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Hydrogen generation from ammonia electrolysis on bifunctional platinum nanocubes electrocatalysts

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Journal of Energy Chemistry 2020年第8期29卷 234-240,I0009页

作者： Hui-Ying Sun guang-Rui Xu Fu-Min Li Qi ng-Li ng Hong Pu-Jun Jin Pei Chen Yu Chen Key Laboratory of Macromolecular Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry(Ministry of Education)Shaanxi Key Laboratory for Advanced Energy DevicesSchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710062ShaanxiChina School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'an 710062ShaanxiChina

The ammonia electrolysis is a highly efficient and energy-saving method for ultra-pure hydrogen generation, which highly relies on electrocatalytic performance of electrocatalysts. In this work, high-quality platinum(Pt) nanocubes(Pt-NCs) with 4.5 nm size are achieved by facile hydrothermal synthesis. The physical morphology and structure of Pt-NCs are exhaustively characterized, revealing that Pt-NCs with special {100} facets have excellent uniformity, good dispersity and high crystallinity. Meanwhile, the electrocatalytic performance of Pt-NCs for ammonia electrolysis are carefully investigated in alkaline solutions, which display outstanding electroactivity and stability for both ammonia electrooxidation reaction(AEOR) and hydrogen evolution reaction(HER) in KOH solution. Furthermore, a symmetric Pt-NCs||Pt-NCs ammonia electrolyzer based on bifunctional Pt-NCs electrocatalyst is constructed, which only requires 0.68 V electrolysis voltage for hydrogen generation. Additionally, the symmetric Pt-NCs||Pt-NCs ammonia electrolyzer has excellent reversible switch capability for AEOR at anode and HER at cathode, showing outstanding alternating operation ability for ammonia electrolysis.

关键词： Ammonia electrolysis Water electrolysis Ammonia oxidation reaction Hydrogen evolution reaction Platinum nanocubes

Genetic Variants in EGFR/PLCE1 Pathway Are Associated with Prognosis of Esophageal Squamous Cell Carcinoma after Radical Resection

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Current Medical Science 2019年第3期39卷 385-390页

作者： Yu-li WAng Ye YUAN Xiao-xiao LUO guang-yuan HU Ping G0ng Department of Oncology the First Affiliated Hospital of the Medical College Shihezi University Shihezi 832008China Department of Clinical Medicine School of Medicine Shihezi University Shihezi 832008China Department of Oncology Tongji HospitalTongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China

Esophageal cancer (EC) is one of the most deadly malignant diseases. Several studies revealed that variations of the phospholipase C epsilon 1 (PLCE1) gene were associated with EC susceptibility. PLCE1 is located downstream of the epidermal growth factor receptor (EGFR) pathway. Presently, the single nucleotide polymorphisms (SNPs) of EGFR/PLCE1 genes and their associations with EC survival remain unclea匚 In this study, the associations between genetic variants in the EGFR/PLCE1 pathway and prognosis in 124 esophageal squamous cell carcinoma (ESCC) patients with radical resection were explored. The results showed that CC genotype of both PLCE1 rsl7109671 and EGFR rs2072454 was associated with ESCC prognosis. Multivariate analysis revealed that patients with the two unfavorable genotypes had the worst overall survival (OS) or disease-free survival (DFS)(HR=6.099, 95%CI=1.903-19.552;HR=3.994, 95%CI=1.49-10.702, respectively). Additionally, combination of SNPs and tumor stage could better predict OS (for AUC, 0.774 vs. 0.709) and PFS (for AUC, 0.773 vs. 0.704) than tumor stage *** conclusion, genetic variants of the EGFR/PLCE1 may be predictors of the prognosis of ESCC after surgery. The individuals with the CC genotype of PLCE1 rsl7109671 and EGFR rs2072454 should receive more aggressive treatments.

关键词： esophageal squamous cell carcinoma prognosis single nucleotide polymorphism survival epidermal growth factor receptor

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考虑弹性的高速旋转轮对振动特性研究

振动工程学报 2016年第4期29卷 714-719页

作者：杨光任尊松孙守光北京交通大学机械与电子控制工程学院北京100044

轮对弹性变形和旋转振动对轮轨系统运行安全性影响需要从理论上进行深入研究。利用ANSYS有限元分析软件对轮对弹性化处理后,在SIMPACK多体动力学软件中建立了包含高速旋转弹性体轮对的车辆系统动力学模型。采用数值方法,得到了轮轴弹性... 详细信息

