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Six-month clinical outcomes of Firebird 2TM sirolimus-eluting stent implantation in real-world patients with coronary artery diseases

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Chinese Medical Journal 2011年第6期124卷 831-835页

作者： ge jun-bo zhang feng qian ju-ying ge lei liu xue-bo zhou jun Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai 200032 China

Background The Firebird 2TM sirolimus-eluting stent （Firebird 2 stent） is a second-generation sirolimus-eluting stent which has a cobalt-chromium alloy stent platform, a brand new bracket structure, and two layers of styrene-butylenes-styrene polymer coatings with better biocompatibility. The Firebird 2TM cObalt-Chromium alloy sirolimus-elUting Stent registry （FOCUS registry） aimed to evaluate the safety and efficacy of the Firebird 2 stent in patients with coronary artery disease in daily *** The FOCUS registry is a prospective, non-randomized, international multi-center, single-arm clinical *** March 2009 and February 2010, 5084 patients receiving at least 1 Firebird 2 stent during daily clinical practice at 83 medical centers were *** Of the 5084 patients enrolled in the registry, 5077 and 5058 were respectively available for 30 days and 6 months follow-up. The 30-day rate of major adverse cardiac events （MACE） was 1.20%, including 13 cardiac deaths, 46 non-fatal myocardial infarction （MI）, and 6 target vessel revascularization （TVR）. At 6 months follow-up, the rate of MACE was 1.80%. There were 32 cardiac deaths, 48 non-fatal MI, and 15 TVR. According to the Academic Research Consortium definition, definite/probable stent thrombosis （ST） occurred in 0.43% （22/5058） of patients, including 8 cases of acute ST, 11 subacute ST, and 3 late *** The Firebird 2 stent showed the promising efficacy and safety at 30 days and 6 months in a real-world population of patients with coronary artery diseases.

关键词： sirolimus-eluting stent percutaneous coronary intervention coronary artery disease cobalt-chromium alloy

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Epigenetics in the modern era of crop improvements

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Science China Life Sciences 2025年

作者： Yan xue Xiaofeng Cao Xiangsong Chen Xian Deng Xingwang Deng Yong Ding Aiwu Dong Chengguo Duan Xiaofeng Fang lei Gong Zhizhong Gong Xiaofeng Gu Chongsheng He Hang He Shengbo He Xinjian He Yan He Yuehui He Guifang Jia Danhua Jiang Jianjun Jiang Jinsheng Lai Zhaobo Lang Chenlong Li Qing Li Xingwang Li Bao liu Bing liu Xiao Luo Yijun Qi Weiqiang qian Guodong Ren Qingxin Song Xianwei Song Zhixi Tian Jiawei Wang Yuan Wang Liang Wu Zhe Wu Rui Xia jun Xiao Lin Xu Zhengyi Xu Wenhao Yan Hongchun Yang Jixian Zhai Yijing zhang Yusheng Zhao xuehua Zhong Daoxiu zhou Ming zhou Yue zhou bo Zhu Jiankang Zhu Qikun liu College of Life Sciences Institute of Life Science and Green Development Hebei University Biotechnology Research Institute Chinese Academy of Agricultural Sciences College of Biology Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan Engineering and Technology Research Center of Hybrid Rapeseed Hunan University Institute of Advanced Agricultural Sciences School of Advanced Agricultural Sciences Peking University State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University National Institute of Biological Sciences Key Laboratory of Seed Innovation Institute of Genetics and Developmental Biology Chinese Academy of Sciences School of Advanced Agricultural Sciences Peking-Tsinghua Center for Life Sciences Peking University Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Key Laboratory of Seed Innovation State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences State Key Laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in Weifang State Key Laboratory of Crop Stress Adaptation and Improvement School of Life Sciences Henan University State Key Laboratory of Maize Bio-breeding National Maize Improvement Center Department of Plant Genetics and Breeding China Agricultural University Frontiers Science Center for Molecular Design Breeding China Agricultural University Center for Crop Functional genomics and Molecular Breeding China Agricultural University Sanya Institute of China Agricultural University Hainan Yazhou Bay Seed Laboratory Institute of Advan

