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Journal of Magnesium and Alloys 2024年第1期12卷 120-138页

作者： Zhao-Qi Zhang bing-Zhi Li Pei-Duo Tong Shao-Kang Guan Li Wang Zheng-Hui Qiu Cun-guo Lin Rong-Chang Zeng School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou 450001China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101China Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao 266590China

Constructing a functional hybrid coating appears to be a promising strategy for addressing the poor corrosion resistance and insufficient endothelialization of Mg-based ***,the steps for preparing composite coatings are usually complicated and ***,a novel composite coating,composed of bioactive magnesium thioctic acid(MTA)layer formed by deposition and corrosion-resistant magnesium hydroxide(Mg(OH)_(2))layer grown in situ,is simply fabricated on ZE21B alloys via one-step *** electron microscopy(SEM)shows that the electrodeposited coating has a compact and uniform *** the high adhesion of the MTA/Mg(OH)_(2)hybrid coating is also confirmed by the micro-scratch *** test,scanning kelvin probe(SKP),and hydrogen evolution measurement indicate that the hybrid coating effectively reduces the degradation rate of Mg *** experiment and cell culture trial detect that the composite coating is of fine ***,the preparation mechanism of MTA/Mg(OH)_(2)hybrid coatings is discussed and *** coating shows a great potential application for cardiovascular stents.

关键词： Magnesium alloy Corrosion resistance Hybrid coating Endothelialization Biocompatibility

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long Jiajia Liu Yu Wang Haidong guo guohong cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells

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Genes & Diseases 2024年第2期11卷 558-560页

作者： Zhicai Peng Zhuo Wang Shuaichi guo bing Tan Ruichao Cao Shengqiang Cheng Jun Chen Chunwang Xie Dehong Mao Zhenming Hu Department of Orthopaedics Yongchuan Traditional Chinese Medicine Hospital of ChongqingChongqing 402160China Department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Spine Surgery The Third Hospital of MianyangSichuan Mental Health CenterMianyangSichuan 621000China

Intervertebral disc degeneration(IDD)is the main cause of lower back *** back pain places a huge burden on society,and all current treatments for IDD cannot restore the original function of the intervertebral *** new treatments for IDD requires clarifying the mechanisms of *** hypoxia is an important feature of the nucleus pulposus because of its special anatomical *** RNA sequencing(RNA-seq),we obtained the whole transcriptome of nucleus pulposus cells(NPCs)under hypoxia and hypoxia-inducible factor(HIF1A)*** demonstrated possible effects of oxygen concentration and HIF1A on *** addition,our results showed that hypoxia can affect lipid metabolism in NPCs.

关键词： structure metabolism degeneration

Inhibiting oxygen vacancies and twisting NbO_(6) octahedron in erbium modified KNN-based multifunctional ceramics

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Journal of Materiomics 2024年第1期10卷 179-189页

作者： Lulu Gao Zhiyong Liu Pengrong Ren Renhong Liang Ting Li Kun guo bing Xie Jinshan Lu Pu Mao Jun Tian Longlong Shu School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Materials Science and Engineering Xi'an University of TechnologyXi'an710048China School of Physics and Materials Science Nanchang UniversityNanchang330031China Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang330096China

It is a challenge to obtain highly tunable multifunctional performances in one ferroelectric system by a simple approach to meet the miniaturization,integration,and functionalization requirements of advanced electronic ***,rare earth erbium(Er)modulated 0.9K_(0.5)Na_(0.5)NbO_(3)-0.1Sr(1-x)Er_(x)Ti_((1-x/4))O_(3),(0.9KNN-0.1ST:xEr)transparent-photoluminescent-ferroelectric energy storage multifunctional ceramics are prepared to solve this *** effect of lattice distortion and oxygen vacancies by Er doping on the optical and electrical properties is systematically *** Er^(3+)ions can introduce a large distortion of the NbO_(6) octahedron by replacing the A-site in KNN-based *** to the higher c/a ratio and lower oxygen vacancy content are simultaneously obtained in 0.9KNN-0.1ST:0.1Er *** effective energy storage density(Wrec)of 0.86 J/cm^(3),excellent near-infrared transmittance of 51.7%(1100 nm)and strong green upconversion photoluminescence are achieved in this multifunctional *** study provides a solid basis for rare earth ions doped ferroelectric ceramics with tunable multifunctional properties and has significant potential for applications in optoelectronic devices.