轮对弹性变形和旋转振动对轮轨系统运行安全性影响需要从理论上进行深入研究。利用ANSYS有限元分析软件对轮对弹性化处理后,在SIMPACK多体动力学软件中建立了包含高速旋转弹性体轮对的车辆系统动力学模型。采用数值方法,得到了轮轴弹性弯曲变形量以及不同轨道不平顺激扰下轮对垂向振动加速度响应等。结果表明,考虑弹性和旋转振动后,轮对车轴发生弯曲变形效应明显且中部变形量最大,车辆运行速度对车轴弯曲变形量和轮轨附加动力有一定的影响,轮对垂向振动加速度频谱出现与旋转速度相关的频率特征。本文方法和结果对揭示轮对真实运动特征和研究高速轮轨安全性具有良好的指导意义。

关键词：弹性轮对高速列车旋转频率特征

Nonnegative Low Rank Matrix Completion by Riemannian Optimalization Methods

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Annals of Applied Mathematics 2023年第2期39卷 181-205页

作者： guang-Jing Song Michael K.ng School of Mathematics and Information Sciences Weifang UniversityWeifangShandong 261061China Department of Mathematics The University of Hong KongHong KongChina

In this paper,we study Riemannian optimization methods for the problem of nonnegative matrix completion that is to recover a nonnegative low rank matrix from its partial observed *** the underlying matrix incohence conditions,we show that when the number m of observed entries are sampled independently and uniformly without replacement,the inexact Riemannian gradient descent method can recover the underlying n_(1)-by-n_(2)nonnegative matrix of rank r provided that m is of O(r^(2)slog^(2)s),where s=max{n_(1),n_(2)}.Numerical examples are given to illustrate that the nonnegativity property would be useful in the matrix *** particular,we demonstrate the number of samples required to recover the underlying low rank matrix with using the nonnegativity property is smaller than that without using the property.

关键词： Manifolds tangent spaces nonnegative matrices low rank

Rutin pretreatment promotes microglial M1 to M2 phenotype polarization

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Neural Regeneration Research 2021年第12期16卷 2499-2504页

作者： guang-Ping Lang Can Li Ying-Ying Han Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyiGuizhou ProvinceChina Special Key Laboratory of Oral Diseases Research Higher Education Institutions of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Microglial cells are important resident innate immune components in the central nervous system that are often activated during *** microglia can display one of two phenotypes,M1 or M2,which each play distinct roles in ***,a dietary flavonoid,exhibits protective effects against ***,whether rutin is able to influence the M1/M2 polarization of microglia remains *** this study,in vitro BV-2 cell models of neuroinflammation were established using 100 ng/mL lipopolysaccharide to investigate the effects of 1-hour rutin pretreatment on microglial *** results revealed that rutin pretreatment reduced the expression of the proinflammatory cytokines tumor necrosis factor-α,interleukin-1β,and interleukin-6 and increased the secretion of *** pretreatment also downregulated the expression of the M1 microglial markers CD86 and inducible nitric oxide synthase and upregulated the expression of the M2 microglial markers arginase 1 and *** pretreatment inhibited the expression of Toll-like receptor 4 and myeloid differentiation factor 88 and blocked the phosphorylation of I kappa B kinase and nuclear factor-kappa *** results showed that rutin pretreatment may promote the phenotypic switch of microglia M1 to M2 by inhibiting the Toll-like receptor 4/nuclear factor-kappa B signaling pathway to alleviate lipopolysaccharide-induced neuroinflammation.

关键词： BV-2 cells flavonoid M1 microglia M2 microglia microglia activation microglia polarization neuroinflammation proinflammatory cytokines rutin TLR-4 signaling

Determination of Biotin in Pharmaceutical Formulations by Potassium Permanganate-luminol-CdTe Nanoparticles Chemiluminescence System

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Chemical Research in Chinese Universities 2012年第4期28卷 604-608页

作者： TRAORE Zoumana Sékou SU Xing-guang College of Chemistry Jilin University

A sensitive flow-injection chemiluminescence method was developed for the determination of biotin in the pharmaceutical *** affinity between avidin and biotin was used to adsorb biotin on the polystyrene,with subsequent quantification of biotin based on its ability to enhance the chemiluminescence（CL） signal generated by the redox reaction of potassium permanganate-luminol-CdTe nanoparticles CL *** investigations prove that apart from 3-aminophthalate,the CdTe quantum dots（QDs） play both catalytic and emitter *** optimum conditions,the linear range for the determination of biotin was 0.01―25 ng/mL with a detection limit of 7.3×10-3 ng/mL（S/N=3）.The relative standard deviation of 5 ng/L biotin was 2.06%（n=7）.The proposed method was used to determine the biotin concentration in the pharmaceutical formulations and the recovery was between 96.4% and 104%.The proposed method is simple,convenient,rapid and sensitive.