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades,our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits. With recent technological advancements, epigenetic regulations at the single-cell level and at the large-scale population level are emerging as new focuses. This review offers an in-depth synthesis of the diverse epigenetic regulations, detailing the catalytic machinery and regulatory functions. It delves into the intricate interplay among various epigenetic elements and their collective influence on the modulation of crop traits. Furthermore, it examines recent breakthroughs in technologies for epigenetic modifications and their integration into strategies for crop improvement. The review underscores the transformative potential of epigenetic strategies in bolstering crop performance, advocating for the development of efficient tools to fully exploit the agricultural benefits of epigenetic insights.

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Prevalence and characteristics of myocardial bridging in coronary angiogram data from consecutive 5525 patients

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Chinese Medical Journal 2009年第6期122卷 632-635页

作者： qian ju-ying zhang feng DONG Min MA Jian-ying ge lei liu xue-bo FAN Bing WANG Qi-bing CUI Shan-jing ge jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China

Background Large discrepancy of the incidence of myocardial bridging （MB） has been reported either among the postmortem studies or among the studies with coronary angiogram. This study was to investigate the prevalence of MB in large number of coronary angiograms and the angiographic characteristics of MB.Methods A total of 5525 consecutive patients who underwent first diagnostic coronary angiography from January 2003 to March 2006 in Zhongshan Hospital were enrolled in this study. MB was diagnosed when the angiographical ＂milking effect＂, defined as the systolic compression and complete or partly release of the compression in diastole, was seen in the epicardial coronary arteries. Angiography was routinely repeated after intracoronary injection of 200 pg nitroglycerin. The systolic compression and length of MB were compared before and after the administration of nitroglycerin and also before and after stent implantation in patients with significant stenosis in segment proximal to the MB.Results Among 5525 patients, MBs were found in a total of 888 patients angiographically with the prevalence of 16.1%. Atherosclerotic lesions were found more often in the segment proximal to the MB with 344/854 （40.3%） patients than in the segment distal to the MB with 47/854 （5.5%）（P 〈0.01）. The systolic compression （（43.3±13.7）% at baseline vs （54.2±14.0）% after nitroglycerine） and the average length （（20.9±7.5） mm at baseline vs （22.7±8.0） mm after nitroglycerine） of the MB segment were increased after intracoronary injection of nitroglycerin （both P 〈0.01）. Stent implantation was performed in 88 patients with significant stenosis in the segment proximal to the MB. The systolic compression and the length of the MB segment were increased after stenting compared with those before stenting （systolic compression, （49.4±14.6）% at baseline vs （57.3±12.3）% after stenting, and length of MB, （19.5±6.1） mm at baseline vs （21.8±6.3） mm after stenting, P 〈0.01）.Conclusions MB was a fr

关键词： myocardial bridging coronary angiography prevalence nitroglycerine stent

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Retrograde approach for the recanalization of coronary chronic total occlusion： preliminary experience of a single center

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Chinese Medical Journal 2010年第7期123卷 857-863页

作者： ge lei qian ju-ying liu xue-bo QIN Qing CUI Shan-jing YAO Kang SHEN Li MA Jian-ying HUANG Dong XU Shi-kun zhang feng WANG Xiang-fei WANG Qi-bing FAN Bing YAN Yan feng Qi WANG Hao SHEN An ZHU Ming-hui ge jun-bo Department of Cardiology Zhongshan Hospital Fudan UniversityShanghai Institute of Cardiovascular Diseases Shanghai 200032China

