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Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women

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Science China(Life Sciences) 2020年第4期63卷 582-591页

作者： Yue-Mei Hu Meng guo chang-gui Li Kai Chu Wen-Gang He Jing zhang Jian-xiang gu Juan Li Hui Zhao xiang-Hong Wu Bi-Zhen lin Zhi-Jie lin xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-rong Pan Ting Wu Jun zhang Ning-Shao xia Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009China The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesCollaborative Innovation Center of Biologic ProductsSchool of Public HealthXiamen UniversityXiamen 361102China National Institute for Food and Drug Control Beijing 102629China Sheyang Center for Disease Control and Prevention Sheyang 244300China xiamen Innovax Biotech Company Xiamen 361022China

A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in *** aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 *** objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with *** the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing *** immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women.

关键词： immunobridging noninferiority human papillomavirus vaccine Escherichia coli girls

Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第14期25卷 1715-1728页

作者： xiao-Hong xiang Li Yang xing zhang xiao-Hua Ma Run-Chen Miao Jing-xian gu Yu-Nong Fu Qing Yao Jing-Yao zhang chang Liu Ting lin Kai Qu Department of Hepatobiliary Surgery the First Affiliated Hospital of Xi'an Jiaotong University Department of Clinical Laboratory Liaocheng People's Hospital Taishan Medical College

BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma(HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC *** To develop a signature of senescence-associated genes(SAGs) that predicts patients' overall survival(OS) to improve prognosis prediction of *** SAGs were identified using two senescent cell models. Univariate COX regression analysis was performed to screen the candidate genes significantly associated with OS of HCC in a discovery cohort(GSE14520) for the least absolute shrinkage and selection operator modelling. Prognostic value of this seven-gene signature was evaluated using two independent cohorts retrieved from the GEO(GSE14520) and the Cancer Genome Atlas datasets, ***-dependent receiver operating characteristic(ROC) curve analysis was conducted to compare the predictive accuracy of the seven-SAG signature and serum α-fetoprotein(AFP).RESULTS A total of 42 SAGs were screened and seven of them, including KIF18 B, CEP55,CIT, MCM7, CDC45, EZH2, and MCM5, were used to construct a prognostic formula. All seven genes were significantly downregulated in senescent cells andupregulated in HCC tissues. Survival analysis indicated that our seven-SAG signature was strongly associated with OS, especially in Asian populations, both in discovery and validation cohorts. Moreover, time-dependent ROC curve analysis suggested the seven-gene signature had a better predictive accuracy than serum AFP in predicting HCC patients' 1-, 3-, and 5-year *** We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC.

关键词： Senescence-associated genes Hepatocellular carcinoma Overall survival Risk model Asian patients

高刺激率听性脑干反应与眩晕反复发作的相关性研究及临床意义

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临床耳鼻咽喉头颈外科杂志 2011年第7期25卷 289-291页

作者：陈曦李平顾晰林少莲张榕福建医科大学附属第一医院耳鼻咽喉头颈外科福州350005

目的:研究高刺激率ABR检测与眩晕反复发作的相关性,探讨眩晕反复发作的病因,为眩晕反复发作的临床诊疗提供重要的帮助。方法:回顾性分析反复眩晕的患者101例,分别观察比较眩晕反复发作患者发作期和间歇期与高刺激率ABR之间的关系。结果... 详细信息

目的:研究高刺激率ABR检测与眩晕反复发作的相关性,探讨眩晕反复发作的病因,为眩晕反复发作的临床诊疗提供重要的帮助。方法:回顾性分析反复眩晕的患者101例,分别观察比较眩晕反复发作患者发作期和间歇期与高刺激率ABR之间的关系。结果:反复眩晕患者发作期多次(2次及其以上)出现高刺激率ABR异常率为56.4%,其中偏头痛性眩晕出现的异常率最高,达到71.9%,良性阵发性位置性眩晕次之;用药期间或发作间歇期多次出现高刺激率ABRⅠ～Ⅴ潜伏期差值异常的患者占总例数的14.9%,各眩晕组出现异常的比率较之发作期都有明显下降。结论:高刺激ABR异常率与眩晕反复发作具有显著的相关性,内耳微循环障碍可能是引发眩晕反复发作的主要原因之一。

关键词：高刺激率听性脑干反应眩晕微循环迷路疾病

Multicenter Clinical Study for Evaluation of Efficacy and Safety of Transdermal Fentanyl Matrix Patch in Treatment of Moderate to Severe Cancer Pain in 474 Chinese Cancer Patients

