检索结果-南通市图书馆

Studies of heavy ion reactions around Coulomb barrier

在线全文

学校读者我要写书评

暂无评论

Studies of heavy ion reactions around Coulomb barrier

Latest results from gRAAL collaboration

“创新——核科学技术发展的不竭源泉”——中国核学会20...

作者： A.Richard A.K.Nasirov g.Mandaglio M.Manganaro g.giardina K.Hagino China Institute of Atomic Energy Universite de Strasbourg(Uds) 67037 StrasbourgFrance Joint Institute of Nuclear Research 141980 DubnaRussia

The angular distributions of fission fragments for the S+W reaction near Coulomb barrier energies were *** experimental fission excitation function is *** measured fission cross sections are decomposed into fusion-fission,quasifission and fast fission contributions by the dinuclear system *** hindrance to complete fusion both at small and large collision energies is *** fusion excitation functions of S+ Zr in an energy range from above to below Coulomb barrier were measured and *** obvious effect of positive Q-value neutron transfers has been observed in the S+Zr *** addition,the excitation functions of quasielastic scattering at a backward angle have been measured for the systems of O + Pb,Pt,W,and Sm at energies well below the Coulomb barrier. Considering the coupling effects,the extracted diffuseness parameters are close to the values extracted from the systematic analysis of elastic and inelastic scattering data.

关键词： fusion-fission quasifission fusion enhancement neutron transfer surface diffuseness parameter

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Physics C 2009年第12期33卷 1249-1253页

作者： V. Vegna V. Bellini J.P. Bouquet L. Casano A. D'Angelo J.P. Didelez R. Di Salvo A. Fantini D. Franco g. gervino F. ghio g. giardina B. girolami A. giusa M. guidal E. Hourany A.S. Ignatov R. Kunnel A. Lapik A. Lleres P. Levi Sandri F. Mammoliti g. Mandaglio M. Manganaro M. Moricciani A.N. Mushkarenkov V.g. Nedorezov C. Randieri D. Rebreyend N.V. Rudnev g. Russo C. Schaerf M.L. Sperduto M.C. Sutera A.Turinge Dip. di Fisica Università degli Studi di Roma 'Tor Vergata' via della Ricerca Scientifica 1 I-00133 Roma Italy INFN - Sezione di Roma 'Tor Vergata' via della Ricerca Scientifica 1 I-00133 Roma Italy Dip. di Fisica e Astronomia Università di Catania via Santa Sofia 44 I-95123 Catania Italy INFN - Sezione di Catania via Santa Sofia 44 I-95123 Catania Italy LPSC Universit Joseph Fourier Grenoble 1 CNRS/IN2P3 Institut National Polytechnique de Grenoble 53 Avenue des Martyres 38026 Grenoble France IPNO Universit de Paris-Sud 11 CNRS/IN2P3 15 rue Georges Clemenceau 91406 Orsay France Dip. di Fisica Sperimentale Università di Torino via P.Giuria I-00125 Torino Italy INFN - Sezione di Torino via P.Giuria I-00125 Torino Italy Istituto Superiore di Sanità viale Regina Elena 299 I-00161 Roma Italy INFN - Sezione di Roma piazzale Aldo Moro 2 I-00185 Roma Italy Dip. di Fisica Universitàdi Messina salita Sperone 31 I-98166 Messina Italy Institute for Nuclear Research RAS 117312 Moscow Russia INFN - Laboratori Nazionali di Frascati via E.Fermi 40 I-00044 Frascati Italy INFN - Sezione di Catania via Santa Sofia 44 I-95123 Catania Italy

The gRAAL experimental set-up consists of a polarized and tagged photon beam that covers an energy range from a minimum of 600 MeV up to a maximum of 1500 MeV, of a liquid Hydrogen or Deuterium target and of the 4π Lagrange detector optimized for photon detection. It allows the study of pseudo-scalar and vector meson photoproduCtion on the nucleon in the energy range corresponding to the second and the third resonance regions. In the following, the ∑ beam asymmetries in η and π0 photoproduction on quasi-free nucleon are shown. Also single and double polarization observables in K＋A photoproduction on free proton are shown; they are important to confirm the role of new or poorly known resonances in the 1900 MeV mass region.

关键词： polarized photon meson photoproduction polarization observables

Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第6期18卷 1243-1248页

作者： Paola Ruffo Francesca De Amicis Emiliano giardina Francesca Luisa Conforti Medical genetics Laboratory Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly Department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaRendeItaly genomic Medicine Laboratory UILDM IRCCS Fondazione Santa LuciaRomeItaly Department of Biomedicine&Prevention Tor Vergata University of RomeRomeItaly

The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding of the mechanisms underlying gene expression *** the epigenome and epitranscriptome directs the fate of the transcript influencing the functional outcome of each *** this context,non-coding RNAs play a decisive role in addressing the expression regulation at the gene and chromosomal ***-noncoding RNAs,consisting of more than 200 nucleotides,have been shown to act as epigenetic regulators in several key molecular processes involving neurodegenerative disorders,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***-noncoding RNAs are abundantly expressed in the central nervous system,suggesting that their deregulation could trigger neuronal degeneration through RNA *** evaluation of their diagnostic significance and therapeutic potential could lead to new treatments for these diseases for which there is no cure.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis epigenetic mechanism Huntington’s disease long-noncoding RNAs neurodegenerative disease non-coding RNAs Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

