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In vitro comparison of the hemocompatibility of diamond-like carbon and carbon nitride coatings with different atomic percentages of N

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Science China(Life Sciences) 2012年第4期55卷 343-348页

作者： ZHAO MengLi LI DeJun ZHANG YiTeng guO MeiXian DENG XiangYun gu hanqing WAN RongXin College of Physics and Electronic Information Science Tianjin Normal University Tianjin 300387 China Tianjin Institute of Urological Surgery Tianjin Medical University Tianjin 300070 China

Carbon nitride （CN,） and diamond-like carbon （DLC） coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of ni- trogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.1〉 the CN0.22 coating showed longer dynamic clotting time （about 42 min）, static clotting time （23.6 min） and recalcification time （45.6 s）, as well as lower platelet adhesion （102 cells μm-2）, aggregation, and activation. The presence of nitrogen in the CNx coatings in- duced their enhanced hemocompatibility compared with DLC.

关键词： carbon nitride magnetron sputtering atomic percentage hemocompatibility

Surface Modification of Medical Polyurethane by Plasma Treatment

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Chinese Physics Letters 1992年第2期9卷 79-82页

作者： LI Dejun ZHAO Jie gu hanqing LU Mozhu DING Fuqing HU Jianfang Department of Physics Tianjin Normal UniversityTianjin 300074 Tianjin Uretie Surgery Institute Tianjin 300076 Department of Physics Central National CollegeBeijing 100081

The wettability and surface structure of plasma treatment on medical polyurethane were *** kinds of gas,N_(2),Ar,were used to create the dow-temperature plasma under low *** wettability was investigated by means of the sessile drop method using water,the results show that the contact angle of water decreases from 78.8°to 61.9°as the treatment time *** results of electron spectroscopy for chemical analysis indicate that original chemical bonds were broken up after plasma,treatment,which was the main reason for the surface *** same time,the results of electron spinning resonance show that the amounts of radicals did not increase significantly after treatment,which is advantageous to clinical practice of polyurethane.

关键词： treatment spinning polyurethane

THE PREPARATION OF CROSSLINKED N,O-CARBOXYMETHYL CHITOSAN RESINSAND THEIR ADSORPTION PROPERTIESFOR TRIGLYCERIDE IN SERUM

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Chinese Journal of Reactive Polymers 1997年第1期6卷 83-86页

作者： Yu Yihau He Binglin gu hanqing Institute of Polymer Chemistry The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation Nankai University Tianjin 300071 P. R. China Tianjin Institute of Urological Surgery Tianjin Institute of Urological Surgery

Crosslinked N, O-carboxymethyl chitosan resins which can selectively adsorb triglyceride, were prepared by the reaction of N, O- carboxymethyl chitosan with glutaraldehyde solution. Adsorption experiments were performed by adding the resins to the serum. The results showed that this type of adsorbent could cut down the concentration of triglyceride in serum by 56. 4% (3. 35mg/gresin ) at most, while concentration of the total protein (TP ) decreased only by 10. 9% at least, so this novel adsorbent can be used to cure hypertriglyceridemia by hemoperfusion in the future.

关键词： Crosslinked N O-carboxymethyl chitosan Triglyceride Serum, Total protein (TP ) Hypertriglyceridemia Adsorption

The Evaluation of Adeuacy for Hemodialysis

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Chinese Journal of Biomedical Engineering(English Edition) 1997年第3期6卷 214-216页

作者： Mozu Lu hanqing gu(Tianjin Institute of Urological Surgery,Tianjin, 300211,China)

In vivo Implantation of Hydrophobic Acrylic Intraocular Lenses with Surface Modification

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眼科学报：英文版 2013年第4期28卷 176-179页

作者： guiqin Wang Liqun Cao Na Li Xiujun Peng Huiqin Tang Rongxin Wan hanqing gu Department of Ophthalmology the Naval General Hospital1Beijing 100048China Department of Ophthalmology the Naval General Hospital Tianjin Medical University Tianjin Institute of Urological Surgery

Purpose:To assess the surface properties of modified hydrophobic acrylic intraocular lenses (IOL) implanted in ***:.The hydrophobic acrylic IOLs were modified with monomer vinyl pyrrolidone by surface modification *** combined with IOL implantation was conducted in 9 rabbits (18 eyes).Postoperative responses were observed by slit-lamp microscope at 3,.7,.15,.30,.90 days after ***:.During the early stage after IOL implantation,corneal edema and anterior chamber fibrin exudation were *** exudate fluid was almost absorbed at the 15th day *** 7th day,the anterior chamber exudation in the modification group was significantly less severe than that in non-modification group(P<0.05).Posterior capsular opacification occurred at 30th day after surgery and was aggravated90 days *** dislocation was seen in 5 eyes and occlusion of pupil in 3 ***:The hydrophobic acrylic IOLs with surface modification have improved surface properties and higher uveal biocompatibility.