关键词： KNN Upconversion photoluminescence Multifunctional ceramics Oxygen vacancy Octahedron

Dynamic tracking of exsolved PdPt alloy/perovskite catalyst for efficient lean methane oxidation

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Chinese Chemical Letters 2024年第4期35卷 170-175页

作者： Yanling Yang Zhenfa Ding Huimin Wang Jianhui Li Yanping Zheng Hongquan guo Li Zhang bing Yang Qingqing Gu Haifeng Xiong Yifei Sun College of Energy Xiamen UniversityXiamen 361005China School of Environment and Civil Engineering Dongguan University of TechnologyDongguan 523808China Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

Supported Pd based catalysts are considered as the efficient candidates for low-carbon alkane oxidation for their outstanding capability to break C-H bond. Whereas, the irreversible deactivation of Pd based catalysts was still frequently observed. Herein, we reinforced the extruded Pd nanoparticles with quantitive Pt to assemble the evenly distributed Pd Pt nanoalloy onto ferrite perovskite(Pd Pt-LCF) matrix with strengthened robustness of metal/oxide support interface. We further co-achieved the enhanced performance, anti-overoxidation as well as resistance of vapor-poisoning in durability measurement. The operando X-ray photoelectron spectroscopy(O-XPS) combined with various morphology characterizations confirms that the accumulation of surface deep-oxidation species of Pd^(4+) is the culprit for fast activity loss in exsolved Pd system, especially at high temperature of 400 ℃. Conversely, it could be completely suppressed by in-situ alloying Pd with equal amount of Pt, which helps maintain the metastable Pd^(2+)/Pd shell and metallic solid-solution core structure. The density function theory(DFT) calculations further buttress that the dissociation of C–H was facilitated on alloy/perovskite interface which is, on the contrary, resistant toward O–H bond cleavage, as compared to Pd/perovskite. Our work suggests that the modification of exsolved metal/oxide catalytic interface could further enrich the toolkit of heterogeneous catalyst design.

关键词： Exsolution PdPt alloy Operando characterization Methane conversion Deep-oxidation

Cold storage alters the fat-trehalose trade-off,decreases the flight ability,and maintains the high survival rate and flight speed of Osmia excavata(Hymenoptera:Megachilidae)

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Insect Science 2024年第3期31卷 927-936页

作者： Yingying Song Li Liu Fang Ouyang Hongying cui Wenxiu guo Suhong Lv Baohua Ye Lili Li Yi Yu Xingyuan Men Institute of Plant Protection Shandong Academy of Agricultural SciencesJinanChina College of Plant Protection Shandong Agricultural UniversityJinanChina State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBejingChina

Osmia solitary bees are important pollinators of various crops *** has been widely used to synchronize the emergence time of Osmia species from cocoons with the blooming time of different crops,but the fitness of Osmia after refrigeration remains ***,the effects of long-term refrigeration at 0℃on the vitality,flight ability,and metabolism of Osmia excavata,which is known as the"king of pollination"in China,were *** survival rate(>90%before 120 d),weight loss rate(<15%after 170 d),and mean flight speed of *** were not greatly affected after long-term *** content of fats,which have antifreeze and energy storage properties,was not significantly altered in *** before 130 d of refrigeration,which might explain why the survival rates and flight speed of *** remained high after long-term ***,the flight duration and distance decreased significantly(P<0.05),and both were positively correlated with the reduced trehalose levels in ***(r=[+0.69]-[+0.71];P<0.05).Overall,these findings indicate that the pollination potential of *** for various crops with different flowering periods is high after long-term refrigeration;however,long-term refrigeration may decrease pollination *** findings highlight new research directions that could improve the ecological service function of refrigerated ***.

关键词： ecological service value flight ability Osmia pollination efficiency refrigeration vitality

Wetting front migration model of ion-adsorption rare earth during the multi-hole unsaturated liquid injection

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 483-496页

作者： Yu Wang Xiaojun Wang Yuchen Qiu Hao Wang Gang Li Kaijian Hu Wen Zhong Zhongqun guo bing Li Chunlei Zhang Guangxiang Ye Jiangxi Key Laboratory of Mining Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Resources and Environment Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Civil Engineering and Surveying&Mapping Engineering Jiangxi University of Science and TechnologyGanzhou341000China Ganzhou Nonferrous Metallurgy Research Institute Ganzhou341000China

In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still ***,wetting front migration distance and leaching time are usually required to optimize the leaching *** this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head *** the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were *** the postintersection stage,the intersection accelerated the wetting front *** using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the ***,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was *** analysis results showed that the proposed model can accurately simulate the infiltration process under experimental *** research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.