Background The success rate of antegrade approach for chronic total occlusions （CTO） recanalization has not dramatically increased, especially in complex CTO subset. The retrograde technique may hold great promise. This report aimed to describe our experience of retrograde recanalization for CTO, focusing on its safety and feasibility. Methods We identified 42 patients who underwent revascularization in CTO with retrograde approach from july 2005 to November 2009 in our *** Three kinds of strategy were applied： retrograde as primary strategy （50.0%）, retrograde immediately after antegrade failure （26.2%） and repeat procedure after previous antegrade failure （23.8%）. Septal collaterals were more frequently used as the retrograde access route （92.9%）. Overall success rate was 88.1%. In patients with successful retrograde wire crossing collateral channel to the distal cap of CTO, the success rate of recanalization was 94.1%. In patient with failure to cross the collaterals, the success rate was 62.5%. Eight different kinds of retrograde techniques were used： kissing wire technique （35.3%）, wire trapped and reverse wire trapped technique （17.6%）, back-end balloon and microcatherer reversal technique （14.7%）, controlled antegrade and retrograde subintimal tracking （CART） technique （8.8%）, reverse CART and modified reverse CART technique （8.8%）, retrograde wire crossing technique （2.9%）. There were 4 complications occurred without in-hospital major adverse cardiac events （MACE）. In-hospital MACE was 7.7%. All of them were non-Q wave myocardial infarction. There were no cases of death or target vessel revascularization, either surgery or *** The retrograde approach can be an effective tool for increasing the success rate of recanalization in the very complex CTO. To ensure the success and safety of the approach, careful case selection and device handling by experienced operators is essential.

关键词： chronic total occlusions retrograde collaterals percutaneous coronary intervention

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Experimental study of a THgeM detector with mini-rims

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Chinese Physics C 2012年第2期36卷 142-145页

作者： zhang Ai-Wu YU bo-Xiang XIE Yu-Guang liu Hong-Bang AN Zheng-Hua WANG Zhi-Cang CAI Xiao SUN Xi-lei SHI feng FANG Jian xue Zhen LÜQi-Wen SUN Li-jun ge Yong-Shuai liu ying-Biao HU Tao zhou Li LÜjun-Guang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Graduate University of Chinese Academy of Sciences Beijing 100049China Shanxi University Taiyuan 030006China

The gas gain and energy resolution of single and double THgeM detectors （5 cm×5 cm effective area） with mini-rims （rim less than 10 um） were studied. The maximum gain was found to reach 5×103 and 2 × 105 for single and double THgeMs respectively, while the energy resolution for 5.9 keV X-rays varied from 18% to 28% for both single and double THgeM detectors of different hole sizes and thicknesses. Different combinations were also investigated of noble gases （argon, neon） mixed with a quantity of other gases （isobutane, methane） at atmospheric pressure.

关键词： THgeM gas gain energy resolution mini-rim

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Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates

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Virologica Sinica 2021年第5期36卷 879-889页

作者： Yan-feng Yao Ze-jun Wang Ren-Di Jiang xue Hu Hua-jun zhang Yi-Wu zhou ge Gao ying Chen Yun Peng Mei-Qin liu Ya-Nan zhang juan Min Jia Lu Xiao-Xiao Gao Jing Guo Cheng Peng Xu-Rui Shen qian Li Kai Zhao Lian Yang Xin Wan bo zhang Wen-Hui Wang Jia Wu Peng zhou Xing-Lou Yang Shuo Shen Chao Shan Zhi-Ming Yuan Zheng-Li Shi Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Wuhan Institute of Biological Products Co.Ltd Jiangxia DistrictWuhan 430024China University of Chinese Academy of Sciences Beijing 100049China Department of Forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430074China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so ***,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative *** is the most effective approach to eradicate a *** tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human *** we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human *** data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested *** addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in *** results warranted positive outcomes in future clinical trials in humans.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Inactivated vaccine Transgenic mouse Non-human primate

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Progress in ceramic materials and structure design toward advanced thermal barrier coatings

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Journal of Advanced Ceramics 2022年第7期11卷 985-1068页

