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Preparation of microparticles and nanoparticles using membrane-assisted dispersion,micromixing,and evaporation processes

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Particuology 2024年第1期84卷 30-44页

作者： goran T.Vladisavljevic Chemical Engineering Department Loughborough UniversityLoughboroughLeicestershire LE113TUUnited Kingdom

Synthetic microporous membranes are increasingly used for energy-efficient and controlled production of micro-and nanoparticles and micro-and nanoemulsions with tuneable morphology and physico-chemical properties through various micromixing,emulsification,and evaporation *** emul-sification processes,the membrane pores are used for dispersed phase injection and size-controlled generation of droplets and droplet-templated *** micromixing processes,membrane is utilised as a micromixer for mixing two miscible liquids,usually solvent and antisolvent-rich solutions,which leads to the creation of supersaturation and subsequent nanoprecipitation or *** mem-brane evaporation processes,membrane is used to prevent phase dispersion while allowing efficient molecular diffusion of solvent and/or antisolvent vapour through gas-filled *** dispersion processes can be operated continuously by decoupling shear stress on the membrane surface from cross flow using tube insets,flow pulsations,swirling flow,membrane oscillations or membrane *** generation and solidification can be performed continuously in a single pass by connecting membrane module with a downstream *** dispersion processes can be used for pro-duction of nanoparticles such as nanovesicles(liposomes,micelles,ethosomes,and niosomes),nanogels,polymeric,lipid and metallic nanoparticles,and *** main advantages of membrane-assisted particle generation are in low energy consumption,controlled geometry and hydrodynamic conditions at the microscale level,flexible throughput due to modular and scalable design of membrane devices,and a wide choice of available microporous membranes with various wall porosities,wetta-bilities,pore sizes,and pore morphologies to suit different applications.

关键词： Nanoparticles Microparticles Nanoemulsions Microemulsions Microporous membrane Crystallisation Flash nanoprecipitation Emulsification Zero liquid discharge

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Ge-on-Si modulators operating at mid-infrared wavelengths up to 8 μm

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Photonics Research 2019年第8期7卷 828-836页

作者： TIANTIAN LI MILOS NEDELJKOVIC NANNICHA HATTASAN WEI CAO ZHIBO QU CALLUM GLITTLEJOHNS JORDI SOLER PENADES LORENZO MASTRONARDI VINITA MITTAL DANIEL BENEDIKOVIC DAVID JTHOMSON FREDERIC YGARDES HEQUAN WU ZHIPING ZHOU goran zmashanovich Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Engineering and Computer SciencePeking UniversityBeijing100871China Silicon Technologies Centre of Excellence Nanyang Technological UniversitySingapore639798Singapore Centre de Nanosciences et de Nanotechnologies CNRSUniv.Paris-SudUniversitéParis-SaclayC2N-Palaiseau91120PalaiseauFrance

We report mid-infrared Ge-on-Si waveguide-based PIN diode modulators operating at wavelengths of 3.8 and8 μm. Fabricated 1-mm-long electro-absorption devices exhibit a modulation depth of >35 dB with a 7 V forward bias at 3.8 μm, and a similar 1-mm-long Mach–Zehnder modulator has a Vπ· L of 0.47 V · cm. Driven by a 2.5 Vpp RF signal, 60 MHz on-off keying modulation was demonstrated. Electro-absorption modulation at 8 μm was demonstrated preliminarily, with the device performance limited by large contact separation and high contact resistance.

关键词： PIN frame EAM Ge-on-Si modulators

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Optimal Offering of Energy Storage in UK Day-Ahead Energy and Frequency Response Markets

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 415-426页

作者： Makedon Karasavvidis Andreas Stratis Dimitrios Papadaskalopoulos goran Strbac Department of Electrical and Electronic Engineering Imperial College LondonLondonUK Statkraft UK Ltd. LondonUK Department of Electrical and Computer Engineering University of PatrasPatrasGreece IEEE

