,but the average area of iceesnow avalanche deposits has decreased by approximately 70%,from 3.4×10^(5) m^(2) in 1988 to 1.2×10^(5) m^(2) in *** evolutionary characteristic of ice avalanches is linked to the impact of glacier retreat(reduction in ice material supply)and increased activity under climate *** glacier movement velocity controls the size of iceesnow avalanches and can be set as an indicator for iceesnow avalanche *** the Annapurna Ⅱ glacier,an iceesnow avalanche occurred when the glacier velocities were greater than 1.5 m d^(-1).These results offer insights into iceesnow avalanche risk assessment and prediction in high-mountain areas,particularly in regions characterised by dense glacier distribution.

关键词： Iceesnow avalanche Glacier instability Climate change Central Himalaya Remote sensing

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冠心病患者阿司匹林抵抗的危险因素分析

中国当代医药 2018年第10期25卷 56-58页

作者：周立尧郭建浩李剑平陈若峰王佳广东省佛山市顺德区北滘医院心血管内科广东佛山528311

目的研究冠心病患者阿司匹林抵抗的危险因素。方法回顾性分析我院2012年1月~2017年4月收治的冠心病患者的临床资料,按纳入与排除标准分别筛选发生阿司匹林抵抗(AR组)与未发生AR患者(NAR组)各40例,比较两组患者的一般临床资料及相关实验... 详细信息

目的研究冠心病患者阿司匹林抵抗的危险因素。方法回顾性分析我院2012年1月~2017年4月收治的冠心病患者的临床资料,按纳入与排除标准分别筛选发生阿司匹林抵抗(AR组)与未发生AR患者(NAR组)各40例,比较两组患者的一般临床资料及相关实验室指标,分析冠心病患者发生AR的危险因素。结果 AR组的视黄醇结合蛋白(RBP)水平低于NAR组,肌酐(SCr)、Hcy、CD62P水平高于NAR组,差异有统计学意义(P<0.05)。以是否发生AR为自变量,Hcy、CD62P均为冠心病患者发生AR的危险因素,以Hcy危险值最高。结论 Hcy、CD62P均为冠心病患者发生AR的危险因素,或可成为预估冠心病患者发生AR风险的有效指标。

关键词：阿司匹林抵抗冠心病危险因素

紫杉醇联合小剂量顺铂和持续静滴低剂量氟尿嘧啶治疗晚期胃癌35例

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临床肿瘤学杂志 2006年第3期11卷 195-197页

作者：夏国豪刘德林许红霞潘良熹江苏省肿瘤医院肿瘤内科南京210009

目的：观察紫杉醇（PTX）联合小剂量顺铂（PDD）和持续静滴低剂量氟尿嘧啶（5-FU）治疗晚期胃癌的疗效和毒副反应.方法：全组35例患者中,贲门癌14例,胃体癌21例,应用PTX 90mg/m^2,第1、8天;5-FU 250mg/m^2持续24小时静滴,连用12天;PDD 6... 详细信息

目的：观察紫杉醇（PTX）联合小剂量顺铂（PDD）和持续静滴低剂量氟尿嘧啶（5-FU）治疗晚期胃癌的疗效和毒副反应.方法：全组35例患者中,贲门癌14例,胃体癌21例,应用PTX 90mg/m^2,第1、8天;5-FU 250mg/m^2持续24小时静滴,连用12天;PDD 6mg/（m^2·d）静滴,连用5天,间隔2天,再用5天,21天为1周期,平均用药3.06个周期.结果：全组35例均可评价,获得CR 3例,PR 17例,SD 10例,PD 5例,有效率（CR＋PR）为57.1%,肿瘤控制率（CR＋PR＋SD）为85.7%,中位TTP为9个月（1～32个月）,中位生存时间13个月（2～35个月）.主要不良反应为骨髓抑制、恶心呕吐和粘膜炎.结论：紫杉醇联合小剂量顺铂和持续静滴低剂量氟尿嘧啶治疗晚期胃癌患者疗效较好,不良反应可以耐受,值得深入研究.

关键词：晚期胃癌紫杉醇顺铂氟尿嘧啶持续静滴化疗

Performance and safety of transport vehicles fueled with alternative fuels in plateau environment:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 930-944页

作者： Wanjiang guo Hui Wang hao Chen Binyan Yu Ying Wang Jianyou Zhao Shaanxi Key Laboratory of New Transportation Energy and Automotive Energy Saving Chang'an UniversityXi'an 710064China School of Civil and Transportation Engineering Qinghai Minzu UniversityXining 810000China