关键词：水性丙烯酸人工晶体表面修饰晶状体植入表面改性技术乙烯基吡咯烷酮体内

THE STUDY ON THE SURFACEMODIFICATION OF THE INTRAOCULAR LENSAND ITS BIOCOMPATIBILITY

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Chinese Journal of Biomedical Engineering(English Edition) 1997年第3期6卷 202-204页

作者： gu hanqing guo Hongyu Lu Mozhu Yuan Jiaqin(Tianjin Medical University,Tianjin, 300070,China)

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用于膀胱癌灌注治疗的纳米药物研究进展

离子交换与吸附 2021年第2期37卷 183-192页

作者：王晓娟顾汉卿天津医科大学第二医院天津市泌尿外科研究所

膀胱癌是泌尿系统多发肿瘤之一,在新发膀胱癌中约75%为非肌层浸润性膀胱癌,其标准治疗手段为行经尿道膀胱肿瘤切除术,并在术后进行膀胱灌注治疗。然而,膀胱组织因其特殊的生理特性,导致排泄过程中,药物在膀胱内滞留时间短,使得膀胱灌注... 详细信息

膀胱癌是泌尿系统多发肿瘤之一,在新发膀胱癌中约75%为非肌层浸润性膀胱癌,其标准治疗手段为行经尿道膀胱肿瘤切除术,并在术后进行膀胱灌注治疗。然而,膀胱组织因其特殊的生理特性,导致排泄过程中,药物在膀胱内滞留时间短,使得膀胱灌注仅在短期内有效。近几年来,膀胱内腔灌注药物载体得到了发展,即通过导管将负载有药物的多种纳米载体材料输送到膀胱内腔中。纳米载体由于其合适的粒径、表面特性及与膀胱壁黏膜层的直接相互作用,可以有效延长药物在膀胱内腔的滞留时间,增加其在膀胱内壁组织的粘附性和穿透力,从临床应用角度讲,是安全的膀胱内药物递送方式,因而引起材料学界和临床医学界的广泛关注。本文针对这一类膀胱内腔给药载体材料进行系统概述,以治疗方法为分类依据,总结了目前多种形式的纳米粒子的治疗效果,还对这些纳米粒子存在的共性问题进行概括,并提出了可能的解决方法,以期为材料的设计研究以及临床应用提供指导与借鉴。

关键词：膀胱癌膀胱内腔给药纳米材料

RESEARCH AND CLINICAL APPLICATION OF A NEW SURFACE MODIFICATION LARGE DIAMETER FOLEY CATHETER

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Chinese Journal of Biomedical Engineering(English Edition) 1997年第4期6卷 249-256页

作者： Yao qingxiang (The Second Hospital of Tianjin Medical University,300211,China)gu hanqing (Tianjin Institute of Urologic Surgery,3000211,China)

-The surface of the large diameter three-way foley catheter we design and produce has been modified with the hydrophilic polyurethane,which makes the inner &.outer cavity very *** from the canning electron microscope,the cracks of the catheter are closed up,and its surface is much smoother than that of the natural latex catheter. Besides these, we also give the catheter very strict physical,chemical & biological *** it matches all the technical targets with those of concerning *** the clinical observations on 40 patients,the surface modiried large di-ameter three-way foley catheter is much better tban the emulsion catheter and catheter with mushroom-like *** catheter has many advantages,such as surface smooth, diameter large, easy for urinating and irrigating or bladder & pelvis, no urine salt sedimentation arter a long Period,stable, good biocompatibility,easy for operation changing,long period for the use of one catheter,and so on.

关键词： Surface modification Large diameter Catheter Cystostomy Nephrostomy

Effect of bombarding energy on ion beam assisted deposited DLC film on UHMWPE

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Chinese Journal of Biomedical Engineering(English Edition) 1998年第4期7卷 186-191页

作者： Dejun LI hanqing gu and Fuzhai CUI(1. Department of physics, Tianjin Normal University, Tianjin 300074, P.R.China2. Institute of Urology Surgery, Tianjin 300211, P.R.China3. Department of Materials Science and Engineering, Tsinghua University, Beijing

Diamond-like carbon (DLC) films on ultra-high molecular weight polyethylene substrates were prepared at CHn+ ion bombarding energies of 200-1000eV at room temperature using ion beam assisted deposition technique. The wear tests exhibited a high wear resistance for all DLC films. X-ray photoelectron spectfoscopy and Raman spectroscopy analysis indicated that DLC film was amorphous with a characteristic high fracdion of sp3 bonds in the structure of mixed sp:2+ sp3 bonding at an optimal bombardingenergy of 600eV.

关键词： Ultra-high molecular weight polyethylene Diamond-like carbon Ion beam assisted deposition Friction coefficient