The offering strategy of energy storage in energy and frequency response(FR) markets needs to account for country-specific market regulations around FR products as well as FR utilization factors, which are highly uncertain. To this end, a novel optimal offering model is proposed for stand-alone price-taking storage participants, which accounts for recent FR market design developments in the UK, namely the trade of FR products in time blocks, and the mutual exclusivity among the multiple FR products. The model consists of a day-ahead stage, devising optimal offers under uncertainty, and a real-time stage, representing the storage operation after uncertainty is materialized. Furthermore, a concrete methodological framework is developed for comparing different approaches around the anticipation of uncertain FR utilization factors(deterministic one based on expected values, deterministic one based on worst-case values, stochastic one, and robust one), by providing four alternative formulations for the real-time stage of the proposed offering model, and carrying out an out-of-sample validation of the four model instances. Finally, case studies employing real data from UK energy and FR markets compare these four instances against achieved profits, FR delivery violations, and computational scalability.

关键词： Energy markets energy storage frequency response optimal offering robust optimization stochastic programming

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Primary hyperparathyroidism-induced acute pancreatitis in pregnancy:A systematic review with a diagnostic-treatment algorithm

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World Journal of Gastroenterology 2024年第32期30卷 3755-3765页

作者： goran Augustin Quirino Lai Maja Cigrovski Berkovic Department of Surgery University Hospital Centre Zagreb and School of Medicine University of ZagrebZagreb 10000Croatia General Surgery and Organ Transplantation Unit Department of SurgerySapienza University of RomeRome 00018Italy Department for Sport and Exercise Medicine Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia

BACKGROUND Primary hyperparathyroidism(PHPT)-induced acute pancreatitis(AP)during pregnancy has rarely been *** to this rarity,there are no diagnostic or treatment algorithms for pregnant *** To determine appropriate diagnostic methods,therapeutic options,and factors related to maternal and fetal outcomes for PHPT-induced AP in *** A literature search of articles in English,Japanese,German,Spanish,and Italian was performed using PubMed(1946-2023),PubMed Central(1900-2023),and Google *** Preferred Reporting Items for Systematic reviews and Meta-Analyses(PRISMA)protocol was *** search terms included“pancreatite acuta,”“iperparatiroidismo primario,”“gravidanza,”“travaglio,”“puerperio,”“postpartum,”“akute pankreatitis,”“primärer hyperparathyreoidismus,”“Schwangerschaft,”“Wehen,”“Wochenbett,”“pancreatitis aguda,”“hiperparatiroidismo primario,”“embarazo,”“parto,”“puerperio,”“posparto,”“acute pancreatitis,”“primary hyperparathyroidism,”“pregnancy,”“labor,”“puerperium,”and“postpartum.”Additional studies were identified by reviewing the reference lists of retrieved ***,imaging,surgical,obstetric,and outcome data were *** Fifty-four cases were collected from the 51 *** median maternal age was 29 ***-induced AP starts at the 20th gestational week;higher gestational weeks were seen in mothers who died(mean gestational week 28).Median values of amylase(1399,Q1-Q3=519-2072),lipase(2072,Q1-Q3=893-2804),serum calcium(3.5,Q1-Q3=3.1-3.9),and parathormone(PTH)(384,Q1-Q3=123-910)were *** 46 cases,adenoma was the cause of PHPT,followed by 2 cases of carcinoma and 1 case of *** the remaining 5 cases,the diagnosis was not *** ultrasound was positive in 34 cases,whereas sestamibi was performed in 3 cases,and neck computed tomography or magnetic resonance imaging was performed in 9 cases(the enlarged parathyroid gland was not localized in 3 cases).Surgery was the prefer

关键词： Primary hyperparathyroidism Acute pancreatitis Pregnancy Diagnosis Maternal mortality Fetal mortality Algorithm

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Neoadjuvant treatment of pancreatic ductal adenocarcinoma:Whom,when and how

