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Single-cell network analysis reveals gene expression programs for Arabidopsis root development and metabolism

Plant Communications 2024年第8期5卷 32-49页

作者： Ershang han Zhenxing geng Yue Qin Yuewei Wang Shisong ma MOE Key Laboratory for Cellular Dynamics School of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaInnovation Academy for Seed DesignChinese Academy of SciencesHefei 230027China School of Data Science University of Science and Technology of ChinaHefei 230027China

Single-cell RNA-sequencing datasets of Arabidopsis roots have been generated,but related comprehensive gene co-expression network analyses are *** conducted a single-cell gene co-expression network analysis with publicly available scRNA-seq datasets of Arabidopsis roots using a SingleCellGGM *** analysis identified 149 gene co-expression modules,which we considered to be gene expression programs(GEPs).By examining their spatiotemporal expression,we identified GEPs specifically expressed in major root cell types along their developmental *** GEPs define gene programs regulating root cell development at different stages and are enriched with relevant developmental *** examples,a GEP specific for the quiescent center(QC)contains 20 genes regulating QC and stem cell niche homeostasis,and four GEPs are expressed in sieve elements(SEs)from early to late developmental stages,with the early-stage GEP containing 17 known SE developmental *** also identified GEPs for metabolic pathways with cell-type-specific expression,suggesting the existence of cell-type-specific metabolism in *** the GEPs,we discovered and verified a columellaspecific gene,NRL27,as a regulator of the auxin-related root gravitropism *** analysis thus systematically reveals GEPs that regulate Arabidopsis root development and metabolism and provides ample resources for root biology studies.

关键词： single-cell RNA sequencing single-cell gene co-expression network analysis gene expression program Arabidopsis root development NRL27 gravitropism

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Artemordins A-S, Cadinane-Type Sesquiterpenoid Dimers from Artemisia ordosica and Their Antihepatoma Activities

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Chinese Journal of Chemistry 2024年第13期42卷 1493-1508页

作者： Yuan Wang Tian-Ze Li Yun-Bao ma Chang-An geng Yong-Cui Wang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Nineteen new cadinane-involving sesquiterpenoid dimers,artemordins A-S(1-—19),together with 13 known SDs(20-32)were isolated from Artemisia *** structures and absolute configurations were established by comprehensive spectral analyses,X-ray single crystal diffraction,theoretical ECD,and NMR ***,artemordins A-F(1—6)were the first examples of two cadinane units constructed by unprecedented C-3−C-15′or C-3−C-13′single bond with an oxido-rearranged 6/5/6/6 fused ring system;artemordins G-K(7-11)were biogenetically connected by[4+2]cycloaddition reaction and artemordins G-J(7-10)possessed a novel 5/6/6/6/6/6/5-heptacyclic fused ring *** L-S(12-19)were formed by esterification,which involved three different types of *** assay suggested that the most active compounds,artemordins B and h(2 and 8),exhibited inhibitory activities on three hepatoma cell lines with IC50 values of 26.9 and 25.1μmol/L(hepG2),29.5 and 18.3μmol/L(huh7),19.7 and 15.7μmol/L(SK-hep-1).

关键词： Artemisia ordosica Artemordins A-s Cadinane-type sesquiterpenoid dimers Antihepatoma activities Terpenoids Natural products Cytotoxicity

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Mixed Dead-time Effect Suppression Strategy for Modular Multilevel Converters

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1075-1084页

作者： Zhi geng Minxiao han School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 102206China IEEE

Dead time is necessary for the coupled power switches to prevent shoot-through,especially in the modular multilevel converters(MMCs)with a large number of power *** paper proposes a dead-time effect suppression strategy for MMCs with nearest level *** operational principles of MMCs are first *** to the operational features of MMCs,the method that removes a switching signal from the coupled switches and the reduced switching frequency voltage balancing algorithms(RSFVBAs)are mixed in the proposed *** the intervals that are furthest away from the zerocrossing points(ZCP)of arm currents,the single switching signal method can completely eliminate the dead-time effect(DTE).Alternatively,the DTE is suppressed by the RSFVBA in intervals that are close to the *** the combination of the two methods,the dependence of the DTE suppression method on currents is reduced and the influences of ZCP are also released without degrading the normal operation performance of ***,the output performance of MMCs is improved and the voltage stress on the arm inductor dramatically ***,the validation of the method is verified by the simulation results with the professional tool matlab/Simulink.

关键词： Dead-time effect modular multilevel converters switching frequency voltage balancing algorithm

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A dual-band wireless communication of spoof plasmonic meta-waveguide

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Science China(Information Sciences) 2024年第7期67卷 337-338页

作者： Xinxin GAO geng-Bo WU Ze GU Qian ma Wenyi CUI Tiejun CUI Chihou ChAN State Key Laboratory of Terahertz and Millimeter Waves City University of Hong Kong State Key Laboratory of Millimeter Waves Southeast University Department of Electrical Engineering City University of Hong Kong

The ever-growing demands in wireless communications,computational imaging, and light detection necessitate the capability to freely manipulate electromagnetic *** and highly integrated devices hold great promise for the future of communications. Spoof plasmonic metamaterials, in particular, have shown potential in creating functional devices and systems due to their ultracompact and low-profile advantages [1–3].

