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Membrane-coated nanoparticles as a biomimetic targeted delivery system for tumour therapy

Biomaterials Translational 2024年第1期5卷 33-45页

作者： guo h. guo M. Xia Z. Shao Z. Department of Orthopaedic Beijing Jishuitan Hospital Capital Medical University Beijing China Department of Orthopaedic Beijing Jishuitan Hospital Fourth Medical College of Peking University Beijing China National Center for Orthopaedics Beijing China Department of Orthopaedics Affiliated Hospital of NCO School of Army Medical University Hebei Province Shijiazhuang China Centre for Nanohealth ILS2 Medical School Swansea University Swansea United Kingdom Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Hubei Province Wuhan China

Drug therapy towards tumours often causes adverse effects because of their non-specific nature. Membrane-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe delivery. By camouflaging the nanoparticles with natural derived or artificially modified cell membranes, the nano-payloads are bestowed with properties from cell membranes such as longer circulation, tumour or inflammation-targeting, immune stimulation, augmenting the performance of traditional therapeutics. In this review, we review the development of membrane coating technology, and summarise the technical details, physicochemical properties, and research status of membrane-coated nanoparticles from different sources in tumour treatment. Finally, we also look forward to the prospects and challenges of transforming membrane coating technology from experiment into clinical use. Taken together, membrane-coated nanoparticles are bound to become one of the most potential anti-tumour strategies in the future. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： biomimetic targeted delivery system membrane-coated nanoparticles membrane-coated technology tumour therapy

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胸部挤压伤致声带麻痹、发声障碍法医学鉴定1例

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法医学杂志 2024年第1期40卷 101-103页

作者：虢洪松刘晓贺韦红红李长征济宁医学院法医学与医学检验学院山东济宁272002 济宁医学院司法鉴定中心山东济宁272002

1案例1.1简要案情桑某,女,13岁,某年10月6日因意外被挤伤胸部后出现声带麻痹、发声障碍。受某法院委托,要求就其声带麻痹、发声障碍与胸部挤压伤之间是否存在因果关系及原因力大小进行法医学鉴定。1.2病史摘要某年10月6日桑某因“被机... 详细信息

1案例1.1简要案情桑某,女,13岁,某年10月6日因意外被挤伤胸部后出现声带麻痹、发声障碍。受某法院委托,要求就其声带麻痹、发声障碍与胸部挤压伤之间是否存在因果关系及原因力大小进行法医学鉴定。1.2病史摘要某年10月6日桑某因“被机器挤压胸部后不省人事、烦躁不安1 h”入住甲医院。体格检查:神志不清,烦躁不安;前胸及后背皮肤散在擦伤;双肺呼吸音粗,可闻及大量湿啰音。胸部CT示:双肺上叶挫伤并肺气囊形成;双侧气胸(肺组织压缩约10%);肋骨多发骨折。

关键词：法医学胸部损伤挤压伤声带麻痹发声障碍

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共享社会经济路径(SSP1~5)中国及分省人口预估数据集_v2

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气候变化研究进展 2024年第4期20卷 492-497页

作者：郭欢欢景丞姜彤苏布达王艳君杨聿铭南京信息工程大学地理科学学院/灾害风险管理研究院南京210044 南京信息工程大学气候与环境治理研究院南京210044 中国科学院新疆生态与地理研究所荒漠与绿洲生态国家重点实验室乌鲁木齐830011 江苏第二师范学院地理科学学院南京210013

政府间气候变化专门委员会(IPCC)第六次评估报告综合报告《气候变化2023》明确指出自工业化以来,人类活动带来的温室气体排放导致全球变暖,使全球极端天气气候事件日益增多,对自然和人类的发展带来巨大挑战[1]。为反映未来社会经济面临... 详细信息

政府间气候变化专门委员会(IPCC)第六次评估报告综合报告《气候变化2023》明确指出自工业化以来,人类活动带来的温室气体排放导致全球变暖,使全球极端天气气候事件日益增多,对自然和人类的发展带来巨大挑战[1]。为反映未来社会经济面临的气候变化适应和减缓挑战,IPCC提出5种共享社会经济路径,包括可持续发展路径(SSP1)、中间路径(SSP2)、区域竞争路径(SSP3)、不均衡路径(SSP4),以及以传统化石燃料为主的路径(SSP5)。开展SSP1~5路径下人口的变化预估,是气候变化影响研究和气候政策制定的核心。