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1223-1230页

作者： Nebojsa Manojlovic goran Savic Stevan Manojlovic Clinic for Gastroenterology and Hepatology Military Medical AcademyFaculty of Medicine of the Military Medical AcademyUniversity of DefenceBelgrade 11000Serbia Military Medical Academy Faculty of Medicine of the Military Medical AcademyUniversity of DefenceBelgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Pancreatic ductal adenocarcinoma(PDAC),which is notorious for its aggressiveness and poor prognosis,remains an area of great unmet medical need,with a 5-year survival rate of 10%-the lowest of all solid *** diagnosis,only 20%of patients have resectable pancreatic cancer(RPC)or borderline RPC(BRPC)disease,while 80%of patients have unresectable tumours that are locally advanced pancreatic cancer(LAPC)or have distant *** 60%of patients who undergo upfront surgery for RPC are unable to receive adequate adjuvant chemotherapy(CHT)because of postoperative complications and early cancer *** important paradigm shift to achieve better outcomes has been the sequence of therapy,with neoadjuvant CHT preceding *** surgical stages have emerged for the preoperative assessment of nonmetastatic pancreatic cancers:RPC,BRPC,and *** main goal of neoadjuvant treatment(NAT)is to improve postoperative outcomes through enhanced selection of candidates for curative-intent surgery by identifying patients with aggressive or metastatic disease during initial CHT,reducing tumour volume before surgery to improve the rate of margin-negative resection(R0 resection,a microscopic margin-negative resection),reducing the rate of positive lymph node occurrence at surgery,providing early treatment of occult micrometastatic disease,and assessing tumour chemosensitivity and tolerance to treatment as potential surgical *** this editorial,we summarize evidence concerning NAT of PDAC,providing insights into future practice and study *** research is needed to establish predictive biomarkers,measures of therapeutic response,and multidisciplinary stra tegies to improve patient-centered outcomes.

关键词： Pancreatic adenocarcinoma Neoadjuvant treatment Chemotherapy Upfront surgery Radiotherapy Response evaluation

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Communication Resources Allocation for Time Delay Reduction of Frequency Regulation Service in High Renewable Penetrated Power System

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 468-480页

作者： Hongjie He Ning Zhang Chongqing Kang Song Ci Fei Teng goran Strbac State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Department of Electrical and Electronic Engineering Imperial College LondonSW72BULondonU.K

The high renewable penetrated power system has severe frequency regulation *** resources can provide frequency regulation services but are limited by com-munication time *** paper proposes a communication resources allocation model to reduce communication time delay in frequency regulation *** device resources and wireless spectrum resources are allocated to distributed resources when they participate in frequency *** reveal impact of communication resources allocation on time delay reduction and frequency regulation ***,we study communication resources allocation solution in high renewable energy penetrated power *** provide a case study based on the HRP-38 *** show communication time delay decreases distributed resources'ability to provide frequency regulation *** the other hand,allocating more communication resources to distributed resources'communica-tion services improves their frequency regulation *** power systems with renewable energy penetration above 70%,required communications resources are about five times as many as 30%renewable energy penetrated power systems to keep frequency performance the *** Terms-Communication resources allocation,commun-ication time delay,distributed resource,frequency regulation,high renewable energy penetrated power system.

关键词： Communication resources allocation communication time delay distributed resource frequency regulation high renewable energy penetrated power system

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Bridge Condition Assessment by Visual Inspection-Croatian Experience

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Journal of Civil Engineering and Architecture 2024年第10期18卷 504-514页

作者： goran Puž Faculty of Civil Engineering University of ZagrebZagreb 10000Croatia

Most decisions relating to bridge maintenance are founded on assessments that are based on visual inspections conducted by specially trained engineers,using procedures and aids defined in the management *** inspection is the main tool for bridge condition assessment,and is therefore of crucial significance for planning periodic maintenance *** shall present the study aimed at harmonizing bridge assessment activities,which was conducted in early 2012 in company Hrvatske ceste-Croatian National Road *** RC bridges were chosen for this study,since visual inspection is usually only tool utilized for their *** obtained by inspection were analyzed using methods of mathematical *** results point to weaknesses in the current assessment system,while the study itself constitutes a good basis for further improvement of management aids,manuals and procedures for bridge inspection.