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Investigation and measurement of old building response to the overlapped shield tunnel of multiple schemes in the sandy cobble stratum

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Underground Space 2024年第2期15卷 260-274页

作者： Xue Li Aopeng geng School of Geoscience and Technology Southwest Petroleum UniversityChengduSichuan 610500China China Railway Construction Bridge Engineering Bureau Group Co. Ltd.Tianjin 300300China

Ground movements due to tunneling are becoming increasingly critical as buildings are located around construction *** study proposes a new combined reinforcement method using a foundation grouting oblique pipe *** former improves the bearing capacity of the subsoil,and the latter blocks the transmission of soil deformation,which weakens the influence of construction during overlapped tunnel *** on this new method,a case study of the shield tunneling response to an old building in Line 6 of China’s Chengdu Metro is ***,three-dimensional numerical models without reinforcement,traditional foundation grouting reinforcement,and the new combined reinforcement schemes were *** numerical simulation performance was verified using a set of field instrumentation data,which demonstrated that the old building response to the overlapped tunnels was under control,and the maximum deformation,angular distortion,and principal tensile strain of the building were 5.25 mm,5.1010–6 rad/m,and 0.0081%,*** with the traditional reinforcement scheme,the deformation,angular distortion,and principal tensile strain in the combined reinforcement scheme were reduced by 54.78%,71.02%,and 70.22%,*** results have important implications for the design and construction of shield tunnels and their response to old buildings.

关键词： Overlapped tunnels Reinforcement schemes Under-crossing Old building Numerical simulation

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Boosting electrocatalytic nitrate reduction to ammonia via Cu_(2)O/Cu(Oh)_(2)heterostructures promoting electron transfer

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Nano Research 2024年第6期17卷 4898-4907页

作者： Jing geng Sihan Ji Anhui Province International Research Center on Advanced Building materials School of Materials Science and Chemical EngineeringAnhui Jianzhu UniversityHefei 230601China Anhui Province Key Laboratory of Advanced Building materials Anhui Jianzhu UniversityHefei 230601China School of Energy materials and Chemical Engineering Hefei UniversityHefei 230601China

Electrocatalytic nitrate(NO_(3)^(−))reduction to ammonia(Nh_(3))offers a viable approach for sustainable Nh_(3)production and environmental ***(Cu)possesses a distinctive electronic structure,which can augment the reaction kinetics of NO_(3)^(−)and impede hydrogen evolution reaction(hER),rendering it a promising contender for the electrosynthesis of Nh_(3)from NO_(3)^(−).Nevertheless,the role of Cu_(2)O in copper-based catalysts still requires further investigation for a more comprehensive ***,the Cu_(2)O/Cu(Oh)_(2)heterostructures are successfully fabricated through liquid laser irradiation using CuO nanoparticles as a *** and theoretical researches reveal that Cu_(2)O/Cu(Oh)_(2)heterostructure exhibits enhanced electrocatalytic performance for NO_(3)^(−)to Nh_(3)because Cu(Oh)_(2)promotes electron transfer and reduces the valence state of Cu active site in Cu_(2)***−0.6 V(*** hydrogen electrode(RhE)),the Nh_(3)yield reaches its maximum at 1630.66±29.72μg·h^(−1)·mgcat^(−1),while the maximum of Faraday efficiency(FE)is 76.95%±5.51%.This study expands the technical scope of copper-based catalyst preparation and enhances the understanding of the electrocatalytic mechanism of NO_(3)^(−)to Nh_(3).

关键词： Cu_(2)O/Cu(Oh)_(2)heterostructures electron transfer ammonia synthesis electrocatalysts nitrate

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Structural engineered living materials

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Nano Research 2024年第2期17卷 715-733页

作者： Yang geng Zian Jia Ling Li 635 Prices Fork Road Department of Mechanical EngineeringVirginia Polytechnic Institute and State UniversityBlacksburg VA24061USA

Biological structural materials not only exhibit remarkable mechanical properties but also often embody dynamic characteristics such as environmental responsiveness,autonomy,and self-healing,which are difficult to achieve in conventional engineering *** merging materials science,synthetic biology,and other disciplines,engineered living materials(ELMs)provide a promising solution to combine living organisms with abiotic components,thus facilitating the construction of functional“living”*** natural materials,ELMs possess vitality and hold immense application potential in areas such as medicine,electronics,and construction,captivating increasing research attention *** an emerging branch of ELMs,structural ELMs aim to mimic living biological structural materials by achieving desired mechanical performance while maintaining important“living”*** we summarize the recent progress and provide our perspectives for this emerging research *** first summarize the superiority of structural ELMs by reviewing biological structural materials and biomimetic material design ***,we provide a systematic discussion on the definition and classifications of structural ELMs,their mechanical performance,and physiological ***,we summarize some critical challenges faced by structural ELMs and highlight directions of future *** hope this review article can provide a timely summary of the state of the art and relevant perspectives for future development of structural ELMs.

