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Preparation and properties of ZrO_(2)-strengthened porous mullite insulation materials using Y_(2)O_(3) additive

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Journal of Iron and Steel Research International 2024年第6期31卷 1514-1521页

作者： Wang-zhi Yu Yi-hong Shi Ping Liu Yong-wan Wu Cheng-hao Song Xian-gong Deng Xiang Ding Song-lin Ran Yi Zhang hai-jun Zhang hai-liang Deng Advanced Ceramics Research Center School of Materials Science and EngineeringAnhui University of TechnologyMa'anshan 243002AnhuiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

ZrO_(2)-strengthened porous mullite insulation materials were prepared by foaming technology utilizing ZrSiO_(4) and Al_(2)O_(3) as primary materials and Y_(2)O_(3) as an *** effects of Y_(2)O_(3) contents on the phase composition,microstructure,mechanical properties,and heat conductivity of the porous mullite insulation materials were investigated.A suitable Y_(2)O_(3) content could promote phase transition of monoclinic ZrO_(2)(m-ZrO_(2))to tetragonal ZrO_(2)(t-ZrO_(2)),reduce pore size,and improve the strengths of as-prepared *** cold crushing strength and bending strength of as-prepared specimens with a 119µm spherical pore size using 6 wt.%Y_(2)O_(3) were 35.2 and 13.0 MPa,respectively,with a heat conductivity being only 0.248 W/(m K).

关键词： Porous mullite insulation material Zirconium oxide Y_(2)O_(3) Mechanical property Heat conductivity

Study on creep deformation and energy development of underground surrounding rock under four‐dimensional support

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Deep Underground Science and Engineering 2024年第1期3卷 25-38页

作者： Zhanguo Ma Junyu Sun Peng gong Pengfei yan Nan Cui Ruichong Zhang School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouChina State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhouChina Department of Mining Engineering Colorado School of MinesGoldenUSA

There is an urgent need to develop optimal solutions for deformation control of deep high‐stress roadways,one of the critical problems in underground *** previously proposed four‐dimensional support(hereinafter 4D support),as a new support technology,can set the roadway surrounding rock under three‐dimensional pressure in the new balanced structure,and prevent instability of surrounding rock in underground ***,the influence of roadway depth and creep deformation on the surrounding rock supported by 4D support is still *** study investigated the influence of roadway depth and creep deformation time on the instability of surrounding rock by analyzing the energy *** elastic strain energy was analyzed using the program redeveloped in *** numerical simulation results indicate that the combined support mode of 4D roof supports and conventional side supports is highly applicable to the stability control of surrounding rock with a roadway depth exceeding 520 *** the increase of roadway depth,4D support can effectively restrain the area and depth of plastic deformation in the surrounding ***,4D support limits the accumulation range and rate of elastic strain energy as the creep deformation time increases.4D support can effectively reduce the plastic deformation of roadway surrounding rock and maintain the stability for a long deformation period of 6 *** confirmed by in situ monitoring results,4D support is more effective for the long‐term stability control of surrounding rock than conventional support.

关键词： coal mines elastic strain energy four‐dimensional support large roadway depth long‐term stability control plastic deformation surrounding rock

Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications

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Neural Regeneration Research 2024年第2期19卷 360-368页

作者： Leyi Huang Wenjie Xiao yan Wang Juan Li Jiaoe gong Ewen Tu Lili Long Bo Xiao Xiaoxin yan Lily Wan Department of Anatomy and Neurobiology Central South University Xiangya Medical SchoolChangshaHunan ProvinceChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Hunan Children’s HospitalChangshaHunan ProvinceChina Department of Neurology Brain Hospital of Hunan ProvinceChangshaHunan ProvinceChina

Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug *** signaling through the excitatory neurotransmitter glutamate is intricately associated with *** glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic *** mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of *** this review,we first introduce the three groups of mGluRs and their associated signaling ***,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in *** addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also *** hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.