关键词： Flow-injection Chemiluminescence Biotin CdTe nanoparticle

《新刊举业明儒论宗》考论——以薛应旂的评点为考察中心

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中国文学研究 2019年第2期 102-108页

作者：朱光明复旦大学中国古代文学研究中心

明中叶以后,时文的写作朝着两个方向发展:一是以时文为古文,科场文章写作观念渗透到日常文章书写;二是以古文为时文,用古文的观念矫正时文写作带来的不良影响。在这两种思潮的影响下,薛应旅编选了《明儒论宗》,呈现独特的价值。根柢六经... 详细信息

明中叶以后,时文的写作朝着两个方向发展:一是以时文为古文,科场文章写作观念渗透到日常文章书写;二是以古文为时文,用古文的观念矫正时文写作带来的不良影响。在这两种思潮的影响下,薛应旅编选了《明儒论宗》,呈现独特的价值。根柢六经,不废王学,重视朱学,是薛应旅时文批评的基本立场。《明儒论宗》折射出中晚明时文写作的特点.体现出古文、时文一体观念,梳理明文统绪以及表达文士的深沉忧思。其价值并不局限于科场时文写作,此编力倡“高古正大”文风,开清初“雅正醇厚”古文风尚之先河;以选本的形式展现一代明文的发展、演变的历程,能够合理看待时文的价值,对我们探察明代文章学的发展具有重要的认识论价值。

关键词：薛应旅《明儒论宗》时文风尚评点

Clinical application of combined detection of SARS-CoV-2-specific antibody and nucleic acid

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World Journal of Clinical Cases 2020年第19期8卷 4360-4369页

作者： Qing-Bin Me ng Jing-Jing Peng Xin Wei Jia-Yao Yang Peng-Cheng Li Zi-Wei Qu Yong-Fen Xiong guang-Jiang Wu Zhi-Min Hu Jian-Chun Yu Wen Su Department of Pulmonary and Critical Care Medicine and Department of Gastrointestinal Surgery Wuhan Integrated TCM and Western Medicine HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Respiratory Medicine General Hospital of the Yangtze River ShippingWuhan 430015Hubei ProvinceChina Department of Gastrointestinal Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina Department of Gastroenterology Wuhan Integrated TCM and Western Medicine HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Transfusion Medicine Wuhan Integrated TCM and Western Medicine HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Gastrointestinal Surgery Wuhan Integrated TCM and Western Medicine HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Infection Management and Disease Control Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Clinical Microbiology and Molecular Biology Wuhan Integrated TCM and Western Medicine HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of General Surgery Peking Union Medicine College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Science and Education Wuhan Integrated TCM and Western Medicine HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND The global outbreak of human severe acute respiratory syndrome coronavirus(SARS-CoV)-2 infection represents an urgent need for readily available,accurate and rapid diagnostic *** acid testing of respiratory tract specimens for SARS-CoV-2 is the current gold standard for diagnosis of coronavirus disease 2019(COVID-19).However,the diagnostic accuracy of reverse transcription polymerase chain reaction(RT-PCR)tests for detecting SARS-CoV-2 nucleic acid may be lower than *** detection of SARS-CoV-2-specific antibodies should be used as a serological non-invasive tool for the diagnosis and management of SARS-CoV-2 *** To investigate the diagnostic value of SARS-CoV-2 IgM/IgG and nucleic acid detection in *** We retrospectively analyzed 652 suspected COVID-19 patients,and 206 non-COVID-19 patients in Wuhan Integrated TCM and Western Medicine *** on SARS-CoV-2 nucleic acid tests and serum antibody tests were collected to investigate the diagnostic value of nucleic acid RT-PCR test kits and immunoglobulin(Ig)M/IgG antibody test *** j2 test was used to compare differences between categorical variables.A 95%confidence interval(CI)was provided by the Wilson score *** analyses were performed with IBM SPSS Statistics version 22.0(IBM Corp.,Armonk,NY,United States).RESULTS Of the 652 suspected COVID-19 patients,237(36.3%)had positive nucleic acid tests,311(47.7%)were positive for IgM,and 592(90.8%)were positive for *** was a significant difference in the positive detection rate between the IgM and IgG test groups(Png the RT-PCR results as a reference,the specificity,sensitivity,and accuracy of IgM/IgG combined tests for SARS-CoV-2 infection were 98.5%,95.8%,and 97.1%,*** the 415 suspected COVID-19 patients with negative nucleic acid test results,366 had positive IgM/IgG tests with a positive detection rate of 88.2%.CONCLUSION Our data indicate that serological IgM/IgG antibody co

关键词： SARS-CoV-2 COVID-19 Nucleic acid detection Immunoglobulin M Immunoglobulin G Diagnosis

Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis

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Protein & Cell 2019年第9期10卷 649-667页

作者： Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song guang-Hui Liu Jing Qu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences Beijing 100101China Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of Biophysics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China

RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem ***, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis.

关键词： RAP1 stem cell telomere RELN methylation