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Phosphine production in anaerobic wastewater treatment under tetracycline antibiotic pressure

Journal of Environmental Sciences 2018年第7期30卷 239-250页

作者： Meiqing Lu Xiaojun Niu Weiyi Chen Zhu Liang Sheng You xiaohong gu School of Environment and Energy South China University of Technology Guangzhou 510006 China State Key Laboratory of Lake Science and Environment Nanjing 210008 China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen Key Laboratory of Soil and Groundwater Pollution Control Shenzhen 518055 China guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control Guangzhou 510640 China China Water Resources Pearl River Planning Surveying & Designing Co. Ltd. Guangzhou 510640 China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSouth China University of Technology Guangzhou Higher Education Mega Centre Guangzhou 510006 China

The influence of tetracycline（TC） antibiotics on phosphine（PH3） production in the anaerobic wastewater treatment was studied. A lab-scale anaerobic baffled reactor with three compartments was employed to simulate this process. The reactor was operated in a TC-absence wastewater and 250 μg/L TC-presence wastewater for three months after a start-up period,respectively. The responses of p H, oxidation–reduction potential（ORP）, chemical oxygen demand（COD）, total phosphorus（TP）, enzymes activity（dehydrogenase and acid phosphatase）,and microbial community were investigated to reveal the effect of TC on PH3 *** suggested that the dehydrogenase（DH） activity, acid phosphatase（ACP） activity and COD have positive relationship with PH3 production, while p H, ORP level and the TP in liquid phase have negative relationship with PH3 production. With prolonged TC exposure, decrease in p H and increase in DH activity are beneficial to PH3 production, while decrease in COD and ACP activity are not the limiting factors for PH3 production.

关键词： Tetracycline antibiotic Anaerobic Wastewater treatment Phosphine production

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Transcatheter Closure of a Right Pulmonary Artery to Left Atrium Fistula Using a Ventricular Septal Defect Occluder

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Congenital Heart Disease 2021年第2期16卷 147-150页

作者： Diqi Zhu xiaohong gu Jie Shen Fen Li Department of Pediatric Cardiology Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of MedicineShanghai200127China Department of Radiology Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Shanghai200127China

Background:Communication between the right pulmonary artery(RPA)and left atrium(LA)is a rare cause of central cyanosis in pediatric *** presentation:We describe a 3-year-old female patient with an oxygen saturation of 70%at *** echocardiogram indicated an abnormal color flow Doppler in the LA and she underwent standard cardiac *** angiography of pulmonary artery revealed a 7.4 mm×7.6 mm fistula between the RPA and LA and achieved successful closure using ventricular septal defect ***:The fistula between pulmonary artery and left atrium is an extremely rare but treatable congenital *** should be considered in differential diagnosis of cyanosis in children.

关键词： Transcatheter closure fistula ventricular septal defect occlude central cyanosis

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Growth and feeding habits of invasive Pseudorasbora parva in the Chabalang Wetland(Lhasa,China) and its trophic impacts on native fish

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Journal of Oceanology and Limnology 2019年第2期37卷 628-639页

作者： DING Huiping gu xiaohong ZHANG Zhiming HUO Bin LI Dapeng XIE Congxin State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography & Limnology Chinese Academy of Sciences Nanjing 210008 China University of Chinese Academy of Sciences Beijing 100049 China College of Fisheries Huazhong Agricultural University Wuhan 430070 China Institute of Hydroecology MWR & CAS Wuhan 430070 China Key Laboratory of Ecological Impacts of Hydraulic-Projects and Restoration of Aquatic Ecosystem Ministry of Water Resources Wuhan 430070 China