作者： Zhi-Yuan WEI Guo-Hui MENG Lin CHEN Guang-Rong LI Mei-jun liu Wei-Xu zhang Li-Na ZHAO qiang zhang Xiao-Dong zhang Chun-lei WAN Zhi-xue QU Lin CHEN Jing feng Ling liu Hui DONG Ze-Bin BAO Xiao-feng ZHAO Xiao-feng zhang lei GUO Liang WANG bo CHENG Wei-Wei zhang Peng-Yun XU Guan-jun YANG Hong-Neng CAI Hong CUI You WANG Fu-Xing YE Zhuang MA Wei PAN Min liu Ke-Song zhou Chang-Jiu LI State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Strength and Vibration of Mechanical Structures Department of Engineering MechanicsSchool of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an Aerospace Composite Research Institute Xi’an 710025China AECC Beijing Institute of Aeronautical Materials Beijing 100095China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of New Ceramics&Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Xi’an Key Laboratory of High Performance Oil and Gas Field Materials School of Materials Science and EngineeringXi’an Shiyou UniversityXi’an 710065China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming Shanghai Jiao Tong UniversityShanghai 200240China National Engineering Laboratory for Modern Materials Surface Engineering Technology the Key Lab of Guangdong for Modern Surface Engineering TechnologyInstitute of New MaterialsGuangdong Academy of SciencesGuangzhou 510650China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Integrated Computational Materials Research Centre Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China State Key Laboratory of Advanced Processing and Recycling of

Thermal barrier coatings(TBCs)can effectively protect the alloy substrate of hot components in aeroengines or land-based gas turbines by the thermal insulation and corrosion/erosion resistance of the ceramic top ***,the continuous pursuit of a higher operating temperature leads to degradation,delamination,and premature failure of the top *** new ceramic materials and new coating structures must be developed to meet the demand for future advanced TBC *** this paper,the latest progress of some new ceramic materials is first ***,a comprehensive spalling mechanism of the ceramic top coat is summarized to understand the dependence of lifetime on various factors such as oxidation scale growth,ceramic sintering,erosion,and calcium–magnesium–aluminium–silicate(CMAS)molten salt ***,new structural design methods for high-performance TBCs are discussed from the perspectives of lamellar,columnar,and nanostructure *** latest developments of ceramic top coat will be presented in terms of material selection,structural design,and failure mechanism,and the comprehensive guidance will be provided for the development of next-generation advanced TBCs with higher temperature resistance,better thermal insulation,and longer lifetime.

关键词： thermal barrier coatings(TBCs) ceramic material degradation and failure structure design long lifetime

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A cross-sectional study of olfactory and taste disorders among COVID-19 patients in China

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Military Medical Research 2022年第3期9卷 376-378页

作者： Jian-Hui Li Yi Sun Mei-Rong Li Hu Yuan Chang-Liang Yang Cheng-Cheng Huang feng-Jie zhou Rui-Yao Chen lei-bo zhang Ning Yu Qiong liu Jing-Jing He xue-jun zhou Xiao-Bing Fu Shi-Ming Yang College of Otolaryngology Head and Neck Surgery Chinese PLA General Hospital National Clinical Research Center for Otolaryngologic Diseases Department of Otolaryngology Head and Neck Surgery Chinese PLA General Hospital Hainan Hospital Hainan Clinical Research Center for Otolaryngologic Diseases Department of Otolaryngology Head and Neck Surgery General Hospital of Central Theater Command of PLA Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center PLA General Hospital and PLA Medical College PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and Regeneration Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences

To determine the prevalence and clinical features of olfactory and taste disorders among coronavirus disease 2019(COVID-19)patients in China.A cross-sectional study was performed in Wuhan from April 3,2020 to April 15,2020.A total of 187 patients with confirmed severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)completed face-to-face interviews or telephone *** found that the prevalence of olfactory and taste disorders was significantly lower in the Chinese cohort than in foreign COVID-19 *** were more prone to olfactory and taste *** some patients,olfactory and taste disorders precede other symptoms and can be used as early screening and warning signs.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Olfactory Taste

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血管内超声评价雷帕霉素洗脱支架再狭窄及早期血栓形成

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中华心血管病杂志 2009年第5期37卷 397-401页

作者：刘学波钱菊英张峰葛雷黄东樊冰王齐兵葛均波复旦大学附属中山医院心内科上海市心血管病研究所上海200032

目的以血管内超声评价雷帕霉素洗脱支架置入术后发生支架内再狭窄及血栓形成的机械性危险因素。方法对雷帕霉素洗脱支架置入术后发生支架内再狭窄或早期（≤30d）血栓形成的60例患者（事件组）及无支架内再狭窄和早期血栓形成的34例患... 详细信息