关键词： structural materials engineered living materials(ELMs) structural ELMs composites mechanical properties

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Optimizing urban block morphologies for net-zero energy cities:Exploring photovoltaic potential and urban design prototype

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Building Simulation 2024年第4期17卷 607-624页

作者： Xiaotian geng Dong Xie Zhonghua Gou School of Urban Design Wuhan UniversityWuhanChina

The morphology of urban areas plays a crucial role in determining solar potential,which directly affects photovoltaic capacity and the achievement of net-zero *** study focuses on the City of Melbourne to investigate the utilization of solar energy across different urban densities and proposes optimized *** analysis encompasses blocks with diverse population densities,examining medium and high-density *** utilizing a multi-objective genetic optimization approach,the urban morphology of these blocks is *** findings indicate that low-density blocks exhibit photovoltaic potential ranging from 1 to 6.6 times their total energy *** and high-density blocks achieve photovoltaic potential levels approximately equivalent to 40%-85%of their overall energy ***,significant variations in photovoltaic potential are observed among different urban forms within medium and high-density ***“elevated corners with central valley”prototype is proposed as an effective approach,enhancing the overall photovoltaic potential by approximately 14%.This study introduces novel analytical concepts,shedding light on the intricate relationship between urban morphologies and photovoltaic potential.

关键词： net-zero energy solar energy urban density urban morphology multi-objective optimization photovoltaic potential

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LA-D-B1,a novel Abemaciclib derivative,exerts anti-breast cancer effects through CDK4/6

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BIOCELL 2024年第5期48卷 847-860页

作者： LING ma ZIRUI JIANG XIAO hOU YUTING XU ZIYUN ChEN SIYI ZhANG hANXUE LI ShAOJIE ma geng ZhANG XIUJUN WANG JING JI Jiangsu Key Laboratory of marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang222000China School of Medicine Xiamen UniversityXiamen361102China

Background:Regulatory proteins involved in h.man cellular division and proliferation,cyclin-dependent kinases 4 and 6(CDK4/6)are overexpressed in numerous cancers,including triple-negative breast cancer(TNBC).TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis,and has a single treatment *** one of the CDK4/6 inhibitors,abemaciclib can effectively inhibit the growth of breast *** this study,we synthesized LA-D-B1,a derivative of Abemaciclib,and investigated its anti-tumor effects in breast ***:Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** cloning and migration abilities were determined by colony formation assay and wound healing *** invasion abilities and adhesion were determined by cell invasion assay and cell adhesion *** impact of compound LA-D-B1 on cell proliferation and the cell cycle was analyzed through Western blotting,which quantified the levels of proteins associated with the cyclin-dependent kinase(CDK)4/6-cyclin D-Rb-E2F *** in vivo anti-tumor activity of compound LA-D-B1 was investigated using a chick chorioallantoic membrane(CAM)***:The study demonstrated that LA-D-B1 effectively suppressed breast cancer cell proliferation,induced apoptosis,and caused cell cycle ***,LA-D-B1 reduced the expression of key proteins in the CDK4/6-cyclin D-Rb-E2F pathway,including CDK4,CDK6 and *** results also indicated significant antitumor activity of LA-D-B1 in a transplanted tumor ***:In this study,LA-D-B1 demonstrated a potent anti-tumor effect by effectively suppressing cell proliferation and inhibiting cell cycle progression in breast *** findings highlight the potential of LA-D-B1 as a valuable compound for enhancing therapeutic outcomes and controlling the progression of breast cancer.

关键词： CDK4/6 inhibitor Breast cancer Antitumor activity Cell cycle

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Point defects in 2-D liquid crystals with a singular potential:Profiles and stability

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Science China math.matics 2024年第11期67卷 2515-2540页

作者： Zhiyuan geng Wei Wang Basque Center for Applied math.matics School of math.matical Sciences Zhejiang University

We study radial symmetric point defects with degree k/2 in the 2-D disk or R2in the Q-tensor framework with a singular bulk energy,which is defined by Bingham ***,we obtain the existence of solutions for the profiles of radial symmetric point defects with degree k/2 in the 2-D disk or ***,we prove that the solution is stable for |k| = 1 and unstable for |k| > *** identities are derived and utilized throughout the proof of existence and stability/instability.

关键词： radial symmetric point defects singular bulk potential Bingham closure stability

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