关键词： antiepileptic drugs epileptogenesis metabotropic glutamate receptors(mGluRs) signal pathways therapeutic potentials

Flux Balance Analysis Reveals Potential Anti-HIV-1 Metabolic Targets

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Infectious Diseases & Immunity 2024年第2期4卷 61-68页

作者： Runpeng Han Fei Luo haisheng Yu Yajun yan yan gong Conghua Xie Liang Cheng Department of Radiation and Medical Oncology Medical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Frontier Science Center for Immunology and Metabolism Zhongnan Hospital of Wuhan UniversityState Key Laboratory of VirologyWuhan UniversityWuhan 430071China Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhou 510440China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Human immunodeficiency virus type 1(HIV-1)remains a persistent global health ***,a continuous exploration of novel therapeutic strategies is essential.A comprehensive understanding of how HIV-1 utilizes the cellular metabolism machinery for replication can provide insights into new therapeutic ***:In this study,we performed a flux balance analysis using a genome-scale metabolic model(GEM)integrated with an HIV-1 viral biomass objective function to identify potential targets for anti–HIV-1 *** generated a GEM by integrating an HIV-1 production reaction into CD4+T cells and optimized for both host and virus optimal states as objective functions to depict metabolic profiles of cells in the status for optimal host biomass maintenance or for optimal HIV-1 virion *** analysis was used to predict biochemical reactions altered optimal for HIV-1 *** addition,we conducted in silico simulations involving gene and reaction knock-outs to identify potential anti–HIV-1 targets,which were subsequently validated by human phytohemagglutinin(PHA)blasts infected with ***:Differential analysis identified several altered biochemical reactions,including increased lysine uptake and oxidative phosphorylation(OXPHOS)activities in the virus optima compared with the host *** silico gene and reaction knock-out simulations revealed de novo pyrimidine synthesis,and OXPHOS could serve as potential anti–HIV-1 metabolic *** vitro assay confirmed that targeting OXPHOS using metformin could suppress the replication of HIV-1 by 56.6%(385.4±67.5 pg/mL in the metformintreated group vs.888.4±32.3 pg/mL in the control group,P<0.001).Conclusion:Our integrated host-virus genome-scale metabolic study provides insights on potential targets(OXPHOS)for anti-HIV therapies.

关键词： HIV-1 Flux balance analysis Genome-scale metabolic models Viral biomass objective function Therapeutic target

双波长高效液相法同时测定双香排石颗粒中的马钱子苷、当药苷、断氧化马钱子苷、迷迭香酸和木通苯乙醇苷B

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国际药学研究杂志 2016年第2期43卷 374-377页

作者：王琳琳龚海燕河南中医学院药学院郑州450008

目的建立高效液相双波长切换法同时测定双香排石颗粒中马钱子苷、当药苷、断氧化马钱子苷、迷迭香酸和木通苯乙醇苷B的含量。方法采用Alltima C18色谱柱（4.6 mm×250 mm,5μm）;以乙腈-甲醇（1∶3）（A）-0.1%磷酸溶液（B）为流动相进... 详细信息

目的建立高效液相双波长切换法同时测定双香排石颗粒中马钱子苷、当药苷、断氧化马钱子苷、迷迭香酸和木通苯乙醇苷B的含量。方法采用Alltima C18色谱柱（4.6 mm×250 mm,5μm）;以乙腈-甲醇（1∶3）（A）-0.1%磷酸溶液（B）为流动相进行梯度洗脱;柱温为35℃;流速为1.0 ml/min;进样量为20μl;马钱子苷、断氧化马钱子苷和当药苷检测波长为240 nm,迷迭香酸和木通苯乙醇苷B检测波长为330 nm。结果马钱子苷、当药苷、断氧化马钱子苷、迷迭香酸和木通苯乙醇苷B在给定浓度范围内线性范围分别为5.91~118.20μg/ml（r=0.9995）、4.10~82.00μg/ml（r=0.9991）、8.13~162.60μg/ml（r=0.9993）、12.57~251.40μg/ml（r=0.9998）和4.95~99.00μg/ml（r=0.9997）,线性关系良好;平均加样回收率（n=6）和RSD值分别为96.88%（1.31%）、99.09%（1.47%）、98.29%（1.59%）、98.82%（1.42%）和97.51%（0.86%）。结论本文建立的双波长HPLC方法同时测定双香排石颗粒中马钱子苷、当药苷、断氧化马钱子苷、迷迭香酸和木通苯乙醇苷B含量。方法灵敏度高、简便、准确、重现性好,为评价双香排石颗粒质量控制提供可靠方法。