In recent years, fish invasion has become one of the main reasons for the decline of native fish stocks. Pseudorasbora parva is considered one of the major invasive species worldwide. The present study investigated the fish resources of the Chabalang Wetland (Lhasa, Tibet) during diff erent seasons in 2009 and 2013. Four hundred and twelve individuals were subsampled to estimate age, growth, and feeding habit of P . parva . Furthermore, food relationships between P . parva and the native Schizothoracinae fish were also examined. The results revealed a significant shift in species composition and community structure characterized by the disappearance of native fish and outbreak of non-native fish. The percentage of nonnative P . parva in the fish collections significantly increased from 33.64% in 2009 to 64.08% in 2013. The standard length (SL) ranged from 22.00 to 78.71 mm, and their age was 1–5 a. The von Bertalanff y function was used to model the observed length-at-age data as L t =112.19(1–e^-0.1495 ( t +0.8012)) for females and as L t =123.12 (1–e^-0.1500 ( t +0.7132)) for males. The results indicated that P . parva in Tibet has lower growth and mortality rates compared with that from the native ranges. Ninety-seven prey taxa belonging to 9 prey categories were identified in the gut of 38 P . parva . P . parva can be considered a generalized and opportunistic predator, competing with the native fish, especially Schizothorax o’connori , Schizopygopsis younghusbandi younghusbandi , and Ptychobarbus dipogon , for Bacillariophyta and Chironomid larvae. This is an important reason for the decline in native fish population.

关键词： Pseudorasbora parva growth feeding habits Schizothoracinae fish biological invasion

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New insights for infection mechanism and potential targets of COVID-19:Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches

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Chinese Herbal Medicines 2023年第2期15卷 157-168页

作者： Kexin Jia Yijie Li Tiegang Liu xiaohong gu Xiaojiaoyang Li School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Institute of Chinese Epidemic Disease Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with high pathogenicity and infectiousness has become a sudden and lethal pandemic ***,there is no accepted specific drug for COVID-19 ***,it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with *** to several reliable reports from China,traditional Chinese medicine(TCM),especially for three Chinese patent medicines and three Chinese medicine formulas,has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western *** this review,we systematically summarized and analyzed the pathogenesis of COVID-19,the detailed clinical practice,active ingredients investigation,network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 ***,we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism,which provides guidance for the development of new drugs against ***,by addressing critical challenges,for example,unclear targets and complicated active ingredients of these medicines and formulas,we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.

关键词： COVID-19 Huashi Baidu Formula Jinhua Qinggan Granules Lianhua Qingwen Capsule Qingfei Paidu Decoction SARS-CoV-2 traditional Chinese medicine Xuanfei Baidu Formula Xuebijing Injection

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The minimization of non-equilibrium plasma source at high pressure

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Chinese Science Bulletin 2008年第21期53卷 3425-3428页

作者： BAI MinDi QIU XiuMei LIU Dong YANG Bo ZHOU JianGang XUE xiaohong gu JianLong Research Institute of Environmental Engineering Dalian Maritime University Dalian 116026 China

The density of plasma produced by atmospheric non-equilibrium plasma source is the function of en-ergy dissipation rate in ionization electric field and gas particles *** experiment shows that the plasma density highly rises with the increasing of energy dissipation rate and gas particles *** the energy dissipation rate of activation field is 2.18 Wh/m3 and the average gas particles momentum is 109×10-22 g·m/s,the air throughput of plasma source whose volume is only 2.5 cm3 can be up to 12 m3/h and the density of plasma can be up to 1010 *** research can develop a method of producing minitype plasma source which is low energy consumption but high ion concen-tration used for chemical industry,environmental engineering and military.

关键词：电离化高压状态等离子体气体微粒物

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Association between gastrointestinal heat retention syndrome and respiratory tract infections in children:A prospective cohort study

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 216-223页

作者： Fei Dong He Yu Liqun Wu Tiegang Liu Xueyan Ma Jiaju Ma xiaohong gu School of Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Pediatric Department Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing100078China Pneumology Department Beijing Hospital of Traditional Chinese MedicineBeijing100010China