关键词：气候变化适应极端天气气候事件气候变化影响经济路径全球变暖化石燃料人口预估 SSP

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu F.M.Cai h.Cai J.J.Cao Q.h.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen h.Chen h.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen h.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.h.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.guo F.K.guo J.C.guo J.guo Y.P.guo Z.h.guo A.Guskov K.L.han L.han M.han X.Q.hao J.B.he S.Q.he X.G.he Y.L.he Z.B.he Z.X.heng B.L.hou T.J.hou Y.R.hou C.Y.hu h.M.hu K.hu R.J.hu W.h.hu X.h.hu Y.C.hu J.hua G.S.huang J.S.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.J.huang Y.B.huang Y.S.huang N.hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.h.Li C.Li D.Y.Li F.Li G.Li G.Li h.B.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li S.Li T.Li W.J.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li Z.J.Li h.Liang J.h.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu h.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.h.Luo h.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer h.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of Science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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A digital earth prototype system:DEPS/CAS

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International Journal of Digital Earth 2009年第1期2卷 3-15页

作者： h.guo X.Fan C.Wang Key Laboratory of Digital Earth Science Center for Earth Observation and Digital EarthChinese Academy of SciencesBeijing 100190China

Digital Earth is an information expression of the real Earth,and is a new way of understanding the Earth in the twenty-first *** paper introduces a Digital Earth Prototype System(DEPS)developed at the Chinese Academy of Sciences(CAS)and supported by the Knowledge Innovation Program of the Chinese Academy of *** are made to the theoretical model and technical framework of the Digital Earth,and its related key technologies on spatial information processing,spatial data warehouse technology,virtual reality technology,high-performance and parallel *** DEPS consists of seven sub-systems including the spatial data,metadata,model database,Grid geoscience computing,spatial information database,maps service and virtual ***,we developed a series of application systems such as the environment monitoring for the Olympic Games 2008 in Beijing,natural disasters evaluation,digital city,digital archeology,Asia regional aerosol and climate *** DEPS/CAS displayed the application ability and potential of the Digital Earth in three levels:the global,national and regional.

关键词： Digital Earth prototype system grid information service virtual reality map services information application

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Two-dimensional numerical algorithm for water quality modeling in the topographically complicated river

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Journal of Environmental Sciences 2000年第4期12卷 469-473页

作者： Zeng, G. Jiang, Y. guo, h. huang, G.G.-h. Environmental Protection Institute Human University Hunan 410082 China

In this paper, a two-dimensional numerical calculation algorithm for the water quality modeling in the hengyang City section of the Xiangjiang River is researched considering the effect of the Dayuandu navigational key project. The research river is winding and has two branches resulted from an isle. The numerical calculation algorithm for the water quality modeling is set up on the basis of applying topographic map of the river course and the finite element method. The calculation result for the water quality modeling includes the concentration fields for various pollutants. The numerical calculation algorithm for the water quality modeling set up in this paper can be applied to shallow river with similar topographically complicated river course.

关键词： Algorithms Finite element method River pollution Rivers

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Diameter-dependent in vitro performance of biodegradable pure zinc wires for suture application

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Journal of Materials Science & Technology 2019年第8期35卷 1662-1670页

作者： h. guo R.h. Cao Y.F. Zheng J. Bai F. Xue C.L. Chu State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China School of Materials Science and Engineering Southeast University Nanjing 211189 China Key Laboratory for Advanced Metallic Materials Southeast University Nanjing 211189 China

In this study, biodegradable pure zinc wires with 3.0 mm and 0.3 mm in diameter were prepared via hot-extrusion and subsequent cold-drawing process respectively. The microstructure, mechanical performance, corrosion behavior, in vitro cytocompatibility and antibacterial effect were comparatively *** cold-drawing, the mechanical property, especially the elongation of the ф0.3 mm pure Zn wire was improved significantly compared with the ф3.0 mm pure Zn wire. The in vitro corrosion study including immersion and electrochemical test showed acceptable corrosion resistance of these two materials in hank's solution. The in vitro human Umbilical Vein Endothelial Cells(hUVECs) viability assay showed obviously different results, in which the ф0.3 mm pure Zn wire demonstrated favorable cytocompatibility, while the ф3.0 mm wire exhibited severe cytotoxic effect with 100% extract concentration. Both of them exhibited partly antibacterial effect on S. aureus. These results demonstrated the feasibility of the prepared 0.3 mm pure Zn wire as the potential suture material with good absorbability.