关键词：双波长HPLC 波长切换法双香排石颗粒马钱子苷当药苷断氧化马钱子苷迷迭香酸木通苯乙醇苷B

An integrated north–south paleo-Dadu-Anning River: New insights from bulk major and trace element analyses of the Xigeda Formation

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China Geology 2024年第1期7卷 91-103页

作者： Yong Zheng hai-bing Li Jia-wei Pan Ping Wang Ya Lai Zheng gong Key Laboratory of Deep-Earth Dynamics Institute of GeologyChinese Academy of Geological SciencesChina Geological SurveyMinistry of Natural ResourcesBeijing 100037China Jiangsu Donghai Continental Deep Hole Crustal Activity National Observaion and Research Station Lianyungang 222300China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China Geophysical Exploration Center China Earthquake AdministrationZhengzhou 450002China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

The Xianshuihe-Anninghe fault extends SE–S and constitutes the southeastern margin of the Tibetan ***,the Dadu River which is associated with the fault does not flow following the path,but makes a 90ºturn within a distance of 1 km at Shimian,heading east,and joins the yangtze River,finally flowing into the East China *** to the abrupt turn,a low and wide pass near the Daqiao reservoir at Mianning separates the N–S course of the Dadu River from the headwater of the Anning River which then flows south into the Yunnan Province along the Anninghe ***,many previous studies assumed southward flow of the paleo-Dadu River from the Shimian to the Anning ***,evidences for the capture of the integrated N–S paleo-Dadu-Anning River,its timing,and causes are still *** study explored the paleo-drainage pattern of the Dadu and Anning Rivers based on bulk mineral and geochemical analyses of the large quantities of fluvial/lacustrine sediments along the trunk of the Dadu and Anning *** with sands in the modern Dadu River,the Xigeda sediments also exhibit a granitoid affinity with the bulk major mineral compositions of quartz(>50%),anorthite(about 10%),orthoclase(about 5%),muscovite(about 5%),and clinochlore(about 4%).Correspondingly,bulk major elements show high SiO_(2),with all samples>60%,and some of them>70%,low TiO_(2)(≤0.75%),P_(2)O_(5)(≤0.55%),FeO*(≤5%),and relatively high CaO(1.02%–8.51%),Na_(2)O(1.60%–2.52%),and K_(2)O(2.17%–2.71%),with a uniform REE ***,synthesizing all these results indicate that these lacustrine sediments have similar material sources,which are mainly derived from its course in the Songpan-Ganzi flysch block,implying that the paleo-Dadu originally flowed southward into the Anning River and provided materials to the Xigeda ancient *** rearrangement of the paleo-Dadu River appears to be closely related to the locally focused uplift driven by strong activities of the Xians

关键词： Dadu River Anninghe fault River diversion Xigeda Formation Tectonic uplift Provenance Songpan-Ganzi flysch Ancient lake Xianshuihe-Xiaojiang fault system Tibetan Plateau

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油分散性氧化锌纳米微粒的制备及表征

无机化学学报 2006年第3期22卷 426-430页

作者：龚海燕李小红张治军河南大学特种功能材料重点实验室开封475001

采用直接沉淀法制备了异丁酸修饰纳米氧化锌微粒,用XRD、TEM、XPS、IR、UV-Vis、PL等检测手段对样品进行结构表征。结果表明:所制的样品为纤锌矿结构的氧化锌颗粒,粒度约为20nm,异丁酸分子与表面锌原子以双齿螯合的形式结合。Zn!2p3/2... 详细信息

