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中国苹果属(Malus Miller)植物两新变种

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植物研究 2005年第2期25卷 132-133页

作者：钱关泽汤庚国南京林业大学森林环境学院

发现苹果属西蜀海棠的一个新变种—光果西蜀海棠,以全株尤其果实光滑无毛区别于原变种;及苹果属另一新变种—裸柱丽江山荆子,以花柱下部合生处光滑无毛区别于原变种。

关键词：苹果属新变种中国植物丽江山荆子原变种海棠无毛光滑

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苹果属植物分类学研究进展

南京林业大学学报（自然科学版） 2005年第3期29卷 94-98页

作者：钱关泽汤庚国南京林业大学森林资源与环境学院

对苹果属植物分类学250年研究简史进行回顾,评述了各主要分类系统,以及实验分类学对苹果属系统研究的作用和当前研究概况,认为植物化学分类学和分子系统学方法是苹果属系统研究的重要辅助证据,苹果属植物分类系统尚不完善,需要参照更多... 详细信息

对苹果属植物分类学250年研究简史进行回顾,评述了各主要分类系统,以及实验分类学对苹果属系统研究的作用和当前研究概况,认为植物化学分类学和分子系统学方法是苹果属系统研究的重要辅助证据,苹果属植物分类系统尚不完善,需要参照更多实验证据,同时做更深入的分析。另外,在分析苹果属系统演化路线的基础上,赞同中国云南东南部、广西西南部和老挝北部及越南北部地区是苹果属植物起源中心的论断。

关键词：苹果属分类学系统演化研究进展

Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression

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Chinese Journal of Cancer Research 2023年第2期35卷 140-162页

作者： qian guan Huiran Lin Wenfeng Hua Lei Lin Jiabin Liu Linqing Deng Jiao Zhang Jiwen Cheng Zhonghua Yang Yong Li Jun Bian Haixia Zhou Suhong Li Li Li Lei Miao Huimin Xia Jing He Zhenjian Zhuo School of Medicine South China University of TechnologyGuangzhou 510006China Department of Pediatric Surgery Guangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangdong Provincial Clinical Research Center for Child HealthGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Faculty of Medicine Macao University of Science and TechnologyMacao 99078China Research Institute for Maternal and Child Health Guangdong Second Provincial General HospitalGuangzhou 510317China Department of Pediatric Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Pediatric Surgery the Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatric Surgery Shengjing Hospital of China Medical UniversityShenyang 110004China Department of Pediatric Surgery Hunan Children's HospitalChangsha 410004China Department of General Surgery Xi'an Children's HospitalXi'an Jiaotong University Affliated Children's HospitalXi'an 710003China Department of Hematology The Second Affliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027China Department of Pathology Children Hospital and Women Health Center of ShanxiTaiyuan 030013China Kunming Key Laboratory of Children Infection and Immunity Yunnan Key Laboratory of Children's Major Disease ResearchYunnan Institute of Pediatrics ResearchYunnan Medical Center for Pediatric DiseasesKunming Children's HospitalKunming 650228China Laboratory Animal Center School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Objective:AlkB homolog 5(ALKBH5)has been proven to be closely related to ***,the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely been ***:The potential functional single-nucleotide polymorphisms(SNPs)in ALKBH5 were identified by National Center for Biotechnology Information(NCBI)dbSNP screening and SNPinfo *** probes were used for genotyping.A multiple logistic regression model was used to evaluate the effects of different SNP loci on the risk of *** expression of ALKBH5 in neuroblastoma was evaluated by Western blotting and immunohistochemistry(IHC).Cell counting kit-8(CCK-8),plate colony formation and 5-ethynyl-2'-deoxyuridine(EdU)incorporation assays were used to evaluate cell *** healing and Transwell assays were used to compare cell migration and *** modelling was performed to predict the ability of miRNAs to bind to ALKBH5 with the rs8400 G/A *** sequencing,N6-methyladenosine(mA)sequencing,mA methylated RNA immunoprecipitation(MeRIP)and a luciferase assay were used to identify the targeting effect of ALKBH5 on ***:ALKBH5 was highly expressed in *** down ALKBH5 inhibited the proliferation,migration and invasion of cancer ***-186-3p negatively regulates the expression of ALKBH5,and this ability is affected by the rs8400 *** the G nucleotide was mutated to A,the ability of miR-186-3p to bind to the 3'-UTR of ALKBH5 decreased,resulting in upregulation of *** is the downstream target gene of the ALKBH5 *** down SPP1 partially restored the inhibitory effect of ALKBH5 downregulation on *** of ALKBH5 can improve the therapeutic efficacy of carboplatin and etoposide in ***:We first found that the rs8400 G>A polymorphism in the m6A demethylase-encoding gene ALKBH5 increases neuroblastoma susceptibility and determines the related mechanism