用血清α—左旋岩藻糖甙酶诊断肝癌

中西医结合肝病杂志 1993年第2期3卷 26-26页

作者： giardina M.g 眺昌绶

背景与方法在对21例肝细胞癌患者、76例肝硬变患者、22例与肝脏无关的恶性肿瘤患者以及23名健康人进行调查研究后。确定了血清α—左旋岩藻糖甙酶对于肝细胞癌的诊断价值。结果肝癌患者血清α—左旋岩藻糖甙酶的活性水平575.76±212.8... 详细信息

背景与方法在对21例肝细胞癌患者、76例肝硬变患者、22例与肝脏无关的恶性肿瘤患者以及23名健康人进行调查研究后。确定了血清α—左旋岩藻糖甙酶对于肝细胞癌的诊断价值。结果肝癌患者血清α—左旋岩藻糖甙酶的活性水平575.76±212.86n mol/ml/h,明显高于健康对照组(221.23±114.45n mol/ml/h,P<0.001);也明显高于肝硬变患者(274.55±138.97n mol/ml/h,P<0.001)和别的肿瘤患者(257.91±128.12n mol/ml/h,P<0.001)。

关键词：岩藻糖肝细胞癌患者左旋肝外肿瘤活性水平甲胎蛋白超声波检查法无显著性差异特异度临界值

Shared(epi)genomic background connecting neurodegenerative diseases and type 2 diabetes

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2020年第5期11卷 155-164页

作者： Valerio Caputo Andrea Termine Claudia Strafella Emiliano giardina Raffaella Cascella Department of Biomedicine and Prevention Tor Vergata UniversityRome 00133Italy Molecular genetics Laboratory UILDM Santa Lucia FoundationRome 00142Italy Experimental and Behavioral Neurophysiology Laboratory Santa Lucia FoundationRome 00142Italy Department of Biomedical Sciences Catholic University Our Lady of Good CounselTirana 1000Albania

The progressive aging of populations has resulted in an increased prevalence of chronic pathologies,especially of metabolic,neurodegenerative and movement *** particular,type 2 diabetes(T2D),Alzheimer’s disease(AD)and Parkinson’s disease(PD)are among the most prevalent age-related,multifactorial pathologies that deserve particular attention,given their dramatic impact on patient quality of life,their economic and social burden as well the etiopathogenetic mechanisms,which may overlap in some ***,the existence of common triggering factors reflects the contribution of mutual genetic,epigenetic and environmental features in the etiopathogenetic mechanisms underlying T2D and AD/*** this subject,this review will summarize the shared(epi)genomic features that characterize these complex *** particular,genetic variants and gene expression profiles associated with T2D and AD/PD will be discussed as possible contributors to determine the susceptibility and progression to these ***,potential shared epigenetic modifications and factors among T2D,AD and PD will also be ***,this review shows that findings from genomic studies still deserves further research to evaluate and identify genetic factors that directly contribute to the shared ***,a common epigenetic background still needs to be investigated and *** evidences discussed in this review underline the importance of integrating largescale(epi)genomic data with additional molecular information and clinical and social background in order to finely dissect the complex etiopathogenic networks that build up the“disease interactome”characterizing T2D,AD and PD.

关键词： Type 2 diabetes Alzheimer’s disease Parkinson’s disease Metabolism Neurodegeneration Neuroinflammation genetic variants Epigenomic background Disease interactome

Preterm Birth,From the Biological Knowledges to the Prevention:An Overview

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Maternal-Fetal Medicine 2020年第3期2卷 162-171页

作者： Tosto Valentina giardina Irene Tsibizova Valentina Di Renzo gian Carlo Department of Obstetrics and gynecology and Center for Perinatal and Reproductive Medicine University of PerugiaSanta Maria della Misericordia University HospitalPerugia 06132Italy Department of Obstetrics and gynecology Almazov National Medical Research CenterSt.Petersburg 191014Russia

The time of birth is a critical determinant of perinatal and long-term outcomes,and even trans-generational *** birth is still the leading cause of infant mortality and ***,rates of preterm birth remain high *** parturition is a complex syndrome,which can be induced by several factors such as infection,cervical pathology,uterine overdistension,progesterone deficiency,vascular alterations(utero-placental ischemia,decidual hemorrhage),maternal and fetal stress,allograft reaction,allergic phenomena,and probably other several unknown *** mechanisms responsible for early labor activation have been partially identified and involve receptors,chemokines,and inflammatory *** is very useful to understand the cellular and biochemical pathways responsible for preterm labor activation to identify,treat,and prevent negative outcome in a timely *** and clinicians play a key role in improving biochemical knowledge on preterm delivery,identifying risk factors,and applying multilevel preventive strategies.