采用直接沉淀法制备了异丁酸修饰纳米氧化锌微粒,用XRD、TEM、XPS、IR、UV-Vis、PL等检测手段对样品进行结构表征。结果表明:所制的样品为纤锌矿结构的氧化锌颗粒,粒度约为20nm,异丁酸分子与表面锌原子以双齿螯合的形式结合。Zn!2p3/2的结合能与Zn的标准峰位相比,向低结合能方向移动了1.5eV,其在可见光区比紫外区的荧光发射显著增强。分散性实验表明,样品在有机溶剂中有良好的分散性。

关键词：氧化锌纳米微粒表面修饰分散性

Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing

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Chinese Chemical Letters 2024年第8期35卷 491-497页

作者： Peizhe Li Qiaoling Liu Mengyu Pei Yuci Gan yan gong Chuchen gong Pei Wang Mingsong Wang Xiansong Wang Da-Peng yang Bo Liang Guangyu Ji Research Institute of Plastic Surgery Weifang Medical UniversityWeifang 261000China The Second Affiliated Hospital of Fujian Medical University Quanzhou 362000China Department of Thoracic surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China The Third Affiliated Hospital of Xinxiang Medical University Institutes of Health Central PlainClinical Medical Center of Tissue Engineering and RegenerationXinxiang Medical UniversityXinxiang 453003China School of Rehabilitation Science and Engineering University of Health and Rehabilitation SciencesQingdao 266024China

Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)*** this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug *** patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-l-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster ***,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.

关键词： Chlorogenic acid Strontium Microneedle patch Strontium polyphenol network Exudate absorption Diabetic wound healing

Bilayer Compounded Polytetrafluoroethylene Membrane for Enhanced Oil-Water Emulsion Separation

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Chinese Journal of Polymer Science 2024年第6期42卷 838-850页

作者： Yu-Liang yang Tai-Ran Zhang yan-Ting Han Shao-Yun Guo Qin-gong Rong Jia-Bin Shen State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversitySichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyChengdu610065China West China Hospital/West China School of Nursing Sichuan UniversityChengdu610041China Shandong Senrong New Materials Co. Ltd.Zibo256401China

In order to achieve efficient and durable oil-water emulsion separation,the membranes possessing high separation efficiency and mechanical strength attract extensive attention and are in great *** present study,a kind of polytetrafluoroethylene(PTFE)-based bilayer membrane was fabricated by electrospinning fibrous PTFE(fPTFE)on an expanded PTFE(ePTFE)*** morphological observation revealed that the fibrous structure of the fPTFE layer could be tailored by controlling the formulation of spinning *** addition of appropriate polyoxyethylene(PEO)would make the fibers in the fPTFE layer finer and more *** a result,the compounded membrane exhibited a small pore size of approximately 1.25µm and a substantial porosity nearing 80%.This led to super-hydrophobicity,characterized by a high water contact angle(WCA)of 149.8°,and facilitated rapid oil *** water-in-oil emulsion separation experiment further confirmed that the compounded membrane not only had a high separation efficiency closing 100%,but such an outstanding separation capacity could be largely retained,either through multiple cycles of use or through strong acid(pH=1),strong alkali(pH=12),or high-temperature(100°C)***,the mechanical behavior of the bilayer membrane was basically contributed by that of each layer in terms of their volume *** significantly,the poor creep resistance of fPTFE layer was suppressed by compounding with ePTFE ***,this study has laid the groundwork for a novel approach to create PTFE-based compounded membranes with exceptional overall characteristics,showing promise for applications in the realm of emulsion separation.

关键词： ePTFE Electrospinning membrane Bilayer compounding Emulsion separation