Alternative fuels including natural gas,alcohols and biodiesel for transport vehicles have been applied ***,the performance and safety of alternative fuel vehicles have changed when the application environment varies from plain condition to the plateau,resulting from the variation of air density and atmospheric *** gasfueled vehicles exhibited lower output and greater fuel consumption than gasoline-fueled vehicles in plateau *** oxygenated additives including alcohols and biodiesel can supply extra oxygen into the cylinder,which may benefit the engine performances compared with traditional petroleum in plateau ***,compared with plain environment,vehicles fueled with oxygenated fuels worsen the engine thermal efficiency,the power performance and the fuel economy in the *** the increase of altitude,HC and CO emissions increase;whereas NO_(x)emissions show no evident change at various *** boosting,spark or injection timing optimization,and intake manifold optimization can effectively improve the combustion and performance of vehicles in the *** is another significant factor for application of alternative *** with plain environment,safeties of vehicles fueled with natural gas or biodiesel in the plateau have not been reduced,whereas safety of methanol and ethanol vehicles decrease,because they are easier to form air fuel mixture,have lower flash points,and have higher possibilities of gas *** study proves that the performance and safety and alternative fuel vehicles deteriorate when the application locale varies from the plain region to the plateau region.

关键词： Natural gas Alcohols Biodiesel Safety Plateau

预钻孔斜形尺骨截骨短缩术治疗尺骨撞击综合征的临床疗效分析

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中华手外科杂志 2017年第6期33卷 444-446页

作者：尹善青王欣潘佳栋黄耀鹏丁文全周丹亚王胜伟王科杰郭浩宁波市第六医院手外科浙江315000

目的探讨预钻孔斜形尺骨截骨短缩术治疗尺骨撞击综合征的临床疗效。方法自2012年5月至2015年7月，我们采用预钻孔斜形尺骨截骨短缩术治疗35例尺骨撞击综合征患者，记录手术时间，比较术前、术后的疼痛及功能恢复情况，根据VAS评分以及... 详细信息

目的探讨预钻孔斜形尺骨截骨短缩术治疗尺骨撞击综合征的临床疗效。方法自2012年5月至2015年7月，我们采用预钻孔斜形尺骨截骨短缩术治疗35例尺骨撞击综合征患者，记录手术时间，比较术前、术后的疼痛及功能恢复情况，根据VAS评分以及改良的Mayo腕关节评分和上肢功能评价表（DASH）对临床效果进行评价。结果平均手术时间45．7min（32～60min），术后平均随访时间15个月（6。36个月），所有病例截骨部位均获得骨性愈合，平均愈合时间为12周，VAS评分由术前（7．4±0．6）分改善为术后（2．8±1．3）分，差异有统计学意义（P〈O．05），改良的Mayo腕关节评分由术前（53．0±16．3）分提高至术后（84．0±10．2）分，差异有统计学意义（P〈0．05），其中优23例，良10例，可2例。DASH评分由术前（57．0±18．2）分降低至术后（26．1±18．5）分，差异有统计学意义俨〈0．05），5例患者术后有钢板激惹症状。结论预钻孔斜形尺骨截骨短缩术能减少软组织的损伤，截骨的骨愈合率较高，并发症较少，能明显改善患者的症状，实现与采用截骨工具截骨同样满意的临床效果。

关键词：尺骨治疗结果截骨尺骨撞击综合征

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变频调速节能技术在石油化工工业的应用

化工设计通讯 2019年第3期45卷 56-56页

作者：郭浩王哲中石油管道有限责任公司西气东输分公司陕西西安710016

企业生产规模不断扩大,生产的能耗非常高,节能降耗任务非常严峻。为了有效降低石油化工生产过程中的能耗,可以将变频调速技术应用在生产过程中。

关键词：变频调速石油化工工业应用

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一起由乌盖利沙门菌引起的食物中毒调查

预防医学情报杂志 2010年第3期26卷 230-230页

作者：郭皓陈松达州市疾病预防控制中心四川达州635000

目的在区域性食源性疾病监测网络实验室中了解本区域内沙门菌的病原分布情况、流行情况、生化鉴定、血清分型、抗生素敏感性试验和致病基因情况。方法按照区域性食源性疾病监测网络实验室平台建立的研究和达州市食源性疾病监测方案实施... 详细信息

目的在区域性食源性疾病监测网络实验室中了解本区域内沙门菌的病原分布情况、流行情况、生化鉴定、血清分型、抗生素敏感性试验和致病基因情况。方法按照区域性食源性疾病监测网络实验室平台建立的研究和达州市食源性疾病监测方案实施。结果对5份患者肛拭,7份食品进行细菌分离、生化试验与血清学诊断,其中1份患者肛拭,3份食品检出乌盖利沙门菌。结论证实这是1起由乌盖利沙门菌引起的食物中毒暴发事件。乌盖利沙门菌是一个极少见的血清型,为四川省首次分离出来。

关键词：区域性食源性疾病监测网络实验室乌盖利沙门菌