关键词： Ion-adsorption rare earth ore Multi-hole unsaturated liquid injection In situ leaching Intersection effect Calculation model

Development of red phosphor Li_(8)CaLa_(2)Ta_(2)O_(13):Eu^(3+)for WLEDs and anti-counterfeiting applications

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ChemPhysMater

ChemPhysMater 2024年第2期3卷 194-203页

作者： Jingjing Ru Fan Zeng bing Zhao Chenqing Ye Tonghui Zhong Feiyun guo Jianzhong Chen College of Chemistry and Materials Fujian Province University Key Laboratory of Green Energy and Environment CatalysisNingde Normal UniversityNingde 352100China School of Environment and Resources School of Carbon Neutral and Modern IndustryFujian Normal UniversityFuzhou 350007China College of Information and Mechanical&Electrical Engineering Ningde Normal UniversityNingde 352100China College of Chemistry Fuzhou UniversityFuzhou 350108China

A set of novel red phosphors Li_(8)CaLa_(2)Ta_(2)O_(13):Eu^(3+)(LCLTO:xEu^(3+))were successfully prepared using a solid-state reaction *** properties of the prepared samples,including phase purity,elemental composition,and morphology,were systematically investigated using X-ray diffraction,scanning electron microscopy,and diffuse reflectance spectroscopy *** 610 nm maximum emission peak is attributed to the^(5)D_(0)→^(7)F_(2)transition of Eu^(3+)ion under 394 nm *** all the LCLTO:xEu^(3+)phosphors,LCLTO:0.6Eu^(3+)showed the strongest emission intensity because of the concentration quenching effect of the electric dipole-dipole in-teraction among the Eu^(3+)ions,which was also demonstrated by the decay ***,the emission intensity of the optimal LCLTO:0.6Eu^(3+)phosphor,which exhibited a high internal quantum efficiency of 49.30%and excellent color purity of 96.79%,was approximately 2.29 times higher than that of commercial Y203:Eu^(3+)red *** thermal stability of the LCLTO:0.6Eu^(3+)sample with good color stability was meticulously *** fabricated white-light-emitting diode(WLED)exhibited a superior color-rendering index of Ra=82 and chromaticity coordinates of(0.3260,0.3639),suggesting that LCLTO:0.6Eu^(3+)has potential applicability in developing efficient and high-quality ***,the prepared LCLTO:0.6Eu^(3+)/PDMS composite film demonstrated exceptional flexural resistance and chemical stability,indicating considerable promise for practical anti-counterfeitingapplications.

关键词： Phosphor Tantalate Luminescence LED device

New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

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Science China Earth Sciences 2024年第2期67卷 531-551页

作者： Junyi GE Xiaoling ZHANG Shejiang WANG Linhui LI Wei HE Yingshuai JIN Peiqi ZhANG bing XU Chenglong DENG John WOLSEN Zhengtang guo Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating

Development of a clinical nomogram for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 396-408页

作者： bing Liu Yu-Jie Xu Feng-Ran Chu Guang Sun guo-Dong Zhao Sheng-Zhong Wang Department of Gastrointestinal Surgery Central South University Xiangya School of Medicine Affiliated Haikou HospitalHaikou 570208Hainan ProvinceChina Clinical College Hainan Medical UniversityHaikou 571199Hainan ProvinceChina

BACKGROUND The efficacy of neoadjuvant chemotherapy(NAC)in advanced gastric cancer(GC)is still a controversial *** To find factors associated with chemosensitivity to NAC treatment and to provide the optimal therapeutic strategies for GC patients receiving *** The clinical information was collected from 230 GC patients who received NAC treatment at the Central South University Xiangya School of Medicine Affiliated Haikou Hospital from January 2016 to December *** absolute shrinkage and selection operator logistic regression analysis was used to find the possible predictors.A nomogram model was employed to predict the response to *** In total 230 patients were finally included in this study,including 154 males(67.0%)and 76 females(33.0%).The mean age was(59.37±10.60)years,ranging from 24 years to 80 *** to the tumor regression grade standard,there were 95 cases in the obvious response group(grade 0 or grade 1)and 135 cases in the poor response group(grade 2 or grade 3).The obvious response rate was 41.3%.Least absolute shrinkage and selection operator analysis showed that four risk factors significantly related to the efficacy of NAC were tumor location(P<0.001),histological differentiation(P=0.001),clinical T stage(P=0.008),and carbohydrate antigen 724(P=0.008).The C-index for the prediction nomogram was *** calibration curve revealed that the predicted value exhibited good agreement with the actual *** curve analysis showed that the nomogram had a good value in clinical *** A nomogram combining tumor location,histological differentiation,clinical T stage,and carbohydrate antigen 724 showed satisfactory predictive power to the response of NAC and can be used by gastrointestinal surgeons to determine the optimal treatment strategies for advanced GC patients.

关键词： Advanced gastric cancer Predictor Neoadjuvant chemotherapy Nomogram Tumor regression grade