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Chinese Journal of Cancer Research 2011年第4期23卷 317-322页

作者： Yu-lin Zhu guo-hong Song Duan-qi Liu xi zhang Kui-feng Liu Ai-hua Zang Ying Cheng guo-chun Cao Jun Liang Xue-zhen Ma xin Ding Bin Wang Wei-lian Li Zuo-wei Hu Gang Feng Jiang-jin Huang xiao Zheng Shun-chang Jiao rong Wu Jun Ren Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Breast Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100142 China The PLA Military Genera/Hospital of Beijing Beijing 100009 China No. 3 People's Hospital of Chengdu Chengdu 610031 China The First Affiliated Hospital of guangdong Pharmaceutical University Guangzhou 510080 China Hubei Cancer Hospital Wuhan 430079 China Jilin Cancer Hospital Changchun 130012 China Jiangsu Cancer Hospital Nonjing 210009 China The Affilicated Hospital of Medical College Qingdao University Qingdao 266003 China Shanghai Huaihai Hospital Shanghai 200031 China Suzhou Municipal Hospital Suzhou 215001 China Tianjin People's Hospital Tianjin 300121 China Wuhan Integrated TCM & Western Medicine Hospital Wuhan 30070 China Pu Ai Hospital of Wuhan City Wuhan 430070 China Second Affiliated Hospital Zhejiang University College of Medicine Hangzhou 310009 China Zhejiang Cancer Hospital Hangzhou 310022 China The General Hospital of the People's Liberation Army Beijing 100853 Chino Shengjing Hospital of China Medical University 5henyang 110004 China

Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods: A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 ?g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. Results: After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63?1.26 to 2.03?1.46 (P<0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P<0.0001). Conclusion: The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life.

关键词： Transdermal fentanyl matrix patch (TDF) Cancer pain Efficacy Safety Quality of life

大豆巢式关联作图(NAM)群体构建及花色和种皮色遗传分析

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作物学报 2024年第3期50卷 556-575页

作者：宋健熊亚俊陈伊洁徐瑞新刘康林郭庆元洪慧龙高华伟谷勇哲张丽娟郭勇阎哲刘章雄关荣霞李英慧王晓波郭兵福孙如建闫龙王好让姬月梅常汝镇王俊邱丽娟长江大学湖北荆州434025 中国农业科学院作物科学研究所/农作物基因资源与遗传改良国家重大科学工程/农业农村部北京大豆生物学重点实验室北京100081 安徽农业大学农学院安徽合肥230036 江西省农业科学院作物研究所江西南昌330200 呼伦贝尔市农业科学研究所内蒙古呼伦贝尔162650 农业农村部长江中游作物绿色高效生产重点实验室(部省共建)/长江大学农学院湖北荆州434025 河北省农林科学院粮油作物研究所河北石家庄050035 江苏徐怀地区徐州农业科学研究所江苏徐州210031 宁夏农林科学院作物研究所宁夏银川750021

巢式关联作图(Nested Association Mapping,NAM)群体在作物学遗传与育种研究中具有广泛的应用。本研究在前期大豆种质资源评价基础上,利用35份不同地区来源的代表性种质与中豆41(公共母本)杂交,构建了一套大豆NAM群体。PCA和聚类分析发... 详细信息

巢式关联作图(Nested Association Mapping,NAM)群体在作物学遗传与育种研究中具有广泛的应用。本研究在前期大豆种质资源评价基础上,利用35份不同地区来源的代表性种质与中豆41(公共母本)杂交,构建了一套大豆NAM群体。PCA和聚类分析发现,不同亲本组合的RIL群体基本聚在一起,显示出清晰的遗传结构。利用该NAM群体亲本间花色和种皮色具有显著差异的RIL群体进行全基因组关联分析,定位到1个主要位点qFC13-1与花色显著关联,该位点与W1位点重合;定位到12个位点与种皮色显著相关,其中9个位点为3种以上方法共定位,3个位点为2种方法共定位,包括4个已知位点和8个新位点。研究结果表明,构建的NAM群体适于进行大豆相关性状遗传分析,为大豆复杂性状的遗传解析和育种实践提供了良好的基础材料。

关键词：大豆 NAM群体花色种皮色遗传分析

Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China

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Current Medical Science 2020年第2期40卷 275-280页

