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Communications in Theoretical Physics 2006年第4期45卷 614-616页

作者： gui wei-jun gui jia-zhang tang gang Department of Machinery and Electronic Engineering Nanchang institute of Technology Nanchang 330099 China

In this paper, we find the invariant eigen-operators （IEOs） and the energy-level gap of a system with a two-level atom interacting with single mode cavity field through multi-photon transition in the presence of a Kerr-like medium. From this work, one can see that the IEO method in many eases is simpler and easier on obtaining the energy-level gap formula than the usual way.

关键词： energy-level gap Kerr-like medium invariant eigen-operator

Laboratory astrophysics with laser-driven strong magnetic fields in China

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High Power Laser Science and Engineering 2016年第3期4卷 67-70页

作者： Fei-Lu Wang Xiao-Xing Pei Bo Han Hui-gang wei Da-wei Yuan gui-Yun Liang gang Zhao jia-Yong Zhong Zhe zhang Bao-jun Zhu Yan-Fei Li Fang Li Yu-Tong Li Si-Liang Zeng Shi-Yang Zou Jie zhang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Astronomy Beijing Normal University Beijing National Laboratory of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Institute of Applied Physics and Computational Mathematics Shanghai jiao Tong University

In this paper, the recent studies of laboratory astrophysics with strong magnetic fields in China have been *** the Shenguang-II laser facility of the National Laboratory on High-Power Lasers and Physics, a laser-driven strong magnetic field up to 200 T has been achieved. The experiment was performed to model the interaction of solar wind with dayside magnetosphere. Also the low beta plasma magnetic reconnection(MR) has been studied. Theoretically, the model has been developed to deal with the atomic structures and processes in strong magnetic field. Also the study of shock wave generation in the magnetized counter-streaming plasmas is introduced.

关键词： Laboratory astrophysics laser strong magnetic fields

Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

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Military Medical Research 2023年第1期10卷 64-77页

作者： Peng Gao Yan-Qing Liu wei Xiao Fei Xia jia-Yun Chen Li-wei Gu Fan Yang Liu-Hai Zheng jun-Zhe zhang Qian zhang Zhi-Jie Li Yu-Qing Meng Yong-Ping Zhu Huan tang Qiao-Li Shi Qiu-Yan Guo Ying zhang Cheng-Chao Xu Ling-Yun Dai Ji-gang Wang Artemisinin Research Center Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Geriatrics the Second Clinical Medical College of Jinan Universitythe First Affiliated Hospital of Southern University of Science and TechnologyShenzhen People’s HospitalShenzhen 518020GuangdongChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)Singapore 138673Singapore Department of Biological Sciences National University of SingaporeSinga‑pore 117543Singapore

Background: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine(CQ) has played an indispensable role, however, its mechanism of action(MoA) is not fully ***: We used the principle of photo-affinity labeling and click chemistry-based functionalization in the design of a CQ probe and developed a combined deconvolution strategy of activity-based protein profiling(ABPP) and mass spectrometry-coupled cellular thermal shift assay(MS-CETSA) that identified the protein targets of CQ in an unbiased manner in this study. The interactions between CQ and these identified potential protein hits were confirmed by biophysical and enzymatic ***: We developed a novel clickable, photo-affinity chloroquine analog probe(CQP) which retains the antimalarial activity in the nanomole range, and identified a total of 40 proteins that specifically interacted and photocrosslinked with CQP which was inhibited in the presence of excess CQ. Using MS-CETSA, we identified 83 candidate interacting proteins out of a total of 3375 measured parasite proteins. At the same time, we identified 8 proteins as the most potential hits which were commonly identified by both ***: We found that CQ could disrupt glycolysis and energy metabolism of malarial parasites through direct binding with some of the key enzymes, a new mechanism that is different from its well-known inhibitory effect of hemozoin formation. This is the first report of identifying CQ antimalarial targets by a parallel usage of labeled(ABPP)and label-free(MS-CETSA) methods.

关键词： Chloroquine Antimalaria Activity-based protein profiling(ABPP) Cellular thermal shift assay(CETSA) Quantitative proteomics

An all-round Al-Chemist with a scientific mind

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National Science Review 2022年第10期9卷 158-168页

作者： Qing Zhu Fei zhang Yan Huang Hengyu Xiao Lu Yuan Zhao Xu Chun zhang Tao Song Xin Sheng tang Xiang Li Guo He Bao Chen Chong jun Yi Zhou Yi Han zhang Baicheng zhang jia Qi Cao Man Luo Song Wang gui Lin Ye Wan jun zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li jialei Li gang Zou wei wei Shang jun jiang Yi Luo Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials Science University of Science and Technology of China School of Information Science and Technology University of Science and Technology of China Hefei Ji Shu Quantum Technology Co.Ltd Hefei National Laboratory University of Science and Technology of China

The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI) *** AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains ***,we present an all-round AI-Chemist e quipped with scientific data intelligence that is capable of performing basic tasks generally re quired in chemical *** on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans *** can control a mobile robot in-house or online to automatically execute the complete experimental process on 14workstations,including synthesis,characterization and performance *** experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be *** competence of the AI-Chemist has been scrutinized by three different chemical *** the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory.