关键词： Premature birth Biological pathways Inflammation Prevention strategies

In vitro gastrointestinal digestion study of two wheat cultivars and evaluation of xylanase supplementation

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2015年第3期6卷 355-368页

作者： Mickael Lafond Bernard Bouza Sandrine Eyrichine Friedrich Rouffineau Luc Saulnier Thierry giardina Estelle Bonnin Aurélie Preynat iSm2-BiosCiences UMR 7313 Aix Marseille Université Adisseo France S.A.S. Centre d'Expertise et de Recherche en Nutrition INRA UR 1268-BiopolymeresInteractions-Assemblages

Background： The filamentous fungus Talaromyces versatifis is known to improve the metabolizable energy of wheat- based poultry diets thanks to its ability to produce a pool of CAZymes and particularly endo-β（1,4）-xylanases. In order to appreciate their in vivo mode of action, the supplementation effect of two of its xylanases, XynD and XynB from families gH10 and gHll respectively, have been evaluated on two different wheat cultivars Caphorn and Isengrain, which were chosen amongst 6 varieties for their difference in non starch polysaccharides content and arabinoxylan composition. Results： Polysaccharides digestion was followed during 6 h along the digestive tract using the TNO gastrointestinal model-1, to mimic monogastric metabolism. Polysaccharide degradation appeared to occur mainly at the jejunal level and was higher with Isengrain than with Caphorn. For both cultivars, XynD and XynB supplementation increased notably the amount of reducing end sugars into the jejuno-ileal dialysates, which has been confirmed by a valuable increase of the soluble glucose into the jejunal dialysates. Conclusions： The amounts of arabinose and xylose into the dialysates and ileal deliveries increased consequently mainly for Caphorn, suggesting that XynD and XynB supplementation in wheat-based diet could alleviate the anti-nutritional effects of arabinoxylans by limiting the physical entrapment of starch and could increase the available metabolizable energy.

关键词： in vitro TNO gastrointestinal model-1 Talaromyces versatilis Wheat cultivars XynB XynD

S100b protects IMR-32 cells against Ab(1-42) induced neurotoxicity via modulation of apoptotic genes expression

在线全文

学校读者我要写书评

暂无评论

Advances in Alzheimer's Disease 2013年第3期2卷 99-108页

作者： M. Elisabetta Clementi Beatrice Sampaolese Doriana Triggiani Antonio Tiezzi Bruno giardina 1CNR-ICRM Institute of Chimica del Riconoscimento Molecolare Department for Innovation in Biological Agro-food and Forest Systems (DIBAF) Tuscia University Viterbo Italy Institute of Biochemistry and Clinical Biochemistry Catholic University School of Medicine Rome Italy

Amyloid beta (1-42) peptide is considered responsible for the formation of senile plaques that accumulate in the brain of patients with Alzheimer’s disease (AD). In the past years considerable attention has been focused on identifying new protective substances that prevent or almost retard the appearance of amyloid beta (1-42)-related neurotoxic effects. In this study, human neuroblastoma cells (IMR-32) was used as system model to evaluate the protective role of S100b, a neurotrophic factor and neuronal survival protein, that is highly expressed by reactive astrocytes in close vicinity of beta-amyloid deposits, against amyloid beta (1-42)-dependent toxicity. Our results show that at nanomolar concentrations, S100b protects cells against Aβmediated cytotoxicity, as assessed by MTS vitality test. The protective mechanism seems to be related to the effect on bcl-2 (an anti-apoptotic gene) expression, which is highly down-regulated by amyloid beta (1-42) treatment, while resulted more expressed in the presence of S100b. On the contrary, Bax, a proapoptotic gene, resulted down-regulated by the treatment with S100 compared with the results obtained in the presence of amyloid beta (1-42) peptide. However, at micromolar doses, S100b is toxic for IMR-32 cells and its toxicity adds to that of the Aβpeptide, suggesting that additional molecular mechanisms may be involved in theneurotoxic process.

关键词： S100b Neurodegeneration Oxidate Methionine Apoptotic genes Expression

产生鼠抗人B细胞白血病及淋巴瘤个体基因型单克隆抗体的两种方法学评价

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

细胞与分子免疫学杂志 1987年第2期 93-96页

作者： Steven L giardina et al ,方美玉

产生抗人B细胞肿瘤个体基因型单克隆抗体的常规免疫方法是:首先用50～100μg纯化的Ig腹腔免疫,7天以后用等量蛋白质静脉免疫。为了缩短时间和减少成功地免疫所需的个体基因型Ig的用量,本文评价了两种免疫方法。当用常规方法免疫时,获... 详细信息

产生抗人B细胞肿瘤个体基因型单克隆抗体的常规免疫方法是:首先用50～100μg纯化的Ig腹腔免疫,7天以后用等量蛋白质静脉免疫。为了缩短时间和减少成功地免疫所需的个体基因型Ig的用量,本文评价了两种免疫方法。当用常规方法免疫时,获得抗个体基因型杂交瘤的百分率为0.3％～1.0％。为了增加抗个体基因型杂交瘤的比例,作者采用不聚集的人γ-球蛋白于免疫前14天给公鼠和母鼠注射以

关键词：单克隆抗体个体基因型骨髓瘤细胞杂交瘤淋巴瘤抗个体基因型抗体 IgM 白血病血癌