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Two-way predation between immature stages of the hoverfly Eupeodes corollae and the invasive fall armyworm(Spodoptera frugiperda ***)

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Journal of Integrative Agriculture 2021年第3期20卷 829-839页

作者： LI Hui JIANG Shan-shan ZHANG Hao-wen geng ting Kris AGWYCKHUYS WU Kong-ming Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193P.R.China

Since its 2018 invasion of eastern Asia,the fall armyworm Spodoptera frugiperda(Lepidoptera:Noctuidae)has become a key pest in local maize *** pesticides have been widely used to mitigate the initial *** attack,biological control is receiving ample attention as a desirable,environmentally-sound alternative to chemical ***(Diptera:Syrphidae)are abundant natural enemies in Chinese maize fields and have been observed to consume *** *** this study,we use laboratory assays to study the two-way interaction between immature stages of *** and the endemic syrphid Eupeodes *** mimic natural conditions,assays were performed in the presence of fresh maize *** 2 nd or 3 rd instar larvae of *** preyed on 1 st and 2 nd instar *** larvae with a Holling type III response,consuming a respective theoretical maximum of 43.48 and 83.33 larvae over a 24-h ***,once *** larvae reached 3 rd instar,they exhibited aggressive behavior and equally preyed on syrphid larvae with a Holling type III *** 5 th and 6 th instar larvae of *** consumed a respective 16.39-19.23,6.02-19.61 and 6.76-8.26 of 1 st,2 nd and 3 rd instar *** larvae per *** our results await field-level validation,*** agonistic(i.e.,defensive)and consumptive behavior towards resident natural enemies such as *** possibly degrades biotic resistance and raises its invasion *** findings shine new light on the interaction between lepidopteran herbivores and their natural enemies,and can help advance the development of conservation biological control and other integrated pest management(IPM)strategies against *** in China and abroad.

关键词： Eupeodes corollae Spodoptera frugiperda predation functional response conservation biological control invasion biology trophic ecology

Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxygenistein derivatives

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Chinese Journal of Natural Medicines 2017年第11期15卷 871-880页

作者： geng Xiao-ting TANG Jing-Jing CHENG Kun-Peng FU Yuan-Tao HU Rong LU Jin-Rong Department of Organic Chemistry China Pharmaceutical University Nanjing 210009 China State Key Laboratory of Natrual Medicines Department of Phystology Chma Pharmaceutzcal University Nanjing 210009China

Soy isoflavones exhibit various biological activities, such as antioxidant, anti-tumor, anti-inflammatory, and cardiovascular protective effects. The present study was designed to investigate the effects of sixteen synthesized 3-amino-2-hydroxypropoxy genistein derivatives on cell proliferation and activation of Nrf2(Nuclear factor erythroid 2-related factor 2)/ARE(antioxidant response elements) pathway in human cancer cell lines. Most of the tested compounds exerted greater cytotoxic activity than genistein, as measured by MTT assay. Moreover, compound 8 c showed the highest ARE-luciferase reporter activity among the test compounds. It strongly promoted Nrf2 nuclear translocation and up-regulated the expression of total Nrf2 and downstream targets NQO-1 and HO-1 at protein level. The present study may provide a basis for the application of isoflavone derivatives as Nrf2/ARE pathway inducers for cancer therapy and cancer prevention.

关键词： Genistein derivatives Nrf2/ARE pathway Cytotoxicity Anti-cancer Isoflavone

Biosynthesis of artemisinic acid in engineered Saccharomyces cerevisiae and its attractiveness to the mirid bug Apolygus lucorum

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Journal of Integrative Agriculture 2022年第10期21卷 2984-2994页

作者： TENG Dong LIU Dan-feng Khashaveh ADEL SUN Pei-yao geng ting ZHANG Da-wei ZHANG Yong-jun State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Laboratory of Ecology and Evolutionary Biology Yunnan UniversityKunming 650091P.R.China Langfang Scientific Research Trial Station Institute of Plant ProtectionChinese Academy of Agricultural SciencesLangfang 065000P.R.China Institute of Plant Protection Gansu Academy of Agricultural SciencesLanzhou 730070P.R.China