Objective:To explore the relationship between gastrointestinal heat retention syndrome and the incidence of pneumonia and recurrent respiratory tract infections(RRTIs)in ***:A prospective cohort study was conducted in the pediatric outpatient department of Beijing Dongfang *** without respiratory tract infections(RTIs)were consecutively recruited according to the selection criteria.A semi-structured questionnaire was used to record traditional Chinese medicine(TCM)symptoms and demographic and physiological *** heat retention syndrome was considered to be a predisposing factor and was diagnosed according to a scale with reliability and *** participants were followed up for 12 *** and their parents or guardians were contacted via clinical interviews and telephone every 6 *** of pneumonia and RTIs were recorded in ***:A total of 420 children were *** participants,370(88.10%)were followed up for 12 *** mean number of RTI episodes per participant was 5.37(95%CI:5.14 to 5.60).In total,186 participants in the gastrointestinal heat retention syndrome group and 184 participants in the nongastrointestinal heat retention syndrome group completed the 12-month follow-up *** baseline of both groups was *** incidence of RRTIs in children with gastrointestinal heat retention syndrome was 1.27(95%CI:1.01 to 1.59)times that in children without gastrointestinal heat retention *** regression analysis revealed that abnormally increased appetite with frequent hunger,foul breath,dry stools,and dark red or purple fingerprints were positively correlated with the incidence of *** and feverish feelings in the palms and soles were positively correlated with the occurrence of ***:Gastrointestinal heat retention syndrome is a risk factor for RRTIs in *** with larger sample sizes and longer follow-up tim

关键词： Gastrointestinal heat retention syndrome Pneumonia Recurrent respiratory tract infections Children Prospective cohort study

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Reveal the mechanisms of prescriptions for liver cancer'treatment based on two illustrious senior TCM physicians

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Journal of Traditional Chinese Medicine 2023年第1期43卷 188-197页

作者： WANG Bochuan ZHANG Yong ZHANG Qiuyun ZHANG Zhiqiang LUO Changyong WANG Zhendong BAI Chen WANG Yuhan GE Xueyi QIAN Ying YU He gu xiaohong School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 10029China Liver Disease Branch Shandong Hospital of Traditional Chinese MedicineJinan 250013China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Beijing Tcmages Pharmaceutical Co. Ltd.Beijing 101399China Dongfang Hospital Beijing University of Chinese Medicine Beijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To explore the core herbs of two illustrious senior Traditional Chinese Medicine(TCM)Physicians for the treatment of liver cancer,and to further clarify the gene targets and pathway mechanisms of liver cancer that the core prescription(CP)may ***:We used the patient information of two illustrious senior TCM physicians from the Affiliated Hospital of Shandong University of Traditional Chinese Medicine and the Affiliated Hospital of Capital Medical University as the *** CP was analyzed using the community network *** pathway mechanism was analyzed using network pharmacology *** the prognostic survival genes were identified using Single factor cox regression *** Pharmacology-based Research Platform of Traditional Chinese Medicine(TCMIP),Herb,Online Mendelian Inheritance in Man(OMIM),Genecards,Kyoto Encyclopedia of Genes and Genomes(KEGG),Genomic Data Commons(GDC),The Cancer Genome Atlas(TCGA),Gephi and R were used to mine CP,building a pathway network *** the analyses were ***:We found that the CP consistes of Huangqi(Radix Astragali Mongolici),Danshen(Radix Salviae Miltiorrhizae),Shuihonghuazi(Polygoni Orientalis Fructus),Baihuasheshecao(Herba Hedyotdis),Banzhilian(Herba Scutellariae Barbatae),and Ezhu(Rhizoma Curcumae Phaeocaulis),which were attributed to the two physicians *** CP played an anticancer role through such pathways as signal transduction,energy metabolism,immune system and other pathways,covering a total of 112 pathways and 176 herb-diseaserelated *** genes have a significant impact on the prognosis and survival of liver ***:Based on the liver cancer cases of two illustrious senior TCM physicians,we obtained the CP through data *** CP may mainly exert anticancer effects by inhibiting inflammatory response,angiogenesis,and enhancing the body’s immune *** screened out 14 genes in the CP that may be related to the pro

关键词： liver neoplasms prognosis network analysis bioinformatics analysis machine learning medicine,Chinese traditional

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Research on Influence of Clopidogrel on Life Quality in Patients with Transient Ischemic Attack and its Influencing Factors

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Journal of Advances in Medicine Science 2018年第1期1卷 16-21页

作者： Lanbo Chen xiaohong gu Bo Dong Department of Health Management Institute of Field SurgeryDaping HospitalThird Military Medical UniversityChongqing MunicipalityChongqing400042China