关键词： Visual inspection concrete bridges bridge management bridge rating

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市场环境下智能配用电系统分层协同优化运行:研究挑战、进展与展望

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中国电机工程学报 2024年第6期44卷 2078-2096,I0001页

作者：叶宇剑吴奕之胡健雄汤奕陈涛 goran STRBAC 东南大学电气工程学院江苏省南京市210096 伦敦帝国理工学院电气与电子工程系英国伦敦SW72AZ

随着分布式资源在配电网中的比例不断提高,如何在市场化交易机制下实现配用电系统安全经济运行成为当下的研究热点。在市场环境下,配用电系统各层的运行管理面临着不确定性逐层加剧、市场规模快速扩展、市场交易与系统安全运行难以有效... 详细信息

随着分布式资源在配电网中的比例不断提高,如何在市场化交易机制下实现配用电系统安全经济运行成为当下的研究热点。在市场环境下,配用电系统各层的运行管理面临着不确定性逐层加剧、市场规模快速扩展、市场交易与系统安全运行难以有效衔接等多重挑战。该文首先梳理市场环境下配用电系统运行优化的关键问题;其次,对传统解析优化方法的研究成果与研究中仍待解决的问题进行总结;然后,针对配用电系统市场交易、运行优化等问题特点,系统性地介绍深度强化学习技术,分析归纳深度强化学习在配用电系统中的研究现状。最后,提炼出贯穿配用电系统多层多主体协同优化问题中的三重研究需求,并对深度强化学习技术未来的应用路径与发展趋势进行展望。

关键词：配电市场运营配电系统调度可交易能源需求侧管理强化学习多智能体系统

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3D micro-devices for enhancing the lateral resolution in optical microscopy

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Light(Advanced Manufacturing) 2024年第2期5卷 50-63页

作者： Gordon Zyla goran Maconi Anton Nolvi Jan Marx Dimitra Ladika Ari Salmi Vasileia Melissinaki Ivan Kassamakov Maria Farsari Institute of Electronic Structure and Laser Foundation for Research and Technology-HellasHeraklionGreece Electronics Research Laboratory Department of PhysicsUniversity of HelsinkiHelsinkiFinland Applied Laser Technologies Ruhr University BochumBochumGermany

Although optical microscopy is a widely used technique across various multidisciplinary fields for inspecting small-scale objects,surfaces or organisms,it faces a significant limitation:the lateral resolution of optical microscopes is fundamentally constrained by light *** micro-spheres,however,offer a promising solution to this issue as they are capable of significantly enhancing lateral resolution through extraordinary phenomena,such as a photonic *** upon the potential of dielectric micro-spheres,this paper introduces a novel approach for fabricating 3D micro-devices designed to enhance lateral resolution in optical *** proposed 3D micro-device comprises a modified coverslip and a micro-sphere,facilitating easy handling and integration into any existing optical *** manufacture the device,two advanced femtosecond laser techniques are employed:femtosecond laser ablation and multi-photon *** laser ablation was employed to create a micro-hole in the coverslip,which allows light to be focused through this ***-photon lithography was used to fabricate a micro-sphere with a diameter of 20μm,along with a cantilever that positions the above the processed micro-hole and connect it with the *** this context,advanced processing strategies for multi-photon lithography to produce a micro-sphere with superior surface roughness and almost perfect geometry(λ/8)from a Zr-based hybrid photoresist are *** performance of the micro-device was evaluated using Mirau-type coherence scanning interferometry in conjunction with white light illumination at a central wavelength of 600 nm and a calibration grid(Λ=0.28μm,h>50 nm).Here,the 3D micro-device proved to be capable of enhancing lateral resolution beyond the limits achievable with conventional lenses or microscope objectives when used in ***,it maintained the high axial resolution characteristic of Mirau-type coherenc

关键词： Photonic nanojet Multi-photon lithography Optical microscopy Micro-optics Multi-photon grayscale lithography Extreme manufacturing

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Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

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Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat goran Sedeeq Hama Faraj Fattma Abodi Ali Abbas Salihi Aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy Wojciech Branicki Mohammad Taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

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