Artemisia annua is an important preferred host of the mirid bug Apolygus lucorum in *** emitted from *** attract *** artemisinic acid of *** is a precursor of artemisinin that has been widely investigated in the Chinese herbal medicine ***,little is known at this point about the biological roles of artemisinic acid in regulating the behavioral trends of *** this study,we collected volatiles from *** at the seedling stage by using headspace solid phase microextraction(HS-SPME).Gas chromatography-mass spectrometry(GC-MS) analysis showed that approximately 11.03±6.00 and 238.25±121.67 ng hartemisinic acid were detected in volatile samples and milled samples,***,a key gene for artemisinic acid synthesis,the cytochrome P450 gene cyp71 av1,was expressed in engineered Saccharomyces cerevisiae to catalyze the production of artemisinic *** the addition of exogenous artemisinic alcohol or artemisinic aldehyde,artemisinic acid was identified as the product of the expressed *** electroantennogram(EAG) recordings,3-day-old adult *** showed significant electrophysiological responses to artemisinic alcohol,artemisinic aldehyde and artemisinic ***,3-day-old female bugs were significantly attracted by artemisinic acid and artemisinic alcohol at a concentration of 10 mmol L,whereas 3-day-old male bugs were attracted significantly by 10 mmol Lartemisinic acid and artemisinic *** propose that artemisinic acid and its precursors could be used as potential attractant components for the design of novel integrated pest management strategies to control ***.

关键词： artemisinic acid CYP71AV1 biosynthesis Apolygus lucorum electrophysiological responses behavioral trends

Quantifying the influence factors and the multi-factor interaction on Cadmium accumulation in limestone-derived agricultural soil by machine learning methord

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Quantifying the influence factors and the multi-factor inter...

Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

2020年中国地球科学联合学术年会

作者： geng ting School of Earth Science and Geological Engineering Sun Yat-sen University

Cadmium(Cd) is a highly toxic heavy metal element that exists widely in the environment and can cause extensive threats to human beings, animals, and plants. Karst soils, which have many unique hydraulic and hydrogeological characteristics, are particularly problematic for their high response to pollution caused by human activities.

关键词： Quantifying the influence factors and the multi-factor interaction on Cadmium accumulation in limestone-derived agricultural soil by machine learning methord

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-Yuan Niu geng-ting Dong Yi Li Qing Luo Liu Cao Xi-Min Wang Qi-Wen Wang Yi-ting Wang Zhe Zhang Xi-Wen Zhong Wei-Bo Dai Le-Yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

相关反馈结合鲁棒局部二值模式的CBIR算法

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北京邮电大学学报 2016年第5期39卷 16-19页

作者：孙挺耿国华周口师范学院网络工程学院河南周口466001 西北大学可视化研究所西安710069

提出了一种鲁棒局部二值模式结合相关反馈的基于内容的图像检索算法.鲁棒局部二值模式是一种性能较好的特征提取算子,对噪声和光照变化具有较强的鲁棒性,且不会造成原始数据的改变,可提高特征提取的准确性.相关反馈使系统可获知用户的偏... 详细信息

提出了一种鲁棒局部二值模式结合相关反馈的基于内容的图像检索算法.鲁棒局部二值模式是一种性能较好的特征提取算子,对噪声和光照变化具有较强的鲁棒性,且不会造成原始数据的改变,可提高特征提取的准确性.相关反馈使系统可获知用户的偏好,对检索结果具有导向作用.多个纹理数据库的实验结果表明,提出算法的检索准确性和鲁棒性优于同类算法.

关键词：鲁棒局部二值模式图像检索相关反馈特征提取

Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs

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Chinese Journal of Natural Medicines 2017年第10期15卷 775-784页

作者： WANG Shu-Yao A Ji-Ye FEI Fei geng Jian-Liang PENG Ying OUYANG Bing-Chen WANG Pei JIN Xiao-Liang ZHAO Yu-Qing WANG Jian-Kun geng ting LI Yan-Jing HUA NG Wen-Zhe WANG Zhen-Zhong XIAO Wei WANG Guang-Ji School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China Jiangsu Kanion Modern Chinese Medicine Institute Nanjing 210017 China State Key Labonatory of Pharmaceutical New-Techfor Chinese Medicine Jiangsu Kanion Pharmaceutical Co. Ltd. Lianyungang222001 China Key Lab of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009 China

Ginkgo diterpene lactones meglumine injection(GDLI)is a commercially available product used for ***,the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI,i.e.,ginkgolide A(GA),ginkgolide B(GB),and ginkgolide K(GK),have never been fully evaluated in beagle *** this work,a simple,sensitive,and reliable method based on ultra-fast liquid chromatography-tandem mass spectrometry(UFLC-MS/MS)was developed,and the prototypes and total amounts of GA,GB,and GK were determined in beagle dog *** plasma concentrations of the hydrolyzed carboxylic forms were calculated by subtracting the prototype concentrations from the total lactone *** the first time,the pharmacokinetics of GA,GB,and GK were fully assessed in three forms,i.e.,the prototypes,the hydrolyzed carboxylic forms,and the total amounts,after intravenous administration of GDLI in beagle *** was shown that ginkgolides primarily existed in the hydrolyzed form in plasma,and the ratio of hydrolysates to prototype forms of GA and GB decreased gradually to a homeostatic *** of the three forms of the three ginkgolides showed linear exposure of AUC to the ***,GB,and GK showed a constant half-life approximately 2.7,3.4,and 1.2 h,respectively,which were consistent for the forms at three dose levels(0.3,1.0,and 3.0 mg·kg^(-1))and after a consecutive injection of GDLI for 7 days(1.0 mg·kg^(-1)).