Purpose:To analyze the basic situation and health related quality of life(HRQOL)results of patients with transient ischemic attack(TIA),and to study the influencing factors of health related quality of life in patients receiving ***:Divide the TIA patients into clopidogrel group,aspirin group and untreated *** HRQOL scores of TIA patients using the short form 36 questionnaire(SF-36)scale and analyze influencing factors of HRQOL with one-way ANOVA and multivariate stepwise linear regression statistical ***:The differences of HRQOL scores among three groups are of statistical significance(F=4.29,P=0.00).There is no difference in HRQOL score between clopidogrel group and aspirin group(t=5.35,P=0.00),but HRQOL scores of clopidogrel group and aspirin group are higher than those of the untreated group(t=6.14,P=0.00;t=5.16,P=0.00).The HRQOL scores of clopidogrel group are positively correlated with diet,exercise,gender and family harmony(P<0.05),but negatively correlated with diabetes,hypertension,smoking,drinking,hyperlipidemia,age,career and ABCD2 score(P<0.05).Conclusion:TIA patients who received secondary prevention with clopidogrel and aspirin show better life quality results than those who did *** were many factors influencing clopidogrel's treatment *** attention to middle-aged and elderly,the obese,mental workers and female TIA patients,teach TIA patients to quit smoking,drinking and eating low-salt and low-fat food,actively treating their hypertension,hyperlipidemia and diabetes and laying emphasis on psychological counseling and exercise can significantly improve the treatment effect of clopidogrel.

关键词： Transient ischemic attack Clopidogrel Life quality Influencing factors

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Effect of gastrointestinal heat retention syndrome on gut microbiota in children with upper respiratory tract infection and lung-heat syndrome

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Journal of Traditional Chinese Medical Sciences 2022年第1期9卷 13-21页

作者： Shuangcheng Wang Xueyan Ma Liqun Wu He Yu Yanran Shan Yuanshuo Tian Tiegang Liu xiaohong gu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Department of Pediatrics Dongfang Hospital of Beijing University of Chinese MedicineBeijing100078China

Objective:Gastrointestinal heat retention syndrome(GHRS)is associated with lung-heat syndrome and is related to recurrent respiratory *** respiratory tract infection(URTI)lung heat syndrome is common in *** study will explore the effect of GHRS on the structure and function of gut microbiota in children with URTI lung-heat ***:Participants were divided into both groups using the self-developed URTI scale and the“GHRS Diagnostic Scale$Pediatric Part”:GHRS-positive children(LS group)and GHRS-negative children(L group).General information,clinical symptoms,and stool were *** used 16S rRNA amplicon sequencing technology to determine the gene sequence of the V3eV4 region in feces and measure the gut microbiota of the both groups at the genus ***:A total of 23 children were included in the both *** were 12 cases in the LS group and 11 cases in the L *** was no statistical difference between the both groups in age,gender,height,weight,and body mass *** effective sequences shared by the both groups accounted for 85.66%of the *** the gut microbiota,there was no difference in the a diversity and the b diversity between the both *** with the L group,the LS group had a significant increase in the relative abundance of the Ruminococcus gnavus group,Prevotella-9,Staphylococcus,and Actinomyces(Pgut microbiota.

关键词： Gastrointestinal heat retention syndrome Upper respiratory tract infection gut microbiota Lung-heat syndrome Lung-stomach heat retention syndrome 16S rRNA gene sequencing Redundancy analysis Diversity

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Vagus nerve plays a pivotal role in CD4+T cell differentiation during CVB3-induced murine acute myocarditis

Vagus nerve plays a pivotal role in CD4+T cell differentiati...

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2018年浙江省医学会儿科学分会学术年会

作者： xiaohong gu Maoping Chu the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University

Aims:Abnormalities in CD4+T cell (Th cell) differentiation play an important role in the pathogenesis of viral myocarditis (VMC).Our previous studies demonstrated that activation of the cholinergic anti-inflammatory pathway(CAP) alleviated the inflammatory *** addition,we observed that right cervical vagotomy aggravates VMC by inhibiting ***,the vagus nerve’s effect on differentiation of CD4+T cells has not been studied in VMC mice to date.

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