Determination of Biotin in Pharmaceutical Formulations by Potassium Permanganate-luminol-CdTe Nanoparticles Chemiluminescence System

作     者：TRAORE Zoumana Sékou SU Xing-guang 

作者机构：College of ChemistryJilin University 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2012年第28卷第4期

页      面：604-608页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(No.21075050) the Science and Technology Development Project of Jilin Province,China(No.20110334) 

主　　题：Flow-injection Chemiluminescence Biotin CdTe nanoparticle 

摘      要：A sensitive flow-injection chemiluminescence method was developed for the determination of biotin in the pharmaceutical *** affinity between avidin and biotin was used to adsorb biotin on the polystyrene,with subsequent quantification of biotin based on its ability to enhance the chemiluminescence（CL） signal generated by the redox reaction of potassium permanganate-luminol-CdTe nanoparticles CL *** investigations prove that apart from 3-aminophthalate,the CdTe quantum dots（QDs） play both catalytic and emitter *** optimum conditions,the linear range for the determination of biotin was 0.01―25 ng/mL with a detection limit of 7.3×10-3 ng/mL（S/N=3）.The relative standard deviation of 5 ng/L biotin was 2.06%（n=7）.The proposed method was used to determine the biotin concentration in the pharmaceutical formulations and the recovery was between 96.4% and 104%.The proposed method is simple,convenient,rapid and sensitive.