关键词： AI-Chemist computational brain mobile robot machine reading all-round research

Consensus on the digestive endoscopic tunnel technique

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World Journal of Gastroenterology 2019年第7期25卷 744-776页

作者： Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian zhang Yu Bao wei-gang Chen Philip WY Chiu Tong Dang wei Gong Shu-tang Han jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu jun Liu Xiao-gang Liu Zhi-Guo Liu Ying-Cai Ma gui-Yong Peng Long Rong wei-Hong Sha Pateek Sharma jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-gang Yu Ping-Hong Zhou Bin zhang Xiao-Feng zhang Ya-Qi Zhai Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology the First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an 710000Shaanxi ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endoscopy Eastern Hepatobiliary Surgical Hospital Affiliated to Naval Medical UniversityShanghai 200438China Department of Gastroenterology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Division of Gastroenterology and Hepatology the Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Gastrointestinal Endoscopy Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Gastroenterology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Second Xiangya Hospital of Central South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Gastroenterology General Hospital of Chinese People’s Armed Police ForcesBeijing 100039China Division of Gastroenterology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Gastroenterology Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Xijing HospitalAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Digestion Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Gastroenterology Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Gastroenterology Peking Univ

With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) *** present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative *** International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations).

关键词： Digestive endoscopic tunnel technique Endoscopic submucosal tunnel dissection Per-oral endoscopic myotomy Submucosal tunnelling endoscopic resection Gastrointestinal tract

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富勒烯氢化物的合成研究进展

有机化学 2006年第7期26卷 922-927页

作者：张军平王乃兴汪武卫赵嘉王桂霞唐石中国科学院理化技术研究所北京100101

综述了十几年来富勒烯氢化物各种合成方法,不同的氢化方法所得的氢化物不同;并对富勒烯氢化物在储氢材料方面的应用作了展望.

关键词：富勒烯富勒烯氢化物合成储氢材料

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU Yuan Yue ZHENG Rui Zhi WANG gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN gui jun WAN Qin CHEN gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen zhang Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO jia jun CHEN Lu Lu MU Yi Ming tang Xu Lei HU Ru Ying WANG wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin University Changchun 130021JinlinChina Qilu Hospital of Shandong University Jinan 250012ShandongChina Affiliated Hospital of guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai jiaotong University School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical University Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical University Nanning 530021GuangxiChina jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical University Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai jiading District Shanghai 201800China jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical University Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering

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Nuclear Science and Techniques 2021年第5期32卷 101-106页

作者： wei Nan Bing Guo Cheng-jian Lin Lei Yang Dong-Xi Wang Yang-Ping Shen Bing tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming jia Yun-Ju Li Chen Chen Li-Hua Chen Qi-Wen Fan Xin-Yue Li gang Lian jian-Cheng Liu Tian-Peng Luo Nan-Ru Ma Rui-gang Ma Xie Ma Ying-jun Ma wei-Ke Nan Dan-Yang Pang You-Bao Wang Pei-wei Wen Feng Yang Yong-Jin Yao Sheng Zeng Hao zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong Li Tian-Jue zhang wei-Ping Liu BRIF Collaboration China Institute of Atomic Energy(CIAE) P.O.Box 275(10)Beijing 102413China Department of Physics Guangxi Normal UniversityGuilin 541004China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China School of Physics Beihang UniversityBeijing 100191China Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China

The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current *** scattering is a useful probe for investigating the size and surface diffuseness of exotic *** development of rare isotope accelerators offers opportunities for such *** date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite *** this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb *** angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same *** work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei.

关键词： BRIF Exotic nuclei Elastic scattering Angular distribution

Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-gang Yao Li Lu Rong-jun Ni Rui Bi Ceshi Chen jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer Bao-Ci Shan Fang Shen An-Zhou tang Jing Wang wei Xia Xueshan Xia Ling Xu Dandan Yu Feng zhang Ping Zheng Yong-tang Zheng Jumin Zhou jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

VEGF、PCNA、Ki-67、P53表达与垂体腺瘤侵袭性的相关研究

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中华神经外科杂志 2008年第1期24卷 28-31页

作者：吉宏明贾贵军张钢利张汉伟山西省人民医院神经外科太原030012

目的研究VEGF、PCNA、Ki-67、P53在垂体腺瘤中的表达，探讨其与垂体腺瘤侵袭性的关系。方法采用SP免疫组化技术，检测45例垂体腺瘤中VEGF、PCNA、Ki-67、P53的表达，并计数MVD，结合影像、手术及病理结果等进行统计学分析。结果（1）垂... 详细信息

目的研究VEGF、PCNA、Ki-67、P53在垂体腺瘤中的表达，探讨其与垂体腺瘤侵袭性的关系。方法采用SP免疫组化技术，检测45例垂体腺瘤中VEGF、PCNA、Ki-67、P53的表达，并计数MVD，结合影像、手术及病理结果等进行统计学分析。结果（1）垂体腺瘤中VEGF、PCNA、P53表达在非侵袭性与侵袭性组之间差异有统计学意义（P〈0．05），Ki-67在非侵袭性与侵袭性组之间无统计学意义（x^2=0．020，P〉0．05）；（2）垂体腺瘤中VEGF、MVD的表达与垂体腺瘤病理分型之间有一定关系，在垂体腺瘤PRL病理型组中有统计学意义（x^2=9．396，P〈0．05），PCNA、P53、Ki-67的表达在病理分型PRL、GH组中无统计学意义。结论（1）VEGF、PCNA、P53的表达在非侵袭性与侵袭性组之间有统计学意义，可作为判断垂体腺瘤侵袭性的重要指标；Ki-67的表达在非侵袭性与侵袭性组之间无统计学意义，Ki-67更多地反映恶性肿瘤的增殖性及预后；（2）VEGF、MVD在垂体腺瘤PRL病理型组中有统计学意义，PCNA、P53、Ki-67在病理分型PRL、GH组中无统计学意义，提示血管密度的改变不能完全代表垂体腺瘤的侵袭性，或者仅在垂体腺瘤某些病理型中可以代表一定的侵袭性。

关键词：侵袭性垂体腺瘤血管内皮生长因子增殖细胞核抗原 Ki-67核抗原 P53蛋白