关键词： Neuroblastoma risk ALKBH5 polymorphism progression

基于撤稿论文的生命科学数据管理问题与对策研究——以基础生命科学领域为例

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图书与情报 2021年第3期 47-56页

作者：管茜董克夏义堃武汉大学信息资源研究中心湖北武汉430072 武汉大学信息管理学院湖北武汉430072

数据管理直接影响科研数据和科研结果的可发现、可获取、互操作和可重用性,是规范学术行为的重要前提。论文撤稿是保证论文科学性,建立学术信任的重要手段,近年来生命科学领域频发撤稿事件反映了包括数据管理在内的多种学术不端行为。... 详细信息

数据管理直接影响科研数据和科研结果的可发现、可获取、互操作和可重用性,是规范学术行为的重要前提。论文撤稿是保证论文科学性,建立学术信任的重要手段,近年来生命科学领域频发撤稿事件反映了包括数据管理在内的多种学术不端行为。在分析生命科学领域撤稿论文基本特征基础上,对撤稿原因进行归类,对与数据、图像有关的撤稿论文进一步分析,发现其在时间、时滞、国家、学科、期刊等方面的相对发展趋势。数据、图像问题是生命科学论文撤稿的主要原因之一,并呈现波动上升趋势,数据、图像问题发生频率与学科、期刊等级有关。应当从能力提升、制度完善、主体责任机制、过程监督、约束激励手段等方面来加强科研数据管理。

关键词：数据管理撤稿生命科学数据

生命科学数据管理的主体责任与驱动机制研究——基于利益相关者理论的分析

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图书与情报 2021年第3期 35-46页

作者：夏义堃管茜周艳武汉大学信息资源中心湖北武汉430072 武汉大学信息管理学院档案系湖北武汉430072 湖北国际旅行卫生保健中心湖北武汉430070

生命科学数据管理是推进生物技术创新和医疗健康水平提升的重要基础与关键要素,从责任主体驱动机制与数据行为角度展开分析能够为完善生命科学数据管理提供实践指导和理论启发。基于利益相关者理论和科学数据管理框架,运用文献调研法和... 详细信息

生命科学数据管理是推进生物技术创新和医疗健康水平提升的重要基础与关键要素,从责任主体驱动机制与数据行为角度展开分析能够为完善生命科学数据管理提供实践指导和理论启发。基于利益相关者理论和科学数据管理框架,运用文献调研法和网络调查法、案例分析法,归纳和分析不同责任主体的生命科学数据管理行为。生命科学数据管理的责任体系多元复杂、价值诉求与数据管理方式多样,只有激发研究人员、资助方、期刊出版方、数据仓储/平台、学术共同体多主体数据管理参与热情,形成协同管理模式才能够营造高效的生命科学数据管理生态体系。

关键词：生命科学数据科学数据管理数据共享利益相关者数据管理责任

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F_(4~m)上厄米特自正交常循环码

电子学报 2017年第6期45卷 1469-1474页

作者：管乾清开晓山朱士信合肥工业大学数学学院安徽合肥230009 东南大学移动通信国家重点实验室江苏南京210096

有限域上常循环码具有丰富的代数结构,其编译码电路容易实现,因而在信息传输实践中具有重要的应用.该文研究了一类有限域上任意长度的厄米特自正交常循环码的结构,给出了此类有限域上厄米特自正交常循环码的生成多项式与存在条件,确立... 详细信息

有限域上常循环码具有丰富的代数结构,其编译码电路容易实现,因而在信息传输实践中具有重要的应用.该文研究了一类有限域上任意长度的厄米特自正交常循环码的结构,给出了此类有限域上厄米特自正交常循环码的生成多项式与存在条件,确立了此类有限域上厄米特自正交常循环码的计数公式,并且利用此类有限域上偶长度的厄米特自正交常循环码构造了最优的量子码.

关键词：常循环码厄米特自正交码生成多项式量子码

Bone marrow mesenchymal stem cell transplantation downregulates plasma level and the microglia expression of transforming growth factor β1 in the acute phase of cerebral cortex ischemia

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Chronic Diseases and Translational Medicine 2020年第4期6卷 270-280页

作者： Zhao-Hui Liang Jian-Juan Gu Wen-Xiu Yu Yun-qian guan Mostafa Khater Xiao-Bo Li Department of Neurology The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Neurology Northern Jiangsu People's HospitalClinical Medical School of Yangzhou UniversityYangzhouJiangsu 225001China Department of Obstetrics and Gynecology Northern Jiangsu People's HospitalClinical Medical School of Yangzhou UniversityYangzhouJiangsu 225001China Department of Cell Biology Beijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityBeijing 100053China Pharmacology and Toxicology Department Augusta UniversityGeorgia 30912USA

