Comparison of body weight and food consumption in young adult SD rats
作者单位：WuXi AppTec Co.Ltd.
会议日期：2013年
学科分类：10[医学]
摘 要：An meta-analysis was performed for control animals from over 25 toxicology studies to assess potential differences in body weight gain and food consumption between Sprague-Dawley rats sourced from commercial suppliers in the USA(Charles River-CR),***(Vital River-VR) and Taiwan(BioLasco-BL).The mean body weight and food consumption was calculated weekly for animals in the age range 6 to 35 *** to approximately 15 weeks of age,CR males were generally lighter than BL males,after this time the growth rate of the CR males appeared to exceed that of those from BL.A similar pattern was seen for female rats with the CR animals exhibiting lower body weight than BL rats before approximately 11 weeks of *** age 11 weeks the CR rats were heavier than BL *** VR animals, initial growth was similar to CR rats,and followed closer to the BL growth rate from approximately week *** general, the CR male and female SD rats grew faster than those from either BL or *** the male rats there were no clear differences in food consumption between CR and BL animals,in comparison food consumption for the VR rats was a little lower. For the females,CR rats tended to show a higher food intake than both BL and VR,with the food for consumption from animals from the latter two sources being generally *** observed differences between the three sources of animals demonstrate the need to be consistent in the source of animals for different studies in toxicology development programs with a single compound,and also the need for maintaining separate back ground data bases.