目的以血管内超声评价雷帕霉素洗脱支架置入术后发生支架内再狭窄及血栓形成的机械性危险因素。方法对雷帕霉素洗脱支架置入术后发生支架内再狭窄或早期（≤30d）血栓形成的60例患者（事件组）及无支架内再狭窄和早期血栓形成的34例患者（无事件组）的血管内超声资料进行分析比较。结果事件组发生支架内再狭窄43例，早期血栓形成17例。与无事件组比较，事件组的最小支架面积（MSA）[（4.6±1.6）mm^2比（5.8±1.6）mm^2，P〈0.01]、最小支架直径[（2.2±0.5）mm比（2.5±0.4）mm，P〈0.01]和支架扩张率[（69.2±20.7）％比（80.6±17.2）％，P〈0.01]较小、纵向支架对称性较差（2.0±0.6比1.7±0.6，P〈0.05）。MSA〈4mm^2（43.3％比14.7％，P〈0.01）和支架扩张率〈60％（40.7％比11.8％，P〈0.01）在事件组较常见。与无事件组比较，事件组的近段残余斑块负荷较大[（49.0±15.5）％比（38.4±17.6）％，P〈0.01]。Logistic回归分析显示，MSA（OR：0.7，95％ CI：0.5-0.8，P〈0.01）和近段残余斑块负荷（OR：280.7，95％ CI：17.2-40583.6，P〈0.01）是药物洗脱支架发生再狭窄或早期血栓形成的独立预测因素。结论较小的MSA和较重的近段残余病变易导致雷帕霉素洗脱支架发生支架内再狭窄及早期血栓形成。

关键词：冠状动脉疾病支架超声检查介入性

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左主干冠状动脉病变的血管内超声研究

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中华心血管病杂志 2008年第11期36卷 975-979页

作者：刘学波钱菊英葛雷张峰樊冰王齐兵路艳葛均波复旦大学附属中山医院心内科上海市心血管病研究所 200032

目的血管内超声评价非严重钙化性左主干病变的形态特点，探讨开口和非开口部位形成狭窄的不同机制。方法2004年10月至2007年10月，共人选造影确诊或可疑的狭窄病变并行血管内超声检查的153例（开口47例，非开口106例）非严重钙化性左主... 详细信息

目的血管内超声评价非严重钙化性左主干病变的形态特点，探讨开口和非开口部位形成狭窄的不同机制。方法2004年10月至2007年10月，共人选造影确诊或可疑的狭窄病变并行血管内超声检查的153例（开口47例，非开口106例）非严重钙化性左主干病变，定性和定量分析血管内超声图像；负性重构定义为重构指数〈0．95。结果左主干参考节段平均管腔直径和血管（外弹力膜）直径为（4．1±0．8）mm和（5．3±0．8）mm。开口病变的纤维性、钙化性和软斑块分别为70．2％、19．2％和8．5％，而非开口病变为35．8％、43．4％和3．8％，两者差异有统计学意义（P=0．01）。总体来说，31．1％病例的最小管腔面积〈6mm。，其中开口组29．5％，非开口组31．9％（P=0．87）。最小管腔面积在两组相似，但非开口组的斑块面积[（13．3±5．4）mm。比（10．8±4．5）mm^2，P=0．007]和斑块负荷（61．9％±14．5％比54．8％±15．9％，P=0．020）均显著大于开口组，斑块负荷〉50％的比例更高（84．8％比61．3％，P=0．002）。开口病变的重构系数显著低于非开口病变（0．9±0．2比1．0±0．2，P=0．000），而且负性重构更多见（74．5％和34．9％，P=0．000）。logistic回归分析发现，病变部位（OR=4．9，P=0．004）、斑块面积（OR=1．2，P=0．01）和斑块负荷（OR=0．003，P=0．000）是左主干发生重构的独立预测因素。结论负性重构现象在左主干开口病变中更常见，可能是其狭窄形成的机制之一。狭窄程度不确定的冠状动脉左主干病变需要血管内超声精确评价。

关键词：冠状动脉疾病超声检查介入性

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