Background:Both bone marrow mesenchymal stem cell(BM-MSC)and transforming growth factor-β1(TGF-β1)have a strong anti-inflammatory capacity in *** their relationship has not been well *** this study,we investigated how intravenous BM-MSC transplantation in rats effected the expression of TGF-β148 h post cerebral ischemia,and we analyzed the main cells that produce TGF-β***:We used a distal middle cerebral artery occlusion(dMCAO)model in twenty Sprague-Dawley(SD)*** rats were randomly divided into two groups:the ischemic control group and the postischemic BM-MSC transplantation *** hour after the dMCAO model was established,the rats were injected in the tail vein with either 1 ml saline or 1×106 BM-MSCs suspended in 1 ml *** were used to detect TGF-β1 content in the brain infarct core area,striatum and the plasma at 48 h after cerebral *** staining of brain tissue sections for TGF-β1,Iba-1,CD68 and NeuN was performed to determine the number and the proportion of double stained cells and to detect possible TGF-β1 producing cells in the brain ***:Forty-eight hours after ischemia,the TGF-β1 content in the infarcted area of the BM-MSC transplantation group(23.94±4.48 pg/ml)was significantly lower than it was in the ischemic control group(34.18±4.32 pg/ml)(F=13.534,P=0.006).The TGF-β1 content in the rat plasma in the BM-MSC transplantation group(75.91±12.53 pg/ml)was significantly lower than it was in the ischemic control group(131.18±16.07 pg/ml)(F=36.779,P=0.0002),suggesting that after transplantation of BM-MSCs,TGF-β1 levels in the plasma decreased,but there was no significant change in the striatum *** staining showed that the total number of nucleated cells(1037.67±222.16 cells/mm2)in the infarcted area after transplantation was significantly higher than that in the ischemic control group(391.67±69.50 cells/mm2)(F=92.421,P<0.01);the number of TGF-β1+cells after transplan

关键词： Cerebral infarction Mesenchymal stem cell Transplantation Transforming growth factor-β1 Microglia

Applying RNA sequencing technology to explore repair mechanism of Tuina on gastrocnemius muscle in sciatic nerve injury rats

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Chinese Medical Journal 2022年第19期135卷 2378-2379页

作者： Taotao Lyu Zhifeng Liu Tianyuan Yu Mengqian Lu Yingqi Zhang Yi Jiao Hourong Wang Yajing Xu qian guan School of Acupuncture Moxibustion and TuinaBejing University of Chinese MedicineBeijing 100029China Tuina Research Center of Beijing University of Chinese Medicine Bejing 100029China

To the Editor:Peripheral nerve injury(PNI)refers to the injury of the peripheral nerve plexus,nerve trunk,or its branches undertheaction of *** muscle-derived cells servea strong secretory,function while they can differentiate into Schwann cell-like cells or other ceil types,so that it can,effectively promote regeneration'of peripheral *** some specific acupuncture points with mild mechanical stimulation on the surface can have a positive effect on nerve repair.2i Tuina helps relieve symptoms such as muscle spasms and pain caused by nerve *** are three points belonging to the Bladder meridian of foot Taiyang(BL)and the Gallbladder meridian of foot Shaoyang(GB),which usually are selected to carry out *** to the anatomical nerve position,Yinmen(BL37)is on the sciatic nerve trunk,Chengshan(BL57)is on the tibial nerve,and Yanglingquan(GB34)is on the common peroneal nerve;meanwhile,the three points are on the sciatic nerve or its *** three points are on the biceps femoris,gastrocnemius,and tibial anterior muscles.

关键词： meridian gastro acupuncture

响应面法优化台湾林檎中总黄酮提取工艺及抗氧化活性研究

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粮食与油脂 2023年第5期36卷 148-152页

作者：刘岩钱关泽聊城大学生命科学学院山东聊城252059

采用超声辅助提取台湾林檎叶片总黄酮。以总黄酮得率为指标,在单因素试验基础上通过响应面法优化提取工艺,并研究总黄酮的体外抗氧化活性。结果表明:最佳提取工艺为提取时间43 min、乙醇体积分数63%、料液比1∶41(g/mL)时,在此条件下总... 详细信息

采用超声辅助提取台湾林檎叶片总黄酮。以总黄酮得率为指标,在单因素试验基础上通过响应面法优化提取工艺,并研究总黄酮的体外抗氧化活性。结果表明:最佳提取工艺为提取时间43 min、乙醇体积分数63%、料液比1∶41(g/mL)时,在此条件下总黄酮得率12.23%;台湾林檎总黄酮对DPPH·清除率高达88.5%,接近于维生素C,表明其具有较强的抗氧化活性。

关键词：台湾林檎总黄酮响应面法抗氧化活性