作者： Fang ZHENG Chun LIAO Qi-hong FAN Hong-bo CHEN Xue-gong ZHAO Zhong-guo xiE xi-lin LI Chun-xi CHEN xiao-xia LU Zhi-sheng LIU Wei LU Chun-bao CHEN rong JIAO Ai-ming zhang Jin-tang WANG xi-wei DING Yao-guang ZENG Li-ping CHENG Qing-feng HUANG Jiang WU xi-chang LUO Zhu-jun WANG Yan-yan ZHONG Yan BAI xiao-yan WU Run-ming JIN Deparment of Pediatrics Union HospitalTongji Medical CollegeHuazhong University 0f Science and TechnologyWuhan 430022China Deparment of Pediatrics Yichang No.3 People's HospitalYichang 443000China Department of Pediarics Jingzhou First People's HospitalJingzhou 434000China xishui People's Hospital Huanggang 438000China Wuhan Children's Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Pediatrics Yichang Central HospialYichang 443000China Deparment of Pediatrics Xiangyang First People's HospitalXiangyang 441000China Deparment of Pediatrics Shiyan People's HospitalShiyan 442000China Department of Pediatrics Huanggang Central HospitalHuanggang 438000China Department of Pediatrics Jiangling People's HospitalJingzhou 434101China Huangshi Maternity and Child Health Care Hospital Huangshi 435000China Department of Pediatrics Huazhong University of Science and Technology HospitalWuhan 430074China

Since December 2019,COVID-19 has occurred unexpectedly and emerged as a health problem worldw *** the rapidly increasing number of cases in subsequent weeks,the clinical characteristics of pediatric cases are rarely described.A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province.A total of 25 confirmed pediatric cases of COVID-19 were *** demographic data,epidemiological history,underlying discascs,clinical mani festations,laboratory and radiological data,treatments,and outcomes were *** 25 hospitalized patients with COVID-19,the boy to girl ratio was 1.27:*** median age was 3 ***-19 cases in children agedlinical diagnoses included upper respiratory tract infection(n=8),mild pneumonia(n=15),and critical cases(n=2).Two critical cases(8%)were given invasive mechanical ventilation,corticosteroids,and *** symptoms in 24(96%)of 25 patients were alleviated and one patient had been *** was concluded that children were susceptible to COVID-19 like adults,while the clinical presentations and outcomes were more favorable in ***,children less than 3 years old accounted for majority cases and critical cases lied in this age group,which demanded extra attentions during home caring and hospitalization treatment.

关键词： SARS-CoV-2 COVID-19 coronavirus children

双清合剂治疗卫气同病证流行性感冒有效性和安全性多中心随机对照非劣效性试验

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中国中西医结合杂志 2024年第9期44卷 1036-1043页

作者：林江涛孙增涛封继宏吴建华陆光兵郭瑞斌麻晓李月荣申云红王光恩马晓斌黄滔郭安张常喜赵小兵孙绪武江柏华甄会陈红平丁俊平中日友好医院呼吸与危重症医学科北京100029 天津中医药大学热病与呼吸疾病研究所天津300250 天津中医药大学第二附属医院呼吸与危重症医学科天津300250 山西省汾阳医院呼吸与危重症医学科山西032200 眉山市中医医院呼吸与危重症医学科四川620000 阳煤集团总医院呼吸与危重症医学科四川620000 漯河市中医院急诊科河南462000 济南市章丘区人民医院感染性疾病科济南250200 长治市第二人民医院感染疾病科山西046000 邯郸市中医院呼吸科河北056001 山东省立医院呼吸与危重症医学科济南250000 眉山市人民医院发热门诊四川620000 天津中医药大学研究生院天津300250 宁夏回族自治区中医医院肺病科银川750000 枣庄妇幼保健院呼吸科山东277000 牡丹江市中医医院呼吸科黑龙江157000 黑龙江省中医医院肺病科哈尔滨150036 中国中药协会呼吸病药物研究专业委员会北京100061 北京药海宁康医药科技有限公司北京100101 哈尔滨康赛思医药科技开发有限公司哈尔滨150001

目的观察双清合剂治疗卫气同病证流行性感冒的有效性及安全性。方法采用多中心、随机、双盲、双模拟平行对照、非劣效性试验设计,将240例卫气同病证流行性感冒患者采用分层区组随机化方法,使用SAS软件按1:1随机分为试验组和对照组,每组... 详细信息