关键词： Hydrolysates of ginkgolides LC-MS/MS Pharmacokinetics Ginkgo diterpene lactones Beagle dog

Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population

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World Journal of Gastroenterology 2015年第22期21卷 6898-6904页

作者： ting-ting geng Xiao-Jie Xun Sen Li Tian Feng Li-Ping Wang Tian-Bo Jin Peng Hou Department of Endocrinology the First Affiliated Hospital of Xi’an Jiaotong University School of Medicine National Engineering Research Center for Miniaturized Detection Systems School of Life Sciences Northwest University School of Life Sciences University of Liverpool Crown Street

AIM: To investigate the association between colorectal cancer(CRC) genetic susceptibility variants and esophageal cancer in a Chinese Han ***: A case-control study was conducted including 360 esophageal cancer patients and310 healthy controls. Thirty-one single-nucleotide polymorphisms(SNPs) associated with CRC risk from previous genome-wide association studies were analyzed. SNPs were genotyped using Sequenom Mass-ARRAY technology, and genotypic frequencies in controls were tested for departure from HardyWeinberg equilibrium using a Fisher's exact test. The allelic frequencies were compared between cases and controls using a χ 2 test. Associations between the SNPs and the risk of esophageal cancer were tested using various genetic models(codominant, dominant,recessive, overdominant, and additive). ORs and95%CIs were calculated by unconditional logistic regression with adjustments for age and ***: The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold(95%CI:1.15-2.06; P = 0.004) and 1.28-fold(95%CI: 1.03-1.60;P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively. In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model(OR = 0.52, 95%CI:0.31-0.88; P = 0.033) and recessive model(OR =0.55, 95%CI: 0.34-0.87; P = 0.010). The rs4939827C/T-T/T genotype was associated with a 0.67-fold(95%CI: 0.46-0.98; P = 0.038) decreased esophageal cancer risk under the dominant model. In addition,rs6687758, rs1321311, and rs4444235 were associated with an increased risk. In particular, the T/T genotype of rs1321311 was associated with an 8.06-fold(95%CI: 1.96-33.07; P = 0.004) increased risk in the codominant ***: These results provide evidence that known genetic variants associated with CRC risk confer risk for esophageal cancer, and may bring risk for other digestive system tumors.

关键词： Colorectal cancer Esophageal cancer Single-nucleotide polymorphism Susceptibility

Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2

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Chinese Medical Journal 2007年第3期120卷 204-210页

作者： YIN Xiao-xue CHEN Zhong-qiang LIU Zhong-jun MA Qing-jun DANG geng-ting Department of Orthopaedics Peking University Third HospitalBeijing 100083 China

Background Icafiine is a flavonoid isolated from a traditional Chinese medicine Epimedium pubescens and is the main active compound of it. Recently, Epimedium pubescens was found to have a therapeutic effect on osteoporosis. But the mechanism is unclear. The aim of the study was to research the effect of Icariine on the proliferation and differentiation of human osteoblasts. Methods Human osteoblasts were obtained by inducing human marrow mesenchymal stem cells （hMSCs） directionally and were cultured in the presence of vadous concentrations of Icariine. 3-（4,5-dimethylthiazol-2-yl）-2,5- diphenyltetrazolium bromide （MTT） test was used to observe the effect of Icariine on cell proliferation. The activity of alkaline phosphatase （ALP） and the amount of calcified nodules were assayed to observe the effect on cell differentiation. The expression of bone morphogenetic protein 2 （BMP-2） mRNA was detected by reverse transcriptase-polymerase chain reaction （RT-PCR）. Results Icadine （20 μg/ml） increased significantly the proliferation of human osteoblasts. And, IcarUne （10 μg/ml and 20 μg/ml） increased the activity of ALP and the amount of calcified nodules of human osteoblasts significantly （P〈0.05）. BMP-2 mRNA synthesis was elevated significantly in response to Icariine （20 μg/ml）. Conclusions Icadine has a direct stimulatory effect on the proliferation and differentiation of cultured human osteoblast cells in vitro, which may be mediated by increasing production of BMP-2 in osteoblasts.

关键词： Icariine osteoblasts cell proliferation cell differentiation bone morphogenetic protein