关键词： Pure zinc Wire Biodegradable metal Suture

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MICROSTRUCTURE AND MEChANICAL PROPERTIES OF Mg-Li ALLOY WITh Ca ADDITION

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Acta Metallurgica Sinica(English Letters) 2006年第5期19卷 355-361页

作者： h.B. Li G. C. Yao Z.Q. guo Y.h. Liu h.J. Yu h.B. Ji School of Materials ＆ Metallurgy Northeastern University Shenyang 110004 China

Mg-9wt%Li-2wt%Zn alloy was prepared and studied in this article. The addition of Ca to the alloy from 0.1wt% to 1wt% can refine the α-Mg and the best effect of refinement occurs when Ca content is 0.4wt%-0.5wt%. The billets can be rolled to thin sheets at room temperature, from which it is obvious that the addition of Ca improves alloys ormalin. while it decreases with the excess addition of Ca. The results also show that the ultimate tensile strength （UTS） and yield strength （YS） of the alloy with lwt% Ca may rise by 28% and 25%, respectively, however, the elongation decreases. It is clarified that the adsorption of proper Ca on the grain boundaries refines α-Mg and improves the tensile properties, but the presence of excess Ca and stable Ca2Mg6Zn3phase worsens the elongation.

关键词： calcium Mg-Li-Zn alloy cold rolling microstructure tensile property

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A Quantitative Analysis of Mn Segregation at Partitioned Ferrite/Austenite Interface in a Fe-C-Mn-Si Alloy

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Journal of Materials Science & Technology 2009年第3期25卷 383-388页

作者： h. guo S.W. Yang C.J.Shang X.M. Wang X.L. he Department of Materials Physics and Chemistry University of Science and Technology Beijing Beijing 100083 China

Mn segregation at austenite/ferrite interface is studied in a Fe-C-Mn-Si alloy held at 656℃. Mn is partitioned during the growth of ferrite and as a result, a Mn pile-up exists in front of interface on the matrix side. An approach to evaluate Mn segregation quantitatively is developed by combining STEM raster window scanning and simulation of the interaction of the electron beam with the sample to subtract the contribution of Mn pile-up and obtain pure Mn segregation value. The evaluated maximum Mn interfacial segregation is in the order of a half-monolayer.

关键词： Interfacial segregation Phase transformation STEM Beam broadening

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CREVICE CORROSION BEhAVIOR OF X70 STEEL IN hCO_3^- SOLUTION UNDER CAThODIC POLARIZATION

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Acta Metallurgica Sinica(English Letters) 2008年第4期21卷 235-244页

作者： C.W. Du X.G. Li X. Chen P. Liang h. guo School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Liaoning University of Petroleum and Chemical Technology ~shun 113001 China

The crevice corrosion behavior of XTO steel was investigated with a wedge-shaped crevice assembly under -1000 m V （SCE） cathodic polarization in the solutions with various hCO3 concentrations. The potential, current, ph and the oxygen content within the crevice were measured with or without outside coupled specimen. The results indicated that the polarization potential of XTO steel in the crevice dropped with the increase of time under the cathodic polarization. There was a remarkable influence of hCO3 concentration on the potential of XTO steel in the crevice. When hCO3 concentration was up to 0.125%, the surface of the metal was covered with the corrosion products that resulted in the polarization extent of XTO steel decreased. The ph value in the crevice rose and it dropped gradually from the crevice mouth to the bottom under the cathodic polarization. With the increasing of hCO3 concentration, the hydrolyzation reaction of metal in the crevice bottom aggravated. Most of the dissolved oxygen in the crevice was consumed by the cathodic current. The maximum cathodic current on the metal surface was at the crevice mouth and it was much more than that at the crevice bottom.

关键词： Cathodic polarization XTO steel Potential ph value Oxygen

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