目的观察双清合剂治疗卫气同病证流行性感冒的有效性及安全性。方法采用多中心、随机、双盲、双模拟平行对照、非劣效性试验设计,将240例卫气同病证流行性感冒患者采用分层区组随机化方法,使用SAS软件按1:1随机分为试验组和对照组,每组120例。试验组服用双清合剂和磷酸奥司他韦胶囊模拟剂,对照组服用磷酸奥司他韦胶囊和双清合剂模拟剂,两组疗程均为5日。分别于治疗前、治疗3日、治疗5日时进行访视,评价其主要临床症状缓解时间、完全退热时间、退热起效时间、对乙酰氨基酚使用量、中医证候积分、中医证候疗效、重要临床症状缓解时间、重症/危重流感发生率及安全性。结果试验期间,共脱落/剔除16例(试验组8例、对照组8例),最终纳入符合方案集224例,其中试验组112例,对照组112例。与对照组比较,试验组可缩短头痛缓解时间[28.00(17.75,42.99)h vs.41.00(18.75,59.00)h]、减少肌肉或关节酸痛缓解时间[37.83(12.88,52.77)h vs.38.07(13.50,69.25)h](P0.05)。两组患者不良反应发生率,试验组为4.17%和对照组为1.67%,差异无统计学意义(χ^(2)=1.36,P>0.05)。结论双清合剂可有效缓解卫气同病证流行性感冒的头痛、肌肉或关节酸痛症状,效果优于磷酸奥司他韦胶囊;在改善发热、咳嗽、汗出、面赤、咳黄痰临床症状,减少对乙酰氨基酚使用量,降低中医证候积分方面与磷酸奥司他韦胶囊疗效相当;安全性与磷酸奥司他韦胶囊相当。(中国临床试验注册中心注册***2400087831)。

关键词：流行性感冒卫气同病双清合剂随机对照试验中西医结合

庆大霉素对小鼠耳蜗螺旋神经节细胞损伤机制初步研究

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中华耳科学杂志 2009年第3期7卷 256-260页

作者：顾晰林昶张榕福建医科大学附属第一医院耳鼻咽喉头颈外科福州350005

目的探讨庆大霉素对小鼠耳蜗螺旋神经节细胞(spiral ganglion cell,SGC)的损伤机制。方法取出生后2～6天昆明种乳小鼠耳蜗,利用酶消化和机械分离相结合的方法分离出SGC,并进行体外培养。将培养4天的SGC用4%多聚甲醛室温固定30min,以小... 详细信息

目的探讨庆大霉素对小鼠耳蜗螺旋神经节细胞(spiral ganglion cell,SGC)的损伤机制。方法取出生后2～6天昆明种乳小鼠耳蜗,利用酶消化和机械分离相结合的方法分离出SGC,并进行体外培养。将培养4天的SGC用4%多聚甲醛室温固定30min,以小鼠源神经纤维细丝蛋白(Neurofilament-68/200kDa,NF-L+H)单克隆抗体作为一抗,按照SP法(streptavidin-perosidase法,链霉菌抗生物素蛋白-过氧化物酶连结法)对所培养细胞进行免疫细胞化学染色,对SGC作出鉴定。将培养第4天的细胞分为4组:空白对照组及3种浓度的庆大霉素干预组(庆大霉素终浓度分别为50mg/L、100mg/L、150mg/L),作用48h后收集各组细胞进行透射电镜分析。结果SGC原代培养获得成功,经NF-L+H抗体免疫细胞化学染色,其胞质及突起均呈阳性反应,染成棕黄色,一般有相对生长的两个突起,为典型的双极神经元。在透射电镜下观察SGC超微结构,3种浓度的庆大霉素组SGC与空白对照组相比,均出现明显的形态学改变,这种改变与凋亡相关。结论庆大霉素对小鼠耳蜗SGC有直接毒性作用,可导致细胞凋亡,线粒体损伤在这一过程中可能具有重要意义。

关键词：庆大霉素类螺旋神经节细胞,培养的显微镜检查,电子,透射细胞凋亡

New vacuum solar telescope and observations with high resolution

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Research in Astronomy and Astrophysics 2014年第6期14卷 705-718页

作者： Zhong Liu Jun Xu Bo-Zhong gu Sen Wang Jian-Qi You Long-xiang Shen Ru-Wei Lu Zhen-Yu Jin lin-Fei Chen Ke Lou Zhi Li guang-Qian Liu Zhi Xu chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-xian Bao Ming-Chan Wu Bo-rong zhang Yunnan Observatories Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences Institute of Optics and Electronics Chinese Academy of Sciences Kunming University of Science and Technology

The New Vacuum Solar Telescope （NVST） is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown.

关键词： telescopes -- instrumentation: adaptive optics -- instrumentation: spec-trographs -- techniques: high angular resolution -- Sun: magnetic fields